#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35438	uniprotkb:P05480	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P70175	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9QVP9	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-299061|ensembl:ENSMUSP00000022622|ensembl:ENSMUSP00000137008|uniprotkb:B2RQ16|uniprotkb:G3X8V1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:fak2_mouse(display_long)|uniprotkb:Pyk2(gene name synonym)|uniprotkb:Raftk(gene name synonym)|uniprotkb:Ptk2b(gene name)|psi-mi:Ptk2b(display_short)|uniprotkb:Fak2(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000059456(gene)|ensembl:ENSMUST00000022622(transcript)|ensembl:ENSMUST00000178730(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q9QVP9|reactome:R-MMU-391160|reactome:R-MMU-4420097|reactome:R-MMU-9020558|refseq:XP_006518789.1|refseq:XP_011243296.1|refseq:NP_001155838.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wFolkPm20C8WJ9CP/rnhc2FxqT410090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P16054	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63318	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P68404	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P28652	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99P24	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397022	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:q99p24_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR028745|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007165"(signal transduction)|go:"GO:0060090"(molecular adaptor activity)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:B/ilFvvr30BrJ29KEQIhEgYV65k10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9Z2Y3	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62108	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P39087	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P97772	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396863|uniprotkb:Q6AXG4|uniprotkb:Q9EPV6|ensembl:ENSMUSP00000037255	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:grm1_mouse(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001107805.1|refseq:NP_058672.1|refseq:XP_006512612.1|ensembl:ENSMUSG00000019828(gene)|ensembl:ENSMUST00000044306(transcript)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:P97772|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:WJAWpEEcB6PLmPlnp8R9/mV+rW410090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P05132	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400564|uniprotkb:Q9JID0|ensembl:ENSMUSP00000005606	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kapca_mouse(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)|uniprotkb:Pkaca(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001264827.1|refseq:NP_032880.1|reactome:R-MMU-8963896|reactome:R-MMU-983231|ensembl:ENSMUSG00000005469(gene)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P05132|ensembl:ENSMUST00000005606(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|rcsb pdb:1APM|rcsb pdb:1ATP|rcsb pdb:1BKX|rcsb pdb:1BX6|rcsb pdb:1FMO|rcsb pdb:1J3H|rcsb pdb:1JBP|rcsb pdb:1JLU|rcsb pdb:1L3R|rcsb pdb:1PVK|rcsb pdb:1RDQ|rcsb pdb:1RE8|rcsb pdb:1REJ|rcsb pdb:1REK|rcsb pdb:1SYK|rcsb pdb:2CPK|rcsb pdb:2ERZ|rcsb pdb:2QCS|rcsb pdb:2QUR|rcsb pdb:2QVS|rcsb pdb:3FHI|rcsb pdb:3FJQ|rcsb pdb:3IDB|rcsb pdb:3IDC|rcsb pdb:3J4Q|rcsb pdb:3J4R|rcsb pdb:3O7L|rcsb pdb:3OW3|rcsb pdb:3PVB|rcsb pdb:3QAL|rcsb pdb:3QAM|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:3X2U|rcsb pdb:3X2V|rcsb pdb:3X2W|rcsb pdb:4DFX|rcsb pdb:4DFY|rcsb pdb:4DFZ|rcsb pdb:4DG0|rcsb pdb:4DG2|rcsb pdb:4DG3|rcsb pdb:4DH1|rcsb pdb:4DH3|rcsb pdb:4DH5|rcsb pdb:4DH7|rcsb pdb:4DH8|rcsb pdb:4DIN|rcsb pdb:4HPT|rcsb pdb:4HPU|rcsb pdb:4IAC|rcsb pdb:4IAD|rcsb pdb:4IAF|rcsb pdb:4IAI|rcsb pdb:4IAK|rcsb pdb:4IAY|rcsb pdb:4IAZ|rcsb pdb:4IB0|rcsb pdb:4IB1|rcsb pdb:4IB3|rcsb pdb:4NTS|rcsb pdb:4NTT|rcsb pdb:4O21|rcsb pdb:4O22|rcsb pdb:4WBB|rcsb pdb:4X6Q|rcsb pdb:4X6R|rcsb pdb:4XW4|rcsb pdb:4XW5|rcsb pdb:4XW6|rcsb pdb:5JR7|rcsb pdb:5X3F|rcsb pdb:6E21|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|rcsb pdb:6MM8|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-512988|reactome:R-MMU-5578775|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8854518|dip:DIP-6086N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:HdW51RuiujpUxo0Fu8TbWz3Yk8c10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P68369	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35438	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99104	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8K2I5	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400191	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:q8k2i5_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR016024(Armadillo-type fold)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0016192"(vesicle-mediated transport)|mint:Q8K2I5	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:EPDjDpRmxZyGxbnjUbOFfGZAx+810090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q80Z38	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P60710	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8R071	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400175|uniprotkb:A2AQ20|ensembl:ENSMUSP00000028758	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ip3ka_mouse(display_long)|uniprotkb:Itpka(gene name)|psi-mi:Itpka(display_short)|uniprotkb:Inositol 1,4,5-trisphosphate 3-kinase A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_666237.1|ensembl:ENSMUSG00000027296(gene)|ensembl:ENSMUST00000028758(transcript)|go:"GO:0000828"(inositol hexakisphosphate kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0016301"(kinase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0097062"(dendritic spine maintenance)|interpro:IPR005522(Inositol polyphosphate kinase)|interpro:IPR038286|mint:Q8R071|reactome:R-MMU-1855204	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:jbKxFPr5BAsFC6V2IFEW7U6PBcA10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8BFV3	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400167|ensembl:ENSMUSP00000033930	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dus4_mouse(display_long)|uniprotkb:Dusp4(gene name)|psi-mi:Dusp4(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_795907.1|ensembl:ENSMUSG00000031530(gene)|ensembl:ENSMUST00000033930(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1990439"(MAP kinase serine/threonine phosphatase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|reactome:R-MMU-112409|reactome:R-MMU-202670|reactome:R-MMU-5675221	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Zrlzfp0Oi23I3RL7zgh8nDc8rQg10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P31324	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-455340|uniprotkb:Q3UTZ1|uniprotkb:Q80ZM4|uniprotkb:Q8BRZ7|uniprotkb:B1B199|ensembl:ENSMUSP00000003079|ensembl:ENSMUSP00000039797	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kap3_mouse(display_long)|uniprotkb:Prkar2b(gene name)|psi-mi:Prkar2b(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035288.2|refseq:XP_006515077.1|dip:DIP-31571N|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P31324|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:4WBB|rcsb pdb:4X6Q|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-983231|ensembl:ENSMUSG00000002997(gene)|ensembl:ENSMUST00000003079(transcript)|ensembl:ENSMUST00000036497(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007612"(learning)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:0097546"(ciliary base)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0097338"(response to clozapine)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:/d/0NSAnglWjmZAcQUn6ATpbJnE10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9D415	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q91XM9	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q01097	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35436	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P46460	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9WV31	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P15116	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P11627	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397964	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:l1cam_mouse(display_long)|uniprotkb:L1cam(gene name)|psi-mi:L1cam(display_short)|uniprotkb:Caml1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043621"(protein self-association)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045121"(membrane raft)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0061564"(axon development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|reactome:R-MMU-210991|reactome:R-MMU-373760|reactome:R-MMU-437239|reactome:R-MMU-445095|reactome:R-MMU-445144|go:"GO:0005178"(integrin binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042734"(presynaptic membrane)|mint:P11627|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4w9IOynYuXaAAxr6N/EQjwJBOFo10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q60598	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q61495	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397946|uniprotkb:Q8CE03|ensembl:ENSMUSP00000076393|uniprotkb:A8WFQ4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dsg1a_mouse(display_long)|uniprotkb:Desmosomal glycoprotein I(gene name synonym)|uniprotkb:DG1(gene name synonym)|uniprotkb:DGI(gene name synonym)|uniprotkb:Dsg1a(gene name)|psi-mi:Dsg1a(display_short)|uniprotkb:Dsg1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034209.2|ensembl:ENSMUSG00000069441(gene)|ensembl:ENSMUST00000077146(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:qT1MQ4BvfgVXy4wU4AwVIz3SueY10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q02248	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P20357	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397863|ensembl:ENSMUSP00000109646|uniprotkb:E9QLE1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mtap2_mouse(display_long)|uniprotkb:Map2(gene name)|psi-mi:Map2(display_short)|uniprotkb:Mtap2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000015222(gene)|ensembl:ENSMUST00000114013(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043203"(axon hillock)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097442"(CA3 pyramidal cell dendrite)|go:"GO:0150001"(primary dendrite)|go:"GO:0150002"(distal dendrite)|go:"GO:0150014"(apical distal dendrite)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1903744"(positive regulation of anterograde synaptic vesicle transport)|go:"GO:1903827"|go:"GO:1904527"(negative regulation of microtubule binding)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990769"(proximal neuron projection)|go:"GO:2000575"(obsolete negative regulation of microtubule motor activity)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR013588(MAP2/Tau projection)|interpro:IPR030797|mint:P20357|refseq:XP_006495817.1|refseq:NP_001297563.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:iZ9zGAAalOtaFcgpzAQ80o+lCj010090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62261	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9JI91	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-299169|ensembl:ENSMUSP00000067708|ensembl:ENSMUSP00000129609|uniprotkb:G3UW84	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:actn2_mouse(display_long)|uniprotkb:Actn2(gene name)|psi-mi:Actn2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000052374(gene)|ensembl:ENSMUST00000064204(transcript)|ensembl:ENSMUST00000168193(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:Q9JI91|reactome:R-MMU-114608|reactome:R-MMU-390522|reactome:R-MMU-438066|reactome:R-MMU-5673001|refseq:NP_150371.4	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:r5g0YjP9pqmJjxEfxmBL7xMzjBI10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P39053	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9Z0J4	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397596|uniprotkb:Q64208|uniprotkb:Q3UR10|ensembl:ENSMUSP00000120421|ensembl:ENSMUSP00000127432	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nos1_mouse(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032738.1|refseq:XP_017176196.1|dip:DIP-31556N|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0070402"(NADPH binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR001094(Flavodoxin-like)|interpro:IPR039261|rcsb pdb:2O60|reactome:R-MMU-1222556|reactome:R-MMU-392154|reactome:R-MMU-5578775|ensembl:ENSMUSG00000029361(gene)|ensembl:ENSMUST00000142742(transcript)|ensembl:ENSMUST00000171055(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:BuPBvQk0jEhDNZNi82D3OidmYwE10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99N57	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P18654	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q63932	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P31938	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63085	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q63844	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397682|uniprotkb:Q61531|uniprotkb:Q8K0X5|uniprotkb:Q91YW5|ensembl:ENSMUSP00000051619	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mk03_mouse(display_long)|uniprotkb:Mapk3(gene name)|psi-mi:Mapk3(display_short)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:MNK1(gene name synonym)|uniprotkb:Erk1(gene name synonym)|uniprotkb:Prkm3(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_036082.1|dip:DIP-31078N|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSMUSG00000063065(gene)|ensembl:ENSMUST00000057669(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|reactome:R-MMU-9627069|reactome:R-MMU-982772|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63844|reactome:R-MMU-110056|reactome:R-MMU-112409|reactome:R-MMU-1169408|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6811558|reactome:R-MMU-73728|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:I2hStA4IjS6t6Ky7fb9zFPOcZag10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P47713	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62077	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63087	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P62204	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P17879	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397360|uniprotkb:Q61689|uniprotkb:Q925V6|ensembl:ENSMUSP00000133815	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:hs71b_mouse(display_long)|uniprotkb:Hspa1b(gene name)|psi-mi:Hspa1b(display_short)|uniprotkb:Hcp70.1(gene name synonym)|uniprotkb:Hsp70-1(gene name synonym)|uniprotkb:Hsp70a1(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1(gene name synonym)|uniprotkb:Hspa1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034608.2|dip:DIP-31549N|ensembl:ENSMUSG00000090877(gene)|ensembl:ENSMUST00000172753(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009408"(response to heat)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|mint:P17879|reactome:R-MMU-3371453|go:"GO:0005739"(mitochondrion)|reactome:R-MMU-3371497|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-450408|reactome:R-MMU-6798695|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:IjedYF1eneAZUEXux0xxZLvp6oI10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q04690	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P49025	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q80ZJ1	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397246|uniprotkb:Q3USK1|uniprotkb:Q7TSK4|uniprotkb:Q810A2|uniprotkb:Q9D3D5|ensembl:ENSMUSP00000056433	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:rap2a_mouse(display_long)|uniprotkb:Rap2a(gene name)|psi-mi:Rap2a(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_083795.2|ensembl:ENSMUSG00000051615(gene)|ensembl:ENSMUST00000062117(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035690"|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|go:"GO:0048814"(regulation of dendrite morphogenesis)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:LH08P2tTzdf9ZmkH6UZ+X84ZEXI10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63001	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35235	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q60676	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397224|uniprotkb:O35299|uniprotkb:G5E819|ensembl:ENSMUSP00000003183	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ppp5_mouse(display_long)|uniprotkb:Ppp5c(gene name)|psi-mi:Ppp5c(display_short)|uniprotkb:Protein phosphatase T(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035285.2|ensembl:ENSMUSG00000003099(gene)|ensembl:ENSMUST00000003183(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071944"(cell periphery)|go:"GO:0004721"(phosphoprotein phosphatase activity)|interpro:IPR029052|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|interpro:IPR041753|mint:Q60676|go:"GO:1990635"(proximal dendrite)|reactome:R-MMU-5675221|reactome:R-MMU-5693565|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|reactome:R-MMU-8939211|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:W369yNvNab/lTJQdGihK5Bnxkis10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63328	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63330	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-396959	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse Shank1, AKAP150 and SynGAP 1 also formed part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	intact-crc:30B2BF20931B6354|rigid:TBRVoy2U7I5NKpetNbC2I4E9On8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q02248	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P05132	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400564|uniprotkb:Q9JID0|ensembl:ENSMUSP00000005606	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kapca_mouse(display_long)|uniprotkb:Prkaca(gene name)|psi-mi:Prkaca(display_short)|uniprotkb:Pkaca(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001264827.1|refseq:NP_032880.1|reactome:R-MMU-8963896|reactome:R-MMU-983231|ensembl:ENSMUSG00000005469(gene)|go:"GO:0097546"(ciliary base)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044109|mint:P05132|ensembl:ENSMUST00000005606(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048792"(spontaneous exocytosis of neurotransmitter)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0097225"(sperm midpiece)|rcsb pdb:1APM|rcsb pdb:1ATP|rcsb pdb:1BKX|rcsb pdb:1BX6|rcsb pdb:1FMO|rcsb pdb:1J3H|rcsb pdb:1JBP|rcsb pdb:1JLU|rcsb pdb:1L3R|rcsb pdb:1PVK|rcsb pdb:1RDQ|rcsb pdb:1RE8|rcsb pdb:1REJ|rcsb pdb:1REK|rcsb pdb:1SYK|rcsb pdb:2CPK|rcsb pdb:2ERZ|rcsb pdb:2QCS|rcsb pdb:2QUR|rcsb pdb:2QVS|rcsb pdb:3FHI|rcsb pdb:3FJQ|rcsb pdb:3IDB|rcsb pdb:3IDC|rcsb pdb:3J4Q|rcsb pdb:3J4R|rcsb pdb:3O7L|rcsb pdb:3OW3|rcsb pdb:3PVB|rcsb pdb:3QAL|rcsb pdb:3QAM|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:3X2U|rcsb pdb:3X2V|rcsb pdb:3X2W|rcsb pdb:4DFX|rcsb pdb:4DFY|rcsb pdb:4DFZ|rcsb pdb:4DG0|rcsb pdb:4DG2|rcsb pdb:4DG3|rcsb pdb:4DH1|rcsb pdb:4DH3|rcsb pdb:4DH5|rcsb pdb:4DH7|rcsb pdb:4DH8|rcsb pdb:4DIN|rcsb pdb:4HPT|rcsb pdb:4HPU|rcsb pdb:4IAC|rcsb pdb:4IAD|rcsb pdb:4IAF|rcsb pdb:4IAI|rcsb pdb:4IAK|rcsb pdb:4IAY|rcsb pdb:4IAZ|rcsb pdb:4IB0|rcsb pdb:4IB1|rcsb pdb:4IB3|rcsb pdb:4NTS|rcsb pdb:4NTT|rcsb pdb:4O21|rcsb pdb:4O22|rcsb pdb:4WBB|rcsb pdb:4X6Q|rcsb pdb:4X6R|rcsb pdb:4XW4|rcsb pdb:4XW5|rcsb pdb:4XW6|rcsb pdb:5JR7|rcsb pdb:5X3F|rcsb pdb:6E21|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|rcsb pdb:6MM8|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|reactome:R-MMU-432040|reactome:R-MMU-4420097|reactome:R-MMU-442720|reactome:R-MMU-512988|reactome:R-MMU-5578775|reactome:R-MMU-5610785|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-5621575|reactome:R-MMU-5687128|reactome:R-MMU-8853659|reactome:R-MMU-8854518|dip:DIP-6086N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:HdW51RuiujpUxo0Fu8TbWz3Yk8c10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P68369	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9Z1B3	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397636|uniprotkb:Q62075|uniprotkb:Q8K5A5|uniprotkb:Q8K5A6|uniprotkb:Q9Z0E5|uniprotkb:Q9Z2T5|uniprotkb:Q6PDH1|ensembl:ENSMUSP00000105743	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:plcb1_mouse(display_long)|uniprotkb:Plcb1(gene name)|psi-mi:Plcb1(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-1(gene name synonym)|uniprotkb:Phospholipase C-beta-1(gene name synonym)|uniprotkb:PLC-154(gene name synonym)|uniprotkb:Plcb(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001139302.1|refseq:NP_062651.2|ensembl:ENSMUSG00000051177(gene)|ensembl:ENSMUST00000110116(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007613"(memory)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031161"(phosphatidylinositol catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032417"("positive regulation of sodium:proton antiporter activity")|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032957"(inositol trisphosphate metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034284"(response to monosaccharide)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0060466"(activation of meiosis involved in egg activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0080154"(regulation of fertilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099178"(regulation of retrograde trans-synaptic signaling by endocanabinoid)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902618"(cellular response to fluoride)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1904637"(cellular response to ionomycin)|go:"GO:1905631"(cellular response to glyceraldehyde)|go:"GO:2000344"(positive regulation of acrosome reaction)|go:"GO:2000438"(negative regulation of monocyte extravasation)|go:"GO:2000560"(positive regulation of CD24 production)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR009535(Protein of unknown function DUF1154)|go:"GO:0043209"(myelin sheath)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028400|interpro:IPR035892|interpro:IPR037862|interpro:IPR042531|mint:Q9Z1B3|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657|interpro:IPR011992(EF-Hand type)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:OdorlKjHTBQOboAmplMz5kjIwAs10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35436	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99104	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8K2I5	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400191	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:q8k2i5_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR016024(Armadillo-type fold)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0016192"(vesicle-mediated transport)|mint:Q8K2I5	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:EPDjDpRmxZyGxbnjUbOFfGZAx+810090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q80Z38	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-770338|uniprotkb:E9QPH7|uniprotkb:Q3UTK4|uniprotkb:Q5DU07	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:shan2_mouse(display_long)|uniprotkb:Cortactin-binding protein 1(gene name synonym)|uniprotkb:Shank2(gene name)|psi-mi:Shank2(display_short)|uniprotkb:Cortbp1(gene name synonym)|uniprotkb:Kiaa1022(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001074839.2|refseq:NP_001106844.2|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR001452(Src homology-3)|refseq:XP_006508596.1|reactome:R-MMU-6794361|interpro:IPR036028|interpro:IPR036034|interpro:IPR041489|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007416"(synapse assembly)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030160"(synaptic receptor adaptor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030534"(adult behavior)|go:"GO:0031526"(brush border membrane)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035640"(exploration behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060170"(ciliary membrane)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0071625"(vocalization behavior)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099562"(maintenance of postsynaptic density structure)|go:"GO:0043005"(neuron projection)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:OTohbAMxKtx7/WWwWXDc+c24HvQ10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P60710	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-353957|ensembl:ENSMUSP00000098066|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|uniprotkb:Q3TI89|uniprotkb:Q3TVP6|uniprotkb:Q64316|uniprotkb:Q6ZWM3	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:actb_mouse(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000029580(gene)|ensembl:ENSMUST00000100497(transcript)|refseq:NP_031419.1|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1904030"(negative regulation of cyclin-dependent protein kinase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60710|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5250924|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-5689603|reactome:R-MMU-5696394|reactome:R-MMU-8856828|reactome:R-MMU-9035034|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0070160"(tight junction)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|dip:DIP-31574N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8R071	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400175|uniprotkb:A2AQ20|ensembl:ENSMUSP00000028758	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ip3ka_mouse(display_long)|uniprotkb:Itpka(gene name)|psi-mi:Itpka(display_short)|uniprotkb:Inositol 1,4,5-trisphosphate 3-kinase A(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_666237.1|ensembl:ENSMUSG00000027296(gene)|ensembl:ENSMUST00000028758(transcript)|go:"GO:0000828"(inositol hexakisphosphate kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0016301"(kinase activity)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0097062"(dendritic spine maintenance)|interpro:IPR005522(Inositol polyphosphate kinase)|interpro:IPR038286|mint:Q8R071|reactome:R-MMU-1855204	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:jbKxFPr5BAsFC6V2IFEW7U6PBcA10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q8BFV3	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400167|ensembl:ENSMUSP00000033930	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dus4_mouse(display_long)|uniprotkb:Dusp4(gene name)|psi-mi:Dusp4(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_795907.1|ensembl:ENSMUSG00000031530(gene)|ensembl:ENSMUST00000033930(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0001706"(endoderm formation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008330"(protein tyrosine/threonine phosphatase activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017017"(MAP kinase tyrosine/serine/threonine phosphatase activity)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1990439"(MAP kinase serine/threonine phosphatase activity)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR008343(MAP kinase phosphatase)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR020422|interpro:IPR029021|interpro:IPR036873|reactome:R-MMU-112409|reactome:R-MMU-202670|reactome:R-MMU-5675221	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Zrlzfp0Oi23I3RL7zgh8nDc8rQg10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P31324	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-455340|uniprotkb:Q3UTZ1|uniprotkb:Q80ZM4|uniprotkb:Q8BRZ7|uniprotkb:B1B199|ensembl:ENSMUSP00000003079|ensembl:ENSMUSP00000039797	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kap3_mouse(display_long)|uniprotkb:Prkar2b(gene name)|psi-mi:Prkar2b(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035288.2|refseq:XP_006515077.1|dip:DIP-31571N|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P31324|rcsb pdb:3TNP|rcsb pdb:3TNQ|rcsb pdb:4WBB|rcsb pdb:4X6Q|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-5620912|reactome:R-MMU-8854518|reactome:R-MMU-983231|ensembl:ENSMUSG00000002997(gene)|ensembl:ENSMUST00000003079(transcript)|ensembl:ENSMUST00000036497(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0007612"(learning)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030425"(dendrite)|go:"GO:0030552"(cAMP binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045121"(membrane raft)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:0097546"(ciliary base)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0097338"(response to clozapine)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:/d/0NSAnglWjmZAcQUn6ATpbJnE10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9D415	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35438	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q91XM9	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q01097	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P46460	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9WV31	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397779|ensembl:ENSMUSP00000023268|ensembl:ENSMUSP00000105636|uniprotkb:Q9ES15	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:arc_mouse(display_long)|uniprotkb:Arc(gene name)|psi-mi:Arc(display_short)|uniprotkb:Activity-regulated gene 3.1 protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001263613.1|ensembl:ENSMUSG00000022602(gene)|ensembl:ENSMUST00000023268(transcript)|ensembl:ENSMUST00000110009(transcript)|refseq:NP_061260.1|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003729"(mRNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007492"(endoderm development)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031901"(early endosome membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0045121"(membrane raft)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098845"(postsynaptic endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|go:"GO:0110077"(vesicle-mediated intercellular transport)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1900452"(regulation of long-term synaptic depression)|go:"GO:1903561"(extracellular vesicle)|go:"GO:2000969"(positive regulation of AMPA receptor activity)|interpro:IPR023263|interpro:IPR040814|dip:DIP-31565N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:vZutgYl26hWTDm9UgMeY8dtgbg810090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P15116	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397974|uniprotkb:Q64260|uniprotkb:Q6GU11|intact:EBI-2255565|ensembl:ENSMUSP00000025166	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:cadh2_mouse(display_long)|uniprotkb:Cdh2(gene name)|psi-mi:Cdh2(display_short)|uniprotkb:Neural cadherin(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031690.3|ensembl:ENSMUSG00000024304(gene)|ensembl:ENSMUST00000025166(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007416"(synapse assembly)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030315"(T-tubule)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|interpro:IPR027397|interpro:IPR030051|interpro:IPR039808|mint:P15116|rcsb pdb:1NCG|rcsb pdb:1NCH|rcsb pdb:1NCI|rcsb pdb:1NCJ|rcsb pdb:1OP4|rcsb pdb:2QVI|rcsb pdb:3Q2W|rcsb pdb:4NUM|rcsb pdb:4NUP|rcsb pdb:4NUQ|reactome:R-MMU-381426|reactome:R-MMU-418990|reactome:R-MMU-525793|reactome:R-MMU-8957275|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090497"(mesenchymal cell migration)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099060"(integral component of postsynaptic specialization membrane)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|go:"GO:0043005"(neuron projection)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060563"(neuroepithelial cell differentiation)|go:"GO:0070445"(regulation of oligodendrocyte progenitor proliferation)|dip:DIP-31564N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:Yon1udPwyvjKP2+GVGUcrsZtFng10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P11627	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397964	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:l1cam_mouse(display_long)|uniprotkb:L1cam(gene name)|psi-mi:L1cam(display_short)|uniprotkb:Caml1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043621"(protein self-association)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045121"(membrane raft)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0061564"(axon development)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|reactome:R-MMU-210991|reactome:R-MMU-373760|reactome:R-MMU-437239|reactome:R-MMU-445095|reactome:R-MMU-445144|go:"GO:0005178"(integrin binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0042734"(presynaptic membrane)|mint:P11627|interpro:IPR026966|interpro:IPR036116|interpro:IPR036179	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4w9IOynYuXaAAxr6N/EQjwJBOFo10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q60598	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397955|intact:EBI-4281621|uniprotkb:Q3UGC2|ensembl:ENSMUSP00000099368	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:src8_mouse(display_long)|uniprotkb:Cttn(gene name)|psi-mi:Cttn(display_short)|uniprotkb:Ems1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031829.2|ensembl:ENSMUSG00000031078(gene)|ensembl:ENSMUST00000103079(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0005522"(profilin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030054"(cell junction)|go:"GO:0030427"(site of polarized growth)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR003134(Hs1/Cortactin)|interpro:IPR015503(Cortactin)|interpro:IPR035716|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051015"(actin filament binding)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0097062"(dendritic spine maintenance)|go:"GO:0097581"(lamellipodium organization)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|interpro:IPR036028|mint:Q60598|rcsb pdb:2F9X|rcsb pdb:3ULR|rcsb pdb:5NV1|rcsb pdb:5NVJ|rcsb pdb:5NXJ|reactome:R-MMU-8856828|dip:DIP-31562N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4hLyMrquWdlJnIX2pHuXqYtQgkE10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q61495	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397946|uniprotkb:Q8CE03|ensembl:ENSMUSP00000076393|uniprotkb:A8WFQ4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dsg1a_mouse(display_long)|uniprotkb:Desmosomal glycoprotein I(gene name synonym)|uniprotkb:DG1(gene name synonym)|uniprotkb:DGI(gene name synonym)|uniprotkb:Dsg1a(gene name)|psi-mi:Dsg1a(display_short)|uniprotkb:Dsg1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034209.2|ensembl:ENSMUSG00000069441(gene)|ensembl:ENSMUST00000077146(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696270	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:qT1MQ4BvfgVXy4wU4AwVIz3SueY10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P20357	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397863|ensembl:ENSMUSP00000109646|uniprotkb:E9QLE1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mtap2_mouse(display_long)|uniprotkb:Map2(gene name)|psi-mi:Map2(display_short)|uniprotkb:Mtap2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000015222(gene)|ensembl:ENSMUST00000114013(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005519"(cytoskeletal regulatory protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034399"(nuclear periphery)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043194"(axon initial segment)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043203"(axon hillock)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097442"(CA3 pyramidal cell dendrite)|go:"GO:0150001"(primary dendrite)|go:"GO:0150002"(distal dendrite)|go:"GO:0150014"(apical distal dendrite)|go:"GO:1901953"(positive regulation of anterograde dense core granule transport)|go:"GO:1902513"(regulation of organelle transport along microtubule)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1903744"(positive regulation of anterograde synaptic vesicle transport)|go:"GO:1903827"|go:"GO:1904527"(negative regulation of microtubule binding)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990769"(proximal neuron projection)|go:"GO:2000575"(obsolete negative regulation of microtubule motor activity)|interpro:IPR001084(Tubulin-binding Tau protein)|interpro:IPR013588(MAP2/Tau projection)|interpro:IPR030797|mint:P20357|refseq:XP_006495817.1|refseq:NP_001297563.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:iZ9zGAAalOtaFcgpzAQ80o+lCj010090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62261	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9JI91	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-299169|ensembl:ENSMUSP00000067708|ensembl:ENSMUSP00000129609|uniprotkb:G3UW84	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:actn2_mouse(display_long)|uniprotkb:Actn2(gene name)|psi-mi:Actn2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000052374(gene)|ensembl:ENSMUST00000064204(transcript)|ensembl:ENSMUST00000168193(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:Q9JI91|reactome:R-MMU-114608|reactome:R-MMU-390522|reactome:R-MMU-438066|reactome:R-MMU-5673001|refseq:NP_150371.4	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:r5g0YjP9pqmJjxEfxmBL7xMzjBI10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P39053	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9Z0J4	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397596|uniprotkb:Q64208|uniprotkb:Q3UR10|ensembl:ENSMUSP00000120421|ensembl:ENSMUSP00000127432	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nos1_mouse(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032738.1|refseq:XP_017176196.1|dip:DIP-31556N|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0070402"(NADPH binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR001094(Flavodoxin-like)|interpro:IPR039261|rcsb pdb:2O60|reactome:R-MMU-1222556|reactome:R-MMU-392154|reactome:R-MMU-5578775|ensembl:ENSMUSG00000029361(gene)|ensembl:ENSMUST00000142742(transcript)|ensembl:ENSMUST00000171055(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:BuPBvQk0jEhDNZNi82D3OidmYwE10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99N57	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P18654	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397744|ensembl:ENSMUSP00000033671|uniprotkb:Q03140|uniprotkb:Q8K3J8|uniprotkb:B1AXN4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ks6a3_mouse(display_long)|uniprotkb:Rps6ka3(gene name)|psi-mi:Rps6ka3(display_short)|uniprotkb:Rps6ka-rs1(gene name synonym)|uniprotkb:Rsk2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 3(gene name synonym)|uniprotkb:Mapkapk1b(gene name synonym)|uniprotkb:Ribosomal S6 kinase 2(gene name synonym)|uniprotkb:pp90RSK2(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1b(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000031309(gene)|ensembl:ENSMUST00000033671(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041905|interpro:IPR041906|mint:P18654|rcsb pdb:2QR7|rcsb pdb:2QR8|rcsb pdb:3G51|rcsb pdb:3UBD|rcsb pdb:4EL9|rcsb pdb:4GUE|rcsb pdb:4M8T|rcsb pdb:4MAO|rcsb pdb:5O1S|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|refseq:NP_683747.1|dip:DIP-31554N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:5h7ZnIO/ZD+MvfouRrhQzWM3Q0010090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q63932	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P31938	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298860|ensembl:ENSMUSP00000005066	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mp2k1_mouse(display_long)|uniprotkb:Map2k1(gene name)|psi-mi:Map2k1(display_short)|uniprotkb:Mek1(gene name synonym)|uniprotkb:Prkmk1(gene name synonym)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000004936(gene)|ensembl:ENSMUST00000005066(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043204"(perikaryon)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032402"(melanosome transport)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045933"(positive regulation of muscle contraction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048313"(Golgi inheritance)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-110056|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|refseq:NP_032953.1|dip:DIP-467N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:OOj1juW9l4rnEH/W3CjXWZFKMvw10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63085	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q63844	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397682|uniprotkb:Q61531|uniprotkb:Q8K0X5|uniprotkb:Q91YW5|ensembl:ENSMUSP00000051619	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:mk03_mouse(display_long)|uniprotkb:Mapk3(gene name)|psi-mi:Mapk3(display_short)|uniprotkb:Extracellular signal-regulated kinase 1(gene name synonym)|uniprotkb:Insulin-stimulated MAP2 kinase(gene name synonym)|uniprotkb:p44-ERK1(gene name synonym)|uniprotkb:ERT2(gene name synonym)|uniprotkb:MAP kinase isoform p44(gene name synonym)|uniprotkb:Microtubule-associated protein 2 kinase(gene name synonym)|uniprotkb:MNK1(gene name synonym)|uniprotkb:Erk1(gene name synonym)|uniprotkb:Prkm3(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_036082.1|dip:DIP-31078N|go:"GO:0007568"(aging)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0014032"(neural crest cell development)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051403"(stress-activated MAPK cascade)|ensembl:ENSMUSG00000063065(gene)|ensembl:ENSMUST00000057669(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006975"(DNA damage induced protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|reactome:R-MMU-9627069|reactome:R-MMU-982772|go:"GO:0060440"(trachea formation)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000657"(negative regulation of apolipoprotein binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63844|reactome:R-MMU-110056|reactome:R-MMU-112409|reactome:R-MMU-1169408|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6811558|reactome:R-MMU-73728|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:I2hStA4IjS6t6Ky7fb9zFPOcZag10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P47713	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62077	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63087	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-80040|uniprotkb:O09186|uniprotkb:O09189|uniprotkb:P37139|uniprotkb:Q64679|ensembl:ENSMUSP00000099587	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp1g_mouse(display_long)|uniprotkb:Ppp1cc(gene name)|psi-mi:Ppp1cc(display_short)|uniprotkb:Protein phosphatase 1C catalytic subunit(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030496"(midbody)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0046872"(metal ion binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|interpro:IPR037981|rcsb pdb:4V0U|rcsb pdb:4V0V|rcsb pdb:4V0W|rcsb pdb:4V0X|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:0005856"(cytoskeleton)|ensembl:ENSMUSG00000004455(gene)|ensembl:ENSMUST00000102528(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|refseq:NP_038664.2|refseq:XP_006508478.1|refseq:XP_006530263.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:67YjuOIxqIl6Qj+bQnfLBo4iRAg10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P62204	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P17879	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397360|uniprotkb:Q61689|uniprotkb:Q925V6|ensembl:ENSMUSP00000133815	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:hs71b_mouse(display_long)|uniprotkb:Hspa1b(gene name)|psi-mi:Hspa1b(display_short)|uniprotkb:Hcp70.1(gene name synonym)|uniprotkb:Hsp70-1(gene name synonym)|uniprotkb:Hsp70a1(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1(gene name synonym)|uniprotkb:Hspa1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_034608.2|dip:DIP-31549N|ensembl:ENSMUSG00000090877(gene)|ensembl:ENSMUST00000172753(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009408"(response to heat)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|mint:P17879|reactome:R-MMU-3371453|go:"GO:0005739"(mitochondrion)|reactome:R-MMU-3371497|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-450408|reactome:R-MMU-6798695|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:IjedYF1eneAZUEXux0xxZLvp6oI10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q04690	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397326|uniprotkb:Q61956|uniprotkb:Q61957|ensembl:ENSMUSP00000071289	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:nf1_mouse(display_long)|uniprotkb:Nf1(gene name)|psi-mi:Nf1(display_short)|uniprotkb:Neurofibromatosis-related protein NF-1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035027.1|refseq:XP_006532504.1|go:"GO:0007420"(brain development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008429"(phosphatidylethanolamine binding)|go:"GO:0008542"(visual learning)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014044"(Schwann cell development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0021510"(spinal cord development)|go:"GO:0021764"(amygdala development)|go:"GO:0021897"(forebrain astrocyte development)|go:"GO:0021915"(neural tube development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0045685"(regulation of glial cell differentiation)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046929"(negative regulation of neurotransmitter secretion)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0050890"(cognition)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR023152|interpro:IPR036865|interpro:IPR039360|mint:Q04690|go:"GO:0030424"(axon)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035021"(negative regulation of Rac protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045124"(regulation of bone resorption)|go:"GO:0045545"(syndecan binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|ensembl:ENSMUSG00000020716(gene)|ensembl:ENSMUST00000071325(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001656"(metanephros development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001889"(liver development)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007154"(cell communication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|reactome:R-MMU-5658442	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:aegHzgNy813/APoCjeM166e+MFE10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P49025	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397301|intact:EBI-487846|uniprotkb:O88528|uniprotkb:O88937|uniprotkb:O88938|uniprotkb:Q3UM99|uniprotkb:Q8CIJ1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ctro_mouse(display_long)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001180(Citron-like)|interpro:IPR017405(Citron Rho-interacting kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|refseq:XP_006530214.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001726"(ruffle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR037708|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005773"(vacuole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0005856"(cytoskeleton)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048699"(generation of neurons)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013149|reactome:R-MMU-5625900	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q80ZJ1	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397246|uniprotkb:Q3USK1|uniprotkb:Q7TSK4|uniprotkb:Q810A2|uniprotkb:Q9D3D5|ensembl:ENSMUSP00000056433	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:rap2a_mouse(display_long)|uniprotkb:Rap2a(gene name)|psi-mi:Rap2a(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_083795.2|ensembl:ENSMUSG00000051615(gene)|ensembl:ENSMUST00000062117(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035690"|go:"GO:0045184"(establishment of protein localization)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|go:"GO:0048814"(regulation of dendrite morphogenesis)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:LH08P2tTzdf9ZmkH6UZ+X84ZEXI10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63001	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P35235	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q60676	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397224|uniprotkb:O35299|uniprotkb:G5E819|ensembl:ENSMUSP00000003183	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:ppp5_mouse(display_long)|uniprotkb:Ppp5c(gene name)|psi-mi:Ppp5c(display_short)|uniprotkb:Protein phosphatase T(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035285.2|ensembl:ENSMUSG00000003099(gene)|ensembl:ENSMUST00000003183(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071944"(cell periphery)|go:"GO:0004721"(phosphoprotein phosphatase activity)|interpro:IPR029052|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|interpro:IPR041753|mint:Q60676|go:"GO:1990635"(proximal dendrite)|reactome:R-MMU-5675221|reactome:R-MMU-5693565|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|reactome:R-MMU-8939211|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:W369yNvNab/lTJQdGihK5Bnxkis10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63328	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63330	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397144|uniprotkb:O88591|uniprotkb:P13353|uniprotkb:Q5SNY5|ensembl:ENSMUSP00000020608	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:pp2aa_mouse(display_long)|uniprotkb:Ppp2ca(gene name)|psi-mi:Ppp2ca(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_062284.1|ensembl:ENSMUSG00000020349(gene)|ensembl:ENSMUST00000020608(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007498"(mesoderm development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048156"(tau protein binding)|go:"GO:0050811"(GABA receptor binding)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1904528"(positive regulation of microtubule binding)|go:"GO:1990405"(protein antigen binding)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:P63330|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2995383|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-9648025|reactome:R-MMU-975957	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:gpR5Fal3vi6O6cteeGwW72EuctY10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P70175	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9QVP9	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-299061|ensembl:ENSMUSP00000022622|ensembl:ENSMUSP00000137008|uniprotkb:B2RQ16|uniprotkb:G3X8V1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:fak2_mouse(display_long)|uniprotkb:Pyk2(gene name synonym)|uniprotkb:Raftk(gene name synonym)|uniprotkb:Ptk2b(gene name)|psi-mi:Ptk2b(display_short)|uniprotkb:Fak2(gene name synonym)|uniprotkb:Focal adhesion kinase 2(gene name synonym)|uniprotkb:Proline-rich tyrosine kinase 2(gene name synonym)|uniprotkb:Cell adhesion kinase beta(gene name synonym)|uniprotkb:Calcium-dependent tyrosine kinase(gene name synonym)|uniprotkb:Related adhesion focal tyrosine kinase(gene name synonym)|uniprotkb:Calcium-regulated non-receptor proline-rich tyrosine kinase(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000059456(gene)|ensembl:ENSMUST00000022622(transcript)|ensembl:ENSMUST00000178730(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001525"(angiogenesis)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006968"(cellular defense response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009725"(response to hormone)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0010752"(regulation of cGMP-mediated signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0010758"(regulation of macrophage chemotaxis)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014009"(glial cell proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032960"(regulation of inositol trisphosphate biosynthetic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043423"(3-phosphoinositide-dependent protein kinase binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000538"(positive regulation of B cell chemotaxis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR030610|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:Q9QVP9|reactome:R-MMU-391160|reactome:R-MMU-4420097|reactome:R-MMU-9020558|refseq:XP_006518789.1|refseq:XP_011243296.1|refseq:NP_001155838.1	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wFolkPm20C8WJ9CP/rnhc2FxqT410090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P05480	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298680|ensembl:ENSMUSP00000029175|ensembl:ENSMUSP00000105157|ensembl:ENSMUSP00000105159|uniprotkb:Q2M4I4|intact:EBI-7361449|intact:MINT-142018|uniprotkb:F8WI90	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:src_mouse(display_long)|uniprotkb:Src(gene name)|psi-mi:Src(display_short)|uniprotkb:pp60c-src(gene name synonym)|uniprotkb:Proto-oncogene c-Src(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009615"(response to virus)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0020037"(heme binding)|go:"GO:0022407"(regulation of cell-cell adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033146"(regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035306"(positive regulation of dephosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036035"(osteoclast development)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045087"(innate immune response)|go:"GO:0045453"(bone resorption)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051385"(response to mineralocorticoid)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060065"(uterus development)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071253"(connexin binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071393"(cellular response to progesterone stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0086098"(angiotensin-activated signaling pathway involved in heart process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000386"(positive regulation of ovarian follicle development)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|go:"GO:2001286"(regulation of caveolin-mediated endocytosis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036028|interpro:IPR036860|mint:P05480|rcsb pdb:6F3F|reactome:R-MMU-1227986|reactome:R-MMU-1251985|reactome:R-MMU-1253288|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-177929|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-191650|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-418592|reactome:R-MMU-418594|reactome:R-MMU-418885|reactome:R-MMU-430116|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-456926|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-6811558|reactome:R-MMU-69231|reactome:R-MMU-8853659|reactome:R-MMU-8874081|reactome:R-MMU-8934903|reactome:R-MMU-8941858|reactome:R-MMU-9009391|reactome:R-MMU-9603381|ensembl:ENSMUSG00000027646(gene)|ensembl:ENSMUST00000029175(transcript)|ensembl:ENSMUST00000109531(transcript)|ensembl:ENSMUST00000109533(transcript)|go:"GO:0001545"(primary ovarian follicle growth)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|refseq:NP_001020566.1|refseq:NP_033297.2|dip:DIP-31071N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:SY8bQUpE/ni7hRMp4F02ygRsU7Q10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P16054	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-298451|ensembl:ENSMUSP00000094873|ensembl:ENSMUSP00000094874	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpce_mouse(display_long)|uniprotkb:Prkce(gene name)|psi-mi:Prkce(display_short)|uniprotkb:Pkce(gene name synonym)|uniprotkb:Pkcea(gene name synonym)|uniprotkb:nPKC-epsilon(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000045038(gene)|ensembl:ENSMUST00000097274(transcript)|ensembl:ENSMUST00000097275(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0004699"(calcium-independent protein kinase C activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014376(Protein kinase C, delta/epsilon/eta/theta types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR027274|interpro:IPR034669|interpro:IPR035892|reactome:R-MMU-114508|reactome:R-MMU-1250196|reactome:R-MMU-1489509|reactome:R-MMU-2029485|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0005829"(cytosol)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035276"(ethanol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0051562"(negative regulation of mitochondrial calcium ion concentration)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0071944"(cell periphery)|go:"GO:0043278"(response to morphine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046872"(metal ion binding)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2001031"(positive regulation of cellular glucuronidation)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050996"(positive regulation of lipid catabolic process)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051280"(negative regulation of release of sequestered calcium ion into cytosol)|interpro:IPR000961(Protein kinase, C-terminal)|go:"GO:0051301"(cell division)|refseq:NP_035234.1|dip:DIP-31066N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:LBpr5ejW6fnkKwlXL6akJYv3H1M10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P63318	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397096|uniprotkb:P05697|ensembl:ENSMUSP00000097874	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpcg_mouse(display_long)|uniprotkb:Pkcc(gene name synonym)|uniprotkb:Pkcg(gene name synonym)|uniprotkb:Prkcc(gene name synonym)|uniprotkb:Prkcg(gene name)|psi-mi:Prkcg(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_035232.1|ensembl:ENSMUSG00000078816(gene)|ensembl:ENSMUST00000100301(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032425"(positive regulation of mismatch repair)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043278"(response to morphine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0044305"(calyx of Held)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048265"(response to pain)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060384"(innervation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:0005829"(cytosol)|go:"GO:1990911"(response to psychosocial stress)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|interpro:IPR020454|interpro:IPR035892|mint:P63318|reactome:R-MMU-111933|reactome:R-MMU-114516|reactome:R-MMU-416993|reactome:R-MMU-5099900|reactome:R-MMU-76005	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:t4ukCPPAnYUtHCH1hnQE+uiyfEM10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P68404	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397048|uniprotkb:F2Z441|uniprotkb:P04410|uniprotkb:P04411|uniprotkb:A0JNZ5|intact:EBI-4304045|ensembl:ENSMUSP00000064812	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kpcb_mouse(display_long)|uniprotkb:Prkcb(gene name)|psi-mi:Prkcb(display_short)|uniprotkb:Pkcb(gene name synonym)|uniprotkb:Prkcb1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_032881.1|refseq:NP_001303601.1|ensembl:ENSMUSG00000052889(gene)|ensembl:ENSMUST00000064921(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006915"(apoptotic process)|go:"GO:0008091"(spectrin)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010827"(regulation of glucose transmembrane transport)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031526"(brush border membrane)|go:"GO:0035403"("histone kinase activity (H3-T6 specific)")|go:"GO:0035408"(histone H3-T6 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042113"(B cell activation)|go:"GO:0042393"(histone binding)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044305"(calyx of Held)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050861"(positive regulation of B cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014375(Protein kinase C, alpha/beta/gamma types)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034664|interpro:IPR035892|mint:P68404|reactome:R-MMU-114516|reactome:R-MMU-1169091|reactome:R-MMU-416993|reactome:R-MMU-4419969|reactome:R-MMU-5099900|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-76005|dip:DIP-31583N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:wPR+19jsOpjLky/X5fpkIK5o5SM10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P28652	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q99P24	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-397022	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:q99p24_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	interpro:IPR028745|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007165"(signal transduction)|go:"GO:0060090"(molecular adaptor activity)	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:B/ilFvvr30BrJ29KEQIhEgYV65k10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q9Z2Y3	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396980|uniprotkb:Q8K3E1|uniprotkb:Q8K4M8|uniprotkb:Q9Z0E9|uniprotkb:Q9Z216|ensembl:ENSMUSP00000079026	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:home1_mouse(display_long)|uniprotkb:Homer1(gene name)|psi-mi:Homer1(display_short)|uniprotkb:Vesl1(gene name synonym)|uniprotkb:VASP/Ena-related gene up-regulated during seizure and LTP 1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_036112.1|refseq:NP_671705.2|refseq:NP_687036.1|refseq:NP_001271118.1|refseq:NP_001334527.1|ensembl:ENSMUSG00000007617(gene)|ensembl:ENSMUST00000080127(transcript)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035256"(G protein-coupled glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043034"(costamere)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044309"(neuron spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048875"(chemical homeostasis within a tissue)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098794"(postsynapse)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099186"(structural constituent of postsynapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:2001256"(regulation of store-operated calcium entry)|go:"GO:2001257"(regulation of cation channel activity)|interpro:IPR000697(EVH1)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR044100|mint:Q9Z2Y3|reactome:R-MMU-6794361	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:aOI1ZRXwOjFH9a3s6Jf1FNfMdiA10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:Q62108	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P39087	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396914|uniprotkb:Q60933|ensembl:ENSMUSP00000101124|ensembl:ENSMUSP00000151921	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:grik2_mouse(display_long)|uniprotkb:Grik2(gene name)|psi-mi:Grik2(display_short)|uniprotkb:Glur6(gene name synonym)|uniprotkb:Glutamate receptor 6(gene name synonym)|uniprotkb:Glutamate receptor beta-2(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:XP_017169293.1|ensembl:ENSMUSG00000056073(gene)|ensembl:ENSMUST00000105484(transcript)|ensembl:ENSMUST00000218823(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0008328"(ionotropic glutamate receptor complex)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0015277"(kainate selective glutamate receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032983"(kainate selective glutamate receptor complex)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043204"(perikaryon)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048172"(regulation of short-term neuronal synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060080"(inhibitory postsynaptic potential)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:0120169"(detection of cold stimulus involved in thermoception)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR019594|interpro:IPR028082|mint:P39087|reactome:R-MMU-451307|reactome:R-MMU-451308	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:6sgY8SzX07HzilLLeDg3pV+sXkc10090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35438	uniprotkb:P97772	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	intact:EBI-396863|uniprotkb:Q6AXG4|uniprotkb:Q9EPV6|ensembl:ENSMUSP00000037255	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:grm1_mouse(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398049	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	refseq:NP_001107805.1|refseq:NP_058672.1|refseq:XP_006512612.1|ensembl:ENSMUSG00000019828(gene)|ensembl:ENSMUST00000044306(transcript)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:P97772|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361	-	-	-	comment:Affinity purified polyclonal antibodies were generated using multiple-antigen peptides of last 20 aminoacids of NR1.|comment:Mouse homologues of Shank1, SynGAP  and AKAP150 were also part of the complex.|caution:Some proteins could not be analyzed due to comigraton with immunoglobulin chains.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2021/02/11	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	rogid:WJAWpEEcB6PLmPlnp8R9/mV+rW410090	intact-crc:4C60CD2BD66855DB|rigid:hSEJQCFYF/R4i+qf4yzshiG1AIc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q01097	uniprotkb:P46460	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-398006|uniprotkb:A2A646|uniprotkb:Q8BQ65|uniprotkb:Q8C3R2|uniprotkb:Q8CCT9|uniprotkb:Q8CEF0|uniprotkb:Q923C6|ensembl:ENSMUSP00000099364	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nsf_mouse(display_long)|uniprotkb:Nsf(gene name)|psi-mi:Nsf(display_short)|uniprotkb:Skd2(gene name synonym)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 2"(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_032766.2|ensembl:ENSMUSG00000034187(gene)|ensembl:ENSMUST00000103075(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032984"(protein-containing complex disassembly)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46460|reactome:R-MMU-204005|reactome:R-MMU-416993|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811438|reactome:R-MMU-6811440	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:mqNfvBVWEdD4caFZug82c88vwE410090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q9JI91	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-299169|ensembl:ENSMUSP00000067708|ensembl:ENSMUSP00000129609|uniprotkb:G3UW84	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:actn2_mouse(display_long)|uniprotkb:Actn2(gene name)|psi-mi:Actn2(display_short)|uniprotkb:Alpha-actinin skeletal muscle isoform 2(gene name synonym)|uniprotkb:F-actin cross-linking protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	ensembl:ENSMUSG00000052374(gene)|ensembl:ENSMUST00000064204(transcript)|ensembl:ENSMUST00000168193(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005925"(focal adhesion)|go:"GO:0006936"(muscle contraction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030035"(microspike assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031432"(titin binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051015"(actin filament binding)|go:"GO:0051373"(FATZ binding)|go:"GO:0051695"(actin filament uncapping)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0070080"(titin Z domain binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2001137"(positive regulation of endocytic recycling)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR014837(EF-hand, Ca insensitive)|interpro:IPR018159|interpro:IPR036872|mint:Q9JI91|reactome:R-MMU-114608|reactome:R-MMU-390522|reactome:R-MMU-438066|reactome:R-MMU-5673001|refseq:NP_150371.4	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:r5g0YjP9pqmJjxEfxmBL7xMzjBI10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P39053	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-397785|ensembl:ENSMUSP00000122679|uniprotkb:A2AN50|uniprotkb:A2AN51|uniprotkb:A2AN54|uniprotkb:A2AN55|uniprotkb:Q3UNM1|uniprotkb:Q5DTN7|uniprotkb:Q61358|uniprotkb:Q61359|uniprotkb:Q61360|uniprotkb:Q6PDM5|uniprotkb:Q8JZZ4|uniprotkb:Q9CSY7|uniprotkb:Q9QXX1	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dyn1_mouse(display_long)|uniprotkb:Dnm1(gene name)|psi-mi:Dnm1(display_short)|uniprotkb:Dnm(gene name synonym)|uniprotkb:Kiaa4093(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_034195.2|interpro:IPR000375(Dynamin central region)|interpro:IPR001401(Dynamin, GTPase region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR003130(Dynamin GTPase effector)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019762|interpro:IPR020850|interpro:IPR022812|interpro:IPR027417|interpro:IPR027741|interpro:IPR030381|mint:P39053|reactome:R-MMU-166016|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2132295|reactome:R-MMU-437239|reactome:R-MMU-8856828|ensembl:ENSMUSG00000026825(gene)|ensembl:ENSMUST00000139624(transcript)|go:"GO:0000266"(mitochondrial fission)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0003374"(dynamin family protein polymerization involved in mitochondrial fission)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030117"(membrane coat)|go:"GO:0030424"(axon)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043196"(varicosity)|go:"GO:0043209"(myelin sheath)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0098844"(postsynaptic endocytic zone membrane)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1901998"(toxin transport)|go:"GO:1903423"(positive regulation of synaptic vesicle recycling)|go:"GO:1904645"(response to amyloid-beta)|refseq:NP_001288666.1|refseq:XP_006497721.2|refseq:XP_006497722.2|refseq:XP_006497723.2|refseq:XP_006497724.2|refseq:XP_006497718.2|refseq:XP_017170817.1	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:wtPz3gwyxU6tAgh5091LQpt099I10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P17879	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-397360|uniprotkb:Q61689|uniprotkb:Q925V6|ensembl:ENSMUSP00000133815	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:hs71b_mouse(display_long)|uniprotkb:Hspa1b(gene name)|psi-mi:Hspa1b(display_short)|uniprotkb:Hcp70.1(gene name synonym)|uniprotkb:Hsp70-1(gene name synonym)|uniprotkb:Hsp70a1(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 1(gene name synonym)|uniprotkb:Hspa1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_034608.2|dip:DIP-31549N|ensembl:ENSMUSG00000090877(gene)|ensembl:ENSMUST00000172753(transcript)|go:"GO:0002199"(zona pellucida receptor complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0009408"(response to heat)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|mint:P17879|reactome:R-MMU-3371453|go:"GO:0005739"(mitochondrion)|reactome:R-MMU-3371497|reactome:R-MMU-3371568|reactome:R-MMU-3371571|reactome:R-MMU-450408|reactome:R-MMU-6798695|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005813"(centrosome)	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:IjedYF1eneAZUEXux0xxZLvp6oI10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P35235	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P63328	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-397208|uniprotkb:P12816|uniprotkb:P20652|uniprotkb:Q3UCU1|uniprotkb:Q64135|ensembl:ENSMUSP00000053101	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:pp2ba_mouse(display_long)|uniprotkb:Ppp3ca(gene name)|psi-mi:Ppp3ca(display_short)|uniprotkb:Calna(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit alpha isoform(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_032939.1|refseq:NP_001280551.1|ensembl:ENSMUSG00000028161(gene)|ensembl:ENSMUST00000056758(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005955"(calcineurin complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016311"(dephosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0097720"(calcineurin-mediated signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0033192"(calmodulin-dependent protein phosphatase activity)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0036057"(slit diaphragm)|go:"GO:0042383"(sarcolemma)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1903244"(positive regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1905205"(positive regulation of connective tissue replacement)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR041751|interpro:IPR043360|mint:P63328|rcsb pdb:4ORB|reactome:R-MMU-2025928|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-5607763|dip:DIP-31543N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:98yAyDGZZxKYOv22ejceyfJbvao10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P70175	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-396969|ensembl:ENSMUSP00000085299	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dlg3_mouse(display_long)|uniprotkb:Dlg3(gene name)|psi-mi:Dlg3(display_short)|uniprotkb:Dlgh3(gene name synonym)|uniprotkb:Synapse-associated protein 102(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_058027.1|refseq:NP_001171249.1|ensembl:ENSMUSG00000000881(gene)|ensembl:ENSMUST00000087984(transcript)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030426"(growth cone)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035763|interpro:IPR036028|interpro:IPR036034|mint:P70175|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-6794361|reactome:R-MMU-8849932|dip:DIP-31585N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:9dR9P876v8QcvPinxtaWzDgpHwE10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P28652	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q62108	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:O88448	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-301558	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:klc2_mouse(display_long)|uniprotkb:Klc2(gene name)|psi-mi:Klc2(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	mint:O88448|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0032418"(lysosome localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0043005"(neuron projection)|interpro:IPR002151(Kinesin light chain)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015792(Kinesin light chain repeat)|interpro:IPR019734|rcsb pdb:3ZFW|rcsb pdb:5FJY|rcsb pdb:6EJN|reactome:R-MMU-2132295|reactome:R-MMU-5625970|reactome:R-MMU-6811434|reactome:R-MMU-983189|dip:DIP-31518N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:g0zmL5gh0ehRJnJSpKFQpe7Xcps10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P70399	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P39447	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-79508|uniprotkb:E9QK00|ensembl:ENSMUSP00000099652	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:zo1_mouse(display_long)|uniprotkb:Tjp1(gene name)|psi-mi:Tjp1(display_short)|uniprotkb:Zo1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0005516"(calmodulin binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0005634"(nucleus)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0005737"(cytoplasm)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0005829"(cytosol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0005921"(gap junction)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045471"(response to ethanol)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0071000"(response to magnetism)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0071253"(connexin binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:0014704"(intercalated disc)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0016020"(membrane)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035597|interpro:IPR036028|interpro:IPR036034|mint:P39447|rcsb pdb:2RRM|reactome:R-MMU-191650|reactome:R-MMU-2028269|reactome:R-MMU-351906|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|ensembl:ENSMUSG00000030516(gene)|ensembl:ENSMUST00000102592(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:NP_033412.2|dip:DIP-30946N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:wvslyL15GCrtwUReZEC9DiNvPEk10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P46660	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400482|uniprotkb:Q61958|uniprotkb:Q8VCW5|ensembl:ENSMUSP00000041347	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:ainx_mouse(display_long)|uniprotkb:Ina(gene name)|psi-mi:Ina(display_short)|uniprotkb:66 kDa neurofilament protein(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_666212.3|ensembl:ENSMUSG00000034336(gene)|ensembl:ENSMUST00000037636(transcript)|go:"GO:0005883"(neurofilament)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043209"(myelin sheath)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099160"(postsynaptic intermediate filament cytoskeleton)|go:"GO:0099184"(structural constituent of postsynaptic intermediate filament cytoskeleton)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027703|interpro:IPR039008|mint:P46660	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:amjP0AajB8s2oXmV96wzyfz6evE10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P11798	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400384|uniprotkb:Q61284|uniprotkb:Q6ZWN4|ensembl:ENSMUSP00000099952	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:kcc2a_mouse(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_033922.1|refseq:NP_803126.1|refseq:NP_001273738.1|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000102888(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006816"(calcium ion transport)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060996"(dendritic spine development)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099004"(calmodulin dependent kinase signaling pathway)|go:"GO:0099148"(regulation of synaptic vesicle docking)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099573"(glutamatergic postsynaptic density)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990443"(peptidyl-threonine autophosphorylation)|go:"GO:2000124"(regulation of endocannabinoid signaling pathway)|go:"GO:2001222"(regulation of neuron migration)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P11798|rcsb pdb:1HKX|rcsb pdb:4X3I|rcsb pdb:6TS3|reactome:R-MMU-3371571|reactome:R-MMU-399719|reactome:R-MMU-4086398|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|dip:DIP-31593N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:mHdSlhGhe3sMOyO+YGwROtGOGfY10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q8K3H0	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400377|uniprotkb:Q3UJP7|uniprotkb:Q69ZJ9|uniprotkb:Q8BWZ8|uniprotkb:Q8VCJ8|uniprotkb:Q9CUW4|ensembl:ENSMUSP00000042875	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dp13a_mouse(display_long)|uniprotkb:Appl1(gene name)|psi-mi:Appl1(display_short)|uniprotkb:Dip13a(gene name synonym)|uniprotkb:Kiaa1428(gene name synonym)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_660256.1|ensembl:ENSMUSG00000040760(gene)|ensembl:ENSMUST00000036570(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR037929|mint:Q8K3H0|reactome:R-MMU-418889	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:1ZML/W0Qi+jMAeZQ7PXfiHA6YBE10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P35438	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400084|uniprotkb:Q8CFS4|uniprotkb:A2AI15|uniprotkb:A2AI18|ensembl:ENSMUSP00000028335	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nmdz1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit zeta-1(gene name synonym)|uniprotkb:Grin1(gene name)|psi-mi:Grin1(display_short)|uniprotkb:Glurz1(gene name synonym)|uniprotkb:N-methyl-D-aspartate receptor subunit NR1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001171127.1|refseq:NP_001171128.1|refseq:NP_032195.1|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0032590"(dendrite membrane)|go:"GO:0035176"(social behavior)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043278"(response to morphine)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043576"(regulation of respiratory gaseous exchange)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0021586"(pons maturation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060076"(excitatory synapse)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1902952"(positive regulation of dendritic spine maintenance)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:0030425"(dendrite)|go:"GO:1905429"(response to glycine)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|go:"GO:0030426"(growth cone)|interpro:IPR018882|interpro:IPR019594|interpro:IPR028082|mint:P35438|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|ensembl:ENSMUSG00000026959(gene)|ensembl:ENSMUST00000028335(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001661"(conditioned taste aversion)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007616"(long-term memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008355"(olfactory learning)|go:"GO:0008542"(visual learning)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0010646"(regulation of cell communication)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0018964"(propylene metabolic process)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019899"(enzyme binding)|go:"GO:0019902"(phosphatase binding)|dip:DIP-31577N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:JEUDmVL8TNipn1XuGBwsBsu9ofU10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q811D0	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-514290|uniprotkb:Q62402|uniprotkb:Q6PGB5|uniprotkb:Q8CGN7|ensembl:ENSMUSP00000097581|ensembl:ENSMUSP00000110859	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dlg1_mouse(display_long)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:Embryo-dlg/synapse-associated protein 97(gene name synonym)|uniprotkb:Dlg1(gene name)|psi-mi:Dlg1(display_short)|uniprotkb:Dlgh1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_031888.2|refseq:NP_001239362.1|refseq:NP_001239364.1|refseq:XP_006521831.1|refseq:NP_001239363.1|dip:DIP-31591N|ensembl:ENSMUSG00000022770(gene)|ensembl:ENSMUST00000100001(transcript)|ensembl:ENSMUST00000115205(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0030432"(peristalsis)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033268"(node of Ranvier)|go:"GO:0033270"(paranode region of axon)|go:"GO:0034629"|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048639"(positive regulation of developmental growth)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q811D0|rcsb pdb:4OAJ|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5673001|reactome:R-MMU-8849932	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:b8LjYbiuR2K6/jxhwU1hxBJKX6410090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q99104	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400199|uniprotkb:E9PUE5|ensembl:ENSMUSP00000116028	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:myo5a_mouse(display_long)|uniprotkb:Myo5a(gene name)|psi-mi:Myo5a(display_short)|uniprotkb:Dilute(gene name synonym)|uniprotkb:Dilute myosin heavy chain, non-muscle(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_034994.2|ensembl:ENSMUSG00000034593(gene)|ensembl:ENSMUST00000123128(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000149"(SNARE binding)|go:"GO:0001726"(ruffle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006582"(melanin metabolic process)|go:"GO:0006887"(exocytosis)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007601"(visual perception)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014046"(dopamine secretion)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031585"(regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0031982"(vesicle)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032400"(melanosome localization)|go:"GO:0032402"(melanosome transport)|go:"GO:0032433"(filopodium tip)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035249"(synaptic transmission, glutamatergic)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042470"(melanosome)|go:"GO:0042476"(odontogenesis)|go:"GO:0042552"(myelination)|go:"GO:0042641"(actomyosin)|go:"GO:0042642"(actomyosin, myosin complex part)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043473"(pigmentation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048066"(developmental pigmentation)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048820"(hair follicle maturation)|go:"GO:0050808"(synapse organization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051643"(endoplasmic reticulum localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099089"(establishment of endoplasmic reticulum localization to postsynapse)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0099640"(axo-dendritic protein transport)|go:"GO:0150103"(reactive gliosis)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|go:"GO:0030318"(melanocyte differentiation)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR036103|interpro:IPR037988|mint:Q99104|rcsb pdb:2IX7|rcsb pdb:3WB8|rcsb pdb:4KP3|rcsb pdb:4ZLK|rcsb pdb:6KU0|reactome:R-MMU-2029482|interpro:IPR002710(Dilute)|go:"GO:0030141"(secretory granule)|dip:DIP-29542N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:8QtBlLL4DqB3An4CoCFVmvBEXBg10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q8K2I5	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400191	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:q8k2i5_mouse(display_long)|uniprotkb:Cltc(gene name)|psi-mi:Cltc(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	interpro:IPR016024(Armadillo-type fold)|interpro:IPR000547(Clathrin, heavy chain/VPS, 7-fold repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0016192"(vesicle-mediated transport)|mint:Q8K2I5	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:EPDjDpRmxZyGxbnjUbOFfGZAx+810090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P68369	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:O88737	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400493|uniprotkb:Q6ZQB5|uniprotkb:E9QMZ3|ensembl:ENSMUSP00000035208	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:bsn_mouse(display_long)|uniprotkb:Bsn(gene name)|psi-mi:Bsn(display_short)|uniprotkb:Kiaa0434(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_031593.2|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045202"(synapse)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0048788"(cytoskeleton of presynaptic active zone)|go:"GO:0050808"(synapse organization)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098882"(structural constituent of presynaptic active zone)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099526"(presynapse to nucleus signaling pathway)|go:"GO:1904071"(presynaptic active zone assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904666"(regulation of ubiquitin protein ligase activity)|go:"GO:1990257"(piccolo-bassoon transport vesicle)|interpro:IPR008899(Zinc finger, piccolo-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR030627|mint:O88737|ensembl:ENSMUSG00000032589(gene)|ensembl:ENSMUST00000035208(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|refseq:XP_006511697.1	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:W4w0sRW518SHtgLQ/mY/unJDgwc10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q8K2R1	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400535	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:q8k2r1_mouse(display_long)|uniprotkb:Fam171a1(gene name)|psi-mi:Fam171a1(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	interpro:IPR018890|go:"GO:0005886"(plasma membrane)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043149"(stress fiber assembly)	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:n4TqfZHHbWOAQ7gWLJY5FY0ovp410090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P12382	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400474|uniprotkb:Q8VDX7|ensembl:ENSMUSP00000020522	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:pfkal_mouse(display_long)|uniprotkb:Pfkl(gene name)|psi-mi:Pfkl(display_short)|uniprotkb:Pfk-l(gene name synonym)|uniprotkb:Pfkb(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme B(gene name synonym)|uniprotkb:6-phosphofructokinase type B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_032852.2|ensembl:ENSMUSG00000020277(gene)|ensembl:ENSMUST00000020522(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0009749"(response to glucose)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070061"(fructose binding)|go:"GO:0070095"(fructose-6-phosphate binding)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:P12382|reactome:R-MMU-6798695|reactome:R-MMU-70171	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:WlBnp+GuMEVU1PRrdVHwJxZi5gE10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q7TMX2	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400426	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:q7tmx2_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000357(HEAT)|interpro:IPR021133|interpro:IPR031090|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0065003"(protein-containing complex assembly)	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:s8HJI5y072H/cMGIlvxJMhe8Yu010090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q9D415	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400152|uniprotkb:Q52KF6|uniprotkb:Q5DTK5|uniprotkb:Q6P6N4|uniprotkb:Q6XBF4|uniprotkb:Q8BZL7|uniprotkb:Q8BZQ1|uniprotkb:Q8C0G0|ensembl:ENSMUSP00000122896	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dlgp1_mouse(display_long)|uniprotkb:Dlgap1(gene name)|psi-mi:Dlgap1(display_short)|uniprotkb:Guanylate kinase-associated protein(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 1(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 1(gene name synonym)|uniprotkb:Kiaa4162(gene name synonym)|uniprotkb:Gkap(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_081988.3|refseq:NP_808307.2|go:"GO:0014069"(postsynaptic density)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070842"(aggresome assembly)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030524|mint:Q9D415|reactome:R-MMU-6794361|ensembl:ENSMUSG00000003279(gene)|ensembl:ENSMUST00000155016(transcript)|go:"GO:0007268"(chemical synaptic transmission)|refseq:XP_006524236.1|refseq:XP_011244709.1|refseq:NP_001334340.1	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:7KKRXvLLqu9Czb59FFZltFOf+Mg10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q91XM9	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400138|uniprotkb:Q8BXK7|uniprotkb:Q8BYG5|ensembl:ENSMUSP00000102814|uniprotkb:F8VQM7	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:dlg2_mouse(display_long)|uniprotkb:Dlg2(gene name)|psi-mi:Dlg2(display_short)|uniprotkb:Postsynaptic density protein PSD-93(gene name synonym)|uniprotkb:Channel-associated protein of synapse-110(gene name synonym)|uniprotkb:Dlgh2(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	ensembl:ENSMUSG00000052572(gene)|ensembl:ENSMUST00000107196(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019900"(kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043204"(perikaryon)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045161"(neuronal ion channel clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:0099642"(retrograde axonal protein transport)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR035759|interpro:IPR036028|interpro:IPR036034|mint:Q91XM9|rcsb pdb:2WL7|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-6794361|refseq:NP_001229976.1|refseq:NP_035937.2|dip:DIP-31569N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:37/IFbjDNxh87dnN2gglIgDGyIU10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:Q01097	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400125|uniprotkb:Q9DCB2	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P35436	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400115|ensembl:ENSMUSP00000032331|ensembl:ENSMUSP00000111501|ensembl:ENSMUSP00000142900	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:nmde1_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-1(gene name synonym)|uniprotkb:Grin2a(gene name)|psi-mi:Grin2a(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2A(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_032196.2|reactome:R-MMU-8849932|reactome:R-MMU-9609736|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099507"(ligand-gated ion channel activity involved in regulation of presynaptic membrane potential)|go:"GO:1903539"(protein localization to postsynaptic membrane)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-438066|go:"GO:0098839"(postsynaptic density membrane)|ensembl:ENSMUSG00000059003(gene)|ensembl:ENSMUST00000032331(transcript)|ensembl:ENSMUST00000115835(transcript)|ensembl:ENSMUST00000199708(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001964"(startle response)|go:"GO:0001975"(response to amphetamine)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008542"(visual learning)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022843"(voltage-gated cation channel activity)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030431"(sleep)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0033058"(directional locomotion)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040011"(locomotion)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042417"(dopamine metabolic process)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042493"|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048511"(rhythmic process)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|refseq:XP_006521857.1|dip:DIP-31567N	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:5DMFDOh6NuFArDtKp2gp2IpmhWQ10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P97772	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-396863|uniprotkb:Q6AXG4|uniprotkb:Q9EPV6|ensembl:ENSMUSP00000037255	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:grm1_mouse(display_long)|uniprotkb:Grm1(gene name)|psi-mi:Grm1(display_short)|uniprotkb:Gprc1a(gene name synonym)|uniprotkb:Mglur1(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_001107805.1|refseq:NP_058672.1|refseq:XP_006512612.1|ensembl:ENSMUSG00000019828(gene)|ensembl:ENSMUST00000044306(transcript)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0038037"(G protein-coupled receptor dimeric complex)|go:"GO:0038038"(G protein-coupled receptor homodimeric complex)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098712"(L-glutamate import across plasma membrane)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098872"(G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001256(GPCR, family 3, metabotropic glutamate receptor 1)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|mint:P97772|reactome:R-MMU-416476|reactome:R-MMU-420499|reactome:R-MMU-6794361	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:WJAWpEEcB6PLmPlnp8R9/mV+rW410090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q01097	uniprotkb:P56959	intact:EBI-400125|uniprotkb:Q9DCB2	intact:EBI-400452|ensembl:ENSMUSP00000101858	psi-mi:nmde2_mouse(display_long)|uniprotkb:Glutamate [NMDA] receptor subunit epsilon-2(gene name synonym)|uniprotkb:Grin2b(gene name)|psi-mi:Grin2b(display_short)|uniprotkb:N-methyl D-aspartate receptor subtype 2B(gene name synonym)	psi-mi:fus_mouse(display_long)|uniprotkb:Fus(gene name)|psi-mi:Fus(display_short)|uniprotkb:Protein pigpen(gene name synonym)	psi-mi:"MI:0004"(affinity chromatography technology)	Husi et al. (2000)	pubmed:10862698|mint:MINT-5212684	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-398110	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032197.3|go:"GO:0001508"(action potential)|go:"GO:0001662"(behavioral fear response)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001964"(startle response)|go:"GO:0001967"(suckling behavior)|go:"GO:0004970"(ionotropic glutamate receptor activity)|go:"GO:0004972"(NMDA glutamate receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005234"(extracellularly glutamate-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006812"(cation transport)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007423"(sensory organ development)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008306"(associative learning)|go:"GO:0009986"(cell surface)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014049"(positive regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016594"(glycine binding)|go:"GO:0016595"(glutamate binding)|go:"GO:0017146"(NMDA selective glutamate receptor complex)|go:"GO:0022849"(glutamate-gated calcium ion channel activity)|go:"GO:0030018"(Z disc)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036094"(small molecule binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042165"(neurotransmitter binding)|go:"GO:0042596"(fear response)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043083"(synaptic cleft)|go:"GO:0043113"(receptor clustering)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044307"(dendritic branch)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045471"(response to ethanol)|go:"GO:0046960"(sensitization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0048511"(rhythmic process)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0060078"(regulation of postsynaptic membrane potential)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097553"(calcium ion transmembrane import into cytosol)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098989"(NMDA selective glutamate receptor signaling pathway)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099529"(neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1904315"(transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR001320(Ionotropic glutamate receptor)|interpro:IPR001508(NMDA receptor)|go:"GO:0099566"(regulation of postsynaptic cytosolic calcium ion concentration)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR018884|interpro:IPR019594|interpro:IPR028082|reactome:R-MMU-3928662|reactome:R-MMU-438066|reactome:R-MMU-5673001|reactome:R-MMU-8849932|reactome:R-MMU-9609736|mint:Q01097|dip:DIP-31568N	refseq:NP_631888.1|ensembl:ENSMUSG00000030795(gene)|ensembl:ENSMUST00000106251(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0031489"(myosin V binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046872"(metal ion binding)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034459|interpro:IPR034870|interpro:IPR035979|interpro:IPR036443|mint:P56959|reactome:R-MMU-72163	-	-	-	comment:GRIN2B peptide used as bait. Peptide affinity based on the structure of NMDA R2B subunit C-terminus.|comment:Mouse orthologues of SLMAP3 and SynGAP also form part of the complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.	taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain)	-	2004/08/03	2020/01/07	rogid:SvjoNuuHCFT+Yj1woYrEvU6n8B010090	rogid:Vwv/0vlM50l49XaUOHCtEWt/b2A10090	intact-crc:5BE2912EE0640E70|rigid:rv2l6Ec4gD6+G/8dkywfbSVv2c0	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)