MT4033
label: MTV028.05
label: Rv3914
label: UniProt:P0A616
label: trx
label: trxA
label: trxC

MT2272
label: MTCY190.26
label: Rv2215
label: UniProt:P65633 dlaT
label: dlaT
label: sucB

MT0797
label: Rv0773c
label: UniProt:P71828
label: ggt-1
label: ggtA

MT0420
label: Rv0407
label: UniProt:P96253 fgd1
label: fgd
label: fgd1

Carboxymycobactin binds iron from lactoferrin
type: GO_0003674
BFO_0000050: Mtb iron assimilation by chelation
directly activates: Carboxymycobactin and mycobactin exchange their iron load

Nitrogen dioxide is reduced to NO by F420
type: GO_0003674
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages

Nitric oxide is oxidized to nitrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008941
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages

Peroxynitrite is reduced to nitrite by AhpC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051920
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages
directly activates: AhpD reactivates AhpC
directly activates: TrxA reactivates AhpC
directly activates: Catalysis1188
directly activates: Catalysis1191

Peroxynitrite is reduced by AhpE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051920
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages

Peroxynitrite is reduced to nitrite by Tpx
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051920
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages
directly activates: TrxA/B1 reactivates Tpx
directly activates: Catalysis1193

Mycothiol scavenges nitrosyl
type: GO_0003674
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages
directly activates: MscR reduces nitrosomycothiol to ammonia
directly activates: Catalysis1179

MscR reduces nitrosomycothiol to ammonia
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016620
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages
directly activates: TrxB reactivates TrxA
directly activates: Catalysis1192

MsrA/B reduces peptide-methionine S/R-sulfoxides
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008113
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages
directly activates: TrxB reactivates TrxA
directly activates: Catalysis1192

Nitrosoglutathione gets cleaved to Cys(NO)-Gly
type: Restriction
  on property: BFO_0000066
  some values from: GO_0042597
type: Restriction
  on property: enabled by
  some values from: MT0797
type: Restriction
  on property: enabled by
  some values from: MT0797
type: Restriction
  on property: BFO_0000066
  some values from: GO_0042597
type: GO_0003840
BFO_0000050: Tolerance by Mtb to nitric oxide produced by macrophages

SodB gets secreted
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015450
BFO_0000050: Tolerance of reactive oxygen produced by macrophages

SodB reduces superoxide to H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004784
BFO_0000050: Tolerance of reactive oxygen produced by macrophages
directly activates: AhpC reduces H2O2
directly activates: KatG reduces H2O2
directly activates: H2O2 gets scavenged by unsaturated lipid
directly activates: Catalysis1185
directly activates: Catalysis1186

SodC reduces superoxide to H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004784
BFO_0000050: Tolerance of reactive oxygen produced by macrophages
directly activates: AhpC reduces H2O2
directly activates: KatG reduces H2O2
directly activates: H2O2 gets scavenged by unsaturated lipid
directly activates: Catalysis1185
directly activates: Catalysis1186

AhpC reduces H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004601
BFO_0000050: Tolerance of reactive oxygen produced by macrophages
directly activates: AhpD reactivates AhpC
directly activates: TrxA reactivates AhpC
directly activates: Catalysis1188
directly activates: Catalysis1191

KatG reduces H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004096
BFO_0000050: Tolerance of reactive oxygen produced by macrophages

H2O2 gets scavenged by unsaturated lipid
type: GO_0003674
BFO_0000050: Tolerance of reactive oxygen produced by macrophages
directly activates: AhpC reduces peroxidated lipids
directly activates: Catalysis1187

AhpC reduces peroxidated lipids
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008785
BFO_0000050: Tolerance of reactive oxygen produced by macrophages
directly activates: AhpD reactivates AhpC
directly activates: TrxA reactivates AhpC
directly activates: Catalysis1188
directly activates: Catalysis1191

AhpD reactivates AhpC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0015036
BFO_0000050: Cell redox homeostasis
directly activates: DlaT reactivates AhpD
directly activates: Catalysis1189

DlaT reactivates AhpD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MT2272
type: Restriction
  on property: enabled by
  some values from: MT2272
type: GO_0015036
BFO_0000050: Cell redox homeostasis
directly activates: Lpd reactivates dlaT
directly activates: Catalysis1190

Lpd reactivates dlaT
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004148
BFO_0000050: Cell redox homeostasis

TrxA reactivates AhpC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MT4033
type: Restriction
  on property: enabled by
  some values from: MT4033
type: GO_0015036
BFO_0000050: Cell redox homeostasis
directly activates: TrxB reactivates TrxA
directly activates: Catalysis1192

TrxB reactivates TrxA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004791
BFO_0000050: Cell redox homeostasis

TrxA/B1 reactivates Tpx
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0015036
BFO_0000050: Cell redox homeostasis
directly activates: TrxB reactivates TrxA
directly activates: Catalysis1192

Fgd1 reactivates F420
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MT0420
type: Restriction
  on property: enabled by
  some values from: MT0420
type: GO_0016614
BFO_0000050: Cell redox homeostasis

Carboxymycobactin gets secreted
type: GO_0003674
BFO_0000050: Mtb iron assimilation by chelation
directly activates: Carboxymycobactin binds iron from lactoferrin

Mycobactin is exported
type: GO_0015891
BFO_0000050: Mtb iron assimilation by chelation
directly activates: Carboxymycobactin and mycobactin exchange their iron load

Carboxymycobactin and mycobactin exchange their iron load
type: GO_0003674
BFO_0000050: Mtb iron assimilation by chelation
directly activates: Loaded mycobactin gets imported
directly activates: Catalysis1195

Loaded mycobactin gets imported
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0015343
BFO_0000050: Mtb iron assimilation by chelation
directly activates: Iron is reduced and separates from mycobactin
directly activates: Catalysis1196

Iron is reduced and separates from mycobactin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0052873
BFO_0000050: Mtb iron assimilation by chelation

BfrA stores iron
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004322
BFO_0000050: Mtb iron assimilation by chelation

BfrB stores iron
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004322
BFO_0000050: Mtb iron assimilation by chelation

Response of Mtb to phagocytosis
type: GO_0008150

Tolerance by Mtb to nitric oxide produced by macrophages
type: GO_0008150
BFO_0000050: Response of Mtb to phagocytosis

Tolerance of reactive oxygen produced by macrophages
type: GO_0008150
BFO_0000050: Response of Mtb to phagocytosis

Cell redox homeostasis
type: GO_0008150
BFO_0000050: Response of Mtb to phagocytosis

Mtb iron assimilation by chelation
type: GO_0008150
BFO_0000050: Response of Mtb to phagocytosis