Nef mediated disruption of CD4:Lck Complex
type: GO_0003674
BFO_0000050: Nef Mediated CD4 Down-regulation
directly activates: Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex

Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
type: GO_0003674
BFO_0000050: Nef Mediated CD4 Down-regulation
directly activates: Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
directly activates: BiochemicalReaction2730

Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
type: GO_0003674
BFO_0000050: Nef Mediated CD4 Down-regulation
directly activates: Degradation of CD4
directly activates: BiochemicalReaction2731

Formation of a Nef:ARF1:CD4 complex
type: GO_0003674
BFO_0000050: Nef Mediated CD4 Down-regulation
directly activates: Degradation of CD4

Degradation of CD4
type: GO_0003674
BFO_0000050: Nef Mediated CD4 Down-regulation

Nef Mediated CD4 Down-regulation
type: GO_0008150