#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P29352	uniprotkb:P32577	intact:EBI-8654263|ensembl:ENSMUSP00000029433|uniprotkb:Q7TMP9|intact:MINT-1535132	intact:EBI-7482976|intact:MINT-1535121|uniprotkb:Q4G003|ensembl:ENSRNOP00000026358|ensembl:ENSRNOP00000068638	psi-mi:ptn22_mouse(display_long)|uniprotkb:Ptpn22(gene name)|psi-mi:Ptpn22(display_short)|uniprotkb:Ptpn8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym)	psi-mi:csk_rat(display_long)|uniprotkb:Csk(gene name)|psi-mi:Csk(display_short)|uniprotkb:C-Src kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Gregorieff et al. (1998)	pubmed:9582365|mint:MINT-6547857	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8688494|mint:MINT-18529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027843(gene)|ensembl:ENSMUST00000029433(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|refseq:XP_011238343.1|refseq:XP_011238344.1|refseq:NP_033005.1|refseq:XP_006501211.1|refseq:XP_006501212.1|refseq:XP_006501213.1|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:1JEG|reactome:R-MMU-202427|reactome:R-MMU-202430|mint:MINT-1535150(identity)	refseq:NP_001025210.1|rgd:1308800|refseq:XP_006243225.1|refseq:XP_006243226.1|ensembl:ENSRNOG00000019374(gene)|ensembl:ENSRNOT00000026358(transcript)|ensembl:ENSRNOT00000091223(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007420"(brain development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010989"(negative regulation of low-density lipoprotein particle clearance)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0042997"(negative regulation of Golgi to plasma membrane protein transport)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0060368"(regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035027|interpro:IPR036028|interpro:IPR036860|rcsb pdb:1K9A|rcsb pdb:2RSY|reactome:R-RNO-180292|reactome:R-RNO-202427|reactome:R-RNO-354192|reactome:R-RNO-389948|reactome:R-RNO-5674135|reactome:R-RNO-9013407|reactome:R-RNO-9706369|mint:MINT-1535144(identity)	-	comment:mint|comment:homomint|function:May be an effector and/or regulator of tyrosine-protein kinase CSK in T-cells and other hemopoietic cells|comment:"Stoichiometry: 1.0"	function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases|comment:mint|comment:homomint|comment:"Stoichiometry: 1.0"	comment:"The alanine scanning reveals the importance of the following residues in the sequence 613PPPLPERTPESFIV626: P614;L616;P617;R619, in the proline rich core of class 2, and  T620;I625;V626 in the carboxy-terminal part. Mutation of these residues reduce binding by 10- and 5-fold in vitro.The L616;P617 are not required in vivo. Approximatively 25-50% of PEP is bound to Csk in hematopoietic cells."|comment:homomint|comment:mint|partial coverage:partial coverage	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/09/26	2014/10/16	rogid:J/oQL2AmSxShta0Bv8oM7uMLaBM10090	rogid:q6Bbf/thuK3VxDXvpKdgO/8yGEA10116	intact-crc:C1846CD7906C016E|rigid:5ak+MHr9/9NarwSsHm5pLYqwYmg	false	binding-associated region:605-629(MINT-1535151)	binding-associated region:13-96(MINT-1535145)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)