#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02468 uniprotkb:P10493 intact:EBI-7059830|intact:MINT-1031545 intact:EBI-1032117|uniprotkb:Q8BQI3|uniprotkb:Q8C3U8|uniprotkb:Q8C9P6|uniprotkb:Q3TKX9|ensembl:ENSMUSP00000005532 psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:nid1_mouse(display_long)|uniprotkb:Nid1(gene name)|psi-mi:Nid1(display_short)|uniprotkb:Ent(gene name synonym)|uniprotkb:Entactin(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Takagi et al. (2003) pubmed:12931195|mint:MINT-5216807|imex:IM-27284 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7059826|mint:MINT-24867|wwpdb:1NPE|imex:IM-27284-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N|mint:MINT-1031572(identity) refseq:NP_035047.2|interpro:IPR026823|interpro:IPR036857|mint:P10493|rcsb pdb:1GL4|rcsb pdb:1H4U|rcsb pdb:1NPE|reactome:R-MMU-1474228|reactome:R-MMU-3000157|ensembl:ENSMUSG00000005397(gene)|ensembl:ENSMUST00000005532(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003886(Nidogen, extracellular region)|interpro:IPR006605(G2 nidogen and fibulin G2F)|interpro:IPR009017(Green fluorescent protein-like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR024731|mint:MINT-1031565(identity) - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:Supp. Table 1|3d-resolution:2.3A|comment:In the xray complex 1npe, P10493 is chain A and P02468 is chain B Resolution 2.300|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2017/09/13 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 rogid:3dnqHnqAO3PlU6v5pchyqrF4UBg10090 intact-crc:96DE2E46AFE22DED|rigid:dJ07Lz9sURTNxzaPROFF5/7bHSA false sufficient binding region:769-932(MINT-1031573) sufficient binding region:941-1207(MINT-1031566) 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P02468 uniprotkb:P10493 intact:EBI-7059830|intact:MINT-1031545 intact:EBI-1032117|uniprotkb:Q8BQI3|uniprotkb:Q8C3U8|uniprotkb:Q8C9P6|uniprotkb:Q3TKX9|ensembl:ENSMUSP00000005532 psi-mi:lamc1_mouse(display_long)|uniprotkb:Lamc1(gene name)|psi-mi:Lamc1(display_short)|uniprotkb:Lamb-2(gene name synonym)|uniprotkb:Lamc-1(gene name synonym)|uniprotkb:Laminin B2 chain(gene name synonym)|uniprotkb:Laminin-1 subunit gamma(gene name synonym)|uniprotkb:Laminin-2 subunit gamma(gene name synonym)|uniprotkb:Laminin-3 subunit gamma(gene name synonym)|uniprotkb:Laminin-4 subunit gamma(gene name synonym)|uniprotkb:Laminin-6 subunit gamma(gene name synonym)|uniprotkb:Laminin-7 subunit gamma(gene name synonym)|uniprotkb:Laminin-8 subunit gamma(gene name synonym)|uniprotkb:Laminin-9 subunit gamma(gene name synonym)|uniprotkb:Laminin-10 subunit gamma(gene name synonym)|uniprotkb:Laminin-11 subunit gamma(gene name synonym)|uniprotkb:S-laminin subunit gamma(gene name synonym) psi-mi:nid1_mouse(display_long)|uniprotkb:Nid1(gene name)|psi-mi:Nid1(display_short)|uniprotkb:Ent(gene name synonym)|uniprotkb:Entactin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Takagi et al. (2003) pubmed:12931195|mint:MINT-5216807|imex:IM-27284 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-16415610|imex:IM-27284-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P02468|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005606"(laminin-1 complex)|go:"GO:0007155"(cell adhesion)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031175"(neuron projection development)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043259"(laminin-10 complex)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000034(Laminin B)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|rcsb pdb:1KLO|rcsb pdb:1NPE|rcsb pdb:1TLE|rcsb pdb:4AQT|rcsb pdb:5MC9|reactome:R-MMU-3000157|reactome:R-MMU-381426|reactome:R-MMU-8957275|reactome:R-MMU-8874081|dip:DIP-41793N|mint:MINT-1031572(identity) refseq:NP_035047.2|interpro:IPR026823|interpro:IPR036857|mint:P10493|rcsb pdb:1GL4|rcsb pdb:1H4U|rcsb pdb:1NPE|reactome:R-MMU-1474228|reactome:R-MMU-3000157|ensembl:ENSMUSG00000005397(gene)|ensembl:ENSMUST00000005532(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032836"(glomerular basement membrane development)|go:"GO:0043236"(laminin binding)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071944"(cell periphery)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003886(Nidogen, extracellular region)|interpro:IPR006605(G2 nidogen and fibulin G2F)|interpro:IPR009017(Green fluorescent protein-like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR024731|mint:MINT-1031565(identity) - comment:mint|function:Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:Supp. Table 1|3d-resolution:2.3A|comment:In the xray complex 1npe, P10493 is chain A and P02468 is chain B Resolution 2.300|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2004/02/12 2017/09/13 rogid:LTc4oIJUjQ8INjkodiPpXvL/rx010090 rogid:3dnqHnqAO3PlU6v5pchyqrF4UBg10090 rigid:dJ07Lz9sURTNxzaPROFF5/7bHSA false sufficient binding region:769-932(MINT-1031573) sufficient binding region:941-1207(MINT-1031566)|v5 tag:c-c|his tag:c-c 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)