#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q925H0 uniprotkb:Q62083 intact:EBI-8056179|uniprotkb:Q5SUU2|intact:MINT-223604|uniprotkb:Q61203|ensembl:ENSMUSP00000067095 intact:EBI-77550|uniprotkb:E9PY04 psi-mi:asic2_mouse(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym) psi-mi:pick1_mouse(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Duggan et al. (2002) pubmed:11739374|mint:MINT-5214875 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8056172|mint:MINT-58335 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001029185.1|refseq:NP_031410.1|ensembl:ENSMUSG00000020704(gene)|ensembl:ENSMUST00000066197(transcript)|go:"GO:0003026"(regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback)|go:"GO:0005216"(ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035690"|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|mint:MINT-595708(identity) go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|dip:DIP-283N|reactome:R-MMU-416993|mint:MINT-595699(identity) - comment:mint|function:"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F2|comment:"addition of a tyrosine to the C terminus, in ctBNaC1-(481-512)+Y, disrupts the interaction.

"|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/05/10 2014/10/16 rogid:uzd/HVj8ecrECukDAEI3Ucv5stc10090 rogid:veKbDBj2tGZ1NAtPY6jLz0uNk0010090 intact-crc:B5CC38F20A4C0914|rigid:14fCsvWrNpsE4ohJVMxaSpx2eXw false binding-associated region:481-512(MINT-595709)|mutation decreasing interaction:508-512(MINT-595712)|tag:?-?(MINT-595714) tag:?-?(MINT-595703)|mutation decreasing interaction:27-27,28-28(MINT-595700) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q925H0 uniprotkb:Q62083 intact:EBI-8056179|uniprotkb:Q5SUU2|intact:MINT-223604|uniprotkb:Q61203|ensembl:ENSMUSP00000067095 intact:EBI-77550|uniprotkb:E9PY04 psi-mi:asic2_mouse(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym) psi-mi:pick1_mouse(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Duggan et al. (2002) pubmed:11739374|mint:MINT-5214875 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8056300|mint:MINT-58333 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001029185.1|refseq:NP_031410.1|ensembl:ENSMUSG00000020704(gene)|ensembl:ENSMUST00000066197(transcript)|go:"GO:0003026"(regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback)|go:"GO:0005216"(ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035690"|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-MMU-2672351|mint:MINT-595860(identity) go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|dip:DIP-283N|reactome:R-MMU-416993|mint:MINT-595847(identity) - comment:mint|function:"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A F1B|comment:"Deletion of the last four amino acids of BNaC1, or addition of a tyrosine to the C terminus, in ctBNaC1-(481-512)+Y, disrupts the interaction.

"|comment:homomint|comment:domino|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/05/10 2014/10/16 rogid:uzd/HVj8ecrECukDAEI3Ucv5stc10090 rogid:veKbDBj2tGZ1NAtPY6jLz0uNk0010090 intact-crc:768D159E819B75C9|rigid:14fCsvWrNpsE4ohJVMxaSpx2eXw false tag:?-?(MINT-595864)|binding-associated region:481-512(MINT-595861) tag:?-?(MINT-595855)|mutation decreasing interaction:27-27,28-28(MINT-595852)|binding-associated region:22-105(MINT-595848) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P55926 uniprotkb:Q62083 intact:EBI-8056343|uniprotkb:O88762|uniprotkb:Q91YB8|intact:MINT-223538|uniprotkb:Q99NA1|ensembl:ENSRNOP00000068902 intact:EBI-77550|uniprotkb:E9PY04 psi-mi:asic1_rat(display_long)|uniprotkb:Asic1(gene name)|psi-mi:Asic1(display_short)|uniprotkb:Accn2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 2, neuronal(gene name synonym)|uniprotkb:Bnac2(gene name synonym)|uniprotkb:Brain sodium channel 2(gene name synonym) psi-mi:pick1_mouse(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Duggan et al. (2002) pubmed:11739374|mint:MINT-5214875 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8056336|mint:MINT-58334 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077068.1|rgd:71062|refseq:XP_006257440.1|go:"GO:0006812"(cation transport)|go:"GO:0007613"(memory)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0022890"(inorganic cation transmembrane transporter activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0044736"(acid-sensing ion channel activity)|go:"GO:0045202"(synapse)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071467"(cellular response to pH)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|reactome:R-RNO-2672351|ensembl:ENSRNOG00000059765(gene)|ensembl:ENSRNOT00000088191(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0005216"(ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|mint:MINT-595785(identity) go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|dip:DIP-283N|reactome:R-MMU-416993|mint:MINT-595772(identity) - comment:mint|function:"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Isoform 3 discrimates stronger than isoform 1 between monovalent cations. Isoform 3 can flux Ca(2+) while isoform 1 cannot. Heteromeric channels composed of isoform 2 and isoform 3 are active but have a lower pH-sensitivity. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F1A F1B|comment:homomint|comment:domino|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2005/05/10 2014/10/16 rogid:TnOZWwd+jb+kIBQ+84sYQ95WLyw10116 rogid:veKbDBj2tGZ1NAtPY6jLz0uNk0010090 intact-crc:C21223FFFDCF307C|rigid:CaCywyT166D0dOcdnESCrmnoEp0 false tag:?-?(MINT-595789)|binding-associated region:477-526(MINT-595786) mutation decreasing interaction:27-27,28-28(MINT-595777)|binding-associated region:22-105(MINT-595773)|tag:?-?(MINT-595780) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62083 uniprotkb:Q16515 intact:EBI-77550|uniprotkb:E9PY04 intact:EBI-79149|uniprotkb:Q13553|uniprotkb:Q6DJU1|uniprotkb:Q8N3E2|uniprotkb:E9PBX2|ensembl:ENSP00000352934 psi-mi:pick1_mouse(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:asic2_human(display_long)|uniprotkb:ASIC2(gene name)|psi-mi:ASIC2(display_short)|uniprotkb:ACCN(gene name synonym)|uniprotkb:ACCN1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:BNAC1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:MDEG(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Duggan et al. (2002) pubmed:11739374|mint:MINT-5214875 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8056415|mint:MINT-58336 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|dip:DIP-283N|reactome:R-MMU-416993|mint:MINT-595800(identity) refseq:NP_001085.2|refseq:NP_899233.1|ensembl:ENSG00000108684(gene)|ensembl:ENST00000359872(transcript)|go:"GO:0003026"(regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0098662"(inorganic cation transmembrane transport)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|rcsb pdb:6L6P|reactome:R-HSA-2672351|mint:MINT-595809(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3A|comment:homomint|comment:mint taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2005/05/10 2014/10/16 rogid:veKbDBj2tGZ1NAtPY6jLz0uNk0010090 rogid:ZlQ9b+ycydeYv3ubHSV3wf49NQs9606 intact-crc:F58FC5326EF0FECD|rigid:g+brepGXgc4jaKYsoo+Dm6QuYEI false mutation decreasing interaction:28-28,27-27(MINT-595801)|tag:?-?(MINT-595804) tag:?-?(MINT-595813)|binding-associated region:481-512(MINT-595810) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q62962 uniprotkb:Q9EP80 intact:EBI-8056477|uniprotkb:O55163|intact:MINT-223656 intact:EBI-77728|uniprotkb:Q546X4|uniprotkb:Q925D1 psi-mi:asic2_rat(display_long)|uniprotkb:Asic2(gene name)|psi-mi:Asic2(display_short)|uniprotkb:Accn1(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel(gene name synonym)|uniprotkb:Amiloride-sensitive brain sodium channel 2(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel 1, neuronal(gene name synonym)|uniprotkb:Amiloride-sensitive cation channel neuronal 1(gene name synonym)|uniprotkb:Bnac1(gene name synonym)|uniprotkb:Brain sodium channel 1(gene name synonym)|uniprotkb:Mammalian degenerin homolog(gene name synonym)|uniprotkb:Mdeg(gene name synonym) psi-mi:pick1_rat(display_long)|uniprotkb:Pick1(gene name)|psi-mi:Pick1(display_short)|uniprotkb:Prkcabp(gene name synonym)|uniprotkb:Protein kinase C-alpha-binding protein(gene name synonym)|uniprotkb:Protein interacting with C kinase 1(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Duggan et al. (2002) pubmed:11739374|mint:MINT-5214875 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0199"(deformylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8056539|mint:MINT-58337 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_037024.2|refseq:NP_001029186.1|rgd:2017|dip:DIP-41193N|go:"GO:0003026"(regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback)|go:"GO:0005216"(ion channel activity)|go:"GO:0005248"(voltage-gated sodium channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007602"(phototransduction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0022839"(ion gated channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035690"|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0050915"(sensory perception of sour taste)|go:"GO:0050974"(detection of mechanical stimulus involved in sensory perception)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|go:"GO:0043197"(dendritic spine)|reactome:R-RNO-2672351|mint:MINT-595838(identity) rgd:69437|refseq:NP_445912.1|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015844"(monoamine transport)|go:"GO:0015872"(dopamine transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021782"(glial cell development)|go:"GO:0030425"(dendrite)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098843"(postsynaptic endocytic zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|interpro:IPR036034|interpro:IPR037959|rcsb pdb:2LUI|rcsb pdb:2PKU|rcsb pdb:3HPK|rcsb pdb:3HPM|reactome:R-RNO-416993|mint:Q9EP80|dip:DIP-30941N|mint:MINT-595832(identity) - comment:mint|function:"Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Activation by an extracellular pH drop is followed by a rapid pH-independent inactivation. Heteromeric channel assembly seems to modulate channel properties"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F3B|comment:The authors were unable to demonstrate coimmunoprecipitation of PICK1 from cerebellar membrane extracts using a BNaC1 antibody; coimmunoprecipitation may be obscured in this case, because the precipitating antibody migrates with a mobility similar to that of PICK1 and is recognized at a low level by the secondary antibody used for immunoblotting.

|comment:homomint|comment:mint taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2005/05/10 2014/10/16 rogid:ZafUzFIbXkxMXYvzpeJBfQ+jYEI10116 rogid:py6ehB6OMAq34c71Oad5GTeNfHg10116 intact-crc:FE8EEDD0F6FDF276|rigid:PVEUrjTmiO5jCH/NR1jIcQ6uaxo false - tag:?-?(MINT-595833) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0072"(monoclonal antibody western blot)