#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49061	uniprotkb:P08254	intact:EBI-6957334|intact:MINT-269354	intact:EBI-6957351|ensembl:ENSP00000299855|uniprotkb:B2R8B8|intact:MINT-269333|uniprotkb:Q6GRF8|uniprotkb:Q3B7S0	psi-mi:timp1_papcy(display_long)|uniprotkb:TIMP1(gene name)|psi-mi:TIMP1(display_short)|uniprotkb:Tissue inhibitor of metalloproteinases 1(gene name synonym)	psi-mi:mmp3_human(display_long)|uniprotkb:MMP3(gene name)|psi-mi:MMP3(display_short)|uniprotkb:STMY1(gene name synonym)|uniprotkb:Matrix metalloproteinase-3(gene name synonym)|uniprotkb:Transin-1(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Arumugam et al. (2003)	pubmed:12834347|mint:MINT-5216505	taxid:9556(papcy)|taxid:9556(Papio cynocephalus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6957433|mint:MINT-24777	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR030490|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:2001044"(regulation of integrin-mediated signaling pathway)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001820(Proteinase inhibitor I35, tissue inhibitor of metalloproteinase)|interpro:IPR027465|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR015611(Tissue inhibitor of metalloprotease 1)|mint:MINT-736450(identity)	ensembl:ENSG00000149968(gene)|ensembl:ENST00000299855(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010727"(negative regulation of hydrogen peroxide metabolic process)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:1903209"(positive regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|go:"GO:0071492"(cellular response to UV-A)|interpro:IPR006026(Peptidase, metallopeptidases)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0150077"(regulation of neuroinflammatory response)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|rcsb pdb:1B3D|rcsb pdb:1B8Y|rcsb pdb:1BIW|rcsb pdb:1BM6|rcsb pdb:1BQO|rcsb pdb:1C3I|rcsb pdb:1C8T|rcsb pdb:1CAQ|rcsb pdb:1CIZ|rcsb pdb:1CQR|rcsb pdb:1D5J|rcsb pdb:1D7X|rcsb pdb:1D8F|rcsb pdb:1D8M|rcsb pdb:1G05|rcsb pdb:1G49|rcsb pdb:1G4K|rcsb pdb:1HFS|rcsb pdb:1HY7|rcsb pdb:1M1W|rcsb pdb:1OO9|rcsb pdb:1QIA|rcsb pdb:1QIC|rcsb pdb:1SLM|rcsb pdb:1SLN|rcsb pdb:1UEA|rcsb pdb:1UMS|rcsb pdb:1UMT|rcsb pdb:1USN|rcsb pdb:2D1O|rcsb pdb:2JNP|rcsb pdb:2JT5|rcsb pdb:2JT6|rcsb pdb:2SRT|rcsb pdb:2USN|rcsb pdb:3OHL|rcsb pdb:3OHO|rcsb pdb:3USN|rcsb pdb:4DPE|rcsb pdb:4G9L|rcsb pdb:4JA1|rcsb pdb:6MAV|rcsb pdb:6N9D|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-2022090|reactome:R-HSA-2179392|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_002413.1|mint:MINT-736443(identity)	-	function:"Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them"|comment:mint|comment:"Stoichiometry: 1.0"	comment:mint|function:Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase|comment:"Stoichiometry: 1.0"	comment:In the xray complex 1oo9, P08254 is chain A and P49061 is chain B Resolution|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:oE8SbzVU7XT9kLTb/4QdvdAjOZ89556	rogid:5BrHkUrs7cz77Tvm7VTKJue6hWA9606	intact-crc:52C27F11F1DE5979|rigid:M5TM3Q798v25OtD+zWzRG/kG9Yg	false	tag:?-?(MINT-736451)	tag:?-?(MINT-736444)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)