#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06700	uniprotkb:P11978	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	-	crc64:52E6937533654586	crc64:9C698765964F094E	comment:Bait protein is TAP-tagged	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:0279B05B14CC609E|rigid:fbSpirbJuDYRptjF0YPJ5PslH8w	false	-	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:P06700	uniprotkb:Q00684	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	intact:EBI-4192|uniprotkb:Q05180|uniprotkb:Q05673|uniprotkb:D6VTQ8|ensemblfungi:YFR028C	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:cdc14_yeast(display_long)|uniprotkb:CDC14(gene name)|psi-mi:CDC14(display_short)|uniprotkb:OAF3(gene name synonym)|uniprotkb:YFR028C(locus name)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443603	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	sgd:S000001924|refseq:NP_116684.3|dip:DIP-5116N|mint:Q00684|ensemblfungi:YFR028C(gene)|ensemblfungi:YFR028C_mRNA(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030869"(RENT complex)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051229"(meiotic spindle disassembly)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903501"(positive regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR026070|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|rcsb pdb:4ZJ7|rcsb pdb:5XW4|rcsb pdb:5XW5|rcsb pdb:6G84|rcsb pdb:6G85|rcsb pdb:6G86|reactome:R-SCE-176407|reactome:R-SCE-5687128	-	crc64:52E6937533654586	crc64:4EB3985DFA3FD823	comment:Bait protein is TAP-tagged	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	rogid:BD4N0EbP9I/G2s3eSX55Qtq+4L8559292	intact-crc:735B0DF57D47037C|rigid:ldUW5asoeiz0GfFZQBmdKLNdm1Q	false	-	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:P47035	uniprotkb:Q00684	intact:EBI-25953|uniprotkb:D6VWA8|ensemblfungi:YJL076W	intact:EBI-4192|uniprotkb:Q05180|uniprotkb:Q05673|uniprotkb:D6VTQ8|ensemblfungi:YFR028C	psi-mi:net1_yeast(display_long)|uniprotkb:YJL076W(locus name)|uniprotkb:J1038(orf name)|uniprotkb:NET1(gene name)|psi-mi:NET1(display_short)|uniprotkb:CFI1(gene name synonym)|uniprotkb:ESC5(gene name synonym)|uniprotkb:SRM8(gene name synonym)	psi-mi:cdc14_yeast(display_long)|uniprotkb:CDC14(gene name)|psi-mi:CDC14(display_short)|uniprotkb:OAF3(gene name synonym)|uniprotkb:YFR028C(locus name)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443608	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012459.1|sgd:S000003612|mint:P47035|dip:DIP-5153N|ensemblfungi:YJL076W(gene)|ensemblfungi:YJL076W_mRNA(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0007000"(nucleolus organization)|go:"GO:0007049"(cell cycle)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030869"(RENT complex)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0051301"(cell division)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|interpro:IPR018844|interpro:IPR043185	sgd:S000001924|refseq:NP_116684.3|dip:DIP-5116N|mint:Q00684|ensemblfungi:YFR028C(gene)|ensemblfungi:YFR028C_mRNA(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000922"(spindle pole)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005816"(spindle pole body)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0008138"(protein tyrosine/serine/threonine phosphatase activity)|go:"GO:0030869"(RENT complex)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0051229"(meiotic spindle disassembly)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071470"(cellular response to osmotic stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:1903501"(positive regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR026070|interpro:IPR029021|interpro:IPR029260|interpro:IPR044506|rcsb pdb:4ZJ7|rcsb pdb:5XW4|rcsb pdb:5XW5|rcsb pdb:6G84|rcsb pdb:6G85|rcsb pdb:6G86|reactome:R-SCE-176407|reactome:R-SCE-5687128	-	crc64:80EDF9A8065EB5A2	crc64:4EB3985DFA3FD823	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:yjUIbOfA/bCZE9nMIjYS1QTn6EI559292	rogid:BD4N0EbP9I/G2s3eSX55Qtq+4L8559292	intact-crc:607B6EF2C2253BEA|rigid:4ThIvELVv25pr9AHTqqicD8X2oI	false	calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:P47035	uniprotkb:P06700	intact:EBI-25953|uniprotkb:D6VWA8|ensemblfungi:YJL076W	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	psi-mi:net1_yeast(display_long)|uniprotkb:YJL076W(locus name)|uniprotkb:J1038(orf name)|uniprotkb:NET1(gene name)|psi-mi:NET1(display_short)|uniprotkb:CFI1(gene name synonym)|uniprotkb:ESC5(gene name synonym)|uniprotkb:SRM8(gene name synonym)	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443608	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_012459.1|sgd:S000003612|mint:P47035|dip:DIP-5153N|ensemblfungi:YJL076W(gene)|ensemblfungi:YJL076W_mRNA(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005730"(nucleolus)|go:"GO:0007000"(nucleolus organization)|go:"GO:0007049"(cell cycle)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030869"(RENT complex)|go:"GO:0031030"(negative regulation of septation initiation signaling)|go:"GO:0051301"(cell division)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|interpro:IPR018844|interpro:IPR043185	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	-	crc64:80EDF9A8065EB5A2	crc64:52E6937533654586	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:yjUIbOfA/bCZE9nMIjYS1QTn6EI559292	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	intact-crc:607B6EF2C2253BEA|rigid:4ThIvELVv25pr9AHTqqicD8X2oI	false	calmodulin binding peptide plus protein a tag:?-?	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:P06700	uniprotkb:P06701	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	intact:EBI-17230|uniprotkb:D6VZ77|uniprotkb:E9P924|ensemblfungi:YLR442C	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:sir3_yeast(display_long)|uniprotkb:SIR3(gene name)|psi-mi:SIR3(display_short)|uniprotkb:CMT1(gene name synonym)|uniprotkb:MAR2(gene name synonym)|uniprotkb:STE8(gene name synonym)|uniprotkb:L9753.10(orf name)|uniprotkb:YLR442C(locus name)|uniprotkb:Silent information regulator 3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443615	author score:SIR3 protein interaction is weak	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	refseq:NP_013547.3|sgd:S000004434|ensemblfungi:YLR442C(gene)|ensemblfungi:YLR442C_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0042802"(identical protein binding)|go:"GO:0070481"(nuclear-transcribed mRNA catabolic process, non-stop decay)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR020793|interpro:IPR027417|interpro:IPR041083|interpro:IPR043151|rcsb pdb:2FL7|rcsb pdb:2FVU|rcsb pdb:3OWT|rcsb pdb:3TE6|rcsb pdb:3TU4|rcsb pdb:3ZCO|rcsb pdb:4JJN|rcsb pdb:4KUD|rcsb pdb:4KUL|rcsb pdb:4LD9|rcsb pdb:4KUI|dip:DIP-595N|mint:P06701	-	crc64:52E6937533654586	crc64:CA2503D7645397AC	comment:Bait protein is TAP-tagged	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	rogid:M+pLXY5ZyBMA0tQaEIwTkK6U2SE559292	intact-crc:C26019F92A64CECC|rigid:PXwdfJeAFbZCFZ0AEKo1BXvn5Fs	false	-	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:P06700	uniprotkb:P11978	intact:EBI-17219|uniprotkb:D6VRV4|ensemblfungi:YDL042C	intact:EBI-17237|uniprotkb:D6VSK9|ensemblfungi:YDR227W	psi-mi:sir2_yeast(display_long)|uniprotkb:SIR2(gene name)|psi-mi:SIR2(display_short)|uniprotkb:MAR1(gene name synonym)|uniprotkb:YDL042C(locus name)|uniprotkb:D2714(orf name)|uniprotkb:Silent information regulator 2(gene name synonym)|uniprotkb:Regulatory protein SIR2(gene name synonym)	psi-mi:sir4_yeast(display_long)|uniprotkb:STE9(gene name synonym)|uniprotkb:SIR4(gene name)|psi-mi:SIR4(display_short)|uniprotkb:ASD1(gene name synonym)|uniprotkb:UTH2(gene name synonym)|uniprotkb:YDR227W(locus name)|uniprotkb:YD9934.12(orf name)|uniprotkb:Silent information regulator 4(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Tanny et al. (2004)	pubmed:15282295	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-443615	author score:SIR3 protein interaction is weak	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010242.1|sgd:S000002200|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0046970"("NAD-dependent histone deacetylase activity (H4-K16 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0097752"(regulation of DNA stability)|go:"GO:1904524"(negative regulation of DNA amplification)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR007654(Protein of unknown function DUF592)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:2HJH|rcsb pdb:4IAO|go:"GO:0034398"(telomere tethering at nuclear periphery)|ensemblfungi:YDL042C_mRNA(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000792"(heterochromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006325"(chromatin organization)|go:"GO:0006333"(chromatin assembly or disassembly)|go:"GO:0006348"|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016740"(transferase activity)|ensemblfungi:YDL042C(gene)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0030869"(RENT complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|dip:DIP-596N|mint:P06700	refseq:NP_010513.1|sgd:S000002635|ensemblfungi:YDR227W(gene)|ensemblfungi:YDR227W_mRNA(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006348"|go:"GO:0030466"(silent mating-type cassette heterochromatin assembly)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031491"(nucleosome binding)|go:"GO:0031509"(subtelomeric heterochromatin assembly)|go:"GO:0034398"(telomere tethering at nuclear periphery)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|interpro:IPR031556|rcsb pdb:1NYH|rcsb pdb:1PL5|rcsb pdb:4IAO|rcsb pdb:6QSZ|rcsb pdb:6QTM|rcsb pdb:6RR0|rcsb pdb:6RRV|dip:DIP-33N|mint:P11978	-	crc64:52E6937533654586	crc64:9C698765964F094E	comment:Bait protein is TAP-tagged	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/08/29	2014/10/16	rogid:HSrFe/tNeIjMNN3xB+3h7rocgkU559292	rogid:C1HZEbdzRxwODKN1FHzmhYMCl+M559292	intact-crc:C26019F92A64CECC|rigid:PXwdfJeAFbZCFZ0AEKo1BXvn5Fs	false	-	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)