MSK1
RPS6KA5
UniProt:O75582 RPS6KA5
CDC2
CDC28A
CDK1
CDKN1
P34CDC2
UniProt:P06493 CDK1
MAPKAPK2
UniProt:P49137 MAPKAPK2
BMK1
ERK5
MAPK7
PRKM7
UniProt:Q13164 MAPK7
RNF85
TRAF6
UniProt:Q9Y4K3 TRAF6
Activated TRAF6 synthesizes unanchored polyubiquitin chains
Activated TAK1 mediates phosphorylation of the IKK Complex
Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
Released NFkB complex is transported to nucleus
Activated TAK1 phosphorylates MKK4/MKK7
Phosphorylation of human JNKs by activated MKK4/MKK7
Activated human JNKs migrate to nucleoplasm
activated human TAK1 phosphorylates MKK3/MKK6
phosphorylated MKK3/MKK6 migrates to nucleus
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
Active p38 MAPK phosphorylates MAPKAPK2 or 3
Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
Inactivation of MEK1 by p34cdc2
MEK1 binds ERK-1
MEK1 phosphorylates ERK-1
Dissociation of phospho-ERK-1:MEK1
Dimerisation of phospho-ERK-1
Nuclear translocation of phospho-ERK-1 dimer
MEK2 binds ERK-2
MEK2 phosphorylates ERK-2
Dissociation of phospho-ERK-2:MEK2
Dimerisation of phospho-ERK-2
Nuclear translocation of phospho-ERK-2 dimer
ERK1/2 activates ELK1
ERK1/2 phosphorylates MSK1
p38MAPK phosphorylates MSK1
ERK1/2/5 activate RSK1/2/3
ERK5 activates the transcription factor MEF2
ERKs are inactivated by protein phosphatase 2A
ERKs are inactivated by dual-specific phosphatases (DUSPs)
MSK1 activates CREB
MSK1 activates ATF1
RSK1/2/3 phosphorylates CREB at Serine 133
MAPKAPK2 phosphorylates CREB at Serine 133
Phosphorylated MAPKs phosphorylate ATF-2
Activated JNKs phosphorylate c-JUN
c-FOS activation by phospho ERK1/2
Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
TRAM:TLR4:MD2:LPS:CD14 recruits TRIF (TICAM1)
Viral dsRNA:TLR3 recruits TRIF (TICAM1)
Negative regulator SARM binds to TRIF
TRAF3 binds to TRIF:activated TLR3/4 complex
Auto-ubiquitination of TRAF3
Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR
Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
Dimerization of phosphorylated IRF3/IRF7
Dimerized phospho-IRF3/IRF7 is transported to the nucleus
TRIF:activated TLR3/TLR4 complex recruits RIP1
K63-linked ubiquitination of RIP1 bound to the activated TLR complex
Nemo subunit of IKK complex binds polyubiquinated RIP1
TLR3/4-induced ripoptosome assembly
Caspase-8 processing
RIP3 binds TRIF to mediate necroptosis
Activated TLR3/4:TRIF recruits TRAF6
Auto ubiquitination of TRAF6 bound to the activated TLR complex
Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex
Activation of TAK1 complex bound to activated TLR
Phosphorylated TAK1 leaves activated TLR receptor complex
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
MAP kinase activation in TLR cascade
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
ERK activation
ERK1 activation
ERK2 activation
MAPK targets/ Nuclear events mediated by MAP kinases
ERK/MAPK targets
ERKs are inactivated
CREB phosphorylation
Activation of the AP-1 family of transcription factors
MyD88-independent cascade
TRIF-mediated TLR3/TLR4 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRIF-mediated programmed cell death
TRAF6 mediated induction of TAK1 complex