#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13651	uniprotkb:P22301	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	intact:EBI-1031632|ensembl:ENSP00000412237	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Josephson et al. (2001)	pubmed:11485736|mint:MINT-5214351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-1031672|rcsb pdb:1J7V	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	-	-	-	assembly:tetrameric, multimeric|3d-resolution:2.9A|dataset:PDBe - Data obtained from the Protein Data Bank Europe	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	intact-crc:DA95B46CA537A430|rigid:M8K/sxp5hA9AfPReKGbiDg8xUKo	false	sufficient binding region:22-235	sufficient binding region:19-178	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)