#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P70166 uniprotkb:Q9PTG8 intact:EBI-8621413|ensembl:ENSMUSP00000095936|uniprotkb:Q8C5P9|intact:MINT-261117 intact:EBI-65726|uniprotkb:Q52L20 psi-mi:cpeb1_mouse(display_long)|uniprotkb:Cpeb1(gene name)|psi-mi:Cpeb1(display_short)|uniprotkb:Cpeb(gene name synonym) psi-mi:tacc3_xenla(display_long)|uniprotkb:Cytoplasmic polyadenylation element-binding protein-associated factor Maskin(gene name synonym)|uniprotkb:tacc3(gene name)|psi-mi:tacc3(display_short)|uniprotkb:maskin(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Huang et al. (2003) mint:MINT-5216214|pubmed:12629046 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8621409|mint:MINT-24745 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025586(gene)|ensembl:ENSMUST00000098331(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072687"(meiotic spindle)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032292|interpro:IPR032296|interpro:IPR034819|interpro:IPR034977|interpro:IPR035979|interpro:IPR038446|refseq:NP_031781.1|refseq:NP_001239454.1|refseq:NP_001239455.1|dip:DIP-41380N|mint:MINT-730592(identity) refseq:NP_001081964.1|dip:DIP-29250N|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051301"(cell division)|interpro:IPR007707(Transforming acidic coiled-coil-containing)|interpro:IPR039915|mint:MINT-730597(identity) - comment:mint|function:"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with MASKIN is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:f3|comment:mint taxid:10116(rat-b104 neuroblasto)|taxid:10116(Rattus norvegicus) - 2004/02/11 2014/10/16 rogid:gWr51Ie7xVskFIJlCaQ8OWNxSwo10090 rogid:tOVIy78/+hUtpDGCaQOBx6PM72s8355 intact-crc:F5A5228D23B18EE3|rigid:npQwzpvOSFuu4aXnH1NcwSpGeos false - - - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P70166 uniprotkb:O88658 intact:EBI-8621413|ensembl:ENSMUSP00000095936|uniprotkb:Q8C5P9|intact:MINT-261117 intact:EBI-924646|uniprotkb:Q65Z71|uniprotkb:Q8R524|ensembl:ENSRNOP00000074322|ensembl:ENSRNOP00000075522 psi-mi:cpeb1_mouse(display_long)|uniprotkb:Cpeb1(gene name)|psi-mi:Cpeb1(display_short)|uniprotkb:Cpeb(gene name synonym) psi-mi:kif1b_rat(display_long)|uniprotkb:Kif1b(gene name)|psi-mi:Kif1b(display_short) psi-mi:"MI:0416"(fluorescence microscopy) Huang et al. (2003) mint:MINT-5216214|pubmed:12629046 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8621458|mint:MINT-24746 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025586(gene)|ensembl:ENSMUST00000098331(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072687"(meiotic spindle)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032292|interpro:IPR032296|interpro:IPR034819|interpro:IPR034977|interpro:IPR035979|interpro:IPR038446|refseq:NP_031781.1|refseq:NP_001239454.1|refseq:NP_001239455.1|dip:DIP-41380N|mint:MINT-730616(identity) rgd:621520|refseq:NP_476548.1|ensembl:ENSRNOG00000057626(gene)|ensembl:ENSRNOT00000087739(transcript)|ensembl:ENSRNOT00000089099(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010970"(transport along microtubule)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019900"(kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032418"(lysosome localization)|go:"GO:0043005"(neuron projection)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904647"(response to rotenone)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990939"|interpro:IPR000253(Forkhead-associated)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR027640|interpro:IPR032405|interpro:IPR036961|reactome:R-RNO-2132295|reactome:R-RNO-6811434|reactome:R-RNO-983189|mint:MINT-730621(identity) - comment:mint|function:"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with MASKIN is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:f5|comment:homomint|comment:mint taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2004/02/11 2014/10/16 rogid:gWr51Ie7xVskFIJlCaQ8OWNxSwo10090 rogid:pOpPlcTNXi27NgtBAcTpwmRV7EE10116 intact-crc:5EDCE93F76678C8C|rigid:lceLPI0gMCHMKJiZA+EuHgZNLEk false green fluorescent protein tag:?-?(MINT-6939469) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining) uniprotkb:P70166 uniprotkb:P15146 intact:EBI-8621413|ensembl:ENSMUSP00000095936|uniprotkb:Q8C5P9|intact:MINT-261117 intact:EBI-6095638 psi-mi:cpeb1_mouse(display_long)|uniprotkb:Cpeb1(gene name)|psi-mi:Cpeb1(display_short)|uniprotkb:Cpeb(gene name synonym) psi-mi:mtap2_rat(display_long)|uniprotkb:Map2(gene name)|psi-mi:Map2(display_short)|uniprotkb:Mtap2(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Huang et al. (2003) mint:MINT-5216214|pubmed:12629046 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8621490|mint:MINT-24748 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025586(gene)|ensembl:ENSMUST00000098331(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072687"(meiotic spindle)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032292|interpro:IPR032296|interpro:IPR034819|interpro:IPR034977|interpro:IPR035979|interpro:IPR038446|refseq:NP_031781.1|refseq:NP_001239454.1|refseq:NP_001239455.1|dip:DIP-41380N|mint:MINT-730580(identity) interpro:IPR030797|refseq:XP_008765430.1|mint:P15146|rgd:3044|interpro:IPR013588(MAP2/Tau projection)|interpro:IPR001084(Tubulin-binding Tau protein)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043203"(axon hillock)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097442"(CA3 pyramidal cell dendrite)|go:"GO:0150001"(primary dendrite)|go:"GO:0150002"(distal dendrite)|go:"GO:0150014"(apical distal dendrite)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1903744"(positive regulation of anterograde synaptic vesicle transport)|go:"GO:1903827"|go:"GO:1904527"(negative regulation of microtubule binding)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990769"(proximal neuron projection)|go:"GO:2000575"(obsolete negative regulation of microtubule motor activity)|go:"GO:0034399"(nuclear periphery)|mint:MINT-730585(identity) - comment:mint|function:"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with MASKIN is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|figure legend:f7|comment:mint taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2004/02/11 2014/10/16 rogid:gWr51Ie7xVskFIJlCaQ8OWNxSwo10090 rogid:idoGPInRds+FBHZ23KyNC+c5gL810116 intact-crc:4B270F7CD32A7D08|rigid:ABtMi9lpttTpzaSnply+sRilRUM false green fluorescent protein tag:?-?(MINT-6939452) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining) uniprotkb:P70166 uniprotkb:P62628 intact:EBI-8621413|ensembl:ENSMUSP00000095936|uniprotkb:Q8C5P9|intact:MINT-261117 intact:EBI-917939|uniprotkb:O88567|uniprotkb:Q9D812|ensembl:ENSRNOP00000060800 psi-mi:cpeb1_mouse(display_long)|uniprotkb:Cpeb1(gene name)|psi-mi:Cpeb1(display_short)|uniprotkb:Cpeb(gene name synonym) psi-mi:dlrb1_rat(display_long)|uniprotkb:Dynein light chain 2A, cytoplasmic(gene name synonym)|uniprotkb:Dynein-associated protein Km23(gene name synonym)|uniprotkb:Bithoraxoid-like protein(gene name synonym)|uniprotkb:Dynlrb1(gene name)|psi-mi:Dynlrb1(display_short)|uniprotkb:Dnlc2a(gene name synonym)|uniprotkb:Dncl2a(gene name synonym) psi-mi:"MI:0416"(fluorescence microscopy) Huang et al. (2003) mint:MINT-5216214|pubmed:12629046 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0471"(MINT) intact:EBI-8621474|mint:MINT-24747 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000025586(gene)|ensembl:ENSMUST00000098331(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051028"(mRNA transport)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072687"(meiotic spindle)|go:"GO:1900365"(positive regulation of mRNA polyadenylation)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR032292|interpro:IPR032296|interpro:IPR034819|interpro:IPR034977|interpro:IPR035979|interpro:IPR038446|refseq:NP_031781.1|refseq:NP_001239454.1|refseq:NP_001239455.1|dip:DIP-41380N|mint:MINT-730604(identity) rgd:619910|refseq:NP_571985.1|ensembl:ENSRNOG00000025715(gene)|ensembl:ENSRNOT00000067854(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007632"(visual behavior)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009416"(response to light stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR004942(Dynein light chain-related)|interpro:IPR016561(Dynein light chain, roadblock-type)|reactome:R-RNO-5620924|mint:MINT-730609(identity) - comment:mint|function:"Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the 3'-UTR of mRNAs. In absence of phosphorylation and in association with MASKIN is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses. Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation. Induces the assembly of stress granules in the absence of stress"|comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:f5|comment:homomint|comment:mint taxid:10116(rat-hippocampus_neuron)|taxid:10116(Rattus norvegicus) - 2004/02/11 2014/10/16 rogid:gWr51Ie7xVskFIJlCaQ8OWNxSwo10090 rogid:F1i32Asgu8HyhSLSqlkv8XZos2U10116 intact-crc:15C53729F97CF502|rigid:vHw7RLefesbOwhk8S96tpySn8AQ false green fluorescent protein tag:?-?(MINT-6939461) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0422"(immunostaining)