#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91WZ8-1 uniprotkb:O70585 intact:EBI-643199|ensembl:ENSMUSP00000072170 intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194 psi-mi:q91wz8-1(display_long)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)|uniprotkb:Dysbindin 1-A(isoform synonym) psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781689|imex:IM-19237-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643186(dtbp1_mouse)|ensembl:ENSMUSG00000057531(gene)|ensembl:ENSMUST00000072329(transcript) refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 - - - comment:This interaction was detected when both mouse muscle and mouse brain cDNA libraries were screened in yeast two hybrid assays.|comment:Location of binding site taken from Figure 1 B in text.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/01/17 2014/10/16 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090 intact-crc:0E6FC36961298D49|rigid:Et+zwh893JgrpMRaEcUA1QZ2tuM false binding-associated region:88-352 - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O70585 uniprotkb:Q91WZ8-2 intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194 intact:EBI-643203 psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:q91wz8-2(display_long)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0018"(two hybrid) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781699|imex:IM-19237-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 intact:EBI-643186(dtbp1_mouse) - - - comment:Binding between beta dystrobrevin and this dysbindin isoform was only detected when a mouse brain cDNA library was screened using a yeast two hybrid assay.|comment:Location of binding site taken from Figure 1 B in text.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/01/17 2014/10/16 rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090 rogid:x7XSz8gdYq/wwlgZBIFYARfhODY10090 intact-crc:6AFC2B51713820D1|rigid:pYEeUlYYC8M5mMm6GRwDPDKIOUU false - binding-associated region:?-? - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91WZ8-1 uniprotkb:O70585 intact:EBI-643199|ensembl:ENSMUSP00000072170 intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194 psi-mi:q91wz8-1(display_long)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)|uniprotkb:Dysbindin 1-A(isoform synonym) psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:"MI:0018"(two hybrid) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781733|imex:IM-19237-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-643186(dtbp1_mouse)|ensembl:ENSMUSG00000057531(gene)|ensembl:ENSMUST00000072329(transcript) refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/01/17 2014/10/16 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090 intact-crc:6B366E9212FA3973|rigid:Et+zwh893JgrpMRaEcUA1QZ2tuM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9D2N4 uniprotkb:Q91WZ8 intact:EBI-296019|uniprotkb:P97319|uniprotkb:Q61498|uniprotkb:Q61499|uniprotkb:Q9QZZ5|uniprotkb:Q9WUL9|uniprotkb:Q9WUM0 intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43 psi-mi:dtna_mouse(display_long)|uniprotkb:Dtna(gene name)|psi-mi:Dtna(display_short)|uniprotkb:Dtn(gene name synonym)|uniprotkb:Alpha-dystrobrevin(gene name synonym) psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0018"(two hybrid) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-781742|imex:IM-19237-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016014"(dystrobrevin complex)|refseq:NP_001272736.1|refseq:NP_001272739.1|refseq:NP_001272746.1|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045202"(synapse)|go:"GO:0099536"(synaptic signaling)|refseq:NP_034217.2|interpro:IPR017432(Distrobrevin)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR043145|refseq:XP_017173306.1|refseq:XP_017173308.1|refseq:XP_017173310.1|refseq:XP_017173311.1|refseq:XP_017173312.1|refseq:XP_017173313.1|refseq:XP_017173315.1 ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2006/01/17 2014/10/16 rogid:gqIbCFldISt+vbYeRHs3sswGPWU10090 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 intact-crc:C84DF71244BDFEC4|rigid:0q2DjtoRbAlwoBr6Ek0wPZxbcsA false binding-associated region:272-503 - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O70585 uniprotkb:Q91WZ8-1 intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194 intact:EBI-643199|ensembl:ENSMUSP00000072170 psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:q91wz8-1(display_long)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)|uniprotkb:Dysbindin 1-A(isoform synonym) psi-mi:"MI:0416"(fluorescence microscopy) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-782119|imex:IM-19237-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 intact:EBI-643186(dtbp1_mouse)|ensembl:ENSMUSG00000057531(gene)|ensembl:ENSMUST00000072329(transcript) go:"GO:0005737"(cytoplasm) - - comment:Co-transfection of proteins results in the re-distribution of beta-dystrobrevin into the cytoplasm and precise colocalization with dysbindin. Note no colocalisation was seen in the nucleus.|comment:The authors note that their data suggest that both coiled-coils domains within beta-dysbrevin are not essential for the interaction of dysbindin with dystrobrevin.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/01/17 2014/10/16 rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 intact-crc:713969355C26974B|rigid:Et+zwh893JgrpMRaEcUA1QZ2tuM false binding-associated region:487-579,1-384 myc tag:n-n - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9D2N4 uniprotkb:Q91WZ8 intact:EBI-296019|uniprotkb:P97319|uniprotkb:Q61498|uniprotkb:Q61499|uniprotkb:Q9QZZ5|uniprotkb:Q9WUL9|uniprotkb:Q9WUM0 intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43 psi-mi:dtna_mouse(display_long)|uniprotkb:Dtna(gene name)|psi-mi:Dtna(display_short)|uniprotkb:Dtn(gene name synonym)|uniprotkb:Alpha-dystrobrevin(gene name synonym) psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-782172|imex:IM-19237-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016014"(dystrobrevin complex)|refseq:NP_001272736.1|refseq:NP_001272739.1|refseq:NP_001272746.1|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045202"(synapse)|go:"GO:0099536"(synaptic signaling)|refseq:NP_034217.2|interpro:IPR017432(Distrobrevin)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR043145|refseq:XP_017173306.1|refseq:XP_017173308.1|refseq:XP_017173310.1|refseq:XP_017173311.1|refseq:XP_017173312.1|refseq:XP_017173313.1|refseq:XP_017173315.1 ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722 - - - full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/01/17 2014/10/16 rogid:gqIbCFldISt+vbYeRHs3sswGPWU10090 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 intact-crc:4DF1EA744E35331F|rigid:0q2DjtoRbAlwoBr6Ek0wPZxbcsA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91WZ8 uniprotkb:O70585 intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43 intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194 psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-782187|imex:IM-19237-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722 refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 - - - comment:"Co-immunoprecipitated proteins were identified by Western blotting with bCT-FP antibody. However bCT-FP detects b-dystrobrevin and a-dystrobrevin-1 and -2)."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2006/01/17 2014/10/16 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090 intact-crc:809644C8AB106A65|rigid:Et+zwh893JgrpMRaEcUA1QZ2tuM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P84060 uniprotkb:Q5M834 intact:EBI-782242|uniprotkb:Q66HF4|ensembl:ENSRNOP00000057536 intact:EBI-782236|uniprotkb:Q6GX90 psi-mi:dtnb_rat(display_long)|uniprotkb:Beta-dystrobrevin(gene name synonym)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short) psi-mi:dtbp1_rat(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-782254|imex:IM-19237-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1309579|refseq:NP_001012191.1|ensembl:ENSRNOG00000011914(gene)|ensembl:ENSRNOT00000060810(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145 interpro:IPR007531(Dysbindin)|rgd:1590759|refseq:NP_001032753.1|reactome:R-RNO-432722|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007420"(brain development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis) - - - comment:Note the antibody used for detection of immunoprecipitated proteins was cross reactive between alpha-dystrobrevin isoforms and beta-dystrobrevin. Identification of proteins made by molecular weight.|comment:"Note the antibody used for immunoprecipitation of rat dysbindin (Q5M834) was raised against amino acids 196�352 of mouse dysbindin protein."|comment:This interaction was detected in immunoprecipitations of rat brain extracts only.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2006/01/17 2014/10/16 rogid:xIdGWZsVihZGdBmXZ4cg7YMAs7I10116 rogid:ebOBgKePACjqy8iLu6nxUmXUWt410116 intact-crc:7E67E1B656F5C671|rigid:V0VUYv4JBi64raiU+AMP/We+VXM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5M834 uniprotkb:O55147 intact:EBI-782236|uniprotkb:Q6GX90 intact:EBI-780380 psi-mi:dtbp1_rat(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:o55147_rat(display_long)|uniprotkb:Utrn(gene name)|psi-mi:Utrn(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-782267|imex:IM-19237-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR007531(Dysbindin)|rgd:1590759|refseq:NP_001032753.1|reactome:R-RNO-432722|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007420"(brain development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis) refseq:NP_037202.1|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR000433(Zinc finger, ZZ-type)|rcsb pdb:3UUL|rcsb pdb:3UUM|rgd:3947|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045211"(postsynaptic membrane) - - - comment:"Note the antibody used for immunoprecipitation of rat dysbindin (Q5M834) was raised against amino acids 196�352 of mouse dysbindin protein."|comment:Interaction was detected in rat brain extract but not in rat muscle extract.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain) - 2006/01/17 2014/10/16 rogid:ebOBgKePACjqy8iLu6nxUmXUWt410116 rogid:AsZ+a7AeTAV4cM3XFfT+a3Wktpw10116 intact-crc:9DD1F13E836C2A79|rigid:P1LBLh05AwDphxcBVNhZ49Gl11A false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9D2N4 uniprotkb:Q91WZ8 intact:EBI-296019|uniprotkb:P97319|uniprotkb:Q61498|uniprotkb:Q61499|uniprotkb:Q9QZZ5|uniprotkb:Q9WUL9|uniprotkb:Q9WUM0 intact:EBI-643186|ensembl:ENSMUSP00000072170|uniprotkb:Q3TWK1|uniprotkb:Q6WXQ1|uniprotkb:Q80ZN4|uniprotkb:Q9CY43 psi-mi:dtna_mouse(display_long)|uniprotkb:Dtna(gene name)|psi-mi:Dtna(display_short)|uniprotkb:Dtn(gene name synonym)|uniprotkb:Alpha-dystrobrevin(gene name synonym) psi-mi:dtbp1_mouse(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-782272|imex:IM-19237-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016014"(dystrobrevin complex)|refseq:NP_001272736.1|refseq:NP_001272739.1|refseq:NP_001272746.1|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0042995"(cell projection)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045202"(synapse)|go:"GO:0099536"(synaptic signaling)|refseq:NP_034217.2|interpro:IPR017432(Distrobrevin)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR043145|refseq:XP_017173306.1|refseq:XP_017173308.1|refseq:XP_017173310.1|refseq:XP_017173311.1|refseq:XP_017173312.1|refseq:XP_017173313.1|refseq:XP_017173315.1 ensembl:ENSMUSG00000057531(gene)|refseq:NP_080048.2|ensembl:ENSMUST00000072329(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-MMU-432722 - - - comment:The proteins were shown to co-localize at the muscle sarcolemma.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-skeletal-muscle)|taxid:10090(Mus musculus skeletal muscle.) - 2006/01/17 2014/10/16 rogid:gqIbCFldISt+vbYeRHs3sswGPWU10090 rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090 intact-crc:43729C94AF5D2441|rigid:0q2DjtoRbAlwoBr6Ek0wPZxbcsA false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P11530 uniprotkb:Q5M834 intact:EBI-706166|ensembl:ENSRNOP00000029969|uniprotkb:F1M705 intact:EBI-782236|uniprotkb:Q6GX90 psi-mi:dmd_rat(display_long)|uniprotkb:Dmd(gene name)|psi-mi:Dmd(display_short) psi-mi:dtbp1_rat(display_long)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Benson et al. (2001) pubmed:11316798|imex:IM-19237|mint:MINT-5213958 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-782261|imex:IM-19237-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSRNOG00000046366(gene)|ensembl:ENSRNOT00000035692(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005840"(ribosome)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007517"(muscle organ development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0008065"(establishment of blood-nerve barrier)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008307"(structural constituent of muscle)|rgd:2507|refseq:XP_017457399.1|go:"GO:0009414"(response to water deprivation)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014809"(regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014904"(myotube cell development)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0017022"(myosin binding)|go:"GO:0017166"(vinculin binding)|go:"GO:0021629"(olfactory nerve structural organization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030055"(cell-substrate junction)|go:"GO:0030141"(secretory granule)|go:"GO:0030154"(cell differentiation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034622"|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043043"(peptide biosynthetic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045213"(neurotransmitter receptor metabolic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051647"(nucleus localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055001"(muscle cell development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060857"(establishment of glial blood-brain barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0086001"(cardiac muscle cell action potential)|go:"GO:0090287"(regulation of cellular response to growth factor stimulus)|go:"GO:0097449"(astrocyte projection)|go:"GO:0099617"(matrix side of mitochondrial inner membrane)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902083"(negative regulation of peptidyl-cysteine S-nitrosylation)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|reactome:R-RNO-390522 interpro:IPR007531(Dysbindin)|rgd:1590759|refseq:NP_001032753.1|reactome:R-RNO-432722|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006996"(organelle organization)|go:"GO:0007420"(brain development)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061646"(positive regulation of glutamate neurotransmitter secretion in response to membrane depolarization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis) - - - comment:"Note the antibody used for immunoprecipitation of rat dysbindin (Q5M834) was raised against amino acids 196�352 of mouse dysbindin protein."|comment:Interaction was detected in rat muscle extract but not in rat brain extract.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:1016(rat-skeletal_muscle)|taxid:1016(rat skeletal muscle) - 2006/01/17 2016/01/15 rogid:+tB82I1CIAu/nuaXmqNoSWqLp0o10116 rogid:ebOBgKePACjqy8iLu6nxUmXUWt410116 intact-crc:89E701BAA7B16FC8|rigid:fh+tTiAuX3Y7qkMTzYDVCMmrP0A false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)