#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15350	uniprotkb:P09429	intact:EBI-389606|uniprotkb:O15351|uniprotkb:Q17RN8|uniprotkb:Q5TBV5|uniprotkb:Q5TBV6|uniprotkb:Q8NHW9|uniprotkb:Q8TDY5|uniprotkb:Q8TDY6|uniprotkb:Q9NTK8|uniprotkb:B7Z9C1|uniprotkb:B7Z8Z1|uniprotkb:C9J521|uniprotkb:B7Z7J4|ensembl:ENSP00000367545	intact:EBI-389432|uniprotkb:Q6IBE1|uniprotkb:A5D8W9|uniprotkb:Q14321|uniprotkb:Q5T7C3|ensembl:ENSP00000343040|ensembl:ENSP00000345347|ensembl:ENSP00000382417|ensembl:ENSP00000384678	psi-mi:p73_human(display_long)|uniprotkb:TP73(gene name)|psi-mi:TP73(display_short)|uniprotkb:P73(gene name synonym)|uniprotkb:p53-like transcription factor(gene name synonym)|uniprotkb:p53-related protein(gene name synonym)	psi-mi:hmgb1_human(display_long)|uniprotkb:HMGB1(gene name)|psi-mi:HMGB1(display_short)|uniprotkb:HMG1(gene name synonym)|uniprotkb:High mobility group protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stros et al. (2002)	pubmed:11748232	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-389651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000346387|ensembl:ENSP00000340740|ensembl:ENST00000354437|ensembl:ENSP00000346423|ensembl:ENST00000357733|ensembl:ENSP00000350366|ensembl:ENST00000378285|ensembl:ENSP00000367534|ensembl:ENST00000378288|ensembl:ENSP00000367537|ensembl:ENST00000378290|ensembl:ENSP00000367539|ensembl:ENSP00000367545|ensembl:ENST00000603362|ensembl:ENSP00000474626|ensembl:ENST00000604074|ensembl:ENSP00000475143|ensembl:ENST00000604479|ensembl:ENSP00000474322|refseq:NP_001119712.1|refseq:NP_001119713.1|refseq:NP_001119714.1|refseq:NP_001191113.1|refseq:NP_001191114.1|refseq:NP_001191115.1|refseq:NP_001191117.1|refseq:NP_001191118.1|refseq:NP_001191119.1|refseq:NP_001191120.1|refseq:NP_005418.1|refseq:NP_001191121.1|refseq:NP_001191116.1|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|ensembl:ENSG00000078900(gene)|ensembl:ENST00000378295(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0002039"(p53 binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006298"(mismatch repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032646|interpro:IPR036674|interpro:IPR037612|mint:O15350|rcsb pdb:1COK|rcsb pdb:1DXS|rcsb pdb:2KBY|rcsb pdb:2MPS|rcsb pdb:2NB1|rcsb pdb:2WQI|rcsb pdb:2WQJ|rcsb pdb:2WTT|rcsb pdb:2XWC|rcsb pdb:3VD0|rcsb pdb:3VD1|rcsb pdb:3VD2|rcsb pdb:4A63|rcsb pdb:4G82|rcsb pdb:4G83|rcsb pdb:4GUO|rcsb pdb:4GUQ|rcsb pdb:5HOB|rcsb pdb:5HOC|rcsb pdb:5KBD|rcsb pdb:6FGS|rcsb pdb:6IJQ|reactome:R-HSA-139915|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|reactome:R-HSA-8939236|dip:DIP-24202N	refseq:NP_002119.1|refseq:NP_001300821.1|refseq:NP_001300822.1|ensembl:ENSG00000189403(gene)|ensembl:ENST00000339872(transcript)|ensembl:ENST00000341423(transcript)|ensembl:ENST00000399494(transcript)|ensembl:ENST00000405805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001654"(eye development)|go:"GO:0001773"(myeloid dendritic cell activation)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002270"(plasmacytoid dendritic cell activation)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0002643"(regulation of tolerance induction)|go:"GO:0002840"(regulation of T cell mediated immune response to tumor cell)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006265"(DNA topological change)|go:"GO:0006284"(base-excision repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009986"(cell surface)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010858"(calcium-dependent protein kinase regulator activity)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0016829"(lyase activity)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031497"(chromatin assembly)|go:"GO:0032072"(regulation of restriction endodeoxyribonuclease activity)|go:"GO:0032392"(DNA geometric change)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035711"(T-helper 1 cell activation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043371"(negative regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045063"(T-helper 1 cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0051106"(positive regulation of DNA ligation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097100"(supercoiled DNA binding)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000426"(negative regulation of apoptotic cell clearance)|go:"GO:2000819"(regulation of nucleotide-excision repair)|go:"GO:2001200"(positive regulation of dendritic cell differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR017967|interpro:IPR031076|interpro:IPR036910|mint:P09429|rcsb pdb:2LY4|rcsb pdb:2RTU|rcsb pdb:2YRQ|rcsb pdb:6CG0|rcsb pdb:6CIJ|rcsb pdb:6CIK|rcsb pdb:6CIL|rcsb pdb:6CIM|rcsb pdb:6OEM|rcsb pdb:6OEN|rcsb pdb:6OEO|reactome:R-HSA-1236974|reactome:R-HSA-140342|reactome:R-HSA-166058|reactome:R-HSA-445989|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5620971|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-933542|dip:DIP-24195N	go:"GO:0006357"(regulation of transcription by RNA polymerase II)	-	-	comment:"HMGB1 (P09429) was tagged with GST.  The B domain and N-terminal AA 85-91 (TKKKFKD) of HMGB1 are necessary for interaction with p73.    AA 312-381 are necessary for interaction of p73(O15350) with HMGB1(P09429) with AA 382-426 enhancing p73 binding to HMGB1."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/07/21	2014/10/16	rogid:KwI8l1a8t8GHsZwMDi4v2bqwe0c9606	rogid:8iSPxYEMyB6thRmixTeyF5kfDbw9606	intact-crc:329AF028C1982759|rigid:rw7S7ejpWDSumQKPGPD0L92z4OM	false	radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)