#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y5A7-1 uniprotkb:Q15843 intact:EBI-6948038|ensembl:ENSP00000418234|ensembl:ENSP00000454264|intact:MINT-268315 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:q9y5a7-1(display_long)|uniprotkb:NUB1(gene name)|psi-mi:NUB1(display_short)|uniprotkb:NYREN18(gene name synonym)|uniprotkb:Negative regulator of ubiquitin-like proteins 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-18(gene name synonym)|uniprotkb:NUB1L(isoform synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0018"(two hybrid) Tanaka et al. (2003) pubmed:12816948|mint:MINT-5216480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6948049|mint:MINT-50772 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000013374(gene)|ensembl:ENST00000470229(transcript)|ensembl:ENST00000568733(transcript)|intact:EBI-3936907(isoform-parent)|mint:MINT-735812(identity) refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-735822(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7 F8|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2004/12/14 2014/10/16 rogid:RO3+wwxnIE0O0kfXxL8Jnn5bgxY9606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:D995B0A3B525A5C4|rigid:2cZ3gFbiIvfKIt3L0JoBfZImA1g false binding-associated region:550-598(MINT-735813)|tag:?-?(MINT-735816) tag:?-?(MINT-735823) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y5A7-1 uniprotkb:Q15843 intact:EBI-6948038|ensembl:ENSP00000418234|ensembl:ENSP00000454264|intact:MINT-268315 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:q9y5a7-1(display_long)|uniprotkb:NUB1(gene name)|psi-mi:NUB1(display_short)|uniprotkb:NYREN18(gene name synonym)|uniprotkb:Negative regulator of ubiquitin-like proteins 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-18(gene name synonym)|uniprotkb:NUB1L(isoform synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0018"(two hybrid) Tanaka et al. (2003) pubmed:12816948|mint:MINT-5216480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6948101|mint:MINT-50773 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000013374(gene)|ensembl:ENST00000470229(transcript)|ensembl:ENST00000568733(transcript)|intact:EBI-3936907(isoform-parent)|mint:MINT-735793(identity) refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-735802(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F7 F8|comment:homomint|comment:mint taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2004/12/14 2014/10/16 rogid:RO3+wwxnIE0O0kfXxL8Jnn5bgxY9606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:ABB071A31E39E3F9|rigid:2cZ3gFbiIvfKIt3L0JoBfZImA1g false binding-associated region:427-474(MINT-735794)|tag:?-?(MINT-735796) tag:?-?(MINT-735803) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9Y5A7-1 uniprotkb:Q15843 intact:EBI-6948038|ensembl:ENSP00000418234|ensembl:ENSP00000454264|intact:MINT-268315 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:q9y5a7-1(display_long)|uniprotkb:NUB1(gene name)|psi-mi:NUB1(display_short)|uniprotkb:NYREN18(gene name synonym)|uniprotkb:Negative regulator of ubiquitin-like proteins 1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-18(gene name synonym)|uniprotkb:NUB1L(isoform synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0096"(pull down) Tanaka et al. (2003) pubmed:12816948|mint:MINT-5216480 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-6948129|mint:MINT-50774 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000013374(gene)|ensembl:ENST00000470229(transcript)|ensembl:ENST00000568733(transcript)|intact:EBI-3936907(isoform-parent)|mint:MINT-735834(identity) refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N|mint:MINT-735840(identity) - comment:mint|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F9|comment:L464 and L468 define hotspots in the UBA region while L591 and L587 define hotspots in the C-ter region. Both regions can independently bind Nedd8|comment:homomint|comment:mint taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/12/14 2014/10/16 rogid:RO3+wwxnIE0O0kfXxL8Jnn5bgxY9606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:0A296AA01C6E7782|rigid:2cZ3gFbiIvfKIt3L0JoBfZImA1g false tag:?-?(MINT-735835) tag:?-?(MINT-735841) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)