SRC
SRC1
UniProt:P12931-1 SRC
PTP2C
PTPN11
SHPTP2
UniProt:Q06124 PTPN11
MKNK1
MNK1
UniProt:Q9BUB5 MKNK1
PPA2A dephosphorylates SPRY2
SPRY2 translocates to the plasma membrane
SRC phosphorylates SPRY2 on Y55 and Y227
SPRY2 binds GRB2
SPRY2 binds CBL
Phosphorylated SPRY2 is ubiquitinated by CBL
CBL dissociates from ubiquitinated p-SPRY2
SPRY2 is phosphorylated by phosphorylated MNK1
SPRY2 is serine phosphorylated in response to MAPK activation
B-RAF dissociates from S111/S120 p-SPRY2
SHP2 dephosphorylates SPRY2
Spry regulation of FGF signaling