ACOT8
ACTEIII
PTE1
PTE2
UniProt:O14734 ACOT8
ACSVL1
FACVL1
FATP2
SLC27A2
UniProt:O14975 SLC27A2
VLACS
PMP34
SLC25A17
UniProt:O43808 SLC25A17
MLYCD
UniProt:O95822 MLYCD
ACAA
ACAA1
PTHIO
UniProt:P09110 ACAA1
SCP2
UniProt:P22307-1 SCP2
CAT1
CRAT
UniProt:P43155 CRAT
FAR1
MLSTD2
UniProt:Q8WVX9 FAR1
FAR2
MLSTD1
UniProt:Q96K12 FAR2
AMACR
UniProt:Q9UHK6 AMACR
COT
CROT
UniProt:Q9UKG9 CROT
PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
formyl-CoA + H2O => formate + CoASH
pristanal + NAD+ => pristanate + NADH + H+
pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
acetyl-CoA + carnitine => acetylcarnitine + CoASH
acetyl-CoA + H2O => acetate + CoASH
propionyl-CoA + carnitine => propionylcarnitine + CoASH
Peroxisomal uptake of very long-chain fatty acyl CoA
hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA
palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2]
palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH
1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol
Conversion of acylated DHAP to lysophosphatidic acid acid
O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+
isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
Peroxisomal lipid metabolism
Alpha-oxidation of phytanate
Beta-oxidation of pristanoyl-CoA
Beta-oxidation of very long chain fatty acids
Plasmalogen biosynthesis
Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate
NADPH regeneration