TK2
UniProt:O00142 TK2
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
bicarbonate and glutamine combine to form carbamoyl phosphate
carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate
N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)
(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
oxidation of (S)-Dihydroorotate to form Orotate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2
dCMP + H2O => dUMP + NH4+
deamination of dCMP to form dUMP
dUTP + H2O => dUMP + pyrophosphate
hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate
conversion of dUMP to dTMP
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
phosphorylation of 2'-Deoxythymidine to dTMP
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]
deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK]
phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA]
deamination of 2'-Deoxycytidine to 2'-Deoxyuridine
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
reduction of uracil to form dihydrouracil
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
5,6-dihydrouracil + H2O => beta-ureidopropionate
conversion of 5,6-dihydrouracil to 3-ureidopropionate
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
conversion of 3-ureidopropionate to beta-alanine
Mitochondrial uptake of beta-alanine
beta-alanine + pyruvate => 3-oxopropanoate + alanine
reduction of thymine to form 5,6-Dihydrothymine
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
Mitochondrial uptake of (R)-3-aminoisobutyric acid
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
Pyrimidine metabolism
Pyrimidine biosynthesis
Pyrimidine salvage reactions
Pyrimidine catabolism