#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7L0Q8	uniprotkb:P62993	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395457|mint:MINT-50684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211051(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-1211060(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:5646DBAEFE1A2ABD|rigid:/0TJner0UW1QUf8sznW6EtmuVQU	false	binding-associated region:1-47(MINT-1211052)|tag:?-?(MINT-1211055)	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7L0Q8	uniprotkb:Q13153	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395547|mint:MINT-50675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211120(identity)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|mint:MINT-1211126(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F3A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	intact-crc:4CBBF639FB4C8CA8|rigid:O9vvZolgPrvRj69aDuMNsGDlR+I	false	tag:?-?(MINT-1211121)	tag:?-?(MINT-1211127)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7L0Q8	uniprotkb:Q13153	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	intact:EBI-1307|uniprotkb:O75561|uniprotkb:Q13567|uniprotkb:Q32M53|uniprotkb:Q32M54|uniprotkb:Q86W79|intact:EBI-28976107|ensembl:ENSP00000348696	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:pak1_human(display_long)|uniprotkb:PAK1(gene name)|psi-mi:PAK1(display_short)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395528|mint:MINT-50674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211069(identity)	refseq:NP_001122092.1|refseq:NP_002567.3|ensembl:ENST00000278568|ensembl:ENSP00000278568|ensembl:ENSP00000348696|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|refseq:XP_011543382.1|refseq:XP_011543383.1|refseq:XP_011543384.1|refseq:XP_011543385.1|refseq:XP_011543386.1|refseq:XP_016873335.1|refseq:XP_016873336.1|refseq:XP_016873337.1|refseq:XP_016873338.1|refseq:XP_016873339.1|dip:DIP-31016N|ensembl:ENSG00000149269(gene)|ensembl:ENST00000356341(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|mint:Q13153|rcsb pdb:1F3M|rcsb pdb:1YHV|rcsb pdb:1YHW|rcsb pdb:1ZSG|rcsb pdb:2HY8|rcsb pdb:2QME|rcsb pdb:3DVP|rcsb pdb:3FXZ|rcsb pdb:3FY0|rcsb pdb:3Q4Z|rcsb pdb:3Q52|rcsb pdb:3Q53|rcsb pdb:4DAW|rcsb pdb:4EQC|rcsb pdb:4O0R|rcsb pdb:4O0T|rcsb pdb:4P90|rcsb pdb:4ZJI|rcsb pdb:4ZJJ|rcsb pdb:4ZLO|rcsb pdb:4ZY4|rcsb pdb:4ZY5|rcsb pdb:4ZY6|rcsb pdb:5DEW|rcsb pdb:5DEY|rcsb pdb:5DFP|rcsb pdb:5IME|rcsb pdb:5KBQ|rcsb pdb:5KBR|rcsb pdb:6B16|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-2871796|reactome:R-HSA-376172|reactome:R-HSA-389359|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-399954|reactome:R-HSA-428540|reactome:R-HSA-445144|reactome:R-HSA-445355|reactome:R-HSA-5218920|reactome:R-HSA-5621575|reactome:R-HSA-5625740|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-5687128|reactome:R-HSA-8964616|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013423|reactome:R-HSA-9013424|mint:MINT-1211075(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F2B|comment:Wrch-1 activates PAK that autophosphotilates its serine144|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	rogid:SbPL5+9oNR0PaVRo6xfpbAMQKB49606	intact-crc:A3AA837C9ED91546|rigid:O9vvZolgPrvRj69aDuMNsGDlR+I	false	tag:?-?(MINT-1211070)	tag:?-?(MINT-1211076)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7L0Q8	uniprotkb:P62993	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395686|mint:MINT-50683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211085(identity)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-1211094(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:CC8F405B8FE7B031|rigid:/0TJner0UW1QUf8sznW6EtmuVQU	false	binding-associated region:1-47(MINT-1211086)|tag:?-?(MINT-1211089)	tag:?-?(MINT-1211095)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62993	uniprotkb:Q7L0Q8	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395633|mint:MINT-50677	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N|mint:MINT-1211193(identity)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211187(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	intact-crc:9D71D43E77AB8AD6|rigid:/0TJner0UW1QUf8sznW6EtmuVQU	false	tag:?-?(MINT-1211194)	tag:?-?(MINT-1211188)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P16333	uniprotkb:Q7L0Q8	intact:EBI-389883|uniprotkb:B7Z751|ensembl:ENSP00000288986|ensembl:ENSP00000417273|intact:EBI-3448658|uniprotkb:D3DNE3	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	psi-mi:nck1_human(display_long)|uniprotkb:NCK1(gene name)|psi-mi:NCK1(display_short)|uniprotkb:NCK(gene name synonym)|uniprotkb:NCK adaptor protein 1(gene name synonym)|uniprotkb:SH2/SH3 adaptor protein NCK-alpha(gene name synonym)	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395738|mint:MINT-50685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278928.1|ensembl:ENSG00000158092(gene)|ensembl:ENST00000288986(transcript)|ensembl:ENST00000481752(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0007172"(signal complex assembly)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|refseq:NP_001177725.1|refseq:NP_006144.1|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|mint:P16333|rcsb pdb:2CI8|rcsb pdb:2CI9|rcsb pdb:2CUB|rcsb pdb:2JS0|rcsb pdb:2JS2|rcsb pdb:2JW4|rcsb pdb:5QU1|rcsb pdb:5QU2|rcsb pdb:5QU3|rcsb pdb:5QU4|rcsb pdb:5QU5|rcsb pdb:5QU6|rcsb pdb:5QU7|rcsb pdb:5QU8|rcsb pdb:5QUA|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029482|reactome:R-HSA-373753|reactome:R-HSA-418885|reactome:R-HSA-428540|reactome:R-HSA-4420097|reactome:R-HSA-5663213|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9664422|reactome:R-HSA-983695|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|dip:DIP-639N|mint:MINT-1211162(identity)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211153(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:UzgLYRQQ9VjN7eKkgn76At/7cSA9606	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	intact-crc:605F348D5022307E|rigid:opveKcnvlDlAQbznNH0KP0AIf6s	false	tag:?-?(MINT-1211163)	tag:?-?(MINT-1211157)|binding-associated region:1-47(MINT-1211154)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q86UR1	uniprotkb:Q7L0Q8	intact:EBI-949814|ensembl:ENSP00000507846|uniprotkb:O60533|uniprotkb:Q29VU9|uniprotkb:Q29VV0|uniprotkb:Q2TAM1|uniprotkb:Q8IUS3	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	psi-mi:noxa1_human(display_long)|uniprotkb:NCF2-like protein(gene name synonym)|uniprotkb:Antigen NY-CO-31(gene name synonym)|uniprotkb:P67phox-like factor(gene name synonym)|uniprotkb:p51-nox(gene name synonym)|uniprotkb:NOXA1(gene name)|psi-mi:NOXA1(display_short)|uniprotkb:P51NOX(gene name synonym)	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395781|mint:MINT-50687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000188747(gene)|ensembl:ENST00000683555(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010310"(regulation of hydrogen peroxide metabolic process)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0060263"(regulation of respiratory burst)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001452(Src homology-3)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR034899|interpro:IPR036028|reactome:R-HSA-5668599|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_006638.1|refseq:NP_001242996.1|refseq:NP_001242997.1|mint:MINT-1211225(identity)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211217(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:b9yF3AbB0i4feLHukYPjiT5jlJg9606	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	intact-crc:A0821EF7DC9C6C7A|rigid:AfgAAdM0CBr5TTxujuZLUFvAiZY	false	tag:?-?(MINT-1211226)	binding-associated region:1-47(MINT-1211218)|tag:?-?(MINT-1211220)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q7L0Q8	uniprotkb:P19174	intact:EBI-1638043|uniprotkb:B1AKN1|uniprotkb:Q59FE9|uniprotkb:Q8TDQ2|ensembl:ENSP00000355652|ensembl:ENSP00000494673	intact:EBI-79387|uniprotkb:Q2V575|uniprotkb:B9EGH4|uniprotkb:B7ZLY7|uniprotkb:E1P5W4|intact:EBI-3959906|ensembl:ENSP00000362368	psi-mi:rhou_human(display_long)|uniprotkb:RHOU(gene name)|psi-mi:RHOU(display_short)|uniprotkb:ARHU(gene name synonym)|uniprotkb:CDC42L1(gene name synonym)|uniprotkb:G28K(gene name synonym)|uniprotkb:WRCH1(gene name synonym)|uniprotkb:SB128(orf name)|uniprotkb:Wnt-1 responsive Cdc42 homolog 1(gene name synonym)|uniprotkb:Ryu GTPase(gene name synonym)|uniprotkb:CDC42-like GTPase 1(gene name synonym)|uniprotkb:Rho GTPase-like protein ARHU(gene name synonym)|uniprotkb:GTP-binding protein-like 1(gene name synonym)	psi-mi:plcg1_human(display_long)|uniprotkb:PLC-148(gene name synonym)|uniprotkb:PLC1(gene name synonym)|uniprotkb:Phospholipase C-II(gene name synonym)|uniprotkb:PLCG1(gene name)|psi-mi:PLCG1(display_short)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shutes et al. (2004)	pubmed:15556869|mint:MINT-5217345	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7395760|mint:MINT-50686	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067028.1|ensembl:ENSG00000116574(gene)|ensembl:ENST00000366691(transcript)|ensembl:ENST00000646945(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002102"(podosome)|ensembl:ENSG00000284984(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0042995"(cell projection)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q7L0Q8|rcsb pdb:2Q3H|reactome:R-HSA-6785807|reactome:R-HSA-9013420|mint:MINT-1211103(identity)	refseq:NP_002651.2|refseq:NP_877963.1|dip:DIP-100N|ensembl:ENSG00000124181(gene)|ensembl:ENST00000373271(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:P19174|rcsb pdb:1HSQ|rcsb pdb:2HSP|rcsb pdb:4EY0|rcsb pdb:4FBN|rcsb pdb:7NXE|reactome:R-HSA-1169408|reactome:R-HSA-1236382|reactome:R-HSA-1251932|reactome:R-HSA-1489509|reactome:R-HSA-167021|reactome:R-HSA-1855204|reactome:R-HSA-186763|reactome:R-HSA-202433|reactome:R-HSA-2029485|reactome:R-HSA-210990|reactome:R-HSA-212718|reactome:R-HSA-2424491|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-418890|reactome:R-HSA-5218921|reactome:R-HSA-5637810|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-9026527|reactome:R-HSA-9027277|reactome:R-HSA-9034793|reactome:R-HSA-9664323|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|mint:MINT-1211111(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	figure legend:F4C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2004/12/06	2014/10/16	rogid:wrOPjo6G3FraKiREmUiUqoHYuEc9606	rogid:pJsNLrqg3cUj0SdjoyLf+/91yBo9606	intact-crc:8C04548FF4D51E29|rigid:Ygcuigwr+Ad+au7PBlGwb6oAnkw	false	tag:?-?(MINT-1211106)|binding-associated region:1-47(MINT-1211104)	tag:?-?(MINT-1211112)	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)