#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P49651	uniprotkb:P25099	intact:EBI-8499407|intact:MINT-242266|ensembl:ENSRNOP00000019304	intact:EBI-2905080|ensembl:ENSRNOP00000004602|ensembl:ENSRNOP00000073958	psi-mi:p2ry1_rat(display_long)|uniprotkb:P2ry1(gene name)|psi-mi:P2ry1(display_short)|uniprotkb:Purinergic receptor(gene name synonym)|uniprotkb:ATP receptor(gene name synonym)	psi-mi:aa1r_rat(display_long)|uniprotkb:Adora1(gene name)|psi-mi:Adora1(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Yoshioka et al. (2002)	pubmed:12123822|mint:MINT-5215565	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499457|mint:MINT-15168	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036932.1|rgd:3242|go:"GO:0001621"(G protein-coupled ADP receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007568"(aging)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030168"(platelet activation)|go:"GO:0030425"(dendrite)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|go:"GO:0035589"(G protein-coupled purinergic nucleotide receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042755"(eating behavior)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043531"(ADP binding)|go:"GO:0044297"(cell body)|go:"GO:0045028"(G protein-coupled purinergic nucleotide receptor activity)|go:"GO:0045031"(G protein-coupled ATP receptor activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051100"(negative regulation of binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071415"(cellular response to purine-containing compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090075"(relaxation of muscle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000142(P2Y purinoceptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-416476|reactome:R-RNO-417957|reactome:R-RNO-418592|ensembl:ENSRNOG00000014232(gene)|ensembl:ENSRNOT00000019305(transcript)|mint:MINT-717876(identity)	go:"GO:0044297"(cell body)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-418594|ensembl:ENSRNOG00000003442(gene)|ensembl:ENSRNOT00000004602(transcript)|ensembl:ENSRNOT00000078993(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0005783"(endoplasmic reticulum)|rgd:2048|refseq:NP_058851.2|refseq:XP_006249921.1|refseq:XP_006249923.1|mint:MINT-717873(identity)	-	comment:mint|function:Receptor for extracellular adenine nucleotides such as ATP and ADP. In pancreatic islets, may mediate some of the effects of extracellular ATP on insulin secretion|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:Theh formation of heterooligomer is stimulated by the presence of both agonists|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:/UQX+tm+cCwCy2gWUI52pBQpCwo10116	rogid:2JgyElmUGLZ0s/hJ7oLo6ycCo5Q10116	intact-crc:AEFF08040D66A289|rigid:fBS0hlB5TJlmbiUGEpL12HbSvVU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49651	uniprotkb:P25099	intact:EBI-8499407|intact:MINT-242266|ensembl:ENSRNOP00000019304	intact:EBI-2905080|ensembl:ENSRNOP00000004602|ensembl:ENSRNOP00000073958	psi-mi:p2ry1_rat(display_long)|uniprotkb:P2ry1(gene name)|psi-mi:P2ry1(display_short)|uniprotkb:Purinergic receptor(gene name synonym)|uniprotkb:ATP receptor(gene name synonym)	psi-mi:aa1r_rat(display_long)|uniprotkb:Adora1(gene name)|psi-mi:Adora1(display_short)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Yoshioka et al. (2002)	pubmed:12123822|mint:MINT-5215565	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0471"(MINT)	intact:EBI-8499564|mint:MINT-15167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036932.1|rgd:3242|go:"GO:0001621"(G protein-coupled ADP receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001973"(G protein-coupled adenosine receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007568"(aging)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0010700"(negative regulation of norepinephrine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030168"(platelet activation)|go:"GO:0030425"(dendrite)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032962"(positive regulation of inositol trisphosphate biosynthetic process)|go:"GO:0035589"(G protein-coupled purinergic nucleotide receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042755"(eating behavior)|go:"GO:0043270"(positive regulation of ion transport)|go:"GO:0043531"(ADP binding)|go:"GO:0044297"(cell body)|go:"GO:0045028"(G protein-coupled purinergic nucleotide receptor activity)|go:"GO:0045031"(G protein-coupled ATP receptor activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051100"(negative regulation of binding)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0060406"(positive regulation of penile erection)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070848"(response to growth factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071415"(cellular response to purine-containing compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090075"(relaxation of muscle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0099509"(regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000142(P2Y purinoceptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-416476|reactome:R-RNO-417957|reactome:R-RNO-418592|ensembl:ENSRNOG00000014232(gene)|ensembl:ENSRNOT00000019305(transcript)|mint:MINT-717891(identity)	go:"GO:0044297"(cell body)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050890"(cognition)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0070256"(negative regulation of mucus secretion)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099582"(neurotransmitter receptor activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001068(Adenosine A1 receptor)|interpro:IPR001634(Adenosine receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-RNO-417973|reactome:R-RNO-418594|ensembl:ENSRNOG00000003442(gene)|ensembl:ENSRNOT00000004602(transcript)|ensembl:ENSRNOT00000078993(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001609"(G protein-coupled adenosine receptor activity)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001883"(purine nucleoside binding)|go:"GO:0002087"(regulation of respiratory gaseous exchange by nervous system process)|go:"GO:0002674"(negative regulation of acute inflammatory response)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003093"(regulation of glomerular filtration)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0012505"(endomembrane system)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0030673"(axolemma)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032229"(negative regulation of synaptic transmission, GABAergic)|go:"GO:0032244"(positive regulation of nucleoside transport)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0032900"(negative regulation of neurotrophin production)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0035814"(negative regulation of renal sodium excretion)|go:"GO:0042311"(vasodilation)|go:"GO:0042321"(negative regulation of circadian sleep/wake cycle, sleep)|go:"GO:0042323"(negative regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0005783"(endoplasmic reticulum)|rgd:2048|refseq:NP_058851.2|refseq:XP_006249921.1|refseq:XP_006249923.1|mint:MINT-717884(identity)	-	comment:mint|function:Receptor for extracellular adenine nucleotides such as ATP and ADP. In pancreatic islets, may mediate some of the effects of extracellular ATP on insulin secretion|comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:Theh formation of heterooligomer is stimulated by the presence of both agonists|comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2002/09/06	2014/10/16	rogid:/UQX+tm+cCwCy2gWUI52pBQpCwo10116	rogid:2JgyElmUGLZ0s/hJ7oLo6ycCo5Q10116	intact-crc:EF4A4800BCD64B24|rigid:fBS0hlB5TJlmbiUGEpL12HbSvVU	false	tag:?-?(MINT-717892)	tag:?-?(MINT-717885)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)