C3 convertases spontaneously dissociate
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Factor H binds to C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to extracellular Factor H:C3b

Factor H binds host cell surface markers
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor H binds to membrane-associated C3b
directly activates: Control76

Factor H binds to membrane-associated C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to membrane-associated Factor H:C3b

Factor H binds to C3bBb
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor H displaces Bb

Factor H displaces Bb
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Complement factor I complex formation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to extracellular Factor H:C3b
directly activates: Complement factor I binds to membrane-associated Factor H:C3b

Complement factor I binds to extracellular Factor H:C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates plasma Factor H-bound C3b
directly activates: Catalysis391

Factor I inactivates plasma Factor H-bound C3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005576
type: GO_0004252
BFO_0000050: Regulation of Complement cascade

Complement factor I binds to membrane-associated Factor H:C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates Factor H-boundC3b
directly activates: Catalysis392

Factor I inactivates Factor H-boundC3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Regulation of Complement cascade

iC3b proteolysis
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

CR1 binds C3bBb/C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Displacement of C2a/Bb by CR1

Displacement of C2a/Bb by CR1
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to MCP, CR1:C4b, C3b

MCP binds C3b, C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds to MCP, CR1:C4b, C3b

Complement factor I binds to MCP, CR1:C4b, C3b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Factor I inactivates MCP/CR1-bound C4b/C3b
directly activates: Catalysis393

Factor I inactivates MCP/CR1-bound C4b/C3b
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004252
BFO_0000050: Regulation of Complement cascade
directly activates: iC3b proteolysis

DAF binds C3bBb, C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: DAF accelerates C3bBb/C4bC2a dissociation

DAF accelerates C3bBb/C4bC2a dissociation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b-binding protein binds C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I binds C4BP

Complement factor I binds C4BP
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: Complement factor I inactivates C4BP-bound C4b

Complement factor I inactivates C4BP-bound C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b binding protein binds C4bC2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade
directly activates: C4b binding protein displaces C2a

C4b binding protein displaces C2a
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

C4b binding protein binds Protein S
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

CD59 inhibits MAC formation
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Formation of soluble VTN:C5b-C9
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Vitronectin(VTN) binds to C5b:C6:C7
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Hydrolysis of internal thioester in C4b
type: GO_0003674
BFO_0000050: Regulation of Complement cascade

Regulation of Complement cascade
type: GO_0008150