#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9VEZ5	uniprotkb:Q9VEZ5	intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344	intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344	psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name)	psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name)	psi-mi:"MI:0423"(in-gel kinase assay)	Kim et al. (2000)	pubmed:10636911	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-366146	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N	flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N	-	-	-	comment:This reaction was LPS dependent. Ird5 was overexpressed in Drosophila Schneider cells.|resulting-ptm:Auto-phosphorylation of Ird5.	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2004/06/02	2014/10/16	rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227	rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227	intact-crc:CB9601AA586681A8|rigid:gyeKrLyIM/J8/S5fYNEYQ31e1y0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9VEZ5	uniprotkb:Q03017	intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344	intact:EBI-200600|uniprotkb:A4V0S3|uniprotkb:Q0E8Q3|uniprotkb:Q9V3M6|ensemblmetazoa:FBpp0080402|ensemblmetazoa:FBpp0080403|ensemblmetazoa:FBpp0089296|ensemblmetazoa:FBpp0308004	psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name)	psi-mi:cact_drome(display_long)|uniprotkb:CG5848(orf name)|uniprotkb:cact(gene name)|psi-mi:cact(display_short)	psi-mi:"MI:0096"(pull down)	Kim et al. (2000)	pubmed:10636911	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-366151	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N	refseq:NP_476942.1|refseq:NP_476943.1|refseq:NP_723960.1|refseq:NP_995721.1|flybase:FBgn0000250|refseq:NP_001260496.1|dip:DIP-17846N|ensemblmetazoa:FBgn0000250(gene)|ensemblmetazoa:FBtr0080844(transcript)|ensemblmetazoa:FBtr0080845(transcript)|ensemblmetazoa:FBtr0080847(transcript)|ensemblmetazoa:FBtr0337081(transcript)|go:"GO:0002789"(negative regulation of antifungal peptide production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007399"(nervous system development)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048477"(oogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071212"(subsynaptic reticulum)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-DME-1169091|reactome:R-DME-202424|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-445989|reactome:R-DME-5607764|reactome:R-DME-9020702	go:"GO:0005515"(protein binding)	-	-	comment:Ird5 is six His tagged and overexpressed in Drosophila schneider cells.	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2004/06/02	2014/10/16	rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227	rogid:xVqWiRJtkb1WDO5GmztYwgdB9iI7227	intact-crc:005AA68E5B83946D|rigid:50BUsMz3/9W8BsGtpBJlW3gmqq4	false	his tag:?-?	-	-	-	psi-mi:"MI:0072"(monoclonal antibody western blot)	psi-mi:"MI:0072"(monoclonal antibody western blot)
uniprotkb:Q03017	uniprotkb:Q9VEZ5	intact:EBI-200600|uniprotkb:A4V0S3|uniprotkb:Q0E8Q3|uniprotkb:Q9V3M6|ensemblmetazoa:FBpp0080402|ensemblmetazoa:FBpp0080403|ensemblmetazoa:FBpp0089296|ensemblmetazoa:FBpp0308004	intact:EBI-148871|uniprotkb:Q9GYV6|uniprotkb:Q9NJI1|uniprotkb:Q9U698|uniprotkb:Q9U7F5|ensemblmetazoa:FBpp0293344	psi-mi:cact_drome(display_long)|uniprotkb:CG5848(orf name)|uniprotkb:cact(gene name)|psi-mi:cact(display_short)	psi-mi:ikkb_drome(display_long)|uniprotkb:IKKbeta(gene name)|psi-mi:IKKbeta(display_short)|uniprotkb:Cactus kinase IKK(gene name synonym)|uniprotkb:DIK(gene name synonym)|uniprotkb:IKK-like protein(gene name synonym)|uniprotkb:Immune response deficient protein 5(gene name synonym)|uniprotkb:Lipopolysaccharide-activated kinase(gene name synonym)|uniprotkb:ird5(gene name synonym)|uniprotkb:CG4201(orf name)	psi-mi:"MI:0424"(protein kinase assay)	Kim et al. (2000)	pubmed:10636911	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-366163	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476942.1|refseq:NP_476943.1|refseq:NP_723960.1|refseq:NP_995721.1|flybase:FBgn0000250|refseq:NP_001260496.1|dip:DIP-17846N|ensemblmetazoa:FBgn0000250(gene)|ensemblmetazoa:FBtr0080844(transcript)|ensemblmetazoa:FBtr0080845(transcript)|ensemblmetazoa:FBtr0080847(transcript)|ensemblmetazoa:FBtr0337081(transcript)|go:"GO:0002789"(negative regulation of antifungal peptide production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007399"(nervous system development)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0045611"(negative regulation of hemocyte differentiation)|go:"GO:0045751"(negative regulation of Toll signaling pathway)|go:"GO:0046843"(dorsal appendage formation)|go:"GO:0048477"(oogenesis)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0071212"(subsynaptic reticulum)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|reactome:R-DME-1169091|reactome:R-DME-202424|reactome:R-DME-209406|reactome:R-DME-209560|reactome:R-DME-214842|reactome:R-DME-214844|reactome:R-DME-214869|reactome:R-DME-2871837|reactome:R-DME-445989|reactome:R-DME-5607764|reactome:R-DME-9020702	flybase:FBgn0024222|refseq:NP_524751.3|ensemblmetazoa:FBgn0024222(gene)|ensemblmetazoa:FBtr0304804(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006963"(positive regulation of antibacterial peptide biosynthetic process)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0061057"(peptidoglycan recognition protein signaling pathway)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|reactome:R-DME-198323|reactome:R-DME-209447|reactome:R-DME-214399|reactome:R-DME-5607761|reactome:R-DME-5676590|reactome:R-DME-9020702|dip:DIP-31307N	go:"GO:0005515"(protein binding)	-	-	resulting-ptm:Cact is phosphorylated.	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/06/02	2014/10/16	rogid:xVqWiRJtkb1WDO5GmztYwgdB9iI7227	rogid:iXam5xaVfASMnNR7+YkTEGQNXHg7227	intact-crc:B5B70FF12CE037EF|rigid:50BUsMz3/9W8BsGtpBJlW3gmqq4	false	glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)