JAK2 phosphorylation
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: BiochemicalReaction1517
directly activates: BiochemicalReaction1518
directly activates: BiochemicalReaction1524
directly activates: Tyrosine phosphorylation of PRLR
directly activates: Catalysis535
directly activates: Catalysis536

PRLR associates with JAK2
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: PRLR:JAK2 dimerizes

PRLR:JAK2 dimerizes
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: Prolactin receptor ligands bind the prolactin receptor
directly activates: Control113

Prolactin receptor ligands bind the prolactin receptor
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: PRLR activation

PRLR activation
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: JAK2 phosphorylation
directly activates: SH2B binds JAK2
directly activates: PRLR is phosphorylated at Ser-349
directly activates: Control112

SH2B binds JAK2
type: GO_0003674
BFO_0000050: Prolactin receptor signaling

Tyrosine phosphorylation of PRLR
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: PRLR binds STAT5
directly activates: PRLR binds SHP2 (PTPN11)

PRLR binds STAT5
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: PRLR-bound STAT5 is phosphorylated
directly activates: Catalysis544

PRLR-bound STAT5 is phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Prolactin receptor signaling
directly activates: ERBB4s80 binds STAT5A

PRLR binds SHP2 (PTPN11)
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: SHP2 is phosphorylated
directly activates: Catalysis545

SHP2 is phosphorylated
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004715
BFO_0000050: Prolactin receptor signaling

PRLR is phosphorylated at Ser-349
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: PRLR binds SCF beta-TrCP complex

PRLR binds SCF beta-TrCP complex
type: GO_0003674
BFO_0000050: Prolactin receptor signaling
directly activates: Prolactin receptor is internalized

Prolactin receptor is internalized
type: GO_0003674
BFO_0000050: Prolactin receptor signaling

Cleavage of P-ERBB4jmA isoforms by ADAM17
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004222
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Cleavage of ERBB4m80 by gamma-scretase complex
directly activates: Catalysis1845

Cleavage of ERBB4m80 by gamma-scretase complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004175
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Translocation of ERBB4s80 to the nucleus
directly activates: ERBB4s80 binds TAB2:NCOR1 complex
directly activates: WWOX binds ERBB4s80
directly activates: ERBB4s80 binds YAP1
directly activates: ERBB4s80 binds STAT5A
directly activates: Translocation of cytosolic ERBB4s80 to mitochondrial matrix

Translocation of ERBB4s80 to the nucleus
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: ERBB4s80 forms a complex with estrogen receptor ESR1

ERBB4s80 binds TAB2:NCOR1 complex
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: ERBB4:TAB2:NCOR1 complex translocates to the nucleus

ERBB4:TAB2:NCOR1 complex translocates to the nucleus
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Transcription of GFAP and S100B
directly activates: Control313

Transcription of GFAP and S100B
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4

WWOX binds ERBB4s80
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4

ERBB4s80 binds YAP1
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Translocation of ERBB4s80:YAP1 complex to the nucleus

Translocation of ERBB4s80:YAP1 complex to the nucleus
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4

ERBB4s80 binds STAT5A
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: ERBB4s80:STAT5A complex translocates to the nucleus

ERBB4s80:STAT5A complex translocates to the nucleus
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Transcription of beta-casein (CSN2)
directly activates: TemplateReactionRegulation130

ERBB4s80 forms a complex with estrogen receptor ESR1
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4
directly activates: Transcription of NR3C3 and CXCL12
directly activates: Control314

Transcription of NR3C3 and CXCL12
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4

Translocation of cytosolic ERBB4s80 to mitochondrial matrix
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4

Nuclear signaling by ERBB4
type: GO_0008150

Prolactin receptor signaling
type: GO_0008150
BFO_0000050: Nuclear signaling by ERBB4

Transcription of beta-casein (CSN2)
type: GO_0003674
BFO_0000050: Nuclear signaling by ERBB4