#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6Q0C0	uniprotkb:Q99759	intact:EBI-307556|uniprotkb:Q9H073|ensembl:ENSP00000318944	intact:EBI-307281|uniprotkb:Q5BKZ6|intact:EBI-1384243|uniprotkb:B2RCW2|uniprotkb:Q8N3I9|uniprotkb:D3DU15|ensembl:ENSP00000354485	psi-mi:traf7_human(display_long)|uniprotkb:TRAF7(gene name)|psi-mi:TRAF7(display_short)|uniprotkb:TNF receptor-associated factor 7(gene name synonym)|uniprotkb:RING finger and WD repeat-containing protein 1(gene name synonym)|uniprotkb:RING finger protein 119(gene name synonym)|uniprotkb:RFWD1(gene name synonym)|uniprotkb:RNF119(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF7(gene name synonym)	psi-mi:m3k3_human(display_long)|uniprotkb:MAP3K3(gene name)|psi-mi:MAP3K3(display_short)|uniprotkb:MAPKKK3(gene name synonym)|uniprotkb:MEKK3(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Xu et al. (2004)	pubmed:15001576	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-446127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115647.2|ensembl:ENSG00000131653(gene)|ensembl:ENST00000326181(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017907|interpro:IPR019775|interpro:IPR020472|interpro:IPR027370|interpro:IPR036322|mint:Q6Q0C0|reactome:R-HSA-983168	refseq:NP_002392.2|refseq:NP_976226.1|dip:DIP-27521N|ensembl:ENSG00000198909(gene)|ensembl:ENST00000361733(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q99759|rcsb pdb:2C60|rcsb pdb:2JRH|rcsb pdb:2O2V|rcsb pdb:2PPH|rcsb pdb:4Y5O|rcsb pdb:4YL6|reactome:R-HSA-9020702	go:"GO:0007242"|go:"GO:0000185"(obsolete activation of MAPKKK activity)	-	-	comment:Interaction promotes the kinase activity of MAP3K3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2004/09/17	2014/10/16	rogid:46dtsS1OairncB0fnINSW1aY2789606	rogid:zU7/ETPtqBEvBgGHcncZviu4Ssw9606	intact-crc:09D9D24F02A8E82D|rigid:+9gNEFX1CdV0HulN2psov07zP0s	false	ha tag:?-?|necessary binding region:394..394-669..669(IPR001680)	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)