#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P35226 uniprotkb:O75461 intact:EBI-2341576|uniprotkb:Q5T8Z3|uniprotkb:Q96F37|uniprotkb:Q16030|intact:EBI-28989037|ensembl:ENSP00000365851 intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936 psi-mi:bmi1_human(display_long)|uniprotkb:BMI1(gene name)|psi-mi:BMI1(display_short)|uniprotkb:PCGF4(gene name synonym)|uniprotkb:RNF51(gene name synonym)|uniprotkb:Polycomb group RING finger protein 4(gene name synonym)|uniprotkb:RING finger protein 51(gene name synonym) psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Trimarchi et al. (2001) pubmed:11171983|mint:MINT-5213507 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7488984|mint:MINT-19898 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001190991.1|refseq:NP_005171.4|ensembl:ENSP00000365851|dip:DIP-41879N|ensembl:ENSG00000168283(gene)|ensembl:ENST00000376663(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006306"(DNA methylation)|go:"GO:0006342"|go:"GO:0006959"(humoral immune response)|go:"GO:0007379"(segment specification)|go:"GO:0007420"(brain development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031519"(PcG protein complex)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000011"(regulation of adaxial/abaxial pattern formation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P35226|rcsb pdb:2H0D|rcsb pdb:2NA1|rcsb pdb:3RPG|rcsb pdb:4R8P|rcsb pdb:5FR6|rcsb pdb:6WI7|rcsb pdb:6WI8|rcsb pdb:7ND1|reactome:R-HSA-2559580|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-8939243|reactome:R-HSA-8943724|reactome:R-HSA-8953750|mint:MINT-445180(identity) refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|mint:MINT-445174(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4C|comment:BIOSOURCE=C33-A cells|comment:homomint|comment:mint taxid:9606(human-c33a)|taxid:9606(Homo sapiens epihelial cervix carcinoma cells) - 2003/11/10 2014/10/16 rogid:ruyez2gHfd/si8gxYUDZzZ1L4689606 rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606 intact-crc:D2445F10463DB6A7|rigid:HPN6sJwvGC6e3I8lOTmPI2WYMVw false tag:?-?(MINT-445181) tag:?-?(MINT-445175) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O75461 uniprotkb:O35730 intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936 intact:EBI-929310|ensembl:ENSMUSP00000025183|uniprotkb:Q3U242|uniprotkb:Q3U333|uniprotkb:Q4FK33|uniprotkb:Q63ZX8|uniprotkb:Q921Z8 psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short) psi-mi:ring1_mouse(display_long)|uniprotkb:Ring1(gene name)|psi-mi:Ring1(display_short)|uniprotkb:Ring1A(gene name synonym)|uniprotkb:Rnf1(gene name synonym)|uniprotkb:RING finger protein 1(gene name synonym)|uniprotkb:Polycomb complex protein RING1(gene name synonym)|uniprotkb:Transcription repressor Ring1A(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RING1(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Trimarchi et al. (2001) pubmed:11171983|mint:MINT-5213507 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7489026|mint:MINT-19308 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|mint:MINT-445192(identity) ensembl:ENSMUSG00000024325(gene)|ensembl:ENSMUST00000025183(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001739"(sex chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048593"(camera-type eye morphogenesis)|refseq:NP_033092.3|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097027"(ubiquitin-protein transferase activator activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|interpro:IPR042741|interpro:IPR043540|mint:O35730|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|reactome:R-MMU-8953750|mint:MINT-445196(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:"starting point for coimmunoprecipitation experiments:expression vectors transfection/whole-cell lysates"|comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2003/11/10 2014/10/16 rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606 rogid:QwNPWozHIOz6ecIMradUC2NqbJE10090 intact-crc:E06DA9992ECDD696|rigid:r3Pq0luILdM+NjAs9N8Qo85KNtY false - tag:?-?(MINT-445197) - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8N488 uniprotkb:O75461 intact:EBI-752324|uniprotkb:Q9P2W5|uniprotkb:Q9UMW4|ensembl:ENSP00000419494 intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936 psi-mi:rybp_human(display_long)|uniprotkb:Death effector domain-associated factor(gene name synonym)|uniprotkb:YY1 and E4TF1-associated factor 1(gene name synonym)|uniprotkb:Apoptin-associating protein 1(gene name synonym)|uniprotkb:RYBP(gene name)|psi-mi:RYBP(display_short)|uniprotkb:DEDAF(gene name synonym)|uniprotkb:YEAF1(gene name synonym) psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short) psi-mi:"MI:0018"(two hybrid) Trimarchi et al. (2001) pubmed:11171983|mint:MINT-5213507 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7489048|mint:MINT-19309 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036366.3|dip:DIP-41435N|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007275"(multicellular organism development)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR039958|mint:Q8N488|rcsb pdb:3IXS|reactome:R-HSA-8939243|reactome:R-HSA-8953750|ensembl:ENSG00000163602(gene)|ensembl:ENST00000477973(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|mint:MINT-445213(identity) refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|mint:MINT-445207(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" comment:homomint|comment:mint taxid:-4(in vivo)|taxid:-4(in vivo) - 2003/11/10 2014/10/16 rogid:t9ef8aO/5xEAB3hMlElJCktEIOU9606 rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606 intact-crc:9E72E62B68D31F88|rigid:tzTeGEZ8QybKLCOH03qT0H+WoVY false tag:?-?(MINT-445214) tag:?-?(MINT-445208) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:O75461 uniprotkb:P35227 intact:EBI-749694|uniprotkb:O60544|uniprotkb:Q53QY9|uniprotkb:Q7Z2H6|uniprotkb:A8K2Z8|uniprotkb:G5E936|uniprotkb:Q6Q9Z6|ensembl:ENSP00000370936 intact:EBI-2129767|uniprotkb:A6NGD8|ensembl:ENSP00000478517|ensembl:ENSP00000478970|ensembl:ENSP00000482063|ensembl:ENSP00000482815|ensembl:ENSP00000488868|ensembl:ENSP00000488872 psi-mi:e2f6_human(display_long)|uniprotkb:E2F6(gene name)|psi-mi:E2F6(display_short) psi-mi:pcgf2_human(display_long)|uniprotkb:PCGF2(gene name)|psi-mi:PCGF2(display_short)|uniprotkb:MEL18(gene name synonym)|uniprotkb:RNF110(gene name synonym)|uniprotkb:ZNF144(gene name synonym)|uniprotkb:DNA-binding protein Mel-18(gene name synonym)|uniprotkb:RING finger protein 110(gene name synonym)|uniprotkb:Zinc finger protein 144(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Trimarchi et al. (2001) pubmed:11171983|mint:MINT-5213507 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7489072|mint:MINT-19899 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001265204.1|refseq:NP_001265205.1|refseq:NP_001265206.1|refseq:NP_001265207.1|refseq:NP_937987.2|dip:DIP-41699N|ensembl:ENSG00000169016(gene)|ensembl:ENST00000381525(transcript)|go:"GO:0000083"(regulation of transcription involved in G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR015635(Transcription Factor E2F6)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241|mint:O75461|reactome:R-HSA-69205|reactome:R-HSA-8953750|interpro:IPR032198|mint:MINT-445223(identity) refseq:NP_009075.1|refseq:XP_016880505.1|refseq:XP_005257697.1|refseq:XP_005257698.1|refseq:XP_005257699.1|dip:DIP-41880N|ensembl:ENSG00000277258(gene)|ensembl:ENSG00000278644(gene)|ensembl:ENST00000610440(transcript)|ensembl:ENST00000611883(transcript)|ensembl:ENST00000616199(transcript)|ensembl:ENST00000620225(transcript)|ensembl:ENST00000631566(transcript)|ensembl:ENST00000631610(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001739"(sex chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016573"(histone acetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0036353"(histone H2A-K119 monoubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR032443|mint:P35227|reactome:R-HSA-3108214|reactome:R-HSA-3899300|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4655427|reactome:R-HSA-5617472|reactome:R-HSA-8953750|mint:MINT-445229(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" figure legend:F4D|comment:homomint|comment:mint taxid:10090(mouse-l cells)|taxid:10090(Mus musculus embryo fibroblast, Moloney Sarcoma Virus transformed) - 2003/11/10 2014/10/16 rogid:HZpQSfeASNNMLz4NCYOp6T0yXTk9606 rogid:zppw56VrEl6gEFwtJMCN5cQkPxI9606 intact-crc:4E9C120B509BAD14|rigid:CqZrtcDVnBFs82JVOEGEjtklKU8 false tag:?-?(MINT-445224) tag:?-?(MINT-445230) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)