CYP1ALPHA
label: CYP27B
label: CYP27B1
label: UniProt:O15528 CYP27B1

LRP2
label: UniProt:P98164 LRP2

CYP24
label: CYP24A1
label: UniProt:Q07973 CYP24A1

CYP2R1
label: UniProt:Q6VVX0 CYP2R1

LGMN
label: PRSC1
label: UniProt:Q99538 LGMN

Photolytic cleavage and thermal isomerization of 7-dehydrocholesterol
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Vitamin D3 translocates to the blood serum and is transported to the liver

Vitamin D3 translocates to the blood serum and is transported to the liver
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Vitamin D3 translocates into the cytosol

Vitamin D3 translocates into the cytosol
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: 25-Hydroxylation of vitamin D3 in liver
directly activates: Catalysis1093

25-Hydroxylation of vitamin D3 in liver
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: CYP2R1
type: GO_0030343
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Calcidiol binds to DBP in the bloodstream and is delivered to the kidney

Calcidiol binds to DBP in the bloodstream and is delivered to the kidney
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: DBP:Calcidiol is sequestered by cubilin on the cell surface

DBP:Calcidiol is sequestered by cubilin on the cell surface
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Megalin internalizes the cubilin-DBP:Calcidiol complex
directly activates: Catalysis1094

Megalin internalizes the cubilin-DBP:Calcidiol complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: LRP2
type: GO_0042954
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: DBP:Calcidiol translocates into lysosomes

DBP:Calcidiol translocates into lysosomes
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Legumain degrades DBP
directly activates: Catalysis1095

Legumain degrades DBP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: LGMN
type: GO_0004197
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Vitamin D3 translocates to the cytosol and binds to IDBP

Vitamin D3 translocates to the cytosol and binds to IDBP
type: GO_0003674
BFO_0000050: Vitamin D (calciferol) metabolism
directly activates: Further hydroxylation of calcidiol in kidney to form calcitriol
directly activates: Catalysis1096

Further hydroxylation of calcidiol in kidney to form calcitriol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005741
type: Restriction
  on property: enabled by
  some values from: CYP1ALPHA
type: GO_0004498
BFO_0000050: Vitamin D (calciferol) metabolism

1,25-dihydroxyvitamin D3 is deactivated
type: Restriction
  on property: enabled by
  some values from: CYP24
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0030342
BFO_0000050: Vitamin D (calciferol) metabolism

Vitamin D (calciferol) metabolism
type: GO_0008150