The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
directly activates: BiochemicalReaction12
directly activates: BiochemicalReaction13
directly activates: Catalysis3

Cdt1 is displaced from the pre-replicative complex.
type: GO_0003674
BFO_0000050: Removal of licensing factors from origins
directly activates: Cdt1 associates with geminin

Orc1 is phosphorylated by cyclin A/CDK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Orc1 removal from chromatin
directly activates: Phosphorylated Orc1 is ubiquitinated while still associated with chromatin

Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 enters the cytosol

Ubiquitinated Orc1 enters the cytosol
type: GO_0003674
BFO_0000050: Orc1 removal from chromatin
directly activates: Ubiquitinated Orc1 is degraded by the proteasome
directly activates: Catalysis8

Ubiquitinated Orc1 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Orc1 removal from chromatin

Cdc6 protein is phosphorylated by CDK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Phosphorylated Cdc6 is exported from the nucleus

Phosphorylated Cdc6 is exported from the nucleus
type: GO_0003674
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
directly activates: Catalysis10

Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6
directly activates: Ubiquitinated Cdc6 is degraded by the proteasome
directly activates: Catalysis11

Ubiquitinated Cdc6 is degraded by the proteasome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: CDK-mediated phosphorylation and removal of Cdc6

Mcm4,6,7 trimer forms and associates with the replication fork
type: GO_0003674
BFO_0000050: Removal of licensing factors from origins
label: Rearrangement and mobilization of Mcm2-7

Cdt1 associates with geminin
type: GO_0003674
BFO_0000050: Removal of licensing factors from origins

Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
directly activates: BiochemicalReaction8

Orc1 removal from chromatin
type: GO_0008150
BFO_0000050: Removal of licensing factors from origins

CDK-mediated phosphorylation and removal of Cdc6
type: GO_0008150
BFO_0000050: Removal of licensing factors from origins

Regulation of DNA replication
type: GO_0008150

Association of licensing factors with the pre-replicative complex
type: GO_0008150
BFO_0000050: Regulation of DNA replication

Removal of licensing factors from origins
type: GO_0008150
BFO_0000050: Regulation of DNA replication

CDC6 protein is synthesized under the control of E2F transcription factors
type: GO_0003674
BFO_0000050: Association of licensing factors with the pre-replicative complex
directly activates: BiochemicalReaction10