ACOT8
label: ACTEIII
label: PTE1
label: PTE2
label: UniProt:O14734 ACOT8

ACSVL1
label: FACVL1
label: FATP2
label: SLC27A2
label: UniProt:O14975 SLC27A2
label: VLACS

PMP34
label: SLC25A17
label: UniProt:O43808 SLC25A17

MLYCD
label: UniProt:O95822 MLYCD

ACAA
label: ACAA1
label: PTHIO
label: UniProt:P09110 ACAA1

SCP2
label: UniProt:P22307-1 SCP2

CAT1
label: CRAT
label: UniProt:P43155 CRAT

FAR1
label: MLSTD2
label: UNQ2423/PRO4981
label: UniProt:Q8WVX9 FAR1

FAR2
label: MLSTD1
label: UniProt:Q96K12 FAR2

AMACR
label: UniProt:Q9UHK6 AMACR

COT
label: CROT
label: UniProt:Q9UKG9 CROT

PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: PMP34
type: Restriction
  on property: enabled by
  some values from: PMP34
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0000295
BFO_0000050: Alpha-oxidation of phytanate
directly activates: phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
directly activates: pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
directly activates: Catalysis2176
directly activates: Catalysis2180

phytanate + CoA-SH + ATP => phytanoyl-CoA + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0050197
BFO_0000050: Alpha-oxidation of phytanate
directly activates: PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP
directly activates: phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
directly activates: Catalysis2175
directly activates: Catalysis2177

phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0048244
BFO_0000050: Alpha-oxidation of phytanate
directly activates: 2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
directly activates: Catalysis2178

2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016830
BFO_0000050: Alpha-oxidation of phytanate
directly activates: formyl-CoA + H2O => formate + CoASH
directly activates: pristanal + NAD+ => pristanate + NADH + H+
directly activates: Catalysis2179

formyl-CoA + H2O => formate + CoASH
type: GO_0003674
BFO_0000050: Alpha-oxidation of phytanate

pristanal + NAD+ => pristanate + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004029
BFO_0000050: Alpha-oxidation of phytanate
directly activates: pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
directly activates: Catalysis2180

pristanate + CoA-SH + ATP => pristanoyl-CoA + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: Restriction
  on property: enabled by
  some values from: ACSVL1
type: GO_0070251
BFO_0000050: Alpha-oxidation of phytanate
directly activates: Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
directly activates: Catalysis2181

Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: AMACR
type: Restriction
  on property: enabled by
  some values from: AMACR
type: GO_0008111
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
directly activates: (2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
directly activates: Catalysis2182
directly activates: Catalysis2183

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016402
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
directly activates: Catalysis2184

(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016402
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
directly activates: Catalysis2184

trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: 3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
directly activates: Catalysis2185

3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: 3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
directly activates: Catalysis2186

3-ketopristanoyl-CoA + CoASH => 4,8,12-trimethyltridecanoyl-CoA + propionyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: SCP2
type: Restriction
  on property: enabled by
  some values from: SCP2
type: GO_0050632
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: 4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
directly activates: propionyl-CoA + carnitine => propionylcarnitine + CoASH
directly activates: Catalysis2190

4,8,12-trimethyltridecanoyl-CoA + 2 O2 + 2 H2O + 2 NAD+ + 2 CoASH => 4,8-dimethylnonanoyl-CoA + 2 H2O2 + 2 NADH + 2 H+ + acetyl-CoA + propionyl-CoA
type: GO_0003674
BFO_0000050: Beta-oxidation of pristanoyl-CoA
directly activates: 4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: propionyl-CoA + carnitine => propionylcarnitine + CoASH
directly activates: Catalysis2187
directly activates: Catalysis2188
directly activates: Catalysis2189
directly activates: Catalysis2190

4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: COT
type: Restriction
  on property: enabled by
  some values from: COT
type: GO_0008458
BFO_0000050: Beta-oxidation of pristanoyl-CoA

acetyl-CoA + carnitine => acetylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: GO_0004092
BFO_0000050: Beta-oxidation of pristanoyl-CoA
BFO_0000050: Beta-oxidation of very long chain fatty acids

acetyl-CoA + H2O => acetate + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: Restriction
  on property: enabled by
  some values from: ACOT8
type: GO_0003986
BFO_0000050: Beta-oxidation of pristanoyl-CoA
BFO_0000050: Beta-oxidation of very long chain fatty acids

propionyl-CoA + carnitine => propionylcarnitine + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: CAT1
type: Restriction
  on property: enabled by
  some values from: CAT1
type: GO_0004092
BFO_0000050: Beta-oxidation of pristanoyl-CoA

Peroxisomal uptake of very long-chain fatty acyl CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0005325
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
directly activates: Catalysis2192

hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003997
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
directly activates: Catalysis2193

trans-2,3-dehydrohexacosanoyl-CoA + H2O => 3-hydroxyhexacosanoyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016508
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: 3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
directly activates: Catalysis2194

3-hydroxyhexacosanoyl-CoA + NAD+ => 3-ketohexacosanoyl-CoA + NADH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0003857
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: 3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
directly activates: Catalysis2195

3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: ACAA
type: Restriction
  on property: enabled by
  some values from: ACAA
type: GO_0003988
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA
directly activates: Catalysis2188
directly activates: Catalysis2189

tetracosenoyl-CoA + 8 O2 + 8 H2O + 8 NAD+ + 8 CoASH => octanoyl-CoA + 8 H2O2 + 8 NADH + 8 H+ + 8 acetyl-CoA
type: GO_0003674
BFO_0000050: Beta-oxidation of very long chain fatty acids
directly activates: acetyl-CoA + carnitine => acetylcarnitine + CoASH
directly activates: acetyl-CoA + H2O => acetate + CoASH
directly activates: Catalysis2188
directly activates: Catalysis2189

palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: FAR1
type: Restriction
  on property: enabled by
  some values from: FAR1
type: GO_0016491
BFO_0000050: Plasmalogen biosynthesis
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

palmitoyl-CoA + 2 NADPH + 2 H+ => hexadecanol + 2 NADP+ [FAR2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: FAR2
type: Restriction
  on property: enabled by
  some values from: FAR2
type: GO_0016491
BFO_0000050: Plasmalogen biosynthesis
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0016287
BFO_0000050: Plasmalogen biosynthesis
directly activates: 1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
directly activates: Catalysis2199

1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0008609
BFO_0000050: Plasmalogen biosynthesis
directly activates: Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol

Movement of O-hexadecylglycerone phosphate from the peroxisomal matrix to the cytosol
type: GO_0003674
BFO_0000050: Plasmalogen biosynthesis
directly activates: Conversion of acylated DHAP to lysophosphatidic acid acid
directly activates: Catalysis2200

Conversion of acylated DHAP to lysophosphatidic acid acid
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0000140
BFO_0000050: Plasmalogen biosynthesis
directly activates: BiochemicalReaction4760
directly activates: Catalysis2116
label: O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004450
BFO_0000050: NADPH regeneration
directly activates: phytanoyl-CoA + 2-oxoglutarate + O2 => 2-hydroxyphytanoyl-CoA + succinate + CO2
directly activates: Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
directly activates: Catalysis2177
directly activates: Catalysis2203

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004450
BFO_0000050: NADPH regeneration

Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005778
type: GO_0046943
BFO_0000050: NADPH regeneration
directly activates: isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+
directly activates: Catalysis2201

malonyl-CoA is decarboxylated to acetyl-CoA in peroxisome
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: enabled by
  some values from: MLYCD
type: GO_0006637
type: GO_0050080
BFO_0000050: Peroxisomal lipid metabolism

Peroxisomal lipid metabolism
type: GO_0008150

Alpha-oxidation of phytanate
type: GO_0008150
BFO_0000050: Peroxisomal lipid metabolism

Beta-oxidation of pristanoyl-CoA
type: GO_0008150
BFO_0000050: Peroxisomal lipid metabolism

Beta-oxidation of very long chain fatty acids
type: GO_0008150
BFO_0000050: Peroxisomal lipid metabolism

Plasmalogen biosynthesis
type: GO_0008150
BFO_0000050: Peroxisomal lipid metabolism
label: Synthesis of lysophosphatidic acid from dihydroxyacetone phosphate

NADPH regeneration
type: GO_0008150
BFO_0000050: Peroxisomal lipid metabolism