#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q80Z28	uniprotkb:P54762	intact:EBI-80308	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	psi-mi:q80z28_mouse(display_long)|uniprotkb:Grb10(gene name)|psi-mi:Grb10(display_short)	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	-	-	-	comment:"cytoplasmic domain of ELK (AA 566-984) is used in the experiment. CDNA sequences containing SH2 domain (InterPro; IPR000980) of GRB10 were recovered."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/09	2014/10/16	rogid:0heXGFH9uU1Hb3PX6YlatKsNvkg10090	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	intact-crc:EA007DBAE66C5EA5|rigid:ONzwtZtA7I7J72JxaJBGY+0xoRs	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P54762	uniprotkb:Q60631	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80302	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	-	-	-	comment:"Cytoplasmic domain of ELK (aa 566-984) recovered SH2 (interpro-IPR000980) domain containing GRB2 cDNA."	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2003/12/09	2014/10/16	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:DCFDA987F5E8AC10|rigid:HaF2vF6dKB2b88H859DpKzn+NzI	false	phosphorylated residue:?-?	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q13322	uniprotkb:P54762	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	intact-crc:61D006DBD2D01D0A|rigid:aPTOvO/wwoACVA6NGN6mZt2QgZ0	false	-	phosphorylated residue:?-?|binding-associated region:566-984|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54762	uniprotkb:P62993	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0096"(pull down)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:7A3D0C4858E2EA86|rigid:hm9HW8bf9m1YJ5KALNxzM0cfR3Q	false	phosphorylated residue:?-?|binding-associated region:566-984|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54762	uniprotkb:P62993	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80335	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606	intact-crc:E0945D6D33C24995|rigid:jYkosZ6OxbG8VSQrmkbNwCuVINU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P54762	uniprotkb:Q13322	intact:EBI-80252|uniprotkb:A8K593|uniprotkb:Q0VG87|uniprotkb:O43569|uniprotkb:O95142|uniprotkb:O95143|ensembl:ENSP00000381097|uniprotkb:B3KTB2|uniprotkb:B5A969	intact:EBI-80275|uniprotkb:O00427|uniprotkb:O00701|uniprotkb:O75222|uniprotkb:Q92606|uniprotkb:Q92907|uniprotkb:Q92948|intact:EBI-1760363|ensembl:ENSP00000381793|ensembl:ENSP00000385770|intact:EBI-1965437|uniprotkb:A7VJ95|uniprotkb:A4D258|uniprotkb:A8K0E6|uniprotkb:D3DVM9	psi-mi:ephb1_human(display_long)|uniprotkb:EPHB1(gene name)|psi-mi:EPHB1(display_short)|uniprotkb:EPHT2(gene name synonym)|uniprotkb:NET(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH-2(gene name synonym)|uniprotkb:HEK6(gene name synonym)|uniprotkb:ELK(gene name synonym)|uniprotkb:EPH-like kinase 6(gene name synonym)|uniprotkb:EPH tyrosine kinase 2(gene name synonym)|uniprotkb:Neuronally-expressed EPH-related tyrosine kinase(gene name synonym)	psi-mi:grb10_human(display_long)|uniprotkb:GRB10(gene name)|psi-mi:GRB10(display_short)|uniprotkb:GRBIR(gene name synonym)|uniprotkb:KIAA0207(gene name synonym)|uniprotkb:GRB10 adapter protein(gene name synonym)|uniprotkb:Insulin receptor-binding protein Grb-IR(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Stein et al. (1996)	pubmed:8798570|mint:MINT-5221166	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-80335	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0014719"(skeletal muscle satellite cell activation)|go:"GO:0021631"(optic nerve morphogenesis)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0022008"(neurogenesis)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0008046"(axon guidance receptor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060326"(cell chemotaxis)|ensembl:ENSG00000154928(gene)|ensembl:ENST00000398015(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034231|interpro:IPR036116|interpro:IPR042819|rcsb pdb:2DJS|rcsb pdb:2EAO|rcsb pdb:3ZFX|rcsb pdb:5MJA|rcsb pdb:5MJB|rcsb pdb:6UMW|rcsb pdb:7KPL|rcsb pdb:7KPM|reactome:R-HSA-2682334|reactome:R-HSA-3928662|reactome:R-HSA-3928664|reactome:R-HSA-3928665|refseq:NP_004432.1	go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045719"(negative regulation of glycogen biosynthetic process)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904738"(vascular associated smooth muscle cell migration)|interpro:IPR000159(Ras-association)|interpro:IPR000980(SH2 motif)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015042("BPS (Between PH and SH2)")|interpro:IPR029071|interpro:IPR035036|interpro:IPR035037|interpro:IPR036860|interpro:IPR039664|interpro:IPR039665|mint:Q13322|rcsb pdb:1NRV|rcsb pdb:3HK0|reactome:R-HSA-1433557|reactome:R-HSA-74713|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8853659|reactome:R-HSA-9607240|reactome:R-HSA-9648895|ensembl:ENSG00000106070(gene)|ensembl:ENST00000398812(transcript)|ensembl:ENST00000401949(transcript)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010467"(gene expression)|refseq:XP_011513606.1|refseq:XP_011513614.1|refseq:XP_011513618.1|refseq:NP_001001549.1|refseq:NP_001001550.1|refseq:NP_001001555.1|refseq:NP_005302.3|refseq:XP_016867534.1|refseq:XP_016867535.1|refseq:XP_016867552.1|refseq:XP_016867553.1|refseq:XP_016867554.1|refseq:XP_016867555.1|refseq:XP_016867556.1|refseq:XP_016867557.1|dip:DIP-31657N	-	-	-	-	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2003/12/09	2014/10/16	rogid:o3NRwvWL2GQwOZlirn1qoW1VfyA9606	rogid:WBLkjS4iCC2gMTzR3izSFXGrBnk9606	intact-crc:E0945D6D33C24995|rigid:jYkosZ6OxbG8VSQrmkbNwCuVINU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)