#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q14571	uniprotkb:Q9UBN4	intact:EBI-2831342|uniprotkb:O94773|ensembl:ENSP00000370744	intact:EBI-929504|uniprotkb:Q96P03|uniprotkb:Q15721|uniprotkb:Q9UIB0|uniprotkb:Q9UIB1|uniprotkb:Q9UIB2|uniprotkb:B1ALE0|uniprotkb:Q3SWS6|uniprotkb:Q96P05|uniprotkb:B1ALE1|uniprotkb:B1ALE2|uniprotkb:Q96P04|ensembl:ENSP00000369027	psi-mi:itpr2_human(display_long)|uniprotkb:ITPR2(gene name)|psi-mi:ITPR2(display_short)|uniprotkb:IP3 receptor isoform 2(gene name synonym)|uniprotkb:Type 2 inositol 1,4,5-trisphosphate receptor(gene name synonym)	psi-mi:trpc4_human(display_long)|uniprotkb:TRPC4(gene name)|psi-mi:TRPC4(display_short)|uniprotkb:Trp-related protein 4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Mery et al. (2001)	pubmed:11163362|mint:MINT-5213484	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7485391|mint:MINT-14529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123104(gene)|ensembl:ENST00000381340(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_002214.2|mint:MINT-444971(identity)	refseq:NP_001129427.1|refseq:NP_001129428.1|refseq:NP_001129429.1|refseq:NP_001129430.1|refseq:NP_003297.1|refseq:NP_057263.1|ensembl:ENSG00000133107(gene)|ensembl:ENST00000379705(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005460(Transient receptor potential channel 4)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|mint:MINT-444962(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-4(in vivo)|taxid:-4(in vivo)	-	2001/03/15	2014/10/16	rogid:godRDJb6vyJG454Heg9JZhLarLc9606	rogid:2zlD0MSzXrWkNFgQf7I8I6fPZyo9606	intact-crc:499DCB377688F936|rigid:CogxjuAfzXtnPgixCkxSZCbZNNQ	false	binding-associated region:2544-2701(MINT-444972)|tag:?-?(MINT-444975)	tag:?-?(MINT-444966)|binding-associated region:615-977(MINT-444963)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q14571	uniprotkb:Q9UBN4	intact:EBI-2831342|uniprotkb:O94773|ensembl:ENSP00000370744	intact:EBI-929504|uniprotkb:Q96P03|uniprotkb:Q15721|uniprotkb:Q9UIB0|uniprotkb:Q9UIB1|uniprotkb:Q9UIB2|uniprotkb:B1ALE0|uniprotkb:Q3SWS6|uniprotkb:Q96P05|uniprotkb:B1ALE1|uniprotkb:B1ALE2|uniprotkb:Q96P04|ensembl:ENSP00000369027	psi-mi:itpr2_human(display_long)|uniprotkb:ITPR2(gene name)|psi-mi:ITPR2(display_short)|uniprotkb:IP3 receptor isoform 2(gene name synonym)|uniprotkb:Type 2 inositol 1,4,5-trisphosphate receptor(gene name synonym)	psi-mi:trpc4_human(display_long)|uniprotkb:TRPC4(gene name)|psi-mi:TRPC4(display_short)|uniprotkb:Trp-related protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Mery et al. (2001)	pubmed:11163362|mint:MINT-5213484	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7485439|mint:MINT-14530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000123104(gene)|ensembl:ENST00000381340(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005220"(inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043235"(receptor complex)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR000493(Inositol 1,4,5-trisphosphate-binding protein receptor)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR005821(Ion transport)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016093(MIR motif)|interpro:IPR035910|interpro:IPR036300|reactome:R-HSA-112043|reactome:R-HSA-114508|reactome:R-HSA-139853|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-381676|reactome:R-HSA-4086398|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695|refseq:NP_002214.2|mint:MINT-444990(identity)	refseq:NP_001129427.1|refseq:NP_001129428.1|refseq:NP_001129429.1|refseq:NP_001129430.1|refseq:NP_003297.1|refseq:NP_057263.1|ensembl:ENSG00000133107(gene)|ensembl:ENST00000379705(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005460(Transient receptor potential channel 4)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|reactome:R-HSA-3295583|reactome:R-HSA-418890|mint:MINT-444984(identity)	-	comment:"Stoichiometry: 1.0"	comment:"Stoichiometry: 1.0"	comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2001/03/15	2014/10/16	rogid:godRDJb6vyJG454Heg9JZhLarLc9606	rogid:2zlD0MSzXrWkNFgQf7I8I6fPZyo9606	intact-crc:7C206A1511A03BC5|rigid:CogxjuAfzXtnPgixCkxSZCbZNNQ	false	binding-associated region:2544-2701(MINT-444991)	binding-associated region:615-977(MINT-444985)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)