LIG1
label: UniProt:P18858 LIG1

FEN1
label: RAD2
label: UniProt:P39748 FEN1

RFC binding displaces Pol Alpha
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Loading of PCNA - Sliding Clamp Formation

Loading of PCNA - Sliding Clamp Formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: RFC dissociates after sliding clamp formation

RFC dissociates after sliding clamp formation
type: GO_0003674
BFO_0000050: Polymerase switching
directly activates: Formation of Processive Complex

Formation of Processive Complex
type: GO_0003674
BFO_0000050: Polymerase switching

Formation of Okazaki fragments
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003887
BFO_0000050: Processive synthesis on the lagging strand
directly activates: Formation of the Flap Intermediate

Formation of the Flap Intermediate
type: GO_0003674
BFO_0000050: Processive synthesis on the lagging strand
directly activates: RPA binds to the Flap
directly activates: Removal of the Flap Intermediate

RPA binds to the Flap
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Recruitment of Dna2 endonuclease

Recruitment of Dna2 endonuclease
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of RNA primer and dissociation of RPA and Dna2

Removal of RNA primer and dissociation of RPA and Dna2
type: GO_0003674
BFO_0000050: Removal of the Flap Intermediate
directly activates: Removal of remaining Flap
directly activates: Catalysis15

Removal of remaining Flap
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: enabled by
  some values from: FEN1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: FEN1
type: GO_0017108
BFO_0000050: Removal of the Flap Intermediate

Joining of adjacent Okazaki fragments
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: enabled by
  some values from: LIG1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003909
BFO_0000050: Processive synthesis on the lagging strand

Polymerase switching
type: GO_0008150
BFO_0000050: Lagging Strand Synthesis

Lagging Strand Synthesis
type: GO_0008150

Processive synthesis on the lagging strand
type: GO_0008150
BFO_0000050: Lagging Strand Synthesis

Removal of the Flap Intermediate
type: GO_0008150
BFO_0000050: Processive synthesis on the lagging strand