Dissociation of PERK:BiP Heterodimer
Dimerization of PERK
Phosphorylation of eIF2-alpha by PERK
PERK regulated gene expression
Activation of Genes by ATF4
Translation and translocation of ATF4
Expression of ATF3
Expression of Asparagine Synthetase
Expression of CCL2
Expression of HERPUD
Expression of IGFBP1
Expression of IL-8
Expression of CHOP (DDIT3, GADD153)