SRC
label: SRC1
label: UniProt:P12931-1 SRC

PTP1B
label: PTPN1
label: UniProt:P18031 PTPN1

Integrin alpha5beta1 binds fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions
directly activates: BiochemicalReaction2118

Integrin alpha2beta1 collagen adhesion
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Translocation of RIAM to plasma membrane
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activation of Talin

Activation of Talin
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Integrin alphaIIb beta3 activation

Integrin alphaIIb beta3 activation
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Interaction of integrin alphaIIb beta3 with Fibrinogen
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Interaction of integrin alphaIIb beta3 with Fibrinogen
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Clustering of Integrin alphaIIb beta3 complexes

Clustering of Integrin alphaIIb beta3 complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Release of CSK from SRC

Release of CSK from SRC
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Dephosphorylation of inactive SRC by PTPB1
directly activates: Catalysis1029

Dephosphorylation of inactive SRC by PTPB1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: enabled by
  some values from: PTP1B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004725
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of SRC
directly activates: Catalysis1030

Autophosphorylation of SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: enabled by
  some values from: SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of FADK1 to Focal complexes
directly activates: SYK binds to integrin alphaIIb beta3

Translocation of FADK1 to Focal complexes
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Autophosphorylation of FADK1 at Y397
directly activates: Catalysis1031

Autophosphorylation of FADK1 at Y397
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Phosphorylation of pFADK1 by SRC
directly activates: Catalysis1032

Phosphorylation of pFADK1 by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Recruitment of GRB2 to p-FADK1
directly activates: Recruitment of p130Cas to FADK1

Recruitment of GRB2 to p-FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins
directly activates: Interaction of SOS with GRB2 bound to FADK1

Interaction of SOS with GRB2 bound to FADK1
type: GO_0003674
BFO_0000050: GRB2:SOS provides linkage to MAPK signaling for Intergrins

Recruitment of p130Cas to FADK1
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Phosphorylation of p130Cas by SRC-FADK1 complex
directly activates: Catalysis1033

Phosphorylation of p130Cas by SRC-FADK1 complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004672
BFO_0000050: p130Cas linkage to MAPK signaling for integrins
directly activates: Crk binding to p130cas

Crk binding to p130cas
type: GO_0003674
BFO_0000050: p130Cas linkage to MAPK signaling for integrins

Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Activated integrin alphaIIb beta3 binds SHC1

Activated integrin alphaIIb beta3 binds SHC1
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow

SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SHC1 dissociates from integrin alphaIIb beta3

SHC1 dissociates from integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: BiochemicalReaction3816

SYK binds to integrin alphaIIb beta3
type: GO_0003674
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: SYK activation by SRC
directly activates: Catalysis1035

SYK activation by SRC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004713
BFO_0000050: Integrin alphaIIb beta3 signaling

MAC1 binds JAM-C
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

VLA-4 binds JAM-B
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

LFA1 binds JAM-A
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Integrin alphaXbeta2 binds JAM-C
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with PECAM-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Basigin binds to integrins
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha1beta1 with Type IV collagen
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha1beta1 with Laminin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha2beta1 with Lamini-5
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha3beta1 with Laminin-5
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha3beta1 with Thrombospondin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha4beta1 with Fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha4beta1 with Thrombospondin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha4beta1 with Osteopontin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha5beta1 with Osteopontin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha6beta1 with Laminin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha6beta4 with Laminin-5
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha7beta1 with Laminin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha7beta1 with Laminin-2
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha8beta1 with Fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha8beta1 with Osteopontin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha8beta1 with Tenascin-c
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha9beta1 with Osteopontin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha9beta1 with VCAM-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha9beta1 with tenascin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha10beta1 with Collagen-II
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alpha11beta1 with Collagen-I
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaDbeta2 with fibrin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta1 with FN1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta5 with vitronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta6 with Fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta8 with vitronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaXbeta2 with fibrin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with Bone sialoprotein 2
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with vitronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with Fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with Tenascin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with Fibrillin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaVbeta3 with von Willbrand Factor
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaEbeta7 with Cadherin-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaIIbbeta3 with Fibronectin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Adhesion of integrin alphaIIbbeta3 to fibrin network
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaIIbbeta3 with von Willebrand factor
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Interaction of integrin alphaIIb beta 3 with Thrombospondin
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

VCAM-1interacts with VLA-4
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

MADCAM interacts with Integrin alpha4beta7
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

ICAMs 1-4 bind to Integrin LFA-1
type: GO_0003674
BFO_0000050: Integrin cell surface interactions

Activation of Rap1 by membrane-associated GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Activation of Rap1 by cytosolic GEFs
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Integrin alphaIIb beta3 signaling
directly activates: Translocation of RIAM to plasma membrane
directly activates: BiochemicalReaction852
directly activates: BiochemicalReaction853
directly activates: Catalysis323

Integrin cell surface interactions
type: GO_0008150

Integrin alphaIIb beta3 signaling
type: GO_0008150
BFO_0000050: Integrin cell surface interactions

GRB2:SOS provides linkage to MAPK signaling for Intergrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling

p130Cas linkage to MAPK signaling for integrins
type: GO_0008150
BFO_0000050: Integrin alphaIIb beta3 signaling