SRC
label: SRC1
label: UniProt:P12931-1 SRC

PTP2C
label: PTPN11
label: SHPTP2
label: UniProt:Q06124 PTPN11

MKNK1
label: MNK1
label: UniProt:Q9BUB5 MKNK1

PPA2A dephosphorylates SPRY2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004722
BFO_0000050: Spry regulation of FGF signaling
directly activates: SPRY2 translocates to the plasma membrane

SPRY2 translocates to the plasma membrane
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling
directly activates: SRC phosphorylates SPRY2 on Y55 and Y227
directly activates: SPRY2 is phosphorylated by phosphorylated MNK1
directly activates: Catalysis1257
directly activates: Catalysis1259
directly activates: Control217

SRC phosphorylates SPRY2 on Y55 and Y227
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: enabled by
  some values from: SRC
type: GO_0004713
BFO_0000050: Spry regulation of FGF signaling
directly activates: SPRY2 binds GRB2
directly activates: SPRY2 binds CBL

SPRY2 binds GRB2
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling

SPRY2 binds CBL
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling
directly activates: Phosphorylated SPRY2 is ubiquitinated by CBL
directly activates: Catalysis1258

Phosphorylated SPRY2 is ubiquitinated by CBL
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004842
BFO_0000050: Spry regulation of FGF signaling
directly activates: CBL dissociates from ubiquitinated p-SPRY2

CBL dissociates from ubiquitinated p-SPRY2
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling

SPRY2 is phosphorylated by phosphorylated MNK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MKNK1
type: GO_0004674
BFO_0000050: Spry regulation of FGF signaling

SPRY2 is serine phosphorylated in response to MAPK activation
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling
directly activates: B-RAF dissociates from S111/S120 p-SPRY2

B-RAF dissociates from S111/S120 p-SPRY2
type: GO_0003674
BFO_0000050: Spry regulation of FGF signaling

SHP2 dephosphorylates SPRY2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP2C
type: GO_0004725
BFO_0000050: Spry regulation of FGF signaling
directly activates: Catalysis1260

Spry regulation of FGF signaling
type: GO_0008150