#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P58335	uniprotkb:P13423	intact:EBI-456840|uniprotkb:Q59E98|uniprotkb:Q5JPE9|uniprotkb:Q86UI1|uniprotkb:Q8N4J8|uniprotkb:Q8NB13|uniprotkb:Q96NC7|uniprotkb:Q4W5H6|ensembl:ENSP00000306185	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	psi-mi:antr2_human(display_long)|uniprotkb:Capillary morphogenesis gene 2 protein(gene name synonym)|uniprotkb:ANTXR2(gene name)|psi-mi:ANTXR2(display_short)|uniprotkb:CMG2(gene name synonym)	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Lacy et al. (2004)	pubmed:15326297	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-456983|rcsb pdb:1TZN	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139266.1|refseq:NP_477520.2|ensembl:ENSG00000163297|ensembl:ENSG00000163297|refseq:NP_001273709.1|refseq:NP_001273710.1|dip:DIP-32476N|ensembl:ENSG00000163297(gene)|ensembl:ENST00000307333(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:1901998"(toxin transport)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR008399(Anthrax toxin receptor, C-terminal)|interpro:IPR008400(Anthrax toxin receptor, extracellular)|interpro:IPR017360(Anthrax toxin receptor 2)|interpro:IPR036465|rcsb pdb:1SHT|rcsb pdb:1SHU|rcsb pdb:1T6B|rcsb pdb:1TZN|rcsb pdb:7N1O|reactome:R-HSA-5210891	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	go:"GO:0019534"(toxin transmembrane transporter activity)	-	-	comment:"PA-63 corresponds to 197-764 fragment of PA precursor (PAGA)"|comment:"The pH required for pore formation (PA-63 heptamer) drops at least a full unit when receptor (CMG2) is added (from 7-8.3 to 4.9-6.2)"|complex-properties:|3d-resolution:4.30|3d-r-factors:working 32.2%, free 33.0%	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/08	2014/10/16	rogid:mM7cM7SCHSVTyjlntxi2OBTxIws9606	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	intact-crc:4F1311DAAD6B954A|rigid:IIMzOTAAL/wI3U21OR3YbZ5WK5g	false	binding-associated region:32-218(IPR002035)	binding-associated region:197-764	7	7	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P13423	uniprotkb:P13423	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	intact:EBI-456868|uniprotkb:Q937W2|uniprotkb:Q937W3|uniprotkb:Q9F5R7|uniprotkb:Q9KH69|uniprotkb:Q9RQU2|ensemblbacteria:AAT28905	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:pag_bacan(display_long)|uniprotkb:PA-83(gene name synonym)|uniprotkb:Anthrax toxins translocating protein(gene name synonym)|uniprotkb:pagA(gene name)|psi-mi:pagA(display_short)|uniprotkb:pag(gene name synonym)|uniprotkb:pXO1-110(locus name)|uniprotkb:BXA0164(locus name)|uniprotkb:GBAA_pXO1_0164(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Lacy et al. (2004)	pubmed:15326297	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	taxid:1392(bacan)|taxid:1392(Bacillus anthracis)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-456991|rcsb pdb:1TZ0	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	refseq:NP_052806.1|refseq:WP_000746488.1|ensemblbacteria:AAT28905(transcript)|ensemblbacteria:GBAA_pXO1_0164(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0015267"(channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044164"(host cell cytosol)|go:"GO:0044175"(host cell endosome membrane)|go:"GO:0044533"(positive regulation of apoptotic process in another organism)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051844"(translocation of peptides or proteins into symbiont)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090729"(toxin activity)|interpro:IPR003896(Bacterial exotoxin B)|interpro:IPR011658(PA14)|interpro:IPR027439|refseq:WP_000746487.1|refseq:WP_000746486.1|dip:DIP-29841N|mint:P13423|rcsb pdb:3Q8B|rcsb pdb:3Q8C|rcsb pdb:3Q8E|rcsb pdb:3Q8F|rcsb pdb:3TEW|rcsb pdb:3TEX|rcsb pdb:3TEY|rcsb pdb:3TEZ|rcsb pdb:4EE2|rcsb pdb:4H2A|rcsb pdb:4NAM|rcsb pdb:5FR3|rcsb pdb:6PSN|rcsb pdb:6UJI|rcsb pdb:6UZB|rcsb pdb:6UZD|rcsb pdb:6UZE|rcsb pdb:6VRA|rcsb pdb:3Q8A|rcsb pdb:6WJJ|rcsb pdb:6ZXJ|interpro:IPR027441|interpro:IPR035088|interpro:IPR035331|interpro:IPR037149|interpro:IPR037524|rcsb pdb:1ACC|rcsb pdb:1T6B|rcsb pdb:1TX5|rcsb pdb:1TZN|rcsb pdb:1TZO|rcsb pdb:1V36|rcsb pdb:3ETB|rcsb pdb:3INO|rcsb pdb:3J9C|rcsb pdb:3KWV|rcsb pdb:3MHZ|rcsb pdb:6ZXL|rcsb pdb:7O85|reactome:R-HSA-5210891|rcsb pdb:6ZXK	go:"GO:0019534"(toxin transmembrane transporter activity)	-	-	comment:"PA-63 corresponds to 197-764 fragment of PA precursor (PAGA)"|complex-properties:|3d-r-factors:working 20.4%, free 26.1%|3d-resolution:1.84	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/08	2014/10/16	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	rogid:xLr/ydN4I0qJ46G/8A3JfZqAbyE1392	intact-crc:5A6B0A9E97ED2F4A|rigid:1M+pYXYCLuIGvvflw+dFbYkx09k	false	binding-associated region:197-764	binding-associated region:197-764	7	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)