TK2
label: UniProt:O00142 TK2

KIAA0361
label: PFAS
label: UniProt:O15067 PFAS

ADA
label: ADA1
label: UniProt:P00813 ADA

GART
label: PGFT
label: PRGS
label: UniProt:P22102 GART

CMK
label: CMPK
label: CMPK1
label: UCK
label: UMK
label: UMPK
label: UniProt:P30085 CMPK1

GLRX
label: GRX
label: UniProt:P35754 GLRX

GMPS
label: UniProt:P49915 GMPS

ADK2
label: AK2
label: UniProt:P54819 AK2

GMK
label: GUK1
label: UniProt:Q16774 GUK1

MTH3
label: NUDT18
label: UniProt:Q6ZVK8-1 NUDT18

AIRP
label: FKSG85
label: NT5C1B
label: UniProt:Q96P26 NT5C1B

MTH2
label: NUDT15
label: UniProt:Q9NV35 NUDT15

Formation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: GO_0003674
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis

Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer
type: GO_0003674
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis

5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004044
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: BiochemicalReaction296
directly activates: 5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
directly activates: Catalysis111
directly activates: Catalysis2631
directly activates: Control14
label: PRPP + H2O + L-Glutamine => 5-Phosphoribosylamine + L-Glutamate + PPi

5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004637
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
directly activates: Catalysis2632
label: 5-phosphoribosylamine + glycine + ATP => 5-phosphoribosylglycinamide (GAR) + ADP + orthophosphate

5-phosphoribosylglycinamide (GAR) + 10-formyl-tetrahydrofolate => 5'-phosphoribosylformylglycinamide (FGAR) + tetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004644
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
directly activates: Catalysis2633
label: GAR + 10-Formyl-THF => FGAR + THF

5'-phosphoribosylformylglycinamide (FGAR) + L-glutamine + ATP + H2O => 5'-phosphoribosylformylglycinamidine (FGAM) + L-glutamate + adenosine 5'-diphosphate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: Restriction
  on property: enabled by
  some values from: KIAA0361
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004642
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
directly activates: Catalysis2634
label: FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi

5'-phosphoribosylformylglycinamidine (FGAM) + ATP => 5'-phosphoribosyl-5-aminoimidazole (AIR) + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: enabled by
  some values from: GART
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004641
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
directly activates: Catalysis2635
label: FGAM + ATP => AIR + ADP + Pi

5'-phosphoribosyl-5-aminoimidazole (AIR) + CO2 <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004638
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
directly activates: Catalysis2636
label: AIR + CO2 => CAIR

5'-phosphoribosyl-5-aminoimidazole-4-carboxylate (CAIR) + L-aspartate + ATP => 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) + ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004639
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
directly activates: Catalysis2637
label: CAIR + Aspartate + ATP => SAICAR + ADP + Pi

5'-phosphoribosyl-5-aminoimidazole-4-N-succinocarboxamide (SAICAR) <=> 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + fumarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004018
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
directly activates: Catalysis2638
label: SAICAR => AICAR + Fumarate

5'-phosphoribosyl-5-aminoimidazole-4-carboxamide (AICAR) + 10-formyltetrahydrofolate => 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) + tetrahydrofolate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004643
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: 5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
directly activates: Catalysis2639
label: AICAR + 10-Formyl-THF => FAICAR + THF

5'-phosphoribosyl-5-formaminoimidazole-4-carboxamide (FAICAR) <=> inosine 5'-monophosphate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003937
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
directly activates: IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis2640
directly activates: Catalysis2642
directly activates: Catalysis2656
directly activates: Control456
directly activates: Control457
directly activates: Control458
directly activates: Control459
directly activates: Control460
label: FAICAR => IMP + H2O

IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003938
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
directly activates: Catalysis2641
label: inosine 5'-monophosphate (IMP) + NAD+ + H2O => xanthosine 5'-monophosphate (XMP) + NADH + H+

XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GMPS
type: Restriction
  on property: enabled by
  some values from: GMPS
type: Restriction
  on property: enabled by
  some values from: GMPS
type: Restriction
  on property: enabled by
  some values from: GMPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003921
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: BiochemicalReaction296
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: (d)GMP + ATP <=> (d)GDP + ADP [GUK1]
directly activates: Catalysis111
directly activates: Catalysis2656
directly activates: Catalysis2705
directly activates: Control14
label: xanthosine 5'-monophosphate (XMP) + L-glutamine + ATP + H2O => guanosine 5'-monophosphate (GMP) + L-glutamate + adenosine 5'-monophosphate (AMP) + pyrophosphate

IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004019
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: Adenylosuccinate => AMP + Fumarate
directly activates: Catalysis2643
label: inosine 5'-monophosphate + L-aspartate + GTP => adenylosuccinate + guanosine 5'-diphosphate + orthophosphate

Adenylosuccinate => AMP + Fumarate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004018
BFO_0000050: Purine ribonucleoside monophosphate biosynthesis
directly activates: AMP + H2O => IMP + NH3 [AMPD]
directly activates: (d)AMP + ATP <=> (d)ADP + ADP [AK1]
directly activates: Catalysis2648
directly activates: Catalysis2699
label: adenylosuccinate => adenosine 5'-monophosphate + fumarate

(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH3 [ADA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: ADA
type: Restriction
  on property: enabled by
  some values from: ADA
type: Restriction
  on property: enabled by
  some values from: ADA
type: Restriction
  on property: enabled by
  some values from: ADA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004000
BFO_0000050: Purine salvage
directly activates: (deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
directly activates: Catalysis2661

(2'-deoxy)adenosine + ATP => (d)AMP + ADP [ADK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004001
BFO_0000050: Purine salvage
directly activates: (d)AMP + ATP <=> (d)ADP + ADP [AK1]
directly activates: Catalysis2699

deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP [DCK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Purine salvage

dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP [DGUOK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0019206
BFO_0000050: Purine salvage
directly activates: (d)GMP + ATP <=> (d)GDP + ADP [GUK1]
directly activates: Catalysis2705

AMP + H2O => IMP + NH3 [AMPD]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003876
BFO_0000050: Purine salvage
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis2656

Deamination of N6-methyl-AMP to form IMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004000
BFO_0000050: Purine salvage
label: N6-methyl-AMP + H2O => IMP + methylamine

guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine salvage

hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine salvage

Adenine + PRPP => AMP + PPi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003999
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction296
directly activates: AMP + H2O => IMP + NH3 [AMPD]
directly activates: Catalysis111
directly activates: Catalysis2648
directly activates: Control14

guanine or hypoxanthine + PRPP => GMP or IMP + PPi [HPRT1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004422
BFO_0000050: Purine salvage
directly activates: BiochemicalReaction296
directly activates: GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
directly activates: (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
directly activates: Catalysis111
directly activates: Catalysis2654
directly activates: Catalysis2656
directly activates: Control14

GMP + NADPH + H+ => IMP + NADP+ + NH4+ [GMPR,GMPR2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003920
BFO_0000050: Purine salvage

AMP, dAMP, GMP, or IMP + H2O => adenosine, deoxyadenosine, guanosine, or inosine + orthophosphate [NT5E]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008253
BFO_0000050: Purine catabolism

(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate [NT5C2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism
directly activates: (deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
directly activates: Catalysis2660

AMP + H2O => adenosine + orthophosphate [NT5C1B]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AIRP
type: Restriction
  on property: enabled by
  some values from: AIRP
type: Restriction
  on property: enabled by
  some values from: AIRP
type: Restriction
  on property: enabled by
  some values from: AIRP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism

(2'-deoxy)purine nucleoside 5'-monophosphate + H2O => (2'-deoxy)purine nucleoside + orthophosphate [NT5C1A]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism
label: (d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate [NT5C1A]

(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate [NT5C]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Purine catabolism

(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine catabolism
directly activates: Guanine + H2O => Xanthine + NH3
directly activates: Catalysis2662

(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate [NP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004731
BFO_0000050: Purine catabolism
directly activates: Hypoxanthine + H2O + O2 => Xanthine + H2O2
directly activates: Catalysis2663

Guanine + H2O => Xanthine + NH3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008892
BFO_0000050: Purine catabolism
directly activates: Xanthine + H2O + O2 => Urate + H2O2
directly activates: Catalysis2664

Hypoxanthine + H2O + O2 => Xanthine + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004855
BFO_0000050: Purine catabolism
directly activates: Xanthine + H2O + O2 => Urate + H2O2
directly activates: 2 H2O2 => O2 + 2 H2O
directly activates: Catalysis2664
directly activates: Catalysis2666

Xanthine + H2O + O2 => Urate + H2O2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004855
BFO_0000050: Purine catabolism
directly activates: 2 H2O2 => O2 + 2 H2O
directly activates: Catalysis2666

2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004602
BFO_0000050: Purine catabolism

2 H2O2 => O2 + 2 H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005782
type: GO_0004096
BFO_0000050: Purine catabolism

L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004088
BFO_0000050: Pyrimidine biosynthesis
directly activates: carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
directly activates: Catalysis2668
label: bicarbonate and glutamine combine to form carbamoyl phosphate

carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004070
BFO_0000050: Pyrimidine biosynthesis
directly activates: N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
directly activates: Catalysis2669
label: carbamoyl phosphate and L-aspartate combine to form N-Carbamoyl-L-aspartate

N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004151
BFO_0000050: Pyrimidine biosynthesis
directly activates: (S)-dihydroorotate + ubiquinone => orotate + ubiquinol
directly activates: Catalysis2670
label: condensation of N-Carbamoyl-L-aspartate to form (S)-Dihydroorotate (ring closure)

(S)-dihydroorotate + ubiquinone => orotate + ubiquinol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004152
BFO_0000050: Pyrimidine biosynthesis
directly activates: orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
directly activates: Catalysis2671
label: oxidation of (S)-Dihydroorotate to form Orotate

orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004588
BFO_0000050: Pyrimidine biosynthesis
directly activates: BiochemicalReaction296
directly activates: decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
directly activates: Catalysis111
directly activates: Catalysis2672
directly activates: Control14
label: phosphoribosylation of orotate to form oritidine 5'-phosphate (OMP)

decarboxylation of Orotidine 5'-phosphate to form Uridine 5'-phosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004590
BFO_0000050: Pyrimidine biosynthesis
directly activates: (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
directly activates: Catalysis2707
label: orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2

dCMP + H2O => dUMP + NH4+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004132
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
directly activates: Catalysis2675
directly activates: Catalysis2709
label: deamination of dCMP to form dUMP

dUTP + H2O => dUMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004170
BFO_0000050: Pyrimidine biosynthesis
directly activates: conversion of dUMP to dTMP
directly activates: Catalysis2675
label: hydrolysis of 2'-deoxyuridine 5'-triphosphate to form 2'-deoxyuridine 5'-phosphate

conversion of dUMP to dTMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004799
BFO_0000050: Pyrimidine biosynthesis
directly activates: dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
directly activates: Catalysis2709
label: dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate

uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004850
BFO_0000050: Pyrimidine salvage reactions

thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016763
BFO_0000050: Pyrimidine salvage reactions

cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
directly activates: Catalysis2707

cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions

phosphorylation of 2'-Deoxythymidine to dTMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
directly activates: Catalysis2709
label: thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]

deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: TK2
type: Restriction
  on property: enabled by
  some values from: TK2
type: Restriction
  on property: enabled by
  some values from: TK2
type: Restriction
  on property: enabled by
  some values from: TK2
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions

(2'-deoxy)cytidine + ATP => (d)CMP + ADP [DCK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Pyrimidine salvage reactions
directly activates: dCMP + H2O => dUMP + NH4+
directly activates: (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
directly activates: Catalysis2673
directly activates: Catalysis2707
label: phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate

(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ [CDA]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004126
BFO_0000050: Pyrimidine salvage reactions
directly activates: (deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
directly activates: Catalysis2689
label: deamination of 2'-Deoxycytidine to 2'-Deoxyuridine

TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate [NT5C1A]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008253
BFO_0000050: Pyrimidine catabolism

(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate [UPP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004850
BFO_0000050: Pyrimidine catabolism

thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016763
BFO_0000050: Pyrimidine catabolism

reduction of uracil to form dihydrouracil
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017113
BFO_0000050: Pyrimidine catabolism
directly activates: 5,6-dihydrouracil + H2O => beta-ureidopropionate
directly activates: Catalysis2692
label: uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+

5,6-dihydrouracil + H2O => beta-ureidopropionate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004157
BFO_0000050: Pyrimidine catabolism
directly activates: beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
directly activates: Catalysis2693
label: conversion of 5,6-dihydrouracil to 3-ureidopropionate

beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003837
BFO_0000050: Pyrimidine catabolism
directly activates: Mitochondrial uptake of beta-alanine
directly activates: BiochemicalReaction5735
directly activates: Catalysis2892
directly activates: Control482
directly activates: Modulation30
label: conversion of 3-ureidopropionate to beta-alanine

Mitochondrial uptake of beta-alanine
type: GO_0003674
BFO_0000050: Pyrimidine catabolism
directly activates: beta-alanine + pyruvate => 3-oxopropanoate + alanine
directly activates: Catalysis2694

beta-alanine + pyruvate => 3-oxopropanoate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0016223
BFO_0000050: Pyrimidine catabolism

reduction of thymine to form 5,6-Dihydrothymine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017113
BFO_0000050: Pyrimidine catabolism
directly activates: 5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
directly activates: Catalysis2696
label: thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+

5,6-dihydrothymine + H2O => beta-ureidoisobutyrate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004157
BFO_0000050: Pyrimidine catabolism
directly activates: beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
directly activates: Catalysis2697
label: conversion of 5,6-Dihydrothymine to 3-Ureidoisobutyrate

beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003837
BFO_0000050: Pyrimidine catabolism
directly activates: Mitochondrial uptake of (R)-3-aminoisobutyric acid
label: conversion of 3-Ureidoiosbutyrate to 3-Aminoisobutyrate

Mitochondrial uptake of (R)-3-aminoisobutyric acid
type: GO_0003674
BFO_0000050: Pyrimidine catabolism
directly activates: (R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
directly activates: Catalysis2698

(R)-3-aminoisobutyric acid + pyruvate => 2-methyl-3-oxopropanoate + alanine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047305
BFO_0000050: Pyrimidine catabolism

(d)AMP + ATP <=> (d)ADP + ADP [AK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004017
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: BiochemicalReaction5347
directly activates: NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2572
directly activates: Catalysis2713
directly activates: Catalysis2714
directly activates: Control465
directly activates: Control466
directly activates: Control467
directly activates: Control468

(d)ADP + ADP <=> (d)AMP + ATP [AK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004017
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

AMP + ATP <=> ADP + ADP [AK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: enabled by
  some values from: ADK2
type: Restriction
  on property: enabled by
  some values from: ADK2
type: GO_0004017
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

ADP + ADP <=> AMP + ATP [AK2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005758
type: Restriction
  on property: enabled by
  some values from: ADK2
type: Restriction
  on property: enabled by
  some values from: ADK2
type: GO_0004017
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)AMP or (d)CMP + ATP <=> (d)ADP or (d)CDP + ADP [AK5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP [AK5]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0019206
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)GMP + ATP <=> (d)GDP + ADP [GUK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GMK
type: Restriction
  on property: enabled by
  some values from: GMK
type: GO_0004385
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: (d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
directly activates: Catalysis2713
directly activates: Catalysis2714
directly activates: Catalysis2719
directly activates: Control465
directly activates: Control466
directly activates: Control467
directly activates: Control468

(d)GDP + ADP <=> (d)GMP + ATP [GUK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GMK
type: Restriction
  on property: enabled by
  some values from: GMK
type: GO_0004385
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP [CMPK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CMK
type: Restriction
  on property: enabled by
  some values from: CMK
type: GO_0050145
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: (d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
directly activates: Catalysis2713
directly activates: Catalysis2714
directly activates: Catalysis2719
directly activates: Control465
directly activates: Control466
directly activates: Control467
directly activates: Control468

(d)CDP or UDP + ADP <=> (d)CMP or UMP + ATP [CMPK1]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: CMK
type: Restriction
  on property: enabled by
  some values from: CMK
type: GO_0050145
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: dCMP + H2O => dUMP + NH4+
directly activates: Catalysis2673

dUMP or TMP + ATP <=> dUDP or TDP + ADP [DTYMK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050145
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: (d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
directly activates: Catalysis2719
label: phosphorylation of dUMP or TMP to dUDP or TDP

dUDP or TDP + ADP <=> dUMP or TMP + ATP [DTYMK]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0050145
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003883
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: (d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3]
directly activates: Catalysis2720
label: amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003883
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
label: amination of uridine 5'-triphosphate (UTP) to form cytidine 5'-triphosphate (CTP)

NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0036175
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
label: Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (glutaredoxin)

NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0036175
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
label: Reduction of cytosolic ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)

NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004748
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
label: Reduction of nuclear ribonucleoside 5'-diphosphates to deoxyribonucleoside 5'-diphosphates (thioredoxin)

glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: GLRX
type: Restriction
  on property: enabled by
  some values from: GLRX
type: GO_0015038
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: NDP + reduced glutaredoxin => dNDP + oxidized glutaredoxin + H2O
directly activates: glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
directly activates: Catalysis2713
directly activates: Catalysis2717
directly activates: Control465
directly activates: Control466

glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004362
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O
directly activates: Catalysis2665

thioredoxin, oxidized (nucleus) <=> thioredoxin, oxidized (cytosol)
type: GO_0003674
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

regeneration of active (reduced) Thioredoxin
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004791
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2714
directly activates: Control467
directly activates: Control468
label: thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+

thioredoxin, reduced (cytosol) <=> thioredoxin, reduced (nucleus)
type: GO_0003674
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2715

(d)NDP + ATP <=> (d)NTP + ADP [NME1,2,3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004550
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)NTP + ADP <=> (d)NDP + ATP [NME1,2,3]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004550
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)NDP + ATP <=> (d)NTP + ADP [NME4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004550
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

(d)NTP + ADP <=> (d)NDP + ATP [NME4]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005743
type: GO_0004550
BFO_0000050: Synthesis and interconversion of nucleotide di- and triphosphates

adenosine 5'-diphosphate (cytosolic) <=> adenosine 5'-diphosphate (nuclear)
type: GO_0003674
BFO_0000050: Metabolism of nucleotides
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2715

cytidine 5'-diphosphate (cytosolic) <=> cytidine 5'-diphosphate (nuclear)
type: GO_0003674
BFO_0000050: Metabolism of nucleotides
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2715

guanosine 5'-diphosphate (cytosolic) <=> guanosine 5'-diphosphate (nuclear)
type: GO_0003674
BFO_0000050: Metabolism of nucleotides
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2715

uridine 5'-diphosphate (cytosolic) <=> uridine 5'-diphosphate (nuclear)
type: GO_0003674
BFO_0000050: Metabolism of nucleotides
directly activates: NDP + reduced thioredoxin => dNDP + oxidized thioredoxin + H2O
directly activates: Catalysis2715

ITP + H2O => IMP + PPi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0036220
BFO_0000050: Metabolism of nucleotides
label: ITPA hydrolyses ITP to IMP

ITPA hydrolyses dITP to dIMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035870
BFO_0000050: Metabolism of nucleotides
label: dITP + H2O => dIMP + PPi

ITPA hydrolyses XTP to XMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0036222
BFO_0000050: Metabolism of nucleotides
label: XTP + H2O => XMP + PPi

8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035539
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT1 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

8-oxo-dGTP + H2O => 8-oxo-dGMP + PPi (NUDT15)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MTH2
type: Restriction
  on property: enabled by
  some values from: MTH2
type: GO_0035539
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT15 hydrolyses 8-oxo-dGTP to 8-oxo-dGMP

8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT15)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MTH2
type: Restriction
  on property: enabled by
  some values from: MTH2
type: GO_0017110
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

8-oxo-dGDP + H2O => 8-oxo-dGMP + Pi (NUDT18)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MTH3
type: Restriction
  on property: enabled by
  some values from: MTH3
type: GO_0044715
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT18 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP

8-oxo-GDP + H2O => 8-oxo-GMP + Pi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MTH3
type: Restriction
  on property: enabled by
  some values from: MTH3
type: GO_0044715
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT18 hydrolyses 8-oxo-GDP to 8-oxo-GMP

2-hydroxy-dATP + H2O => 2-hydroxy-dAMP + PPi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0044714
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT1 hydrolyses 2-OH-dATP to 2-OH-dAMP

2-hydroxy-ATP + H2O => 2-hydroxy-AMP + PPi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0044713
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT1 hydrolyses 2-OH-ATP to 2-OH-AMP

8-hydroxy-dADP + H2O => 8-hydroxy-dAMP + Pi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MTH3
type: Restriction
  on property: enabled by
  some values from: MTH3
type: GO_0044717
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT18 hydrolyses 8-OH-dADP to 8-OH-dAMP

NUDT16 hydrolyses dIDP to dIMP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0097383
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: dIDP + H2O => dIMP + Pi

IDP + H2O => IMP + Pi
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0090450
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: NUDT16 hydrolyses IDP to IMP

ADP-ribose + H2O => AMP + D-ribose 5-phosphate (cytosolic)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047631
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: Cytosolic NUDT5 hydrolyses ADP-ribose to R5P and AMP

ADP-ribose + H2O => AMP + D-ribose 5-phosphate (mitochondrial)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0047631
BFO_0000050: Phosphate bond hydrolysis by NUDT proteins
label: Mitochondrial NUDT9 hydrolyses ADP-ribose to R5P and AMP

Metabolism of nucleotides
type: GO_0008150
label: Nucleotide metabolism

Purine metabolism
type: GO_0008150
BFO_0000050: Metabolism of nucleotides

Purine ribonucleoside monophosphate biosynthesis
type: GO_0008150
BFO_0000050: Purine metabolism

Purine salvage
type: GO_0008150
BFO_0000050: Purine metabolism

Purine catabolism
type: GO_0008150
BFO_0000050: Purine metabolism

Pyrimidine metabolism
type: GO_0008150
BFO_0000050: Metabolism of nucleotides

Pyrimidine biosynthesis
type: GO_0008150
BFO_0000050: Pyrimidine metabolism

Pyrimidine salvage reactions
type: GO_0008150
BFO_0000050: Pyrimidine metabolism

Pyrimidine catabolism
type: GO_0008150
BFO_0000050: Pyrimidine metabolism

Synthesis and interconversion of nucleotide di- and triphosphates
type: GO_0008150
BFO_0000050: Metabolism of nucleotides

Phosphate bond hydrolysis by NUDT proteins
type: GO_0008150
BFO_0000050: Metabolism of nucleotides