TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
reduction of uracil to form dihydrouracil
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
5,6-dihydrouracil + H2O => beta-ureidopropionate
conversion of 5,6-dihydrouracil to 3-ureidopropionate
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
conversion of 3-ureidopropionate to beta-alanine
Mitochondrial uptake of beta-alanine
beta-alanine + pyruvate => 3-oxopropanoate + alanine
reduction of thymine to form 5,6-Dihydrothymine
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
Mitochondrial uptake of (R)-3-aminoisobutyric acid
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
Pyrimidine catabolism