LIG1
UniProt:P18858 LIG1
FEN1
RAD2
UniProt:P39748 FEN1
RFC binding displaces Pol Alpha
Loading of PCNA - Sliding Clamp Formation
RFC dissociates after sliding clamp formation
Formation of Processive Complex
Formation of Okazaki fragments
Formation of the Flap Intermediate
RPA binds to the Flap
Recruitment of Dna2 endonuclease
Removal of RNA primer and dissociation of RPA and Dna2
Removal of remaining Flap
Joining of adjacent Okazaki fragments
Polymerase switching
Lagging Strand Synthesis
Processive synthesis on the lagging strand
Removal of the Flap Intermediate