#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8BVF7 uniprotkb:P57716 intact:EBI-7188432|ensembl:ENSMUSP00000058846|uniprotkb:Q91VL5|uniprotkb:Q8R1T3|intact:MINT-1176936 intact:EBI-998934|uniprotkb:E9QLZ6|uniprotkb:Q8VE20|ensembl:ENSMUSP00000003550 psi-mi:aph1a_mouse(display_long)|uniprotkb:Aph1a(gene name)|psi-mi:Aph1a(display_short)|uniprotkb:Aph-1alpha(gene name synonym) psi-mi:nica_mouse(display_long)|uniprotkb:Ncstn(gene name)|psi-mi:Ncstn(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188463|mint:MINT-50027 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015750(gene)|ensembl:ENSMUST00000056710(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-9013507|reactome:R-MMU-9017802|refseq:NP_666216.1|refseq:NP_666246.1|mint:MINT-1177072(identity) refseq:NP_067620.3|ensembl:ENSMUSG00000003458(gene)|ensembl:ENSMUST00000003550(transcript)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0021549"(cerebellum development)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030534"(adult behavior)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042983"(amyloid precursor protein biosynthetic process)|go:"GO:0042986"(positive regulation of amyloid precursor protein biosynthetic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0045202"(synapse)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0051117"(ATPase binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0070997"(neuron death)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1990926"(short-term synaptic potentiation)|interpro:IPR008710(Nicastrin)|interpro:IPR041084|mint:P57716|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|go:"GO:0008233"(peptidase activity)|dip:DIP-36334N|mint:MINT-1177076(identity) - comment:mint|function:"Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:b76qtAn4a7T5NXLoRrB4cC2gfIw10090 rogid:l0mFGFYhwC38vnSRAy9oQuroZ8010090 intact-crc:EE9330F0BF551FF5|rigid:ljx1QFqkdOUUuys9Cg58VaOqe5M false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q8BVF7 uniprotkb:P49769 intact:EBI-7188432|ensembl:ENSMUSP00000058846|uniprotkb:Q91VL5|uniprotkb:Q8R1T3|intact:MINT-1176936 intact:EBI-990067|uniprotkb:Q91WK6|uniprotkb:Q9JLP9|ensembl:ENSMUSP00000048363|ensembl:ENSMUSP00000098786 psi-mi:aph1a_mouse(display_long)|uniprotkb:Aph1a(gene name)|psi-mi:Aph1a(display_short)|uniprotkb:Aph-1alpha(gene name synonym) psi-mi:psn1_mouse(display_long)|uniprotkb:Protein S182(gene name synonym)|uniprotkb:Psen1(gene name)|psi-mi:Psen1(display_short)|uniprotkb:Ad3h(gene name synonym)|uniprotkb:Psnl1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188489|mint:MINT-50028 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000015750(gene)|ensembl:ENSMUST00000056710(transcript)|go:"GO:0001656"(metanephros development)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR009294(Aph-1)|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-9013507|reactome:R-MMU-9017802|refseq:NP_666216.1|refseq:NP_666246.1|mint:MINT-1176967(identity) go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001108(Peptidase A22A, presenilin)|interpro:IPR002031(Peptidase A22A, presenilin 1)|interpro:IPR006639(Peptidase A22, presenilin signal peptide)|interpro:IPR042524|mint:P49769|reactome:R-MMU-1251985|reactome:R-MMU-193692|reactome:R-MMU-205043|reactome:R-MMU-3928665|reactome:R-MMU-6798695|reactome:R-MMU-9013507|reactome:R-MMU-9017802|ensembl:ENSMUSG00000019969(gene)|ensembl:ENSMUST00000041806(transcript)|ensembl:ENSMUST00000101225(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000776"(kinetochore)|go:"GO:0001568"(blood vessel development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001756"(somitogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0002038"(positive regulation of L-glutamate import across plasma membrane)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002573"(myeloid leukocyte differentiation)|go:"GO:0003407"(neural retina development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007220"(Notch receptor processing)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008233"(peptidase activity)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0010467"(gene expression)|go:"GO:0021549"(cerebellum development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021870"(Cajal-Retzius cell differentiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022008"(neurogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0030018"(Z disc)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0015031"(protein transport)|go:"GO:0015871"(choline transport)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030900"(forebrain development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0016020"(membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040011"(locomotion)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042383"(sarcolemma)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016235"(aggresome)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0042500"(aspartic endopeptidase activity, intramembrane cleaving)|go:"GO:0016485"(protein processing)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043227"(membrane-bounded organelle)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045296"(cadherin binding)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048666"(neuron development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050820"(positive regulation of coagulation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0051604"(protein maturation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070765"(gamma-secretase complex)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097060"(synaptic membrane)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904797"(negative regulation of core promoter binding)|go:"GO:0048143"(astrocyte activation)|refseq:NP_032969.1|refseq:XP_006515668.1|dip:DIP-36237N|mint:MINT-1176971(identity) - comment:mint|function:"Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:b76qtAn4a7T5NXLoRrB4cC2gfIw10090 rogid:o/Am8u42WLTycj02WRXHancU9Ek10090 intact-crc:E94C27ED40B48FF9|rigid:mm1NcTrsz2ND1MYbOlppk4LZEeE false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:P08226 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-1634131|ensembl:ENSMUSP00000003066|ensembl:ENSMUSP00000133302|ensembl:ENSMUSP00000133371|ensembl:ENSMUSP00000134160 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:apoe_mouse(display_long)|uniprotkb:Apoe(gene name)|psi-mi:Apoe(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188499|mint:MINT-50029 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177138(identity) refseq:NP_001292748.1|refseq:NP_001292772.1|refseq:NP_001292773.1|refseq:NP_033826.2|ensembl:ENSMUSG00000002985(gene)|ensembl:ENSMUST00000003066(transcript)|ensembl:ENSMUST00000173739(transcript)|ensembl:ENSMUST00000174064(transcript)|ensembl:ENSMUST00000174355(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002021"(response to dietary excess)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007568"(aging)|go:"GO:0007616"(long-term memory)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010877"(lipid transport involved in lipid storage)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015909"(long-chain fatty acid transport)|go:"GO:0016209"(antioxidant activity)|go:"GO:0017038"(protein import)|go:"GO:0019068"(virion assembly)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0032805"(positive regulation of low-density lipoprotein particle receptor catabolic process)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034363"(intermediate-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034365"(discoidal high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034382"(chylomicron remnant clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046848"(hydroxyapatite binding)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0046911"(metal chelating activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051055"(negative regulation of lipid biosynthetic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051651"(maintenance of location in cell)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0070326"(very-low-density lipoprotein particle receptor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071813"(lipoprotein particle binding)|go:"GO:0071830"(triglyceride-rich lipoprotein particle clearance)|go:"GO:0071831"(intermediate-density lipoprotein particle clearance)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090207"(regulation of triglyceride metabolic process)|go:"GO:0090209"(negative regulation of triglyceride metabolic process)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:0097006"(regulation of plasma lipoprotein particle levels)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097114"(NMDA glutamate receptor clustering)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901627"(negative regulation of postsynaptic membrane organization)|go:"GO:1901631"(positive regulation of presynaptic membrane organization)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1902991"(regulation of amyloid precursor protein catabolic process)|go:"GO:1902995"(positive regulation of phospholipid efflux)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1902999"(negative regulation of phospholipid efflux)|go:"GO:1903001"(negative regulation of lipid transport across blood-brain barrier)|go:"GO:1903002"(positive regulation of lipid transport across blood-brain barrier)|go:"GO:1905855"(positive regulation of heparan sulfate binding)|go:"GO:1905860"(positive regulation of heparan sulfate proteoglycan binding)|go:"GO:1905890"(regulation of cellular response to very-low-density lipoprotein particle stimulus)|go:"GO:1905906"(regulation of amyloid fibril formation)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990777"(lipoprotein particle)|go:"GO:2000822"(regulation of behavioral fear response)|interpro:IPR000074(Apolipoprotein A1/A4/E)|mint:P08226|rcsb pdb:1YA9|reactome:R-MMU-3000480|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-8963901|reactome:R-MMU-8964026|reactome:R-MMU-8964058|reactome:R-MMU-975634|mint:MINT-1177142(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:fJDvqSxzmdZmV8t1M4yp9jw1jvU10090 intact-crc:98807CC237DBDDD2|rigid:SayV61/WGV5Gf2nv5KrLZSzoO1w false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P13595 uniprotkb:P04925 intact:EBI-774943|uniprotkb:Q61949|uniprotkb:Q61950|intact:EBI-1018667|uniprotkb:P13594|uniprotkb:Q6LBU8|uniprotkb:Q8BQ96|uniprotkb:Q8C4B2|uniprotkb:Q921P2|uniprotkb:Q9R2A7 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:ncam1_mouse(display_long)|uniprotkb:Ncam1(gene name)|psi-mi:Ncam1(display_short)|uniprotkb:Ncam(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188509|mint:MINT-50030 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001074914.1|refseq:NP_001106675.1|refseq:NP_035005.2|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR009138(Neural cell adhesion)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR013106(Immunoglobulin V-set)|refseq:NP_001297994.1|interpro:IPR033019|interpro:IPR036116|interpro:IPR036179|mint:P13595|go:"GO:0001928"(regulation of exocyst assembly)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008201"(heparin binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010288"(response to lead ion)|go:"GO:0019902"(phosphatase binding)|go:"GO:0021794"(thalamus development)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043209"(myelin sheath)|go:"GO:0048666"(neuron development)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2001260"(regulation of semaphorin-plexin signaling pathway)|rcsb pdb:2NCM|rcsb pdb:3NCM|reactome:R-MMU-375165|reactome:R-MMU-419037|reactome:R-MMU-445144|reactome:R-MMU-5673001|mint:MINT-1176920(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176916(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:bEVNNXNFliR5XooeBmVJ5PgeNwc10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:C11E6D0BC61C0C93|rigid:gItHwHHF3Y1mAvEeYTRMS7UcpkU false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9Z218 uniprotkb:P04925 intact:EBI-772777|uniprotkb:Q9QWW2|uniprotkb:Q9Z219|ensembl:ENSMUSP00000071435 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:dpp6_mouse(display_long)|uniprotkb:Dipeptidyl peptidase VI(gene name synonym)|uniprotkb:Dipeptidyl peptidase 6(gene name synonym)|uniprotkb:Dipeptidyl peptidase IV-like protein(gene name synonym)|uniprotkb:Dipeptidyl aminopeptidase-related protein(gene name synonym)|uniprotkb:DPPX(gene name synonym)|uniprotkb:Dpp6(gene name)|psi-mi:Dpp6(display_short)|uniprotkb:Dpp-6(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188518|mint:MINT-50031 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034205.1|refseq:NP_997165.2|ensembl:ENSMUSG00000061576(gene)|ensembl:ENSMUST00000071500(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043266"(regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002469(Peptidase S9B, dipeptidylpeptidase IV N-terminal)|interpro:IPR029058|mint:Q9Z218|mint:MINT-1177219(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177215(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:kH1gdPDxjo/anvByeh1PaFe9Vj410090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:4BFAF7F4C109AE84|rigid:uBSofdP7q3fn8+WM74HCsnq4F38 false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:O35136 uniprotkb:P04925 intact:EBI-774970|uniprotkb:O35962|uniprotkb:Q0VF23|ensembl:ENSMUSP00000063468 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:ncam2_mouse(display_long)|uniprotkb:Neural cell adhesion molecule RB-8(gene name synonym)|uniprotkb:R4B12(gene name synonym)|uniprotkb:Ncam2(gene name)|psi-mi:Ncam2(display_short)|uniprotkb:Ocam(gene name synonym)|uniprotkb:Rncam(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188558|mint:MINT-50035 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106679.1|refseq:NP_035084.1|ensembl:ENSMUSG00000022762(gene)|ensembl:ENSMUST00000067602(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0030424"(axon)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR009138(Neural cell adhesion)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|mint:O35136|mint:MINT-1177372(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177368(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:/mvIONd6Mjq2pQVieZRXLiOSy5M10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:7E61EC47CB05C5FE|rigid:2K2Et6i5uBMQU5sRRtX2jKrPA4s false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P12960 uniprotkb:P04925 intact:EBI-774808|uniprotkb:Q6NXV7|uniprotkb:Q8BR42|uniprotkb:Q8C6A0|ensembl:ENSMUSP00000000109|ensembl:ENSMUSP00000067842|ensembl:ENSMUSP00000133063 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:cntn1_mouse(display_long)|uniprotkb:Neural cell surface protein F3(gene name synonym)|uniprotkb:Cntn1(gene name)|psi-mi:Cntn1(display_short) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188548|mint:MINT-50034 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001153119.1|refseq:NP_001153120.1|refseq:NP_031753.1|refseq:XP_017171911.1|ensembl:ENSMUSG00000055022(gene)|ensembl:ENSMUST00000000109(transcript)|ensembl:ENSMUST00000068378(transcript)|ensembl:ENSMUST00000169825(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0099025"(anchored component of postsynaptic membrane)|go:"GO:0099026"(anchored component of presynaptic membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR036992|mint:P12960|mint:MINT-1177268(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177264(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TftNvfwJlK/7DTczqiV/IzDxhOM10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:E205C61DFDD27F85|rigid:HhMrfhAZ5pelyPqHzOJh4Ro5+JE false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P04925 uniprotkb:P20917 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-774926|uniprotkb:P16880|uniprotkb:A0A087WPR1|ensembl:ENSMUSP00000139881 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:mag_mouse(display_long)|uniprotkb:Siglec-4a(gene name synonym)|uniprotkb:Mag(gene name)|psi-mi:Mag(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188528|mint:MINT-50032 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177331(identity) refseq:NP_001333015.1|refseq:NP_001333016.1|refseq:NP_034888.1|refseq:XP_011248743.1|refseq:NP_001333017.1|refseq:XP_017177497.1|refseq:NP_001333013.1|refseq:NP_001333014.1|refseq:XP_006539653.1|refseq:XP_006539654.1|refseq:XP_011248740.1|refseq:XP_011248741.1|refseq:XP_011248742.1|refseq:XP_017177496.1|ensembl:ENSMUSG00000036634(gene)|ensembl:ENSMUST00000191081(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022010"(central nervous system myelination)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031103"(axon regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0033270"(paranode region of axon)|go:"GO:0033691"(sialic acid binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0043218"(compact myelin)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097453"(mesaxon)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1905576"(ganglioside GT1b binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:P20917|rcsb pdb:5LF5|rcsb pdb:5LFR|rcsb pdb:5LFU|rcsb pdb:5LFV|rcsb pdb:6GZJ|rcsb pdb:6GZL|reactome:R-MMU-193634|reactome:R-MMU-210991|mint:MINT-1177335(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2019/09/20 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:sgxaYqIU4i2tAdeRMT9/UqKO0Qo10090 intact-crc:64650A4418C69A6B|rigid:fsCmX/ZaRrx8isAqXzNwnDgmezI false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:P39053 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188538|mint:MINT-50033 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176926(identity) refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1|mint:MINT-1176930(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:wtPz3gwyxU6tAgh5091LQpt099I10090 intact-crc:781042BEEDA46436|rigid:YXfIH5TlFLgfelHYhrBM9wUIGBA false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:Q61885 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-445084|uniprotkb:P70364|uniprotkb:Q62003 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:mog_mouse(display_long)|uniprotkb:Mog(gene name)|psi-mi:Mog(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188604|mint:MINT-50038 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176819(identity) interpro:IPR003599(Immunoglobulin subtype)|refseq:NP_034944.2|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR016663(Myelin-oligodendrocyte glycoprotein)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0007155"(cell adhesion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050852"(T cell receptor signaling pathway)|rcsb pdb:1PY9|mint:Q61885|interpro:IPR036179|mint:MINT-1176823(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:0pKLIk56EuaULm8g6BqtByU6Eds10090 intact-crc:1785549A1231D8B7|rigid:4PzpBqRvjKPX3qW26/ve7FDZdbA false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:Q8BLK3 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-772993|ensembl:ENSMUSP00000077913 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:lsamp_mouse(display_long)|uniprotkb:Lsamp(gene name)|psi-mi:Lsamp(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188594|mint:MINT-50037 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176839(identity) refseq:NP_780757.1|ensembl:ENSMUSG00000061080(gene)|ensembl:ENSMUST00000078873(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0035641"(locomotory exploration behavior)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q8BLK3|reactome:R-MMU-163125|mint:MINT-1176843(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:IHPNrtGSnJN5gZzIlsyd0WByO3810090 intact-crc:3A51B426C18A0846|rigid:CENxjwUn7cF4sLExuhMSOBDxMOA false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:Q03157 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-399929|uniprotkb:Q8VC38|uniprotkb:A0A0R4IZZ1|uniprotkb:Q3U311|ensembl:ENSMUSP00000006828 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:aplp1_mouse(display_long)|uniprotkb:Amyloid-like protein 1(gene name synonym)|uniprotkb:"Amyloid beta (A4) precursor-like protein 1"(gene name synonym)|uniprotkb:Aplp1(gene name)|psi-mi:Aplp1(display_short) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188568|mint:MINT-50036 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177128(identity) refseq:NP_031493.2|ensembl:ENSMUSG00000006651(gene)|ensembl:ENSMUST00000006828(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007155"(cell adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0031695"(alpha-2B adrenergic receptor binding)|go:"GO:0031696"(alpha-2C adrenergic receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0106072"(negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR024329|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|mint:Q03157|mint:MINT-1177132(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2021/11/30 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:ARlUvp+Cc3LpEud8El1nGZC+HhA10090 intact-crc:9C9523B3F0AA81C0|rigid:9nfkDccla86CnIqqXGFJIv28MmY false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q06890 uniprotkb:P04925 intact:EBI-774758|ensembl:ENSMUSP00000022616 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:clus_mouse(display_long)|uniprotkb:Sulfated glycoprotein 2(gene name synonym)|uniprotkb:Clustrin(gene name synonym)|uniprotkb:Apolipoprotein J(gene name synonym)|uniprotkb:Clu(gene name)|psi-mi:Clu(display_short)|uniprotkb:Apoj(gene name synonym)|uniprotkb:Msgp-2(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188678|mint:MINT-50040 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038520.2|refseq:XP_006518567.1|ensembl:ENSMUSG00000022037(gene)|ensembl:ENSMUST00000022616(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002434"(immune complex clearance)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0017038"(protein import)|go:"GO:0030426"(growth cone)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034366"(spherical high-density lipoprotein particle)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0051788"(response to misfolded protein)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0071944"(cell periphery)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097418"(neurofibrillary tangle)|go:"GO:0097440"(apical dendrite)|go:"GO:0099020"(perinuclear endoplasmic reticulum lumen)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1900221"(regulation of amyloid-beta clearance)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902847"(regulation of neuronal signal transduction)|go:"GO:1902949"(positive regulation of tau-protein kinase activity)|go:"GO:1902998"(positive regulation of neurofibrillary tangle assembly)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:1905892"(negative regulation of cellular response to thapsigargin)|go:"GO:1905895"(negative regulation of cellular response to tunicamycin)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000753(Clusterin-like)|interpro:IPR016014(Clusterin, N-terminal)|interpro:IPR016015(Clusterin, C-terminal)|interpro:IPR016016(Clusterin)|interpro:IPR033986|mint:Q06890|reactome:R-MMU-114608|reactome:R-MMU-166665|reactome:R-MMU-6803157|reactome:R-MMU-977606|go:"GO:0042583"(chromaffin granule)|mint:MINT-1176996(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176992(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:wP6AESslzICF3ojv9a+vJUn61VA10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:5E01A1EE78143B80|rigid:02YU6AODyAYtv9GR8SgKJjlSDzI false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q8BMT5 uniprotkb:P04925 intact:EBI-7188691|intact:MINT-1176859 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:q8bmt5_mouse(display_long)|uniprotkb:Opcml(gene name)|psi-mi:Opcml(display_short) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188688|mint:MINT-50041 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036179|mint:MINT-1176875(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176871(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:z+jNc0rwx4DksUPsnlCEhfUshoI10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:B5DEAA86F1FB8268|rigid:6fZXGhuHAWBSBxMHUJ0pDNwxQvA false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P04925 uniprotkb:Q99PJ0 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-774911|ensembl:ENSMUSP00000110892 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:ntri_mouse(display_long)|uniprotkb:Ntm(gene name)|psi-mi:Ntm(display_short)|uniprotkb:Hnt(gene name synonym)|uniprotkb:Nt(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188708|mint:MINT-50042 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177236(identity) ensembl:ENSMUSG00000059974(gene)|ensembl:ENSMUST00000115237(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030424"(axon)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060076"(excitatory synapse)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|mint:Q99PJ0|reactome:R-MMU-163125|mint:MINT-1177240(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:NEe+6EmToULaWqBgJ5f1x/C2PtU10090 intact-crc:516E6698ED6B84DD|rigid:XGILBEacK2necDBd0+ROo6e+LiM false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q9JKF6 uniprotkb:P04925 intact:EBI-7188613|ensembl:ENSMUSP00000034510|uniprotkb:Q6P9M9|intact:MINT-254710|uniprotkb:Q9JI17|uniprotkb:Q9ERL5 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:nect1_mouse(display_long)|uniprotkb:Nectin1(gene name)|psi-mi:Nectin1(display_short)|uniprotkb:Herpes virus entry mediator C(gene name synonym)|uniprotkb:Hvec(gene name synonym)|uniprotkb:Nectin cell adhesion molecule 1(gene name synonym)|uniprotkb:Poliovirus receptor-related protein 1(gene name synonym)|uniprotkb:Prr1(gene name synonym)|uniprotkb:Pvrl1(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188648|mint:MINT-50039 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUST00000034510(transcript)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0002934"(desmosome organization)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006826"(iron ion transport)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032584"(growth cone membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043296"(apical junction complex)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070166"(enamel mineralization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1902414"(protein localization to cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013162(CD80-like, immunoglobulin C2-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR033314|interpro:IPR036179|interpro:IPR041849|interpro:IPR041850|rcsb pdb:2L7J|rcsb pdb:5B21|reactome:R-MMU-418990|reactome:R-MMU-420597|ensembl:ENSMUSG00000032012(gene)|refseq:NP_067399.2|dip:DIP-41728N|mint:MINT-1177432(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177428(identity) - comment:mint|function:"Probably involved in cell adhesion. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:4HEJEu4oenwtwGXPX+gHeIfPw/810090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:644AF86084A1C710|rigid:JKyxwNVFx41Uh/CeW3uwzcVdAW4 false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:Q9R1V7 uniprotkb:P04925 intact:EBI-642169|uniprotkb:Q6QDY9|uniprotkb:Q6QDZ0|uniprotkb:Q8CC33|ensembl:ENSMUSP00000084633 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:ada23_mouse(display_long)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3(gene name synonym)|uniprotkb:Adam23(gene name)|psi-mi:Adam23(display_short)|uniprotkb:Mdc3(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188747|mint:MINT-50046 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035910.1|refseq:XP_006496032.1|refseq:XP_006496033.1|ensembl:ENSMUSG00000025964(gene)|ensembl:ENSMUST00000087374(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0007155"(cell adhesion)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR024079|interpro:IPR034027|interpro:IPR036436|mint:Q9R1V7|reactome:R-MMU-5682910|mint:MINT-1177193(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177189(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:Im2FK3zBdAvSUbBdOZo2hsEQQ8U10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:05CFD4639729D43C|rigid:BUyrQnsaPe1/C/1j0DFxpKnR5XQ false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P09103 uniprotkb:P04925 intact:EBI-494709|uniprotkb:Q922C8|ensembl:ENSMUSP00000026122 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:pdia1_mouse(display_long)|uniprotkb:Prolyl 4-hydroxylase subunit beta(gene name synonym)|uniprotkb:Cellular thyroid hormone-binding protein(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 59(gene name synonym)|uniprotkb:P4hb(gene name)|psi-mi:P4hb(display_short)|uniprotkb:Pdia1(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188737|mint:MINT-50045 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035162.1|ensembl:ENSMUSG00000025130(gene)|ensembl:ENSMUST00000026122(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0003779"(actin binding)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006457"(protein folding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016222"(procollagen-proline 4-dioxygenase complex)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR005792(Protein disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|mint:P09103|reactome:R-MMU-1650814|reactome:R-MMU-3299685|reactome:R-MMU-381426|reactome:R-MMU-5358346|reactome:R-MMU-8866423|reactome:R-MMU-8957275|reactome:R-MMU-8963888|reactome:R-MMU-9020591|reactome:R-MMU-9020933|mint:MINT-1177104(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177100(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:j20LBPF1r9AYUdJAgzNS/+Uq8GY10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:16207CBED09FF38A|rigid:jFDoFNDrhDbAKmbeksw1Vaoj1xk false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P04925 uniprotkb:P11627 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-397964 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:l1cam_mouse(display_long)|uniprotkb:L1cam(gene name)|psi-mi:L1cam(display_short)|uniprotkb:Caml1(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188718|mint:MINT-50043 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177016(identity) interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043621"(protein self-association)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045121"(membrane raft)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0061564"(axon development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|reactome:R-MMU-210991|reactome:R-MMU-373760|reactome:R-MMU-437239|reactome:R-MMU-445095|reactome:R-MMU-445144|go:"GO:0005178"(integrin binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042734"(presynaptic membrane)|mint:P11627|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179|mint:MINT-1177020(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:4w9IOynYuXaAAxr6N/EQjwJBOFo10090 intact-crc:9EE778A8C9CF504C|rigid:esOt+Nv/SSR91eYmyNO2qiwQWj8 false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P70663 uniprotkb:P04925 intact:EBI-2012890|uniprotkb:E9QPH2|uniprotkb:P97810|uniprotkb:Q99L82|ensembl:ENSMUSP00000031249 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:sprl1_mouse(display_long)|uniprotkb:Sparcl1(gene name)|psi-mi:Sparcl1(display_short)|uniprotkb:Ecm2(gene name synonym)|uniprotkb:Sc1(gene name synonym)|uniprotkb:Matrix glycoprotein Sc1(gene name synonym)|uniprotkb:Extracellular matrix protein 2(gene name synonym) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188727|mint:MINT-50044 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034227.3|refseq:XP_017176145.1|refseq:XP_006534831.1|ensembl:ENSMUSG00000029309(gene)|ensembl:ENSMUST00000031249(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0098965"(extracellular matrix of synaptic cleft)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099560"(synaptic membrane adhesion)|interpro:IPR001999(Osteonectin-like, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR011992(EF-Hand type)|interpro:IPR015369(Follistatin)|interpro:IPR016359(SPARC-like protein 1)|interpro:IPR018247|interpro:IPR019577|interpro:IPR036058|mint:P70663|reactome:R-MMU-381426|reactome:R-MMU-8957275|mint:MINT-1177422(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177418(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:PdnEQBF1vQqXJM9/Qiz/45+Mdc410090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:82027AAB353F5338|rigid:rR0TbFGsdSLyDLjHctov9ZPvkHU false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P04925 uniprotkb:Q9EPL2 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-2013142|uniprotkb:A2A800|uniprotkb:Q69ZV9|uniprotkb:Q7TS67|uniprotkb:Q8K103|uniprotkb:B2KFP1|uniprotkb:B2KFP2|ensembl:ENSMUSP00000036962 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:cstn1_mouse(display_long)|uniprotkb:Clstn1(gene name)|psi-mi:Clstn1(display_short)|uniprotkb:Cs1(gene name synonym)|uniprotkb:Cstn1(gene name synonym)|uniprotkb:Kiaa0911(gene name synonym)|uniprotkb:Alcadein-alpha(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188787|mint:MINT-50050 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177042(identity) refseq:NP_001277918.1|refseq:NP_075538.1|ensembl:ENSMUSG00000039953(gene)|ensembl:ENSMUST00000039144(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0042988"(X11-like protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099065"(integral component of spine apparatus membrane)|interpro:IPR002126(Cadherin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR015919(Cadherin-like)|interpro:IPR026914|mint:Q9EPL2|rcsb pdb:6F9I|mint:MINT-1177046(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:h3agX8346CXgrtG811jKkrlCPuU10090 intact-crc:B29FC0142560D09F|rigid:JCYPwdz0LBF3u2tpeH8aUZWDhz8 false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:Q06335 uniprotkb:P04925 intact:EBI-446708|uniprotkb:Q80US7|ensembl:ENSMUSP00000078694 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:aplp2_mouse(display_long)|uniprotkb:APPL2(gene name synonym)|uniprotkb:"Amyloid beta (A4) precursor-like protein 2"(gene name synonym)|uniprotkb:Amyloid protein homolog(gene name synonym)|uniprotkb:Amyloid-like protein 2(gene name synonym)|uniprotkb:Sperm membrane protein YWK-II(gene name synonym)|uniprotkb:CDEI box-binding protein(gene name synonym)|uniprotkb:Aplp2(gene name)|psi-mi:Aplp2(display_short) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188777|mint:MINT-50049 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001095926.1|ensembl:ENSMUSG00000031996(gene)|ensembl:ENSMUST00000079758(transcript)|go:"GO:0001967"(suckling behavior)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0003677"(DNA binding)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0050885"(neuromuscular process controlling balance)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR024329|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|mint:Q06335|reactome:R-MMU-114608|reactome:R-MMU-381426|reactome:R-MMU-8957275|mint:MINT-1177325(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177321(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:BDGiNfkopwuszDji51N907u40Aw10090 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:97C7EB1946A49634|rigid:kxXmemAP5sHKtTpLBzW4qb3YRkQ false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P04925 uniprotkb:P20029 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-772325|uniprotkb:Q3UFF2|uniprotkb:O35642|uniprotkb:Q61630|intact:EBI-4280750|ensembl:ENSMUSP00000028222|ensembl:ENSMUSP00000097747 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:bip_mouse(display_long)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188757|mint:MINT-50047 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177295(identity) refseq:NP_001156906.1|refseq:NP_071705.3|dip:DIP-32341N|ensembl:ENSMUSG00000026864(gene)|ensembl:ENSMUST00000028222(transcript)|ensembl:ENSMUST00000100171(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P20029|reactome:R-MMU-3371453|reactome:R-MMU-983170|mint:MINT-1177299(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:AyJwwnH8IAQqF/cbTn336A79MOY10090 intact-crc:CC1476AA0DEDADC8|rigid:+xIjAChOxhoAQlK/lHBnaJN4+wI false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P04925 uniprotkb:Q9QXJ1 intact:EBI-768613|ensembl:ENSMUSP00000088833 intact:EBI-81338|uniprotkb:E9QNW5|uniprotkb:O08642|uniprotkb:Q3TPU0|uniprotkb:Q8BNF4|uniprotkb:Q8BSR9|ensembl:ENSMUSP00000079932 psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:apbb1_mouse(display_long)|uniprotkb:Apbb1(gene name)|psi-mi:Apbb1(display_short)|uniprotkb:Fe65(gene name synonym)|uniprotkb:Protein Fe65(gene name synonym)|uniprotkb:Amyloid-beta A4 precursor protein-binding family B member 1(gene name synonym)|uniprotkb:Rir(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188767|mint:MINT-50048 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1176849(identity) ensembl:ENSMUSG00000037032(gene)|ensembl:ENSMUST00000081165(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001764"(neuron migration)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|refseq:NP_033815.1|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007411"(axon guidance)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030027"(lamellipodium)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030426"(growth cone)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0044304"(main axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990812"(growth cone filopodium)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0043197"(dendritic spine)|interpro:IPR039576|mint:Q9QXJ1|reactome:R-MMU-5693565|interpro:IPR036020|refseq:XP_017177435.1|refseq:NP_001240814.1|refseq:NP_001240815.1|refseq:XP_006507293.1|refseq:XP_006507294.1|mint:MINT-1176853(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 rogid:/kCa16NGI0ZXAVezFtBzeVhIqAU10090 intact-crc:7B8E91276B3E13C5|rigid:EDYnmbbdNKXi+yfrPQsyBXzOfW0 false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0082"(peptide massfingerprinting) intact:EBI-7188812 uniprotkb:P04925 intact:MINT-1177378 intact:EBI-768613|ensembl:ENSMUSP00000088833 psi-mi:q8bq87(display_short)|psi-mi:EBI-7188812(display_long) psi-mi:prio_mouse(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:Prnp(gene name)|psi-mi:Prnp(display_short)|uniprotkb:Prn-p(gene name synonym)|uniprotkb:Prp(gene name synonym) psi-mi:"MI:0030"(cross-linking study) Schmitt-Ulms et al. (2004) pubmed:15146195|mint:MINT-5217033 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7188818|mint:MINT-50051 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q8BQ87(Q8BQ87)|mint:MINT-1177385(identity) refseq:NP_001265185.1|refseq:NP_035300.1|dip:DIP-4N|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051087"(chaperone binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|ensembl:ENSMUSG00000079037(gene)|ensembl:ENSMUST00000091288(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|interpro:IPR036924|mint:P04925|rcsb pdb:1AG2|rcsb pdb:1XYX|rcsb pdb:1Y15|rcsb pdb:1Y16|rcsb pdb:2K5O|rcsb pdb:2KFM|rcsb pdb:2KFO|rcsb pdb:2KU5|rcsb pdb:2KU6|rcsb pdb:2L1D|rcsb pdb:2L1E|rcsb pdb:2L1H|rcsb pdb:2L1K|rcsb pdb:2L39|rcsb pdb:2L40|rcsb pdb:3NVG|rcsb pdb:3NVH|rcsb pdb:4H88|rcsb pdb:4J8R|rcsb pdb:4MA7|rcsb pdb:4MA8|rcsb pdb:6AQ7|rcsb pdb:6HER|rcsb pdb:6HHD|reactome:R-MMU-9609523|mint:MINT-1177381(identity) - comment:mint|no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2004/07/12 2014/10/16 - rogid:TRLrkh8lISmZdE7v3kEBmlkunmo10090 intact-crc:11EE52BB1A34A75B false - - - - psi-mi:"MI:0082"(peptide massfingerprinting) psi-mi:"MI:0086"(polyclonal antibody western blot)