#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22777	uniprotkb:Q5S248	intact:EBI-490898	intact:EBI-490889|uniprotkb:Q8BM10|uniprotkb:A4FUP5|ensembl:ENSMUSP00000124534	psi-mi:pai1_mouse(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:Serpine1(gene name)|psi-mi:Serpine1(display_short)|uniprotkb:Mr1(gene name synonym)|uniprotkb:Pai1(gene name synonym)|uniprotkb:Planh1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:tm11e_mouse(display_long)|uniprotkb:Serine protease DESC1(gene name synonym)|uniprotkb:Desc1(gene name synonym)|uniprotkb:Tmprss11e(gene name)|psi-mi:Tmprss11e(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hobson et al. (2004)	pubmed:15328353	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-466244	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR042178|interpro:IPR042185|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|rcsb pdb:3LW2|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008585"(female gonad development)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0001890"(placenta development)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1905043"(positive regulation of epithelium regeneration)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR036186|reactome:R-MMU-114608|reactome:R-MMU-3000178|reactome:R-MMU-75205	refseq:NP_766468.1|ensembl:ENSMUSG00000054537(gene)|ensembl:ENSMUST00000161306(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0035897"(obsolete proteolysis in other organism)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050890"(cognition)|interpro:IPR000082(SEA)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017329(Transmembrane serine proteases, TMPRSS11A)|interpro:IPR018114|interpro:IPR033116|interpro:IPR036364|interpro:IPR043504	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/12/15	2014/10/16	rogid:ygHsqF6wb/PNQjwzFBnL/sHATg410090	rogid:KNYsWkM3ECWgp6z+DQlxO/K61YE10090	intact-crc:9AACF877B3C30CA4|rigid:g0L5He5TTrCS+pvGd/yNP8REW0o	false	-	binding-associated region:177-423(IPR001254)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70458	uniprotkb:Q5S248	intact:EBI-490966|uniprotkb:Q8BU50|uniprotkb:Q5BKQ8|ensembl:ENSMUSP00000021495	intact:EBI-490889|uniprotkb:Q8BM10|uniprotkb:A4FUP5|ensembl:ENSMUSP00000124534	psi-mi:ipsp_mouse(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Serpina5(gene name)|psi-mi:Serpina5(display_short)|uniprotkb:Pci(gene name synonym)	psi-mi:tm11e_mouse(display_long)|uniprotkb:Serine protease DESC1(gene name synonym)|uniprotkb:Desc1(gene name synonym)|uniprotkb:Tmprss11e(gene name)|psi-mi:Tmprss11e(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hobson et al. (2004)	pubmed:15328353	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-490973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766541.2|refseq:XP_006515979.1|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|reactome:R-MMU-140837|reactome:R-MMU-140875|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|ensembl:ENSMUSG00000041550(gene)|ensembl:ENSMUST00000021495(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)	refseq:NP_766468.1|ensembl:ENSMUSG00000054537(gene)|ensembl:ENSMUST00000161306(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0035897"(obsolete proteolysis in other organism)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050890"(cognition)|interpro:IPR000082(SEA)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017329(Transmembrane serine proteases, TMPRSS11A)|interpro:IPR018114|interpro:IPR033116|interpro:IPR036364|interpro:IPR043504	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/12/15	2014/10/16	rogid:h/NQYnvHDK6VIIZHcyi4gLudcw810090	rogid:KNYsWkM3ECWgp6z+DQlxO/K61YE10090	intact-crc:D0B3B80F1F4FF75A|rigid:/MI+uCDwI1ad2lH7Uoj+rMSG3wc	false	-	binding-associated region:177-423	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5S248	uniprotkb:P22777	intact:EBI-490889|uniprotkb:Q8BM10|uniprotkb:A4FUP5|ensembl:ENSMUSP00000124534	intact:EBI-490898	psi-mi:tm11e_mouse(display_long)|uniprotkb:Serine protease DESC1(gene name synonym)|uniprotkb:Desc1(gene name synonym)|uniprotkb:Tmprss11e(gene name)|psi-mi:Tmprss11e(display_short)	psi-mi:pai1_mouse(display_long)|uniprotkb:Endothelial plasminogen activator inhibitor(gene name synonym)|uniprotkb:Serpine1(gene name)|psi-mi:Serpine1(display_short)|uniprotkb:Mr1(gene name synonym)|uniprotkb:Pai1(gene name synonym)|uniprotkb:Planh1(gene name synonym)|uniprotkb:Serpin E1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hobson et al. (2004)	pubmed:15328353	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-491249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766468.1|ensembl:ENSMUSG00000054537(gene)|ensembl:ENSMUST00000161306(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0035897"(obsolete proteolysis in other organism)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050890"(cognition)|interpro:IPR000082(SEA)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017329(Transmembrane serine proteases, TMPRSS11A)|interpro:IPR018114|interpro:IPR033116|interpro:IPR036364|interpro:IPR043504	interpro:IPR042178|interpro:IPR042185|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|rcsb pdb:3LW2|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0008585"(female gonad development)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010757"(negative regulation of plasminogen activation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0001890"(placenta development)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0035491"(positive regulation of leukotriene production involved in inflammatory response)|go:"GO:0035690"|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042583"(chromaffin granule)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051918"(negative regulation of fibrinolysis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090399"(replicative senescence)|go:"GO:0097187"(dentinogenesis)|go:"GO:1901331"(positive regulation of odontoblast differentiation)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1905043"(positive regulation of epithelium regeneration)|go:"GO:2000098"(negative regulation of smooth muscle cell-matrix adhesion)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR036186|reactome:R-MMU-114608|reactome:R-MMU-3000178|reactome:R-MMU-75205	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/12/15	2014/10/16	rogid:KNYsWkM3ECWgp6z+DQlxO/K61YE10090	rogid:ygHsqF6wb/PNQjwzFBnL/sHATg410090	intact-crc:26C92362523B3EFE|rigid:g0L5He5TTrCS+pvGd/yNP8REW0o	false	binding-associated region:177-423	mutation decreasing interaction:369-369|mutation decreasing interaction:356-356,358-358	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70458	uniprotkb:Q5S248	intact:EBI-490966|uniprotkb:Q8BU50|uniprotkb:Q5BKQ8|ensembl:ENSMUSP00000021495	intact:EBI-490889|uniprotkb:Q8BM10|uniprotkb:A4FUP5|ensembl:ENSMUSP00000124534	psi-mi:ipsp_mouse(display_long)|uniprotkb:Serpin A5(gene name synonym)|uniprotkb:Protein C inhibitor(gene name synonym)|uniprotkb:Plasminogen activator inhibitor 3(gene name synonym)|uniprotkb:Serpina5(gene name)|psi-mi:Serpina5(display_short)|uniprotkb:Pci(gene name synonym)	psi-mi:tm11e_mouse(display_long)|uniprotkb:Serine protease DESC1(gene name synonym)|uniprotkb:Desc1(gene name synonym)|uniprotkb:Tmprss11e(gene name)|psi-mi:Tmprss11e(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hobson et al. (2004)	pubmed:15328353	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-491265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766541.2|refseq:XP_006515979.1|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097181"(protein C inhibitor-coagulation factor V complex)|go:"GO:0097182"(protein C inhibitor-coagulation factor Xa complex)|go:"GO:0097183"(protein C inhibitor-coagulation factor XI complex)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|reactome:R-MMU-140837|reactome:R-MMU-140875|go:"GO:0036030"(protein C inhibitor-plasma kallikrein complex)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0031091"(platelet alpha granule)|go:"GO:0031094"(platelet dense tubular network)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032190"(acrosin binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036024"(protein C inhibitor-TMPRSS7 complex)|go:"GO:0036025"(protein C inhibitor-TMPRSS11E complex)|go:"GO:0036026"(protein C inhibitor-PLAT complex)|go:"GO:0036027"(protein C inhibitor-PLAU complex)|go:"GO:0036028"(protein C inhibitor-thrombin complex)|go:"GO:0036029"(protein C inhibitor-KLK3 complex)|ensembl:ENSMUSG00000041550(gene)|ensembl:ENSMUST00000021495(transcript)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)	refseq:NP_766468.1|ensembl:ENSMUSG00000054537(gene)|ensembl:ENSMUST00000161306(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0035897"(obsolete proteolysis in other organism)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050890"(cognition)|interpro:IPR000082(SEA)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017329(Transmembrane serine proteases, TMPRSS11A)|interpro:IPR018114|interpro:IPR033116|interpro:IPR036364|interpro:IPR043504	-	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/12/15	2014/10/16	rogid:h/NQYnvHDK6VIIZHcyi4gLudcw810090	rogid:KNYsWkM3ECWgp6z+DQlxO/K61YE10090	intact-crc:E9316A0582A999DE|rigid:/MI+uCDwI1ad2lH7Uoj+rMSG3wc	false	mutation decreasing interaction:374-374	binding-associated region:177-423	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)