TK2
UniProt:O00142 TK2
KIAA0361
PFAS
UniProt:O15067 PFAS
ADA
ADA1
UniProt:P00813 ADA
GART
PGFT
PRGS
UniProt:P22102 GART
CMK
CMPK
CMPK1
UCK
UMK
UMPK
UniProt:P30085 CMPK1
GLRX
GRX
UniProt:P35754 GLRX
GMPS
UniProt:P49915 GMPS
ADK2
AK2
UniProt:P54819 AK2
GMK
GUK1
UniProt:Q16774 GUK1
MTH3
NUDT18
UniProt:Q6ZVK8-1 NUDT18
AIRP
FKSG85
NT5C1B
UniProt:Q96P26 NT5C1B
MTH2
NUDT15
UniProt:Q9NV35 NUDT15
Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi
5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate
5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
GAR + 10-Formyl-THF => FGAR + THF
5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi
5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
FGAM + ATP => AIR + ADP + Pi
5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
AIR + CO2 => CAIR
5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
CAIR + Aspartate + ATP => SAICAR + ADP + Pi
5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
SAICAR => AICAR + Fumarate
5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
AICAR + 10-Formyl-THF => FAICAR + THF
5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
FAICAR => IMP + H2O
IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+
XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate
IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate
Adenylosuccinate => AMP + Fumarate
adenylosuccinate => adenosine 5'-monophosphate + fumarate
(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA]
(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK]
deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK]
dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK]
AMP + H2O => IMP + NH3 [AMPD]
Deamination of N6-methyl-AMP to form IMP
N6-methyl-AMP + H2O => IMP + methylamine
guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP]
hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP]
Adenine + PRPP => AMP + PPi
guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1]
GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E]
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
AMP + H2O => adenosine + orthophosphate [NT5C1B]
(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A]
(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C]
(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
Guanine + H2O => Xanthine + NH3
Hypoxanthine + H2O + O2 => Xanthine + H2O2
Xanthine + H2O + O2 => Urate + H2O2
2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
2 H2O2 => O2 + 2 H2O
L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
bicarbonate and glutamine combine to form carbamoyl phosphate
carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate
N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)
(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
oxidation of (S)-Dihydroorotate to form Orotate
orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)
decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2
dCMP + H2O => dUMP + NH4+
deamination of dCMP to form dUMP
dUTP + H2O => dUMP + pyrophosphate
hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate
conversion of dUMP to dTMP
dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate
uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
phosphorylation of 2'-Deoxythymidine to dTMP
thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]
deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK]
phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA]
deamination of 2'-Deoxycytidine to 2'-Deoxyuridine
TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A]
TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
reduction of uracil to form dihydrouracil
uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+
5,6-dihydrouracil + H2O => beta-ureidopropionate
conversion of 5,6-dihydrouracil to 3-ureidopropionate
beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
conversion of 3-ureidopropionate to beta-alanine
Mitochondrial uptake of beta-alanine
beta-alanine + pyruvate => 3-oxopropanoate + alanine
reduction of thymine to form 5,6-Dihydrothymine
thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+
5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate
beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate
Mitochondrial uptake of (R)-3-aminoisobutyric acid
(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
(d)AMP + ATP <=> (d)ADP + ADP [AK1]
(d)ADP + ADP <=> (d)AMP + ATP [AK1]
AMP + ATP <=> ADP + ADP [AK2]
ADP + ADP <=> AMP + ATP [AK2]
(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]
(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5]
(d)GMP + ATP <=> (d)GDP + ADP [GUK1]
(d)GDP + ADP <=> (d)GMP + ATP [GUK1]
(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1]
dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
phosphorylation of dUMP or TMP to dUDP or TDP
dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]
amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)
UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]
NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin)
NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)
Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)
glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
thioredoxin, oxidized (nucleus) <=> thioredoxin, oxidized (cytosol)
regeneration of active (reduced) Thioredoxin
thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+
thioredoxin, reduced (cytosol) <=> thioredoxin, reduced (nucleus)
(d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
(d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3]
(d)NDP + ATP <=> (d)NTP + ADP [NME4]
(d)NTP + ADP <=> (d)NDP + ATP [NME4]
adenosine 5'-diphosphate (cytosolic) <=> adenosine 5'-diphosphate (nuclear)
cytidine 5'-diphosphate (cytosolic) <=> cytidine 5'-diphosphate (nuclear)
guanosine 5'-diphosphate (cytosolic) <=> guanosine 5'-diphosphate (nuclear)
uridine 5'-diphosphate (cytosolic) <=> uridine 5'-diphosphate (nuclear)
ITP + H2O => IMP + PPi
ITPA hydrolyses ITP to IMP
ITPA hydrolyses dITP to dIMP
dITP + H2O => dIMP + PPi
ITPA hydrolyses XTP to XMP
XTP + H2O => XMP + PPi
8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT1)
NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP
8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT15)
NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP
8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT15)
NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP
8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT18)
NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP
8-oxo-GDP + H2O => 8-oxo-GMP + Pi
NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP
2-hydroxy-dATP + H2O => 2-hydroxy-dAMP + PPi
NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP
2-hydroxy-ATP + H2O => 2-hydroxy-AMP + PPi
NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP
8-hydroxy-dADP + H2O => 8-hydroxy-dAMP + Pi
NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP
NUDT16 hydrolyses dIDP to dIMP
dIDP + H2O => dIMP + Pi
IDP + H2O => IMP + Pi
NUDT16 hydrolyses IDP to IMP
ADP-ribose + H2O => AMP + D-ribose 5-phosphate (cytosolic)
Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP
ADP-ribose + H2O => AMP + D-ribose 5-phosphate (mitochondrial)
Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP
Metabolism of nucleotides
Nucleotide metabolism
Purine metabolism
Purine ribonucleoside monophosphate biosynthesis
Purine salvage
Purine catabolism
Pyrimidine metabolism
Pyrimidine biosynthesis
Pyrimidine salvage reactions
Pyrimidine catabolism
Synthesis and interconversion of nucleotide di- and triphosphates
Phosphate bond hydrolysis by NUDT proteins