FUR
label: FURIN
label: PACE
label: PCSK3
label: UniProt:P09958 FURIN

C3orf9
label: CLP46
label: KTELC1
label: MDS010
label: MDSRP
label: POGLUT1
label: UNQ490/PRO1006
label: UniProt:Q8NBL1 POGLUT1

FUT12
label: KIAA0180
label: POFUT1
label: UniProt:Q9H488 POFUT1

NOTCH1 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: MIR200B/C microRNAs bind NOTCH1 mRNA
directly activates: MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: NOTCH1 mRNA translation controlled by miRNAs
directly activates: Control321
directly activates: Control322
directly activates: Control323

NOTCH2 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
directly activates: NOTCH2 mRNA translation controlled by miRNAs
directly activates: Control324

NOTCH3 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
directly activates: MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
directly activates: NOTCH3 mRNA translation controlled by miRNAs
directly activates: Control325
directly activates: Control326

NOTCH4 gene transcription
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
directly activates: MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
directly activates: NOTCH4 mRNA translation controlled by miRNAs
directly activates: Control327
directly activates: Control328

p53 positively regulates transcription of MIR34 microRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
directly activates: MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA

MIR34 microRNAs bind 3'UTR of NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR200B/C microRNAs bind NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR449 microRNAs bind 3'UTR of NOTCH1 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR34 microRNAs bind 3'UTR of NOTCH2 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR150 microRNA binds 3'UTR of NOTCH3 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR206 microRNA binds 3'UTR of NOTCH3 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR181C microRNA binds 3'UTR of NOTCH4 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

MIR302A microRNA binds 3'UTR of NOTCH4 mRNA
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation

NOTCH1 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH2 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH3 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

NOTCH4 mRNA translation controlled by miRNAs
type: GO_0003674
BFO_0000050: Pre-NOTCH Transcription and Translation
directly activates: Fucosylation of Pre-NOTCH by POFUT1
directly activates: Catalysis1869

Fucosylation of Pre-NOTCH by POFUT1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: enabled by
  some values from: FUT12
type: Restriction
  on property: enabled by
  some values from: FUT12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0046922
BFO_0000050: Pre-NOTCH Processing in the Endoplasmic Reticulum
directly activates: Glucosylation of Pre-NOTCH by POGLUT1
directly activates: Catalysis1870

Glucosylation of Pre-NOTCH by POGLUT1
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: Restriction
  on property: enabled by
  some values from: C3orf9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0035251
BFO_0000050: Pre-NOTCH Processing in the Endoplasmic Reticulum
directly activates: Transport of NOTCH precursor to Golgi
directly activates: Control329
directly activates: Control330
directly activates: Control331

Transport of NOTCH precursor to Golgi
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: NOTCH precursor cleaved to form mature NOTCH
directly activates: Glycosylation of Pre-NOTCH by FRINGE
directly activates: Catalysis1871
directly activates: Catalysis1872

NOTCH precursor cleaved to form mature NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Mature NOTCH heterodimer traffics to the plasma membrane
directly activates: Control332

Glycosylation of Pre-NOTCH by FRINGE
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0033829
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Galactosylation of Pre-NOTCH
directly activates: Catalysis1873

Galactosylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003831
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Sialylation of Pre-NOTCH
directly activates: Catalysis1874

Sialylation of Pre-NOTCH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0003836
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Fringe-modified Pre-NOTCH is cleaved by FURIN
directly activates: Catalysis1875

Fringe-modified Pre-NOTCH is cleaved by FURIN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: enabled by
  some values from: FUR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0000139
type: GO_0004252
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: Transport of fringe-modified NOTCH to plasma membrane
directly activates: Control333

Mature NOTCH heterodimer traffics to the plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: BiochemicalReaction3260
directly activates: BiochemicalReaction3261
directly activates: BiochemicalReaction3262
directly activates: BiochemicalReaction3263
directly activates: BiochemicalReaction3267
directly activates: BiochemicalReaction3276
directly activates: BiochemicalReaction3277
directly activates: BiochemicalReaction3278
directly activates: BiochemicalReaction4171
directly activates: BiochemicalReaction4172
directly activates: BiochemicalReaction4173
directly activates: BiochemicalReaction4174
directly activates: BiochemicalReaction4176
directly activates: BiochemicalReaction4178

Transport of fringe-modified NOTCH to plasma membrane
type: GO_0003674
BFO_0000050: Pre-NOTCH Processing in Golgi
directly activates: BiochemicalReaction3260
directly activates: BiochemicalReaction3261
directly activates: BiochemicalReaction3278
directly activates: BiochemicalReaction4171
directly activates: BiochemicalReaction4172

Pre-NOTCH Expression and Processing
type: GO_0008150

Pre-NOTCH Transcription and Translation
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing

Pre-NOTCH Processing in the Endoplasmic Reticulum
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing

Pre-NOTCH Processing in Golgi
type: GO_0008150
BFO_0000050: Pre-NOTCH Expression and Processing