MSK1
label: RPS6KA5
label: UniProt:O75582 RPS6KA5

CDC2
label: CDC28A
label: CDK1
label: CDKN1
label: P34CDC2
label: UniProt:P06493 CDK1

MAPKAPK2
label: UniProt:P49137 MAPKAPK2

BMK1
label: ERK5
label: MAPK7
label: PRKM7
label: UniProt:Q13164 MAPK7

RNF85
label: TRAF6
label: UniProt:Q9Y4K3 TRAF6

Activated TRAF6 synthesizes unanchored polyubiquitin chains
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: enabled by
  some values from: RNF85
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: TRAF6 mediated induction of TAK1 complex
directly activates: BiochemicalReaction880
directly activates: Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex

Activated TAK1 mediates phosphorylation of the IKK Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
directly activates: BiochemicalReaction1425
directly activates: Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
directly activates: Catalysis337
directly activates: Catalysis516

Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex
directly activates: Released NFkB complex is transported to nucleus
directly activates: Control55
directly activates: Control56

Released NFkB complex is transported to nucleus
type: GO_0003674
BFO_0000050: TAK1 activates NFkB by phosphorylation and activation of IKKs complex

Activated TAK1 phosphorylates MKK4/MKK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Phosphorylation of human JNKs by activated MKK4/MKK7
directly activates: Catalysis339

Phosphorylation of human JNKs by activated MKK4/MKK7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008545
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Activated human JNKs migrate to nucleoplasm

Activated human JNKs migrate to nucleoplasm
type: GO_0003674
BFO_0000050: JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
directly activates: Phosphorylated MAPKs phosphorylate ATF-2
directly activates: Activated JNKs phosphorylate c-JUN
directly activates: Catalysis357
directly activates: Catalysis358

activated human TAK1 phosphorylates MKK3/MKK6
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: phosphorylated MKK3/MKK6 migrates to nucleus

phosphorylated MKK3/MKK6 migrates to nucleus
type: GO_0003674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
directly activates: Catalysis341

Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004712
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Active p38 MAPK phosphorylates MAPKAPK2 or 3
directly activates: Phosphorylated MAPKs phosphorylate ATF-2
directly activates: Catalysis342
directly activates: Catalysis357

Active p38 MAPK phosphorylates MAPKAPK2 or 3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: activated TAK1 mediates p38 MAPK activation
directly activates: Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3

Nuclear export of human p38 MAPK mediated by its substrate MAPKAPK2 or 3
type: GO_0003674
BFO_0000050: activated TAK1 mediates p38 MAPK activation

Inactivation of MEK1 by p34cdc2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: Restriction
  on property: enabled by
  some values from: CDC2
type: GO_0004674
BFO_0000050: ERK1 activation

MEK1 binds ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: MEK1 phosphorylates ERK-1
directly activates: Catalysis344
directly activates: Control57

MEK1 phosphorylates ERK-1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK1 activation
directly activates: Dissociation of phospho-ERK-1:MEK1

Dissociation of phospho-ERK-1:MEK1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Dimerisation of phospho-ERK-1

Dimerisation of phospho-ERK-1
type: GO_0003674
BFO_0000050: ERK1 activation
directly activates: Nuclear translocation of phospho-ERK-1 dimer

Nuclear translocation of phospho-ERK-1 dimer
type: GO_0000189
BFO_0000050: ERK1 activation
directly activates: ERK1/2 activates ELK1
directly activates: ERK1/2 phosphorylates MSK1
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

MEK2 binds ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: MEK2 phosphorylates ERK-2
directly activates: Catalysis345

MEK2 phosphorylates ERK-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: ERK2 activation
directly activates: Dissociation of phospho-ERK-2:MEK2

Dissociation of phospho-ERK-2:MEK2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Dimerisation of phospho-ERK-2

Dimerisation of phospho-ERK-2
type: GO_0003674
BFO_0000050: ERK2 activation
directly activates: Nuclear translocation of phospho-ERK-2 dimer

Nuclear translocation of phospho-ERK-2 dimer
type: GO_0000189
BFO_0000050: ERK2 activation
directly activates: ERK1/2 activates ELK1
directly activates: ERK1/2 phosphorylates MSK1
directly activates: ERK1/2/5 activate RSK1/2/3
directly activates: Catalysis346
directly activates: Catalysis347
directly activates: Catalysis349

ERK1/2 activates ELK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets

ERK1/2 phosphorylates MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: MSK1 activates CREB
directly activates: MSK1 activates ATF1
directly activates: Catalysis353
directly activates: Catalysis354

p38MAPK phosphorylates MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: MSK1 activates CREB
directly activates: MSK1 activates ATF1
directly activates: Catalysis353
directly activates: Catalysis354

ERK1/2/5 activate RSK1/2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets
directly activates: RSK1/2/3 phosphorylates CREB at Serine 133
directly activates: Catalysis355

ERK5 activates the transcription factor MEF2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: enabled by
  some values from: BMK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: ERK/MAPK targets

ERKs are inactivated by protein phosphatase 2A
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: ERK/MAPK targets
BFO_0000050: ERKs are inactivated

ERKs are inactivated by dual-specific phosphatases (DUSPs)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004725
BFO_0000050: ERKs are inactivated

MSK1 activates CREB
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

MSK1 activates ATF1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: enabled by
  some values from: MSK1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

RSK1/2/3 phosphorylates CREB at Serine 133
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

MAPKAPK2 phosphorylates CREB at Serine 133
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: CREB phosphorylation

Phosphorylated MAPKs phosphorylate ATF-2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.

Activated JNKs phosphorylate c-JUN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004705
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

c-FOS activation by phospho ERK1/2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: Activation of the AP-1 family of transcription factors
directly activates: Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.

Formation of Activated Protein 1 (AP-1) complex. ATF2/c-JUN heterodimer.
type: GO_0003674
BFO_0000050: Activation of the AP-1 family of transcription factors

Formation of Activated Protein 1 (AP-1) complex. cFOS/c-JUN heterodimer.
type: GO_0003674
BFO_0000050: Activation of the AP-1 family of transcription factors

TRAM:TLR4:MD2:LPS:CD14 recruits TRIF (TICAM1)
type: GO_0003674
BFO_0000050: MyD88-independent cascade
directly activates: Negative regulator SARM binds to TRIF
directly activates: TRAF3 binds to TRIF:activated TLR3/4 complex
directly activates: TRIF:activated TLR3/TLR4 complex recruits RIP1
directly activates: Activated TLR3/4:TRIF recruits TRAF6
directly activates: Control60
directly activates: Control62
directly activates: Control63
directly activates: Control65

Viral dsRNA:TLR3 recruits TRIF (TICAM1)
type: GO_0003674
BFO_0000050: MyD88-independent cascade
directly activates: Negative regulator SARM binds to TRIF
directly activates: TRAF3 binds to TRIF:activated TLR3/4 complex
directly activates: TRIF:activated TLR3/TLR4 complex recruits RIP1
directly activates: Activated TLR3/4:TRIF recruits TRAF6
directly activates: Control60
directly activates: Control62
directly activates: Control63
directly activates: Control65

Negative regulator SARM binds to TRIF
type: GO_0003674
BFO_0000050: MyD88-independent cascade

TRAF3 binds to TRIF:activated TLR3/4 complex
type: GO_0003674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
directly activates: Auto-ubiquitination of TRAF3
directly activates: Catalysis360

Auto-ubiquitination of TRAF3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004842
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
directly activates: Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation

Recruitment of TBK1/IKK epsilon to K63-poly-Ub-TRAF3:TRIF:activated TLR3/TLR4 followed by their phosphorylation
type: GO_0003674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
directly activates: IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR
directly activates: Control61

IRF3/IRF7 recruitment to p-TBK1/p-IKK epsilon bound to the activated TLR
type: GO_0003674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
directly activates: Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
directly activates: Catalysis361

Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
directly activates: Dimerization of phosphorylated IRF3/IRF7

Dimerization of phosphorylated IRF3/IRF7
type: GO_0003674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Dimerized phospho-IRF3/IRF7 is transported to the nucleus
type: GO_0003674
BFO_0000050: Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

TRIF:activated TLR3/TLR4 complex recruits RIP1
type: GO_0003674
BFO_0000050: IKK complex recruitment mediated by RIP1
directly activates: K63-linked ubiquitination of RIP1 bound to the activated TLR complex
directly activates: TLR3/4-induced ripoptosome assembly
directly activates: Catalysis362
directly activates: Control64

K63-linked ubiquitination of RIP1 bound to the activated TLR complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004842
BFO_0000050: IKK complex recruitment mediated by RIP1
directly activates: Nemo subunit of IKK complex binds polyubiquinated RIP1

Nemo subunit of IKK complex binds polyubiquinated RIP1
type: GO_0003674
BFO_0000050: IKK complex recruitment mediated by RIP1

TLR3/4-induced ripoptosome assembly
type: GO_0003674
BFO_0000050: TRIF-mediated programmed cell death
directly activates: Caspase-8 processing
directly activates: Catalysis363

Caspase-8 processing
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004197
type: GO_0097190
BFO_0000050: TRIF-mediated programmed cell death
directly activates: BiochemicalReaction6088

RIP3 binds TRIF to mediate necroptosis
type: GO_0060555
BFO_0000050: TRIF-mediated programmed cell death

Activated TLR3/4:TRIF recruits TRAF6
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of TAK1 complex
directly activates: Auto ubiquitination of TRAF6 bound to the activated TLR complex

Auto ubiquitination of TRAF6 bound to the activated TLR complex
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of TAK1 complex
directly activates: Activated TRAF6 synthesizes unanchored polyubiquitin chains
directly activates: Catalysis334

Activated TLR:TRIF:K63-pUb-TRAF6 recruits TAK1complex
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of TAK1 complex
directly activates: Activation of TAK1 complex bound to activated TLR
directly activates: Catalysis364

Activation of TAK1 complex bound to activated TLR
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: Restriction
  on property: BFO_0000066
  some values from: GO_0010008
type: GO_0004674
BFO_0000050: TRAF6 mediated induction of TAK1 complex
directly activates: Activated TAK1 mediates phosphorylation of the IKK Complex
directly activates: Activated TAK1 phosphorylates MKK4/MKK7
directly activates: activated human TAK1 phosphorylates MKK3/MKK6
directly activates: Phosphorylated TAK1 leaves activated TLR receptor complex
directly activates: Catalysis336
directly activates: Catalysis338
directly activates: Catalysis340

Phosphorylated TAK1 leaves activated TLR receptor complex
type: GO_0003674
BFO_0000050: TRAF6 mediated induction of TAK1 complex

TAK1 activates NFkB by phosphorylation and activation of IKKs complex
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling

MAP kinase activation in TLR cascade
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling

JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

activated TAK1 mediates p38 MAPK activation
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK activation
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK1 activation
type: GO_0008150
BFO_0000050: ERK activation

ERK2 activation
type: GO_0008150
BFO_0000050: ERK activation

MAPK targets/ Nuclear events mediated by MAP kinases
type: GO_0008150
BFO_0000050: MAP kinase activation in TLR cascade

ERK/MAPK targets
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

ERKs are inactivated
type: GO_0008150
BFO_0000050: ERK/MAPK targets

CREB phosphorylation
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

Activation of the AP-1 family of transcription factors
type: GO_0008150
BFO_0000050: MAPK targets/ Nuclear events mediated by MAP kinases

MyD88-independent cascade
type: GO_0008150

TRIF-mediated TLR3/TLR4 signaling
type: GO_0008150
BFO_0000050: MyD88-independent cascade

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling

IKK complex recruitment mediated by RIP1
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling

TRIF-mediated programmed cell death
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling

TRAF6 mediated induction of TAK1 complex
type: GO_0008150
BFO_0000050: TRIF-mediated TLR3/TLR4 signaling