#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99741	uniprotkb:Q9H211	intact:EBI-374862|uniprotkb:Q8TB30|ensembl:ENSP00000209728|ensembl:ENSP00000497345	intact:EBI-456953|uniprotkb:Q86XX9|uniprotkb:Q96CJ5|uniprotkb:Q96GK5|uniprotkb:Q96H67|uniprotkb:Q96HE6|uniprotkb:Q9BWM0|ensembl:ENSP00000301019	psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym)	psi-mi:cdt1_human(display_long)|uniprotkb:Double parked homolog(gene name synonym)|uniprotkb:CDT1(gene name)|psi-mi:CDT1(display_short)	psi-mi:"MI:0096"(pull down)	Cook et al. (2004)	pubmed:14672932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457031	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000094804(gene)|ensembl:ENST00000209728(transcript)|ensembl:ENST00000649662(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|mint:Q99741|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:4I5L|rcsb pdb:4I5N|reactome:R-HSA-1362277|reactome:R-HSA-176187|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69205|refseq:NP_001245.1|dip:DIP-28154N	refseq:NP_112190.2|dip:DIP-31089N|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0072708"(response to sorbitol)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1905341"(negative regulation of protein localization to kinetochore)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR014939(DNA replication factor CDT1-like)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|mint:Q9H211|rcsb pdb:2LE8|rcsb pdb:2WVR|rcsb pdb:6QCG|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|ensembl:ENSG00000167513(gene)|ensembl:ENST00000301019(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016604"(nuclear body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)	go:"GO:0000074"|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0005656"(nuclear pre-replicative complex)	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/09	2014/10/16	rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606	rogid:bI5rgPGvSzq78lB8NlXnrPZygNY9606	intact-crc:B6D45E5CB6B2A01D|rigid:Oj+oduuJJRSdkBrVBwRNMpvmlHs	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99741	uniprotkb:Q9H211	intact:EBI-374862|uniprotkb:Q8TB30|ensembl:ENSP00000209728|ensembl:ENSP00000497345	intact:EBI-456953|uniprotkb:Q86XX9|uniprotkb:Q96CJ5|uniprotkb:Q96GK5|uniprotkb:Q96H67|uniprotkb:Q96HE6|uniprotkb:Q9BWM0|ensembl:ENSP00000301019	psi-mi:cdc6_human(display_long)|uniprotkb:CDC6(gene name)|psi-mi:CDC6(display_short)|uniprotkb:CDC18L(gene name synonym)|uniprotkb:CDC6-related protein(gene name synonym)|uniprotkb:"p62(cdc6)"(gene name synonym)|uniprotkb:Cdc18-related protein(gene name synonym)	psi-mi:cdt1_human(display_long)|uniprotkb:Double parked homolog(gene name synonym)|uniprotkb:CDT1(gene name)|psi-mi:CDT1(display_short)	psi-mi:"MI:0096"(pull down)	Cook et al. (2004)	pubmed:14672932	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457078	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000094804(gene)|ensembl:ENST00000209728(transcript)|ensembl:ENST00000649662(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0019900"(kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR015163(CDC6, C terminal)|interpro:IPR016314(Cell division control, Cdc6)|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR041083|mint:Q99741|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:4I5L|rcsb pdb:4I5N|reactome:R-HSA-1362277|reactome:R-HSA-176187|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69205|refseq:NP_001245.1|dip:DIP-28154N	refseq:NP_112190.2|dip:DIP-31089N|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0072708"(response to sorbitol)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1905341"(negative regulation of protein localization to kinetochore)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR014939(DNA replication factor CDT1-like)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|mint:Q9H211|rcsb pdb:2LE8|rcsb pdb:2WVR|rcsb pdb:6QCG|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69205|ensembl:ENSG00000167513(gene)|ensembl:ENST00000301019(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016604"(nuclear body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)	go:"GO:0000074"|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0005656"(nuclear pre-replicative complex)	-	-	-	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/11/09	2014/10/16	rogid:lnIJwO5IfQ8bIhP99eq483hAoTQ9606	rogid:bI5rgPGvSzq78lB8NlXnrPZygNY9606	intact-crc:809808FBF81F2014|rigid:Oj+oduuJJRSdkBrVBwRNMpvmlHs	false	binding-associated region:1-192	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8R4E9	uniprotkb:P97310	intact:EBI-457043|uniprotkb:Q8BUQ1|uniprotkb:Q8BX29|uniprotkb:Q8R3V0|uniprotkb:Q8R4E8|ensembl:ENSMUSP00000006760	intact:EBI-457049|uniprotkb:O08971|uniprotkb:O89057|uniprotkb:Q8C2R0|ensembl:ENSMUSP00000061923	psi-mi:cdt1_mouse(display_long)|uniprotkb:Double parked homolog(gene name synonym)|uniprotkb:Retroviral insertion site 2 protein(gene name synonym)|uniprotkb:Cdt1(gene name)|psi-mi:Cdt1(display_short)|uniprotkb:Ris2(gene name synonym)	psi-mi:mcm2_mouse(display_long)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:Mcm2(gene name)|psi-mi:Mcm2(display_short)|uniprotkb:Bm28(gene name synonym)|uniprotkb:Cdcl1(gene name synonym)|uniprotkb:Kiaa0030(gene name synonym)|uniprotkb:Mcmd2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Cook et al. (2004)	pubmed:14672932	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-457068	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080290.3|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045740"(positive regulation of DNA replication)|ensembl:ENSMUSG00000006585(gene)|ensembl:ENSMUST00000006760(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016604"(nuclear body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|rcsb pdb:2KLO|rcsb pdb:2RQQ|rcsb pdb:2ZXX|rcsb pdb:3A4C|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0072708"(response to sorbitol)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1905341"(negative regulation of protein localization to kinetochore)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR014939(DNA replication factor CDT1-like)	refseq:NP_032590.2|dip:DIP-33057N|ensembl:ENSMUSG00000002870(gene)|ensembl:ENSMUST00000058011(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P97310|reactome:R-MMU-176187|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69052	go:"GO:0000074"|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0005656"(nuclear pre-replicative complex)	-	-	-	taxid:10090(mouse-3t3)|taxid:10090(Mus musculus embryo cells)	-	2004/11/09	2014/10/16	rogid:GkxXG8geC2JHCrw2tNWQzIhf+W410090	rogid:HwAzfjnxpS94H12oI3OiiHTsEm410090	intact-crc:18FA5A958CD210CB|rigid:XSYLK7F1wkXFXSDzGUp0xihYLeA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)