#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20152	uniprotkb:P35465	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	intact:EBI-444379|ensembl:ENSRNOP00000045832|ensembl:ENSRNOP00000073036|uniprotkb:Q62934	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:pak1_rat(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p68-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:Protein kinase MUK2(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Goto et al. (2002)	pubmed:11895474	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-444391	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	ensembl:ENSRNOG00000029784(gene)|ensembl:ENSRNOT00000049321(transcript)|ensembl:ENSRNOT00000091952(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0005518"(collagen binding)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0005524"(ATP binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|rcsb pdb:1E0A|reactome:R-RNO-202433|reactome:R-RNO-2029482|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-389359|reactome:R-RNO-3928662|reactome:R-RNO-3928664|reactome:R-RNO-399954|reactome:R-RNO-445144|reactome:R-RNO-445355|reactome:R-RNO-5218920|reactome:R-RNO-5621575|reactome:R-RNO-5627123|reactome:R-RNO-5687128|reactome:R-RNO-8964616|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013420|reactome:R-RNO-9013423|reactome:R-RNO-9013424|rgd:3250|refseq:NP_058894.1|refseq:XP_006229814.1|refseq:XP_006229815.1|refseq:XP_006229816.1|dip:DIP-32990N	-	-	-	resulting-ptm:"Vimentin is phosphorylted by PAK1. The phosphorylation is restricted to the amino-terminal head domain of vimentin: Ser25, Ser38, Ser50, ser65, and Ser72"	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/09/08	2014/10/16	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rogid:wNLimcsV++XEGSFLp+/JSDAJrps10116	intact-crc:5263D114CBB057B1|rigid:+d3lH9L59yaLmiExJi57Mti7NY4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20152	uniprotkb:P35465	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	intact:EBI-444379|ensembl:ENSRNOP00000045832|ensembl:ENSRNOP00000073036|uniprotkb:Q62934	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:pak1_rat(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p68-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:Protein kinase MUK2(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Goto et al. (2002)	pubmed:11895474	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-444456	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	ensembl:ENSRNOG00000029784(gene)|ensembl:ENSRNOT00000049321(transcript)|ensembl:ENSRNOT00000091952(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0005518"(collagen binding)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0005524"(ATP binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|rcsb pdb:1E0A|reactome:R-RNO-202433|reactome:R-RNO-2029482|reactome:R-RNO-2871796|reactome:R-RNO-376172|reactome:R-RNO-389359|reactome:R-RNO-3928662|reactome:R-RNO-3928664|reactome:R-RNO-399954|reactome:R-RNO-445144|reactome:R-RNO-445355|reactome:R-RNO-5218920|reactome:R-RNO-5621575|reactome:R-RNO-5627123|reactome:R-RNO-5687128|reactome:R-RNO-8964616|reactome:R-RNO-9013148|reactome:R-RNO-9013149|reactome:R-RNO-9013404|reactome:R-RNO-9013406|reactome:R-RNO-9013407|reactome:R-RNO-9013420|reactome:R-RNO-9013423|reactome:R-RNO-9013424|rgd:3250|refseq:NP_058894.1|refseq:XP_006229814.1|refseq:XP_006229815.1|refseq:XP_006229816.1|dip:DIP-32990N	-	-	-	resulting-ptm:"Vimentin is phosphorylated. Antibodies which are specific for phosphorylated state of Ser50 (rat monoclonal antibody TM50) and Ser72 (rabbit polyclonal antibody YG72) of vimentin are used."|comment:"constitutively active form of PAK1 is used: PAK1 L107F"	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2004/09/08	2014/10/16	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rogid:wNLimcsV++XEGSFLp+/JSDAJrps10116	intact-crc:7EAF144CA96E1CCC|rigid:+d3lH9L59yaLmiExJi57Mti7NY4	false	-	myc tag:?-?|mutation:107-107	-	-	psi-mi:"MI:0086"(polyclonal antibody western blot)	psi-mi:"MI:0086"(polyclonal antibody western blot)