#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Z0G0 uniprotkb:A2ARV4 intact:EBI-300855|ensembl:ENSMUSP00000019577 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 psi-mi:gipc1_mouse(display_long)|uniprotkb:Gipc1(gene name)|psi-mi:Gipc1(display_short)|uniprotkb:Gipc(gene name synonym)|uniprotkb:Semcap1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Synectin(gene name synonym)|uniprotkb:SemaF cytoplasmic domain-associated protein 1(gene name synonym)|uniprotkb:Rgs19ip1(gene name synonym) psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300854 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000019433(gene)|ensembl:ENSMUST00000019577(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|mint:Q9Z0G0|rcsb pdb:5V6B|rcsb pdb:5V6E|rcsb pdb:5V6T|rcsb pdb:7NRN|refseq:NP_061241.1|dip:DIP-33281N go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:qOV0/hc2ei7VPYVbbWqUkjF8aBw10090 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 intact-crc:60571523A408777A|rigid:MonUbWvGXW9bn7w02DGo+DbVp/s false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q9WVI9 uniprotkb:A2ARV4 intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym) psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300886 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2 go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 intact-crc:7B78A53DF55C1D60|rigid:WEyTupXo859WRztA6VRxZcfzXB8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q62108 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300894 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090 intact-crc:919425F5DCC7256A|rigid:bYR6pm20RmmBQBbUYbHNCbKT+0s false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q9ERE9 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300907 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090 intact-crc:364C74AAA37DD1EA|rigid:YJJEBUMjyL0eiso+fNmvpl6BUjM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q9D6K5 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300919 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 intact-crc:6056CCE4AEA1C9DC|rigid:+HU/bc46P73uexAHoXfRiZVtcW8 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q8BL58 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300922 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:q8bl58_mouse(display_long)|uniprotkb:Gm10174(gene name)|psi-mi:Gm10174(display_short)|uniprotkb:Nos1ap(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300927 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 - - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:IP4SD55jdNUrtxV4dPulu4ZBRIk10090 intact-crc:E410B678FFF240E6|rigid:HmCjoMaE/ere04ImsApVZjyPYmA false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:P97318 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300934 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:461800CDFF638D49|rigid:gKwdeQDivRVoiEDQE20g+171m/o false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q8K2H6 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300937|uniprotkb:Q9CW24|ensembl:ENSMUSP00000048244|ensembl:ENSMUSP00000148220 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:apc10_mouse(display_long)|uniprotkb:Anapc10(gene name)|psi-mi:Anapc10(display_short)|uniprotkb:Apc10(gene name synonym)|uniprotkb:Cyclosome subunit 10(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300943 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000036977(gene)|ensembl:ENSMUST00000048147(transcript)|ensembl:ENSMUST00000210812(transcript)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR016901(Anaphase-promoting complex, subunit 10, subgroup)|mint:Q8K2H6|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-983168|refseq:NP_081180.1|refseq:XP_006531402.1|refseq:XP_006531403.1|refseq:XP_006531406.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:+ptfebxiUWef4mCp/fEAkrl5rZM10090 intact-crc:6184F08FDCD02731|rigid:eTa1ZdQKxOG3hPt8du773bDnP44 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91ZX7 uniprotkb:Q9WVI9 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300946 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090 intact-crc:514E3F2B81B82073|rigid:R5aU/mL8meFWXoRS/Gm7yOLg1Io false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91ZX7 uniprotkb:Q62108 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300976 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090 intact-crc:1CBADEB2F8BF0834|rigid:1zx6Qz4KlIKpZm/LRFMd8oOMRSU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91ZX7 uniprotkb:Q9ERE9 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300979 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090 intact-crc:1C7AEEBCD799ECF9|rigid:2z29r78iGYGUX76PqB4+nmaY3Ic false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q91ZX7 uniprotkb:P97318 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300982 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:87F547969B0F8366|rigid:s4oQWrPO4AiCJKtYFUdPtpIjQvU false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q924X6 uniprotkb:Q9WVI9 intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644 intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8 psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym) psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-300997 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2 - - - comment:Requires alternatively spliced inset to be present in Lrp8 for binding|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090 rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090 intact-crc:7741FD7B34F92F42|rigid:yB6mZ5iJMtRwZy0yeGaxhy3Qegg false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q924X6 uniprotkb:Q9ERE9 intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644 intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4 psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym) psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301011 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3 - - - comment:Requires alternatively spliced inset to be present for binding|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090 rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090 intact-crc:1240AEDF7A0D348F|rigid:ne96PlKndRSjl1k++iouu3S4yRE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q924X6 uniprotkb:P97318 intact:EBI-432319|uniprotkb:Q8CAK9|uniprotkb:Q8CDF5|uniprotkb:Q921B6|ensembl:ENSMUSP00000115854|ensembl:ENSMUSP00000158644 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:lrp8_mouse(display_long)|uniprotkb:Apolipoprotein E receptor 2(gene name synonym)|uniprotkb:Lrp8(gene name)|psi-mi:Lrp8(display_short)|uniprotkb:Apoer2(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301021 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|reactome:R-MMU-432142|interpro:IPR001881(EGF-like calcium-binding)|reactome:R-MMU-975634|go:"GO:0030425"(dendrite)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|refseq:XP_011238759.1|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006897"(endocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0009986"(cell surface)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021541"(ammon gyrus development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0030424"(axon)|ensembl:ENSMUSG00000028613(gene)|ensembl:ENSMUST00000143601(transcript)|ensembl:ENSMUST00000238569(transcript)|go:"GO:0001540"(amyloid-beta binding)|dip:DIP-33284N reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - comment:Does not require alternatively spliced insert in Lrp8 for binding|dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:FB2l87dbS4aA0V7vavDO3HsBKq810090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:CBE5F00F6DA8614D|rigid:Z4kmelCbmjYG0eK/0YuXdoGqkiM false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P35951 uniprotkb:P97318 intact:EBI-301050|ensembl:ENSMUSP00000034713|uniprotkb:Q6GTJ9 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:ldlr_mouse(display_long)|uniprotkb:Ldlr(gene name)|psi-mi:Ldlr(display_short) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301049 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_034830.2|go:"GO:0030299"(intestinal cholesterol absorption)|go:"GO:0030301"(cholesterol transport)|go:"GO:0034362"(low-density lipoprotein particle)|go:"GO:0034381"(plasma lipoprotein particle clearance)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034384"(high-density lipoprotein particle clearance)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042159"(lipoprotein catabolic process)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043235"(receptor complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061771"(response to caloric restriction)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0070508"(cholesterol import)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090118"(receptor-mediated endocytosis involved in cholesterol transport)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0097443"(sorting endosome)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:1990666"(PCSK9-LDLR complex)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR036055|mint:P35951|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8964026|reactome:R-MMU-8964038|go:"GO:0071398"(cellular response to fatty acid)|ensembl:ENSMUSG00000032193(gene)|ensembl:ENSMUST00000034713(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0002020"(protease binding)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007616"(long-term memory)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0010899"(regulation of phosphatidylcholine catabolic process)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030169"(low-density lipoprotein particle binding)|refseq:NP_001239587.1|refseq:NP_001239588.1 reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:gT4zmR7eUE+aI9h/9hqr29EJ1wU10090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:56D0B608455A3E4F|rigid:9w4U2YA1NT5I3bmUJE2WtR8+1Uc false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P98156 uniprotkb:P97318 intact:EBI-301063|uniprotkb:Q64022|ensembl:ENSMUSP00000127329 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:vldlr_mouse(display_long)|uniprotkb:Vldlr(gene name)|psi-mi:Vldlr(display_short) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0018"(two hybrid) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301073 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000024924(gene)|ensembl:ENSMUST00000167487(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006869"(lipid transport)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0030229"(very-low-density lipoprotein particle receptor activity)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034189"(very-low-density lipoprotein particle binding)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034436"(glycoprotein transport)|go:"GO:0034447"(very-low-density lipoprotein particle clearance)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0038025"(reelin receptor activity)|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0043235"(receptor complex)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1900006"(positive regulation of dendrite development)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|go:"GO:0045177"(apical part of cell)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR032931|interpro:IPR036055|mint:P98156|reactome:R-MMU-8866376|reactome:R-MMU-8866427|reactome:R-MMU-8964046|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_001154892.1|refseq:NP_038731.2|refseq:XP_006526980.1|refseq:XP_006526981.1|dip:DIP-33283N reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2004/03/24 2014/10/16 rogid:47bXFZMsDTZIk3JFU6zdEh7Zio810090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:95E812BA2E91B0BF|rigid:npUV+mLDW/kW1NWVZ70Lat4UQXY false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:A2ARV4 uniprotkb:Q9Z0G0 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300855|ensembl:ENSMUSP00000019577 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:gipc1_mouse(display_long)|uniprotkb:Gipc1(gene name)|psi-mi:Gipc1(display_short)|uniprotkb:Gipc(gene name synonym)|uniprotkb:Semcap1(gene name synonym)|uniprotkb:RGS19-interacting protein 1(gene name synonym)|uniprotkb:GAIP C-terminus-interacting protein(gene name synonym)|uniprotkb:RGS-GAIP-interacting protein(gene name synonym)|uniprotkb:Synectin(gene name synonym)|uniprotkb:SemaF cytoplasmic domain-associated protein 1(gene name synonym)|uniprotkb:Rgs19ip1(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301359 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000019433(gene)|ensembl:ENSMUST00000019577(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0005938"(cell cortex)|go:"GO:0006605"(protein targeting)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014047"(glutamate secretion)|go:"GO:0016020"(membrane)|go:"GO:0017022"(myosin binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR017379(Uncharacterised conserved protein UCP038083, PDZ)|interpro:IPR036034|mint:Q9Z0G0|rcsb pdb:5V6B|rcsb pdb:5V6E|rcsb pdb:5V6T|rcsb pdb:7NRN|refseq:NP_061241.1|dip:DIP-33281N - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:qOV0/hc2ei7VPYVbbWqUkjF8aBw10090 intact-crc:D3210F7F4BF07E07|rigid:MonUbWvGXW9bn7w02DGo+DbVp/s false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WVI9 uniprotkb:A2ARV4 intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym) psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301368 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2 go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 intact-crc:74E312AFE46B13E5|rigid:WEyTupXo859WRztA6VRxZcfzXB8 false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q62108 uniprotkb:A2ARV4 intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym) psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301374 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 intact-crc:565E8083088B34AD|rigid:bYR6pm20RmmBQBbUYbHNCbKT+0s false glutathione s tranferase tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A2ARV4 uniprotkb:Q9ERE9 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301382 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090 intact-crc:F06B23B4069CF844|rigid:YJJEBUMjyL0eiso+fNmvpl6BUjM false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A2ARV4 uniprotkb:Q9D6K5 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301388 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 intact-crc:FCB866E882E729EB|rigid:+HU/bc46P73uexAHoXfRiZVtcW8 false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:A2ARV4 uniprotkb:P97318 intact:EBI-300875|uniprotkb:P70215|uniprotkb:Q3TL35|uniprotkb:Q9JLB3|ensembl:ENSMUSP00000079752 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:lrp2_mouse(display_long)|uniprotkb:Lrp2(gene name)|psi-mi:Lrp2(display_short)|uniprotkb:Megalin(gene name synonym)|uniprotkb:Glycoprotein 330(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301400 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060068"(vagina development)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0140058"(neuron projection arborization)|go:"GO:0140077"(positive regulation of lipoprotein transport)|go:"GO:0140318"(protein transporter activity)|go:"GO:1904447"(folate import across plasma membrane)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006766"(vitamin metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020028"(endocytic hemoglobin import into cell)|go:"GO:0030001"(metal ion transport)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031526"(brush border membrane)|go:"GO:0031904"(endosome lumen)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0042562"(hormone binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044321"(response to leptin)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|ensembl:ENSMUSG00000027070(gene)|ensembl:ENSMUST00000080953(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR036055|mint:A2ARV4|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-975634|refseq:NP_001074557.1 reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:daFSvi86EGJc3bNtEUmoED10K6o10090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:C06BDF8390AEE389|rigid:gKwdeQDivRVoiEDQE20g+171m/o false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZX7 uniprotkb:Q9WVI9 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-74515|ensembl:ENSMUSP00000050773|uniprotkb:O35145|uniprotkb:Q925J8|uniprotkb:Q9R1H9|uniprotkb:Q9R1Z1|uniprotkb:Q9WVI7|uniprotkb:Q9WVI8 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:jip1_mouse(display_long)|uniprotkb:Mapk8ip1(gene name)|psi-mi:Mapk8ip1(display_short)|uniprotkb:Ib1(gene name synonym)|uniprotkb:Jip1(gene name synonym)|uniprotkb:Mapk8ip(gene name synonym)|uniprotkb:Prkm8ip(gene name synonym)|uniprotkb:Islet-brain-1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 1(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301409 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007165"(signal transduction)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0044294"(dendritic growth cone)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0044302"(dentate gyrus mossy fiber)|go:"GO:0045202"(synapse)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:2000564"(regulation of CD8-positive, alpha-beta T cell proliferation)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035638|interpro:IPR036028|rcsb pdb:1UKH|rcsb pdb:1UKI|rcsb pdb:3O17|rcsb pdb:3O2M|rcsb pdb:3V3V|rcsb pdb:6F5E|go:"GO:0005078"(MAP-kinase scaffold activity)|ensembl:ENSMUST00000050312(transcript)|ensembl:ENSMUSG00000027223(gene)|refseq:NP_035292.2 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:r8Xy/vpp0kYLCZ7vw1sE666dk/g10090 intact-crc:7FEF99A36F39E373|rigid:R5aU/mL8meFWXoRS/Gm7yOLg1Io false glutathione s tranferase tag:?-? glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZX7 uniprotkb:Q9ERE9 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-74576|ensembl:ENSMUSP00000023291|uniprotkb:Q9CXI4 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:jip2_mouse(display_long)|uniprotkb:Mapk8ip2(gene name)|psi-mi:Mapk8ip2(display_short)|uniprotkb:Ib2(gene name synonym)|uniprotkb:Jip2(gene name synonym)|uniprotkb:Islet-brain-2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 8-interacting protein 2(gene name synonym)|uniprotkb:JNK MAP kinase scaffold protein 2(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301415 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N ensembl:ENSMUSG00000022619(gene)|ensembl:ENSMUST00000023291(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001662"(behavioral fear response)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007254"(JNK cascade)|go:"GO:0035176"(social behavior)|go:"GO:0007617"(mating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046958"(nonassociative learning)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000311"(regulation of AMPA receptor activity)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0014069"(postsynaptic density)|interpro:IPR001452(Src homology-3)|go:"GO:0019894"(kinesin binding)|interpro:IPR006020(Phosphotyrosine interaction region)|go:"GO:0019901"(protein kinase binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035637|mint:Q9ERE9|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|refseq:NP_068740.3 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:NUVswDC52pSAuf8BL8b9wqVc8ng10090 intact-crc:9AF6DF57AC74D09F|rigid:2z29r78iGYGUX76PqB4+nmaY3Ic false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZX7 uniprotkb:Q62108 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-300895|ensembl:ENSMUSP00000104229|uniprotkb:Q5NCV5|uniprotkb:Q5NCV6|uniprotkb:Q5NCV7|uniprotkb:Q91WJ1 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:dlg4_mouse(display_long)|uniprotkb:Dlg4(gene name)|psi-mi:Dlg4(display_short)|uniprotkb:Dlgh4(gene name synonym)|uniprotkb:Psd95(gene name synonym)|uniprotkb:Postsynaptic density protein 95(gene name synonym)|uniprotkb:Synapse-associated protein 90(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301421 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N ensembl:ENSMUSG00000020886(gene)|ensembl:ENSMUST00000108588(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016188"(synaptic vesicle maturation)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019894"(kinesin binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031812"(P2Y1 nucleotide receptor binding)|go:"GO:0032281"(AMPA glutamate receptor complex)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0035176"(social behavior)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042220"(response to cocaine)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044300"(cerebellar mossy fiber)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044309"(neuron spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071625"(vocalization behavior)|go:"GO:0071944"(cell periphery)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097109"(neuroligin family protein binding)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097113"(AMPA glutamate receptor clustering)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098794"(postsynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099031"(anchored component of postsynaptic density membrane)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1904719"(positive regulation of AMPA glutamate receptor clustering)|go:"GO:2000310"(regulation of NMDA receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000821"(regulation of grooming behavior)|go:"GO:0060076"(excitatory synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR019583|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|mint:Q62108|reactome:R-MMU-399719|reactome:R-MMU-438066|reactome:R-MMU-451308|reactome:R-MMU-5625900|reactome:R-MMU-5673001|reactome:R-MMU-5682910|reactome:R-MMU-6794361|reactome:R-MMU-8849932|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|refseq:NP_001103222.1|refseq:NP_031890.1|dip:DIP-29888N - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:9Ylvs2goE8Z/6ff4AqFCEKrPanY10090 intact-crc:505E4B231917F6D2|rigid:1zx6Qz4KlIKpZm/LRFMd8oOMRSU false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZX7 uniprotkb:Q9D6K5 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-300910|uniprotkb:Q2TTN6|uniprotkb:Q6YNE6|uniprotkb:Q78HT9|uniprotkb:Q8K4F3|uniprotkb:Q9D8G4|ensembl:ENSMUSP00000129224 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:syj2b_mouse(display_long)|uniprotkb:Synj2bp(gene name)|psi-mi:Synj2bp(display_short)|uniprotkb:Arip2(gene name synonym)|uniprotkb:Omp25(gene name synonym)|uniprotkb:Activin receptor-interacting protein 2(gene name synonym)|uniprotkb:Activin receptor-interacting protein 4(gene name synonym)|uniprotkb:Mitochondrial outer membrane protein 25(gene name synonym) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301424 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N ensembl:ENSMUSG00000090935(gene)|ensembl:ENSMUST00000163402(transcript)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005739"(mitochondrion)|go:"GO:0006605"(protein targeting)|go:"GO:0006897"(endocytosis)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0043005"(neuron projection)|go:"GO:0043113"(receptor clustering)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|refseq:NP_001296743.1|refseq:NP_001296777.1|refseq:NP_079568.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:wk17BZEj6qjxzJ4OyQcS8ud5O1w10090 intact-crc:96259A0B280F0130|rigid:8j2sCXYl6F8O3OuYzIBddiEw6MQ false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91ZX7 uniprotkb:P97318 intact:EBI-300955|uniprotkb:Q61291|uniprotkb:Q920Y4 intact:EBI-81680|uniprotkb:A2A963|uniprotkb:A2A964|uniprotkb:A2A967|uniprotkb:A2A965|uniprotkb:A2A966|uniprotkb:A2A970|uniprotkb:P97316|uniprotkb:P97317|uniprotkb:Q9DAP9 psi-mi:lrp1_mouse(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:A2mr(gene name synonym) psi-mi:dab1_mouse(display_long)|uniprotkb:Dab1(gene name)|psi-mi:Dab1(display_short) psi-mi:"MI:0096"(pull down) Gotthardt et al. (2000) pubmed:10827173 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-301434 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q91ZX7|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-MMU-2168880|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0045807"(positive regulation of endocytosis)|reactome:R-MMU-975634|refseq:NP_032538.2|dip:DIP-47785N reactome:R-MMU-8866376|go:"GO:0001764"(neuron migration)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007417"(central nervous system development)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0021517"(ventral spinal cord development)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021766"(hippocampus development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0007494"(midgut development)|go:"GO:0021813"(cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042493"|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0007628"(adult walking behavior)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0097477"(lateral motor column neuron migration)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|rcsb pdb:1NTV|rcsb pdb:1NU2|rcsb pdb:1OQN|refseq:NP_034144.1|refseq:NP_796233.2|ensembl:ENSMUSG00000028519|ensembl:ENSMUSG00000028519|dip:DIP-30902N|refseq:XP_011238731.1 - - - dataset:Synapse - Interactions of proteins with an established role in the presynapse. taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/03/24 2014/10/16 rogid:lX7IFHEMgDZnvC069QGK9D4BL1Y10090 rogid:Q9M7gpZkbDqd6D6pIKi66jrnDDo10090 intact-crc:F0705AB33617D83B|rigid:s4oQWrPO4AiCJKtYFUdPtpIjQvU false - glutathione s tranferase tag:?-? - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)