TK2
label: UniProt:O00142 TK2

L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004088
BFO_0000050: Pyrimidine biosynthesis
directly activates: carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
directly activates: Catalysis2668
label: bicarbonate and glutamine combine to form carbamoyl phosphate

carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004070
BFO_0000050: Pyrimidine biosynthesis
directly activates: N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
directly activates: Catalysis2669
label: carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate

N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004151
BFO_0000050: Pyrimidine biosynthesis
directly activates: (S)-dihydroorotate + ubiquinone => orotate + ubiquinol
directly activates: Catalysis2670
label: condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)

(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004152
BFO_0000050: Pyrimidine biosynthesis
directly activates: orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
directly activates: Catalysis2671
label: oxidation of (S)-Dihydroorotate to form Orotate

orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004588
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction296
directly activates: decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
directly activates: Catalysis111
directly activates: Catalysis2672
directly activates: Control14
label: phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)

decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004590
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction5521
directly activates: Catalysis2707
label: orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2

dCMP + H2O => dUMP + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004132
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: BiochemicalReaction5523
directly activates: Catalysis2675
directly activates: Catalysis2709
label: deamination of dCMP to form dUMP

dUTP + H2O => dUMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004170
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: Catalysis2675
label: hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate

conversion of dUMP to dTMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004799
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction5523
directly activates: Catalysis2709
label: dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004850
BFO_0000050: Pyrimidine salvage reactions

thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016763
BFO_0000050: Pyrimidine salvage reactions

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: BiochemicalReaction5521
directly activates: Catalysis2707

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions

phosphorylation of 2'-Deoxythymidine to dTMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: BiochemicalReaction5523
directly activates: Catalysis2709
label: thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]

deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: TK2
type: Restriction
  on property: enabled by
  some values from: TK2
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions

(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: dCMP + H2O => dUMP + NH4+
directly activates: BiochemicalReaction5521
directly activates: Catalysis2673
directly activates: Catalysis2707
label: phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate

(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004126
BFO_0000050: Pyrimidine salvage reactions
directly activates: (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
directly activates: Catalysis2689
label: deamination of 2'-Deoxycytidine to 2'-Deoxyuridine

TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004850
BFO_0000050: Pyrimidine catabolism

thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016763
BFO_0000050: Pyrimidine catabolism

reduction of uracil to form dihydrouracil
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017113
BFO_0000050: Pyrimidine catabolism
directly activates: 5,6-dihydrouracil + H2O => beta-ureidopropionate
directly activates: Catalysis2692
label: uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

5,6-dihydrouracil + H2O => beta-ureidopropionate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004157
BFO_0000050: Pyrimidine catabolism
directly activates: beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
directly activates: Catalysis2693
label: conversion of 5,6-dihydrouracil to 3-ureidopropionate

beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003837
BFO_0000050: Pyrimidine catabolism
directly activates: Mitochondrial uptake of beta-alanine
directly activates: BiochemicalReaction5735
directly activates: Catalysis2892
directly activates: Control482
directly activates: Modulation30
label: conversion of 3-ureidopropionate to beta-alanine

Mitochondrial uptake of beta-alanine
type: GO_0003674
BFO_0000050: Pyrimidine catabolism
directly activates: beta-alanine + pyruvate => 3-oxopropanoate + alanine
directly activates: Catalysis2694

beta-alanine + pyruvate => 3-oxopropanoate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016223
BFO_0000050: Pyrimidine catabolism

reduction of thymine to form 5,6-Dihydrothymine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017113
BFO_0000050: Pyrimidine catabolism
directly activates: 5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
directly activates: Catalysis2696
label: thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+

5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004157
BFO_0000050: Pyrimidine catabolism
directly activates: beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
directly activates: Catalysis2697
label: conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate

beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003837
BFO_0000050: Pyrimidine catabolism
directly activates: Mitochondrial uptake of (R)-3-aminoisobutyric acid
label: conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate

Mitochondrial uptake of (R)-3-aminoisobutyric acid
type: GO_0003674
BFO_0000050: Pyrimidine catabolism
directly activates: (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
directly activates: Catalysis2698

(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047305
BFO_0000050: Pyrimidine catabolism

Pyrimidine metabolism
type: GO_0008150

Pyrimidine biosynthesis
type: GO_0008150
BFO_0000050: Pyrimidine metabolism

Pyrimidine salvage reactions
type: GO_0008150
BFO_0000050: Pyrimidine metabolism

Pyrimidine catabolism
type: GO_0008150
BFO_0000050: Pyrimidine metabolism