The geminin component of geminin:Cdt1 complexes is ubiquitinated, releasing Cdt1
Cdt1 is displaced from the pre-replicative complex.
Orc1 is phosphorylated by cyclin A/CDK2
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin
Ubiquitinated Orc1 enters the cytosol
Ubiquitinated Orc1 is degraded by the proteasome
Cdc6 protein is phosphorylated by CDK
Phosphorylated Cdc6 is exported from the nucleus
Cytoplasmic phosphorylated Cdc6 is ubiquitinated by the anaphase-promoting complex
Ubiquitinated Cdc6 is degraded by the proteasome
Mcm4,6,7 trimer forms and associates with the replication fork
Rearrangement and mobilization of Mcm2-7
Cdt1 associates with geminin
Orc1 associates with Orc4:Orc5:Orc3:Orc2:origin complexes
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Regulation of DNA replication
Association of licensing factors with the pre-replicative complex
Removal of licensing factors from origins
CDC6 protein is synthesized under the control of E2F transcription factors