#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q08369	uniprotkb:P42582	intact:EBI-297008|ensembl:ENSMUSP00000113891|uniprotkb:P97491|uniprotkb:Q9QZK4|uniprotkb:B9EHF7	intact:EBI-297021|ensembl:ENSMUSP00000015723|uniprotkb:P97335	psi-mi:gata4_mouse(display_long)|uniprotkb:Gata4(gene name)|psi-mi:Gata4(display_short)|uniprotkb:Gata-4(gene name synonym)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:nkx25_mouse(display_long)|uniprotkb:Nkx2-5(gene name)|psi-mi:Nkx2-5(display_short)|uniprotkb:Csx(gene name synonym)|uniprotkb:Nkx-2.5(gene name synonym)|uniprotkb:Nkx2e(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Garg et al. (2003)	pubmed:12845333	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-297037	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|ensembl:ENSMUSG00000021944(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|ensembl:ENSMUST00000118022(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0008584"(male gonad development)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060464"(lung lobe formation)|go:"GO:0060540"(diaphragm morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071371"(cellular response to gonadotropin stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1905204"(negative regulation of connective tissue replacement)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|reactome:R-MMU-983231|refseq:NP_032118.2|dip:DIP-33032N	go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:5FLV|ensembl:ENSMUSG00000015579(gene)|ensembl:ENSMUST00000015723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003168"(Purkinje myocyte differentiation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003285"(septum secundum development)|go:"GO:0003342"(proepicardium development)|go:"GO:0003350"(pulmonary myocardium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|refseq:NP_032726.1|refseq:XP_006523860.1|dip:DIP-33031N	go:"GO:0007507"(heart development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)	-	-	comment:"Gata4 was Myc tagged and Nkx2-5 was Flag tagged. Coexpressed in COS1 cells. Both wild type and mutant (G295S) Gata4 interact with Nkx2-5."	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2004/02/24	2014/10/16	rogid:Xh3S+YdNUH7mCty5YVJh1pJdups10090	rogid:/U1x7rZvb4/qIpJkF1tQMZ0UF7A10090	intact-crc:9614DB44981D7B32|rigid:VSYJDLmzlnoYkdhnxcxnK1QOE1o	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q99593	uniprotkb:Q08369	intact:EBI-297043|uniprotkb:O15301|uniprotkb:Q9Y4I2|ensembl:ENSP00000309913|ensembl:ENSP00000384152|uniprotkb:A6ND77|uniprotkb:Q96TB0	intact:EBI-297008|ensembl:ENSMUSP00000113891|uniprotkb:P97491|uniprotkb:Q9QZK4|uniprotkb:B9EHF7	psi-mi:tbx5_human(display_long)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short)	psi-mi:gata4_mouse(display_long)|uniprotkb:Gata4(gene name)|psi-mi:Gata4(display_short)|uniprotkb:Gata-4(gene name synonym)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Garg et al. (2003)	pubmed:12845333	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-297057	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060039"(pericardium development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086054"(bundle of His cell to Purkinje myocyte communication by electrical coupling)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901846"(positive regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903781"(positive regulation of cardiac conduction)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|rcsb pdb:2X6U|rcsb pdb:2X6V|rcsb pdb:4S0H|rcsb pdb:5BQD|reactome:R-HSA-2032785|reactome:R-HSA-5578768|refseq:NP_000183.2|refseq:NP_542448.1|refseq:NP_852259.1|ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003166"(bundle of His development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003218"(cardiac left ventricle formation)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|ensembl:ENSMUSG00000021944(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|ensembl:ENSMUST00000118022(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0008584"(male gonad development)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060464"(lung lobe formation)|go:"GO:0060540"(diaphragm morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071371"(cellular response to gonadotropin stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1905204"(negative regulation of connective tissue replacement)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|reactome:R-MMU-983231|refseq:NP_032118.2|dip:DIP-33032N	go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007507"(heart development)	-	-	comment:"TBX5 was Myc tagged and Gata4 was Flag tagged. Coexpressed in COS1 cells. Gata4 mutation (G295S) abolished its interaction with TBX5."|disease:"Disruption of this interaction by mutations may cause congenital heart defect (CHD)."	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2004/02/24	2014/10/16	rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606	rogid:Xh3S+YdNUH7mCty5YVJh1pJdups10090	intact-crc:6D964079F586F3A6|rigid:HTPRhr4xnYi2R8WE22niEP/nUC8	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q08369	uniprotkb:Q99593	intact:EBI-297008|ensembl:ENSMUSP00000113891|uniprotkb:P97491|uniprotkb:Q9QZK4|uniprotkb:B9EHF7	intact:EBI-297043|uniprotkb:O15301|uniprotkb:Q9Y4I2|ensembl:ENSP00000309913|ensembl:ENSP00000384152|uniprotkb:A6ND77|uniprotkb:Q96TB0	psi-mi:gata4_mouse(display_long)|uniprotkb:Gata4(gene name)|psi-mi:Gata4(display_short)|uniprotkb:Gata-4(gene name synonym)|uniprotkb:GATA-binding factor 4(gene name synonym)	psi-mi:tbx5_human(display_long)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Garg et al. (2003)	pubmed:12845333	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-297066	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|ensembl:ENSMUSG00000021944(gene)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|ensembl:ENSMUST00000118022(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003195"(tricuspid valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003289"(atrial septum primum morphogenesis)|go:"GO:0003290"(atrial septum secundum morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035239"(tube morphogenesis)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043627"(response to estrogen)|go:"GO:0008584"(male gonad development)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060464"(lung lobe formation)|go:"GO:0060540"(diaphragm morphogenesis)|go:"GO:0060575"(intestinal epithelial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0071371"(cellular response to gonadotropin stimulus)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0072148"(epithelial cell fate commitment)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1905204"(negative regulation of connective tissue replacement)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000679(Zinc finger, GATA-type)|interpro:IPR008013(GATA-type transcription activator, N-terminal)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR016375(Transcription factor GATA-4/5/6)|interpro:IPR039355|reactome:R-MMU-983231|refseq:NP_032118.2|dip:DIP-33032N	go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060039"(pericardium development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086054"(bundle of His cell to Purkinje myocyte communication by electrical coupling)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901846"(positive regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903781"(positive regulation of cardiac conduction)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|rcsb pdb:2X6U|rcsb pdb:2X6V|rcsb pdb:4S0H|rcsb pdb:5BQD|reactome:R-HSA-2032785|reactome:R-HSA-5578768|refseq:NP_000183.2|refseq:NP_542448.1|refseq:NP_852259.1|ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003166"(bundle of His development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003218"(cardiac left ventricle formation)	go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007507"(heart development)	-	-	comment:"Gata4 was Myc tagged and TBX5 was Flag tagged. Coexpressed in COS1 cells. Mutations of TBX5 (G80R or R237W) abolished its interaction with Gata4."|disease:"Disruption of this interaction by mutations may cause congenital heart defects (CHD)."	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2004/02/24	2014/10/16	rogid:Xh3S+YdNUH7mCty5YVJh1pJdups10090	rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606	intact-crc:CF7F8AE8722EC087|rigid:HTPRhr4xnYi2R8WE22niEP/nUC8	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:P42582	uniprotkb:Q99593	intact:EBI-297021|ensembl:ENSMUSP00000015723|uniprotkb:P97335	intact:EBI-297043|uniprotkb:O15301|uniprotkb:Q9Y4I2|ensembl:ENSP00000309913|ensembl:ENSP00000384152|uniprotkb:A6ND77|uniprotkb:Q96TB0	psi-mi:nkx25_mouse(display_long)|uniprotkb:Nkx2-5(gene name)|psi-mi:Nkx2-5(display_short)|uniprotkb:Csx(gene name synonym)|uniprotkb:Nkx-2.5(gene name synonym)|uniprotkb:Nkx2e(gene name synonym)|uniprotkb:Homeobox protein NK-2 homolog E(gene name synonym)|uniprotkb:Cardiac-specific homeobox(gene name synonym)|uniprotkb:Homeobox protein CSX(gene name synonym)	psi-mi:tbx5_human(display_long)|uniprotkb:TBX5(gene name)|psi-mi:TBX5(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Garg et al. (2003)	pubmed:12845333	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-297074	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048536"(spleen development)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0055005"(ventricular cardiac myofibril assembly)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0072359"(circulatory system development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|interpro:IPR033629|rcsb pdb:5FLV|ensembl:ENSMUSG00000015579(gene)|ensembl:ENSMUST00000015723(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001947"(heart looping)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003166"(bundle of His development)|go:"GO:0003168"(Purkinje myocyte differentiation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003211"(cardiac ventricle formation)|go:"GO:0003221"(right ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003228"(atrial cardiac muscle tissue development)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003285"(septum secundum development)|go:"GO:0003342"(proepicardium development)|go:"GO:0003350"(pulmonary myocardium development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0007512"(adult heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043586"(tongue development)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045823"(positive regulation of heart contraction)|refseq:NP_032726.1|refseq:XP_006523860.1|dip:DIP-33031N	go:"GO:0003281"(ventricular septum development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007389"(pattern specification process)|go:"GO:0007507"(heart development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051891"(positive regulation of cardioblast differentiation)|go:"GO:0060039"(pericardium development)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060371"(regulation of atrial cardiac muscle cell membrane depolarization)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0060929"(atrioventricular node cell fate commitment)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0072513"(positive regulation of secondary heart field cardioblast proliferation)|go:"GO:0086019"(cell-cell signaling involved in cardiac conduction)|go:"GO:0086054"(bundle of His cell to Purkinje myocyte communication by electrical coupling)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901846"(positive regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903781"(positive regulation of cardiac conduction)|interpro:IPR001699(Transcription factor, T-box)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR018186|interpro:IPR036960|rcsb pdb:2X6U|rcsb pdb:2X6V|rcsb pdb:4S0H|rcsb pdb:5BQD|reactome:R-HSA-2032785|reactome:R-HSA-5578768|refseq:NP_000183.2|refseq:NP_542448.1|refseq:NP_852259.1|ensembl:ENSG00000089225(gene)|ensembl:ENST00000310346(transcript)|ensembl:ENST00000405440(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001708"(cell fate specification)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003166"(bundle of His development)|go:"GO:0003167"(atrioventricular bundle cell differentiation)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003218"(cardiac left ventricle formation)	go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0007507"(heart development)	-	-	comment:"Nkx2-5 was Myc tagged and TBX5 was Flag tagged. Coexpressed in COS1 cells. Mutations of TBX5 (G80R or R237W) abolished its interaction with Nkx2-5."	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2004/02/24	2014/10/16	rogid:/U1x7rZvb4/qIpJkF1tQMZ0UF7A10090	rogid:gjw8Xw7q9o9hhhhjh+DgDZssmwU9606	intact-crc:DD7C37C65F93FC88|rigid:y8xomMwaA7Lt0oMspHZux797d2E	false	-	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)