CYP1ALPHA
CYP27B
CYP27B1
UniProt:O15528 CYP27B1
LRP2
UniProt:P98164 LRP2
CYP24
CYP24A1
UniProt:Q07973 CYP24A1
CYP2R1
UniProt:Q6VVX0 CYP2R1
LGMN
PRSC1
UniProt:Q99538 LGMN
Photolytic cleavage and thermal isomerization of 7-dehydrocholesterol
Vitamin D3 translocates to the blood serum and is transported to the liver
Vitamin D3 translocates into the cytosol
25-Hydroxylation of vitamin D3 in liver
Calcidiol binds to DBP in the bloodstream and is delivered to the kidney
DBP:Calcidiol is sequestered by cubilin on the cell surface
Megalin internalizes the cubilin-DBP:Calcidiol complex
DBP:Calcidiol translocates into lysosomes
Legumain degrades DBP
Vitamin D3 translocates to the cytosol and binds to IDBP
Further hydroxylation of calcidiol in kidney to form calcitriol
1,25-dihydroxyvitamin D3 is deactivated
Vitamin D (calciferol) metabolism