#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y6R4 uniprotkb:P52564 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 intact:EBI-448135|ensembl:ENSP00000468348 psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:mp2k6_human(display_long)|uniprotkb:MAPK/ERK kinase 6(gene name synonym)|uniprotkb:PRKMK6(gene name synonym)|uniprotkb:MAP2K6(gene name)|psi-mi:MAP2K6(display_short)|uniprotkb:MEK6(gene name synonym)|uniprotkb:MKK6(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 3(gene name synonym)|uniprotkb:SKK3(gene name synonym) psi-mi:"MI:0018"(two hybrid) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448103 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 refseq:NP_002749.2|dip:DIP-31346N|reactome:R-HSA-525793|reactome:R-HSA-6811555|reactome:R-HSA-9020702|ensembl:ENSG00000108984(gene)|ensembl:ENST00000590474(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P52564|rcsb pdb:2Y8O|rcsb pdb:3ENM|rcsb pdb:3FME|go:"GO:0002931"(response to ischemia)|rcsb pdb:3VN9|rcsb pdb:5ETF|reactome:R-HSA-168638|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891 - - - comment:"MAP2K6 K82A mutant (kinase-dead)"|comment:Interaction required the C-terminal 20 amino acid region of MAP2K6|comment:MAP2K6 does not interact with full length MAP3K4 due to internal autoinhibition of MAP3K4|comment:Residues 253-553 of MAP3K4 required or interaction|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 rogid:7RQ/LBAms1wKpD6Rv+ijvMIzDXA9606 intact-crc:CD263AA538F5ADEF|rigid:7A/VVG0yc75oDoUpUWtC2j6xfzU false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y6R4 uniprotkb:Q9Y6R4 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448214 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 go:"GO:0006469"(negative regulation of protein kinase activity) - - comment:The N- and C-terminus of MAP3K4 interact, inhibiting the kinase domain and preventing substrate binding|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 intact-crc:12E9076E626DF4E1|rigid:0KrIBFE8dqx3TWnp0466sF2tcVU false binding-associated region:1250-1343 binding-associated region:22-1103 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24522 uniprotkb:Q9Y6R4 intact:EBI-448167|uniprotkb:Q5TCA7|uniprotkb:Q5TCA8|ensembl:ENSP00000360025 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 psi-mi:ga45a_human(display_long)|uniprotkb:DNA damage-inducible transcript 1 protein(gene name synonym)|uniprotkb:GADD45A(gene name)|psi-mi:GADD45A(display_short)|uniprotkb:DDIT1(gene name synonym)|uniprotkb:GADD45(gene name synonym) psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448179 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186671.1|refseq:NP_001915.1|refseq:NP_001186670.1|dip:DIP-24217N|ensembl:ENSG00000116717(gene)|ensembl:ENST00000370986(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0019900"(kinase binding)|go:"GO:0033140"(negative regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:2KG4|reactome:R-HSA-6804114|reactome:R-HSA-9617828|go:"GO:0042803"(protein homodimerization activity) refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:3X3fjZ3b5kaLnfhh5bSDMP4Xu+o9606 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 intact-crc:7F27DAA225BDCCCC|rigid:iT8TXRyjiplOdLVIBmMZvHwT4oQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24522 uniprotkb:P52564 intact:EBI-448167|uniprotkb:Q5TCA7|uniprotkb:Q5TCA8|ensembl:ENSP00000360025 intact:EBI-448135|ensembl:ENSP00000468348 psi-mi:ga45a_human(display_long)|uniprotkb:DNA damage-inducible transcript 1 protein(gene name synonym)|uniprotkb:GADD45A(gene name)|psi-mi:GADD45A(display_short)|uniprotkb:DDIT1(gene name synonym)|uniprotkb:GADD45(gene name synonym) psi-mi:mp2k6_human(display_long)|uniprotkb:MAPK/ERK kinase 6(gene name synonym)|uniprotkb:PRKMK6(gene name synonym)|uniprotkb:MAP2K6(gene name)|psi-mi:MAP2K6(display_short)|uniprotkb:MEK6(gene name synonym)|uniprotkb:MKK6(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 3(gene name synonym)|uniprotkb:SKK3(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448179 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186671.1|refseq:NP_001915.1|refseq:NP_001186670.1|dip:DIP-24217N|ensembl:ENSG00000116717(gene)|ensembl:ENST00000370986(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006915"(apoptotic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0019900"(kinase binding)|go:"GO:0033140"(negative regulation of peptidyl-serine phosphorylation of STAT protein)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:2KG4|reactome:R-HSA-6804114|reactome:R-HSA-9617828|go:"GO:0042803"(protein homodimerization activity) refseq:NP_002749.2|dip:DIP-31346N|reactome:R-HSA-525793|reactome:R-HSA-6811555|reactome:R-HSA-9020702|ensembl:ENSG00000108984(gene)|ensembl:ENST00000590474(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P52564|rcsb pdb:2Y8O|rcsb pdb:3ENM|rcsb pdb:3FME|go:"GO:0002931"(response to ischemia)|rcsb pdb:3VN9|rcsb pdb:5ETF|reactome:R-HSA-168638|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:3X3fjZ3b5kaLnfhh5bSDMP4Xu+o9606 rogid:7RQ/LBAms1wKpD6Rv+ijvMIzDXA9606 intact-crc:7F27DAA225BDCCCC|rigid:iT8TXRyjiplOdLVIBmMZvHwT4oQ false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75293 uniprotkb:Q9Y6R4 intact:EBI-448187|uniprotkb:O75960|ensembl:ENSP00000215631|uniprotkb:Q17R46|uniprotkb:A8KAM2 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 psi-mi:ga45b_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD118(gene name synonym)|uniprotkb:Negative growth regulatory protein MyD118(gene name synonym)|uniprotkb:GADD45B(gene name)|psi-mi:GADD45B(display_short)|uniprotkb:MYD118(gene name synonym) psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448183 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056490.2|ensembl:ENSG00000099860(gene)|ensembl:ENST00000215631(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|dip:DIP-24219N|mint:O75293 refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:YZRMfuD6f4xC3Z4sjnf1IdsqARk9606 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 intact-crc:45CCE1BAC9333DFF|rigid:DHTZ8ItbAoMKkHWGOm2tiUcbSoY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O75293 uniprotkb:P52564 intact:EBI-448187|uniprotkb:O75960|ensembl:ENSP00000215631|uniprotkb:Q17R46|uniprotkb:A8KAM2 intact:EBI-448135|ensembl:ENSP00000468348 psi-mi:ga45b_human(display_long)|uniprotkb:Myeloid differentiation primary response protein MyD118(gene name synonym)|uniprotkb:Negative growth regulatory protein MyD118(gene name synonym)|uniprotkb:GADD45B(gene name)|psi-mi:GADD45B(display_short)|uniprotkb:MYD118(gene name synonym) psi-mi:mp2k6_human(display_long)|uniprotkb:MAPK/ERK kinase 6(gene name synonym)|uniprotkb:PRKMK6(gene name synonym)|uniprotkb:MAP2K6(gene name)|psi-mi:MAP2K6(display_short)|uniprotkb:MEK6(gene name synonym)|uniprotkb:MKK6(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 3(gene name synonym)|uniprotkb:SKK3(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448183 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056490.2|ensembl:ENSG00000099860(gene)|ensembl:ENST00000215631(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|dip:DIP-24219N|mint:O75293 refseq:NP_002749.2|dip:DIP-31346N|reactome:R-HSA-525793|reactome:R-HSA-6811555|reactome:R-HSA-9020702|ensembl:ENSG00000108984(gene)|ensembl:ENST00000590474(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P52564|rcsb pdb:2Y8O|rcsb pdb:3ENM|rcsb pdb:3FME|go:"GO:0002931"(response to ischemia)|rcsb pdb:3VN9|rcsb pdb:5ETF|reactome:R-HSA-168638|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:YZRMfuD6f4xC3Z4sjnf1IdsqARk9606 rogid:7RQ/LBAms1wKpD6Rv+ijvMIzDXA9606 intact-crc:45CCE1BAC9333DFF|rigid:DHTZ8ItbAoMKkHWGOm2tiUcbSoY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95257 uniprotkb:Q9Y6R4 intact:EBI-448202|intact:EBI-5773903|uniprotkb:Q9C076|uniprotkb:Q5VZ87|ensembl:ENSP00000252506 intact:EBI-448104|uniprotkb:Q5VTT8|uniprotkb:Q5VTT9|uniprotkb:Q9H408|uniprotkb:Q92612|uniprotkb:A6H8W0|uniprotkb:B7ZLD3|uniprotkb:B9EG75|ensembl:ENSP00000375986 psi-mi:ga45g_human(display_long)|uniprotkb:DDIT2(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym)|uniprotkb:DNA damage-inducible transcript 2 protein(gene name synonym)|uniprotkb:GADD45G(gene name)|psi-mi:GADD45G(display_short)|uniprotkb:CR6(gene name synonym) psi-mi:m3k4_human(display_long)|uniprotkb:MAPK/ERK kinase kinase 4(gene name synonym)|uniprotkb:MAP three kinase 1(gene name synonym)|uniprotkb:MAP3K4(gene name)|psi-mi:MAP3K4(display_short)|uniprotkb:KIAA0213(gene name synonym)|uniprotkb:MAPKKK4(gene name synonym)|uniprotkb:MEKK4(gene name synonym)|uniprotkb:MTK1(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448198 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006696.1|dip:DIP-24218N|ensembl:ENSG00000130222(gene)|ensembl:ENST00000252506(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:2WAL|rcsb pdb:3FFM refseq:NP_005913.2|refseq:NP_006715.2|refseq:NP_001288001.1|refseq:NP_001278887.1|ensembl:ENSG00000085511(gene)|ensembl:ENST00000392142(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001890"(placenta development)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010225"(response to UV-C)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019100"(male germ-line sex determination)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060718"(chorionic trophoblast cell differentiation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1904355"(positive regulation of telomere capping)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9Y6R4 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:/0gLr1aWX5yOU3Ytc4/IZn700IQ9606 rogid:Yw0J9tkrROWvQB8DaqKml7yLHQc9606 intact-crc:0B22092A3169ECE9|rigid:UYFHvZrfQ/Uy41vPO3yvOucr0ok false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O95257 uniprotkb:P52564 intact:EBI-448202|intact:EBI-5773903|uniprotkb:Q9C076|uniprotkb:Q5VZ87|ensembl:ENSP00000252506 intact:EBI-448135|ensembl:ENSP00000468348 psi-mi:ga45g_human(display_long)|uniprotkb:DDIT2(gene name synonym)|uniprotkb:Cytokine-responsive protein CR6(gene name synonym)|uniprotkb:DNA damage-inducible transcript 2 protein(gene name synonym)|uniprotkb:GADD45G(gene name)|psi-mi:GADD45G(display_short)|uniprotkb:CR6(gene name synonym) psi-mi:mp2k6_human(display_long)|uniprotkb:MAPK/ERK kinase 6(gene name synonym)|uniprotkb:PRKMK6(gene name synonym)|uniprotkb:MAP2K6(gene name)|psi-mi:MAP2K6(display_short)|uniprotkb:MEK6(gene name synonym)|uniprotkb:MKK6(gene name synonym)|uniprotkb:Stress-activated protein kinase kinase 3(gene name synonym)|uniprotkb:SKK3(gene name synonym) psi-mi:"MI:0111"(dihydrofolate reductase reconstruction) Mita et al. (2002) pubmed:12052864 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-448198 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006696.1|dip:DIP-24218N|ensembl:ENSG00000130222(gene)|ensembl:ENST00000252506(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR024824|interpro:IPR029064|rcsb pdb:2WAL|rcsb pdb:3FFM refseq:NP_002749.2|dip:DIP-31346N|reactome:R-HSA-525793|reactome:R-HSA-6811555|reactome:R-HSA-9020702|ensembl:ENSG00000108984(gene)|ensembl:ENST00000590474(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006915"(apoptotic process)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0072709"(cellular response to sorbitol)|go:"GO:0090398"(cellular senescence)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P52564|rcsb pdb:2Y8O|rcsb pdb:3ENM|rcsb pdb:3FME|go:"GO:0002931"(response to ischemia)|rcsb pdb:3VN9|rcsb pdb:5ETF|reactome:R-HSA-168638|reactome:R-HSA-2559580|reactome:R-HSA-450302|reactome:R-HSA-5210891 - - - dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/10/11 2014/10/16 rogid:/0gLr1aWX5yOU3Ytc4/IZn700IQ9606 rogid:7RQ/LBAms1wKpD6Rv+ijvMIzDXA9606 intact-crc:0B22092A3169ECE9|rigid:UYFHvZrfQ/Uy41vPO3yvOucr0ok false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)