#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15569	uniprotkb:Q9C004	intact:EBI-354852|uniprotkb:Q8IXZ8|ensembl:ENSP00000338127|ensembl:ENSP00000481045	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	psi-mi:tesk1_human(display_long)|uniprotkb:TESK1(gene name)|psi-mi:TESK1(display_short)|uniprotkb:Testicular protein kinase 1(gene name synonym)	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:"MI:0018"(two hybrid)	Leeksma et al. (2002)	pubmed:12027893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-354851	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006276.2|ensembl:ENSG00000107140(gene)|refseq:NP_001305159.1|ensembl:ENST00000336395(transcript)|ensembl:ENST00000620767(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015782(Testis-specific kinase 1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-446388	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN	-	-	-	comment:Partial clone suggests TESK residues 459-626 sufficient for interaction	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/05/24	2014/10/16	rogid:ImbgU9Tc//L4ESLNqAyVpYQi9Bs9606	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	intact-crc:6F8ED28EA4ED7F23|rigid:7jovouiglrxFDiYZgPx4OjgnuhY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9C004	uniprotkb:Q15569	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	intact:EBI-354852|uniprotkb:Q8IXZ8|ensembl:ENSP00000338127|ensembl:ENSP00000481045	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:tesk1_human(display_long)|uniprotkb:TESK1(gene name)|psi-mi:TESK1(display_short)|uniprotkb:Testicular protein kinase 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Leeksma et al. (2002)	pubmed:12027893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-354881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN	refseq:NP_006276.2|ensembl:ENSG00000107140(gene)|refseq:NP_001305159.1|ensembl:ENST00000336395(transcript)|ensembl:ENST00000620767(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015782(Testis-specific kinase 1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-446388	-	-	-	-	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2004/05/24	2014/10/16	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	rogid:ImbgU9Tc//L4ESLNqAyVpYQi9Bs9606	intact-crc:74B6A54C78DC010A|rigid:7jovouiglrxFDiYZgPx4OjgnuhY	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15569	uniprotkb:Q9C004	intact:EBI-354852|uniprotkb:Q8IXZ8|ensembl:ENSP00000338127|ensembl:ENSP00000481045	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	psi-mi:tesk1_human(display_long)|uniprotkb:TESK1(gene name)|psi-mi:TESK1(display_short)|uniprotkb:Testicular protein kinase 1(gene name synonym)	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Leeksma et al. (2002)	pubmed:12027893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-354890	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006276.2|ensembl:ENSG00000107140(gene)|refseq:NP_001305159.1|ensembl:ENST00000336395(transcript)|ensembl:ENST00000620767(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015782(Testis-specific kinase 1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-446388	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN	-	-	-	agonist:Interaction increases on EGF-stimulation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2004/05/24	2014/10/16	rogid:ImbgU9Tc//L4ESLNqAyVpYQi9Bs9606	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	intact-crc:44B77F41A24E0A2B|rigid:7jovouiglrxFDiYZgPx4OjgnuhY	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9C004	uniprotkb:Q15569	intact:EBI-354861|uniprotkb:Q6QIX2|uniprotkb:A4FVB3|uniprotkb:Q9C003|uniprotkb:A4FVB2|ensembl:ENSP00000399468	intact:EBI-354852|uniprotkb:Q8IXZ8|ensembl:ENSP00000338127|ensembl:ENSP00000481045	psi-mi:spy4_human(display_long)|uniprotkb:SPRY4(gene name)|psi-mi:SPRY4(display_short)	psi-mi:tesk1_human(display_long)|uniprotkb:TESK1(gene name)|psi-mi:TESK1(display_short)|uniprotkb:Testicular protein kinase 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Leeksma et al. (2002)	pubmed:12027893	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-354896	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001120968.1|refseq:NP_112226.2|refseq:NP_001280218.1|refseq:NP_001280219.1|refseq:XP_011535987.1|refseq:XP_016865399.1|ensembl:ENSG00000187678(gene)|ensembl:ENST00000434127(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0032587"(ruffle membrane)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030790|mint:Q9C004|rcsb pdb:3BUN	refseq:NP_006276.2|ensembl:ENSG00000107140(gene)|refseq:NP_001305159.1|ensembl:ENST00000336395(transcript)|ensembl:ENST00000620767(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015782(Testis-specific kinase 1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-HSA-446388	-	-	-	agonist:Interaction increases on EGF-stimulation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2004/05/24	2014/10/16	rogid:NjkIqofg1Fl1PXj8FXVFz10JOUg9606	rogid:ImbgU9Tc//L4ESLNqAyVpYQi9Bs9606	intact-crc:583E67466FFBB7B4|rigid:7jovouiglrxFDiYZgPx4OjgnuhY	false	ha tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)