Dissociation of PERK:BiP Heterodimer
type: GO_0003674
BFO_0000050: PERK regulated gene expression
directly activates: Dimerization of PERK

Dimerization of PERK
type: GO_0003674
BFO_0000050: PERK regulated gene expression
directly activates: Phosphorylation of eIF2-alpha by PERK
directly activates: Catalysis1630

Phosphorylation of eIF2-alpha by PERK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004674
BFO_0000050: PERK regulated gene expression
directly activates: Translation and translocation of ATF4
directly activates: TemplateReactionRegulation121

PERK regulated gene expression
type: GO_0008150

Activation of Genes by ATF4
type: GO_0008150
BFO_0000050: PERK regulated gene expression

Translation and translocation of ATF4
type: GO_0003674
BFO_0000050: PERK regulated gene expression
directly activates: Expression of ATF3
directly activates: Expression of Asparagine Synthetase
directly activates: Expression of CCL2
directly activates: Expression of HERPUD
directly activates: Expression of IGFBP1
directly activates: Expression of IL-8
directly activates: Expression of CHOP (DDIT3, GADD153)
directly activates: TemplateReactionRegulation122
directly activates: TemplateReactionRegulation123
directly activates: TemplateReactionRegulation124
directly activates: TemplateReactionRegulation125
directly activates: TemplateReactionRegulation126
directly activates: TemplateReactionRegulation127
directly activates: TemplateReactionRegulation128
directly activates: TemplateReactionRegulation69
directly activates: TemplateReactionRegulation70
directly activates: TemplateReactionRegulation71

Expression of ATF3
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of Asparagine Synthetase
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of CCL2
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of HERPUD
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of IGFBP1
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of IL-8
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4

Expression of CHOP (DDIT3, GADD153)
type: GO_0003674
BFO_0000050: Activation of Genes by ATF4