#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92956 uniprotkb:P57083 intact:EBI-1056653|uniprotkb:Q6IB95|uniprotkb:Q8WXR1|uniprotkb:Q96J31|uniprotkb:Q9UM65|uniprotkb:B9DI89|uniprotkb:B3KW30|uniprotkb:Q8N634|ensembl:ENSP00000347948|ensembl:ENSP00000478308 intact:EBI-1031723|uniprotkb:P03171 psi-mi:tnr14_human(display_long)|uniprotkb:TNFRSF14(gene name)|psi-mi:TNFRSF14(display_short)|uniprotkb:HVEA(gene name synonym)|uniprotkb:HVEM(gene name synonym)|uniprotkb:UNQ329/PRO509(orf name)|uniprotkb:Herpes virus entry mediator A(gene name synonym)|uniprotkb:Tumor necrosis factor receptor-like 2(gene name synonym) psi-mi:gd_hhv1p(display_long)|uniprotkb:gD(gene name)|psi-mi:gD(display_short)|uniprotkb:US6(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Carfi et al. (2001) pubmed:11511370|mint:MINT-5214417 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10308(hhv1p)|taxid:10308("Human herpesvirus 1 (strain Patton) (HHV-1)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-1031736|rcsb pdb:1JMA - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003811.2|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:1905675"(negative regulation of adaptive immune memory response)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022332|interpro:IPR034031|rcsb pdb:1JMA|rcsb pdb:2AW2|rcsb pdb:4FHQ|rcsb pdb:4RSU|rcsb pdb:5T2Q|rcsb pdb:6NG3|reactome:R-HSA-388841|reactome:R-HSA-5669034|rcsb pdb:5T2R|ensembl:ENSG00000157873(gene)|ensembl:ENSG00000273936(gene)|ensembl:ENST00000355716(transcript)|ensembl:ENST00000621877(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002720"(positive regulation of cytokine production involved in immune response)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|refseq:XP_016858209.1|dip:DIP-34779N rcsb pdb:1JMA|rcsb pdb:1L2G|rcsb pdb:2C36|rcsb pdb:2C3A|go:"GO:0016021"(integral component of membrane)|go:"GO:0019031"(viral envelope)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0055036"(virion membrane)|go:"GO:0098670"(entry receptor-mediated virion attachment to host cell)|interpro:IPR002896(Herpesvirus glycoprotein D)|interpro:IPR036179 - - - assembly:tetrameric, multimeric|3d-r-factors:working 76.400%, free 74.100%|3d-resolution:2.65A|dataset:PDBe - Data obtained from the Protein Data Bank Europe taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2014/10/16 rogid:h0mNlFr7weiZLHYvGJofgj86y249606 rogid:cXtwGWlMXdK5pUEs0cUkPO/Cx6Q10308 intact-crc:8917AFAEEEBAFED2|rigid:NRs/aFvWSkNFQt+dYd3PvR+3kLI false sufficient binding region:39-200 sufficient binding region:26-310 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)