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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>Molecular Connections</shortLabel>
        <fullName>Molecular Connections Pvt. Ltd.</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1263" refType="identity" refTypeAc="MI:0356"/>
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      </xref>
      <attributeList>
        <attribute name="postal address">2/2, Kariappa Road, Basavanagudi, Bangalore -560 004</attribute>
        <attribute name="url" nameAc="MI:0614">www.molecularconnections.com</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="21172016" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-3402072" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-15304" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis.</attribute>
            <attribute name="journal" nameAc="MI:0885">Mol. Cancer (null)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2010</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Yin X., Truty J., Lawrence R., Johns SC., Srinivasan RS., Handel TM., Fuster MM.</attribute>
            <attribute name="dataset" nameAc="MI:0875">Cancer - Interactions investigated in the context of cancer</attribute>
            <attribute name="exp-modification" nameAc="MI:0627">hLEC: Primary human lymphatic endothelial cells</attribute>
            <attribute name="contact-email" nameAc="MI:0634">mfuster@ucsd.edu</attribute>
            <attribute name="author-announcement">06-April-2011: Contacted by JYOTI.</attribute>
            <attribute name="reviewer">jyoti</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="external curation">Curation by: Molecular Connections Pvt. Ltd</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="21172016" refType="primary-reference" refTypeAc="MI:0358"/>
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        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-endothelium</shortLabel>
              <fullName>Homo sapiens endothelail cells/endothelium</fullName>
            </names>
            <tissue>
              <names>
                <shortLabel>endothelium</shortLabel>
                <fullName>Endothelial cells [endothelium]</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:0205" refType="identity" refTypeAc="MI:0356"/>
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              </xref>
            </tissue>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>pla</shortLabel>
            <fullName>proximity ligation assay</fullName>
            <alias type="go synonym" typeAc="MI:0303">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">pELISA</alias>
            <alias type="synonym" typeAc="MI:1041">PLA</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0813" refType="identity" refTypeAc="MI:0356"/>
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          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>antibody detection</shortLabel>
            <fullName>identification by antibody</fullName>
            <alias type="synonym" typeAc="MI:1041">antibody detection</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0421" refType="identity" refTypeAc="MI:0356"/>
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        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Yin X., Truty J., Lawrence R., Johns SC., Srinivasan RS., Handel TM., Fuster MM.</attribute>
          <attribute name="dataset" nameAc="MI:0875">Cancer - Interactions investigated in the context of cancer</attribute>
          <attribute name="exp-modification" nameAc="MI:0627">hLEC: Primary human lymphatic endothelial cells</attribute>
          <attribute name="contact-email" nameAc="MI:0634">mfuster@ucsd.edu</attribute>
          <attribute name="accepted">Accepted 2011-FEB-09 by JYOTI</attribute>
          <attribute name="author-announcement">06-April-2011: Contacted by JYOTI.</attribute>
          <attribute name="journal" nameAc="MI:0885">Mol. Cancer (null)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2010</attribute>
          <attribute name="reviewer">jyoti</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959"/>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
          <attribute name="external curation">Curation by: Molecular Connections Pvt. Ltd</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>ccr7_human</shortLabel>
          <fullName>C-C chemokine receptor type 7</fullName>
          <alias type="gene name" typeAc="MI:0301">CCR7</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CMKBR7</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EBI1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">EVI1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">BLR2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">CDw197</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Epstein-Barr virus-induced G-protein coupled receptor 1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">MIP-3 beta receptor</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P32248" version="SP_107" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000246657" version="SP_193" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000510" version="SP_193"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000522" version="SP_193"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000669" version="SP_193"/>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001718" version="SP_193"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017452" version="SP_193"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6QZH" version="SP_193"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-380108" version="SP_193"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-418594" version="SP_193"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001829.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001288643.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001288645.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001288646.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001288647.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-5855N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MDLGKPMKSVLVVALLVIFQVCLCQDEVTDDYIGDNTTVDYTLFESLCSKKDVRNFKAWFLPIMYSIICFVGLLGNGLVVLTYIYFKRLKTMTDTYLLNLAVADILFLLTLPFWAYSAAKSWVFGVHFCKLIFAIYKMSFFSGMLLLLCISIDRYVAIVQAVSAHRHRARVLLISKLSCVGIWILATVLSIPELLYSDLQRSSSEQAMRCSLITEHVEAFITIQVAQMVIGFLVPLLAMSFCYLVIIRTLLQARNFERNKAIKVIIAVVVVFIVFQLPYNGVVLAQTVANFNITSSTCELSKQLNIAYDVTYSLACVRCCVNPFLYAFIGVKFRNDLFKLFKDLGCLSQEQLRQWSSCRHIRRSSMSVEAETTTTFSP</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P32248 original sequence version: 139</attribute>
          <attribute name="crc64">D4CB4213841A1BD4</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>ccl21_human</shortLabel>
          <fullName>C-C motif chemokine 21</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Small-inducible cytokine A21</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Beta-chemokine exodus-2</alias>
          <alias type="gene name synonym" typeAc="MI:0302">6Ckine</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Secondary lymphoid-tissue chemokine</alias>
          <alias type="gene name" typeAc="MI:0301">CCL21</alias>
          <alias type="gene name synonym" typeAc="MI:0302">SCYA21</alias>
          <alias type="orf name" typeAc="MI:0306">UNQ784/PRO1600</alias>
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          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR034133" version="SP_185"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036048" version="SP_185"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR039809" version="SP_185"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="O00585" version="SP_185"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="2L4N" version="SP_185"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5EKI" version="SP_185"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-380108" version="SP_185"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-418594" version="SP_185"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR001811" version="SP_185"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002980.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-5854N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELCADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP</sequence>
        <attributeList>
          <attribute name="crc64">FB48C2F71CB4A9D2</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-15304-1">
        <names>
          <shortLabel>ccl21-ccr7-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-3401601" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-15304-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>neutral component</shortLabel>
                  <fullName>neutral component</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0497" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-55" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>proximity</shortLabel>
            <fullName>proximity</fullName>
            <alias type="synonym" typeAc="MI:1041">close-contact colocalization</alias>
            <alias type="synonym" typeAc="MI:1041">neighbourhood interaction</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:2364" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-26564119" refType="identity" refTypeAc="MI:0356"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">fig. 6c</attribute>
          <attribute name="agonist" nameAc="MI:0625">heparan sulfate</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>