APOBEC1
label: UniProt:P41238 APOBEC1

PAP
label: PAPOLA
label: UniProt:P51003 PAPOLA

Cleavage of mRNA at the 3'-end
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: mRNA 3'-end processing
directly activates: mRNA polyadenylation
directly activates: Catalysis114

mRNA polyadenylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: GO_0004652
BFO_0000050: mRNA 3'-end processing
directly activates: Recruitment of TAP to the EJC

Binding of SLBP to Replication-Dependent Histone Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
directly activates: Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA

Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
directly activates: Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA

Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA
type: GO_0003674
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
directly activates: Docking of Mature Replication Dependent Histone mRNA with the NPC
directly activates: Control35

Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP independent Processing of Histone Pre-mRNAs
directly activates: Cleavage of the 3'-end of the Histone Pre-mRNA

Cleavage of the 3'-end of the Histone Pre-mRNA
type: GO_0003674
BFO_0000050: SLBP independent Processing of Histone Pre-mRNAs
directly activates: Docking of Mature Histone mRNA complex:TAP at the NPC
directly activates: Control38

Recognition of AAUAAA sequence by CPSF
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Recruitment of CstF to the CPSF Bound Pre-mRNA

Recruitment of CstF to the CPSF Bound Pre-mRNA
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex

Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Cleavage and polyadenylation of Intronless Pre-mRNA
directly activates: Cleavage of Intronless Pre-mRNA at 3'-end

Cleavage and polyadenylation of Intronless Pre-mRNA
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
directly activates: Control41

Cleavage of Intronless Pre-mRNA at 3'-end
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Cleavage and polyadenylation of Intronless Pre-mRNA

RNA Polymerase II CTD (phosphorylated) binds to CE
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Activation of GT

Activation of GT
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Capping complex formation

Capping complex formation
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
directly activates: Catalysis138

Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004651
BFO_0000050: mRNA Capping
directly activates: Formation of the CE:GMP intermediate complex
directly activates: Catalysis139

Formation of the CE:GMP intermediate complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004484
BFO_0000050: mRNA Capping
directly activates: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
directly activates: Catalysis140

Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004484
BFO_0000050: mRNA Capping
directly activates: Dissociation of transcript with 5'-GMP from GT

Dissociation of transcript with 5'-GMP from GT
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Methylation of GMP-cap by RNA Methyltransferase
directly activates: Catalysis141

Methylation of GMP-cap by RNA Methyltransferase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004482
BFO_0000050: mRNA Capping
directly activates: Recognition and binding of the mRNA cap by the cap-binding complex

Recognition and binding of the mRNA cap by the cap-binding complex
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Binding of SLBP to Replication-Dependent Histone Pre-mRNA
directly activates: Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA
directly activates: Recognition of AAUAAA sequence by CPSF
directly activates: BiochemicalReaction433
directly activates: Internal Methylation of mRNA
directly activates: Catalysis136
directly activates: Catalysis142

Formation of cap binding complex (CBC)
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Recognition and binding of the mRNA cap by the cap-binding complex

Internal Methylation of mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0001734
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Formation of pre-mRNPs
type: GO_0003674
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA
directly activates: Formation of the Spliceosomal E complex
directly activates: Formation of AT-AC A complex
directly activates: mRNA Splicing

Formation of the Spliceosomal E complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the Spliceosomal A Complex

Formation of the Spliceosomal A Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the Spliceosomal B Complex

Formation of the Spliceosomal B Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of an intermediate Spliceosomal C complex

Formation of the Cleavage and Polyadenylation Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of an intermediate Spliceosomal C complex

Formation of an intermediate Spliceosomal C complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the active Spliceosomal C complex

Formation of the active Spliceosomal C complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Lariat Formation and 5'-Splice Site Cleavage

Lariat Formation and 5'-Splice Site Cleavage
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of Exon Junction Complex

Formation of Exon Junction Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Cleavage at the 3'-Splice Site and Exon Ligation

Cleavage at the 3'-Splice Site and Exon Ligation
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Cleavage of mRNA at the 3'-end
directly activates: Formation of stem-loop structure in ApoB mRNA
directly activates: Catalysis113

Formation of AT-AC A complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: Formation of AT-AC B Complex

Formation of AT-AC B Complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: Formation of AT-AC C complex

Formation of AT-AC C complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: ATAC spliceosome mediated Lariat formation,5' splice site cleavage

ATAC spliceosome mediated Lariat formation,5' splice site cleavage
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: ATAC spliceosome mediated 3' splice site cleavage, exon ligation

ATAC spliceosome mediated 3' splice site cleavage, exon ligation
type: GO_0003674
BFO_0000050: U12 Dependent Splicing

Recruitment of TAP to the EJC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Docking of the TAP:EJC Complex with the NPC
directly activates: Control32

Docking of the TAP:EJC Complex with the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Transport of the export-competent complex through the NPC
directly activates: Control33

Transport of the export-competent complex through the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Release from the NPC and Disassembly of the mRNP
directly activates: Control34

Release from the NPC and Disassembly of the mRNP
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: BiochemicalReaction589

Docking of Mature Replication Dependent Histone mRNA with the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
directly activates: Control36

Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
directly activates: Control37

Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: BiochemicalReaction589

Docking of Mature Histone mRNA complex:TAP at the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
directly activates: Control39

Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
type: GO_0006405
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: Release of the SLBP independent Histone mRNA from the NPC
directly activates: Control40

Release of the SLBP independent Histone mRNA from the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: BiochemicalReaction589

Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
directly activates: Control42

Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
directly activates: Control43

Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: BiochemicalReaction589

Formation of stem-loop structure in ApoB mRNA
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: Binding of A1CF to stem-looped RNA

Binding of A1CF to stem-looped RNA
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: Binding of APOBEC-1 to form editosome

Binding of APOBEC-1 to form editosome
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: C4 deamination of cytidine
directly activates: Catalysis143

C4 deamination of cytidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004126
BFO_0000050: mRNA Editing: C to U Conversion
directly activates: Cleavage of mRNA at the 3'-end
directly activates: Catalysis113

Formation of dsRNA structure by looping
type: GO_0003674
BFO_0000050: mRNA Editing: A to I Conversion
directly activates: Binding of ADAR1 homodimer to dsRNA duplex
directly activates: Binding of ADAR2 homodimer to dsRNA duplex

Formation of ADAR1 homodimer
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Binding of ADAR1 homodimer to dsRNA duplex

Binding of ADAR1 homodimer to dsRNA duplex
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Deamination at C6 position of adenosine in Editosome (ADAR1)
directly activates: Catalysis144

Formation of ADAR2 homodimer
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Binding of ADAR2 homodimer to dsRNA duplex

Binding of ADAR2 homodimer to dsRNA duplex
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Deamination at C6 position of adenosine in Editosome (ADAR2)
directly activates: Catalysis145

Deamination at C6 position of adenosine in Editosome (ADAR1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003726
BFO_0000050: C6 deamination of adenosine

Deamination at C6 position of adenosine in Editosome (ADAR2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003726
BFO_0000050: C6 deamination of adenosine

mRNA 3'-end processing
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Processing of Capped Intronless Pre-mRNA
type: GO_0008150
BFO_0000050: mRNA Processing

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

SLBP independent Processing of Histone Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

Processing of Intronless Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

mRNA Capping
type: GO_0008150
BFO_0000050: mRNA Processing

Processing of Capped Intron-Containing Pre-mRNA
type: GO_0008150
BFO_0000050: mRNA Processing

mRNA Splicing
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

U2 Dependent Splicing
type: GO_0008150
BFO_0000050: mRNA Splicing
label: mRNA Splicing - Major Pathway
label: pre-mRNA splicing

U12 Dependent Splicing
type: GO_0008150
BFO_0000050: mRNA Splicing
label: mRNA Splicing - Minor Pathway

Transport of Mature Transcript to Cytoplasm
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Transport of Mature mRNA derived from an Intron-Containing Transcript
type: GO_0008150
BFO_0000050: Transport of Mature Transcript to Cytoplasm

Transport of Mature mRNAs Derived from Intronless Transcripts
type: GO_0008150
BFO_0000050: Transport of Mature Transcript to Cytoplasm

Transport of the SLBP Dependant Mature mRNA
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of the SLBP independent Mature mRNA
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of Mature mRNA Derived from an Intronless Transcript
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

mRNA Editing
type: GO_0008150
BFO_0000050: mRNA Processing

mRNA Editing: C to U Conversion
type: GO_0008150
BFO_0000050: mRNA Editing

Formation of the Editosome
type: GO_0008150
BFO_0000050: mRNA Editing: C to U Conversion

mRNA Editing: A to I Conversion
type: GO_0008150
BFO_0000050: mRNA Editing

Formation of editosomes by ADAR proteins
type: GO_0008150
BFO_0000050: mRNA Editing: A to I Conversion

C6 deamination of adenosine
type: GO_0008150
BFO_0000050: mRNA Editing: A to I Conversion

mRNA Processing
type: GO_0008150