INPP5B
label: OCRL2
label: UniProt:P32019 INPP5B

IMPK
label: IPMK
label: UniProt:Q8NFU5 IPMK

C9orf12
label: IPPK
label: UniProt:Q9H8X2 IPPK

MINPP1
label: MIPP
label: UNQ900/PRO1917
label: UniProt:Q9UNW1 MINPP1

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004435
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: BiochemicalReaction1244
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
directly activates: I(1,4,5)P3 transports from the cytosol to the nucleus
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
directly activates: BiochemicalReaction715
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063
directly activates: Catalysis438
directly activates: Control91

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0004435
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: BiochemicalReaction1244
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
directly activates: I(1,4,5)P3 transports from the cytosol to the nucleus
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
directly activates: BiochemicalReaction715
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063
directly activates: Catalysis438
directly activates: Control91

PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by PLCD4 at the ER membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004435
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
directly activates: I(1,4,5)P3 transports from the cytosol to the nucleus
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
directly activates: BiochemicalReaction715
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008440
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
directly activates: I(1,3,4,5)P4 transports from the cytosol to the nucleus
directly activates: I(1,3,4,5)P4 transports from the cytosol to the ER lumen
directly activates: Catalysis2026
directly activates: Catalysis2027
directly activates: Catalysis2028

I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0051717
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
directly activates: I(1,4,5)P3 transports from the cytosol to the nucleus
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
directly activates: BiochemicalReaction715
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052659
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
directly activates: Catalysis2029
directly activates: Catalysis2030
directly activates: Catalysis2067
directly activates: Catalysis2068

I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
type: Restriction
  on property: enabled by
  some values from: INPP5B
type: Restriction
  on property: enabled by
  some values from: INPP5B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0052659
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
directly activates: Catalysis2029
directly activates: Catalysis2030
directly activates: Catalysis2067
directly activates: Catalysis2068

I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052726
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
directly activates: I(1,3,4,5)P4 transports from the cytosol to the nucleus
directly activates: I(1,3,4,5)P4 transports from the cytosol to the ER lumen
directly activates: Catalysis2026
directly activates: Catalysis2027
directly activates: Catalysis2028

I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052725
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
directly activates: I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
directly activates: I(1,3,4,6)P4 transports from the cytosol to the nucleus
directly activates: Catalysis2031
directly activates: Catalysis2032

I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052830
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
directly activates: I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
directly activates: Catalysis2029
directly activates: Catalysis2030
directly activates: Catalysis2067
directly activates: Catalysis2068

I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052831
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
directly activates: Catalysis2033

I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052835
BFO_0000050: Synthesis of IP3 and IP4 in the cytosol
directly activates: I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
directly activates: I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
directly activates: I(1,3,4,6)P4 transports from the cytosol to the nucleus
directly activates: Catalysis2031
directly activates: Catalysis2032

I(1,4,5)P3 transports from the cytosol to the nucleus
type: GO_0003674
BFO_0000050: IP3 and IP4 transport between cytosol and nucleus
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
directly activates: Catalysis2034

I(1,3,4,5)P4 transports from the cytosol to the nucleus
type: GO_0003674
BFO_0000050: IP3 and IP4 transport between cytosol and nucleus
directly activates: I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
directly activates: Catalysis2035

I(1,3,4,6)P4 transports from the cytosol to the nucleus
type: GO_0003674
BFO_0000050: IP3 and IP4 transport between cytosol and nucleus
directly activates: I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
directly activates: Catalysis2036

I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0008440
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
directly activates: Catalysis2035

I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000825
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
directly activates: I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
directly activates: Catalysis2038
directly activates: Catalysis2039

I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0047326
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
directly activates: I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
directly activates: Catalysis2038
directly activates: Catalysis2039

I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: enabled by
  some values from: IMPK
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000824
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
directly activates: I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
directly activates: Catalysis2038
directly activates: Catalysis2039

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
type: Restriction
  on property: enabled by
  some values from: C9orf12
type: Restriction
  on property: enabled by
  some values from: C9orf12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0035299
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
directly activates: IP6 transports from the nucleus to the ER lumen
directly activates: Catalysis2041

I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000827
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: 5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus
directly activates: 5-PP-IP4 transports from the nucleus to the cytosol
directly activates: Catalysis2040

5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0052839
BFO_0000050: Synthesis of IPs in the nucleus

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000828
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus
directly activates: 5-PP-IP5 transports from the nucleus to the cytosol
directly activates: Catalysis2042

5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0052836
BFO_0000050: Synthesis of IPs in the nucleus

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0000829
BFO_0000050: Synthesis of IPs in the nucleus
directly activates: (PP)2-IP4 transports from the nucleus to the cytosol

I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between nucleus and cytosol
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
directly activates: Catalysis2044
directly activates: Catalysis2046
directly activates: Catalysis2047

5-PP-IP4 transports from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between nucleus and cytosol
directly activates: PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol
directly activates: 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
directly activates: Catalysis2048
directly activates: Catalysis2049

5-PP-IP5 transports from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between nucleus and cytosol
directly activates: 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
directly activates: Catalysis2051
directly activates: Catalysis2054
directly activates: Catalysis2055

(PP)2-IP4 transports from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between nucleus and cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
directly activates: Catalysis2056
directly activates: Catalysis2058

I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052825
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol
directly activates: Catalysis2045

I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0047325
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
directly activates: Catalysis2044
directly activates: Catalysis2046
directly activates: Catalysis2047

I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
type: Restriction
  on property: enabled by
  some values from: C9orf12
type: Restriction
  on property: enabled by
  some values from: C9orf12
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0035299
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
directly activates: IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
directly activates: IP6 transports from the cytosol to the nucleus
directly activates: IP6 transports from the cytosol to the ER lumen
directly activates: Catalysis2050
directly activates: Catalysis2052

I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000827
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol
directly activates: 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
directly activates: Catalysis2048
directly activates: Catalysis2049

PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052840
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
directly activates: Catalysis2044
directly activates: Catalysis2046
directly activates: Catalysis2047

1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052839
BFO_0000050: Synthesis of pyrophosphates in the cytosol

IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000828
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
directly activates: Catalysis2051
directly activates: Catalysis2054
directly activates: Catalysis2055

5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052842
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
directly activates: IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
directly activates: IP6 transports from the cytosol to the nucleus
directly activates: IP6 transports from the cytosol to the ER lumen
directly activates: Catalysis2050
directly activates: Catalysis2052

IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000828
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
directly activates: 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
directly activates: 1/3-PP-IP5 transports from the cytosol to the nucleus
directly activates: Catalysis2053
directly activates: Catalysis2057

1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052842
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
directly activates: IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
directly activates: IP6 transports from the cytosol to the nucleus
directly activates: IP6 transports from the cytosol to the ER lumen
directly activates: Catalysis2050
directly activates: Catalysis2052

5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052836
BFO_0000050: Synthesis of pyrophosphates in the cytosol

5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000829
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
directly activates: Catalysis2056
directly activates: Catalysis2058

(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052841
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: 5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
directly activates: 5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
directly activates: Catalysis2051
directly activates: Catalysis2054
directly activates: Catalysis2055

1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000829
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol
directly activates: (PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
directly activates: Catalysis2056
directly activates: Catalysis2058

(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052841
BFO_0000050: Synthesis of pyrophosphates in the cytosol
directly activates: 1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
directly activates: 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
directly activates: 1/3-PP-IP5 transports from the cytosol to the nucleus
directly activates: Catalysis2053
directly activates: Catalysis2057

IP6 transports from the cytosol to the nucleus
type: GO_0003674
BFO_0000050: IP6 and IP7 transport between cytosol and nucleus
directly activates: IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
directly activates: IP6 transports from the nucleus to the ER lumen
directly activates: Catalysis2041

1/3-PP-IP5 transports from the cytosol to the nucleus
type: GO_0003674
BFO_0000050: IP6 and IP7 transport between cytosol and nucleus
directly activates: 1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
directly activates: Catalysis2043

I(1,3,4,5)P4 transports from the cytosol to the ER lumen
type: GO_0003674
BFO_0000050: IPs transport between cytosol and ER lumen
directly activates: I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen
directly activates: Catalysis2059

I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
type: GO_0003674
BFO_0000050: IPs transport between cytosol and ER lumen
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
directly activates: I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus
directly activates: Catalysis2060

IP6 transports from the cytosol to the ER lumen
type: GO_0003674
BFO_0000050: IPs transport between cytosol and ER lumen
directly activates: IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
directly activates: Catalysis2061

I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0051717
BFO_0000050: Synthesis of IPs in the ER lumen
directly activates: I(1,4,5)P3 transports from the ER lumen to the cytosol

I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0030351
BFO_0000050: Synthesis of IPs in the ER lumen
directly activates: I(1,4,5,6)P4 transports from the ER lumen to the nucleus

IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: enabled by
  some values from: MINPP1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005788
type: GO_0052826
BFO_0000050: Synthesis of IPs in the ER lumen
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
directly activates: I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus
directly activates: Catalysis2060

I(1,4,5)P3 transports from the ER lumen to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between ER lumen and cytosol
directly activates: I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
directly activates: I(1,4,5)P3 transports from the cytosol to the nucleus
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
directly activates: I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
directly activates: BiochemicalReaction715
directly activates: Catalysis2025
directly activates: Catalysis2062
directly activates: Catalysis2063

I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol
type: GO_0003674
BFO_0000050: IPs transport between ER lumen and cytosol
directly activates: I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
directly activates: I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
directly activates: Catalysis2044
directly activates: Catalysis2046
directly activates: Catalysis2047

I(1,4,5,6)P4 transports from the ER lumen to the nucleus
type: GO_0003674
BFO_0000050: IPs transport between ER lumen and nucleus
directly activates: I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
directly activates: Catalysis2037

I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus
type: GO_0003674
BFO_0000050: IPs transport between ER lumen and nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
directly activates: I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
directly activates: I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
directly activates: Catalysis2038
directly activates: Catalysis2039

IP6 transports from the nucleus to the ER lumen
type: GO_0003674
BFO_0000050: IPs transport between nucleus and ER lumen
directly activates: IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
directly activates: Catalysis2061

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052658
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
directly activates: Catalysis2064

I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0052658
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
directly activates: Catalysis2064

I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004441
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol
directly activates: Catalysis2065

I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052833
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol

I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0008934
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol

I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017161
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol

I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052829
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol
directly activates: Catalysis2069

I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052828
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol
directly activates: Catalysis2071

Glc6P is isomerised to I3P by ISYNA1 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004512
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol
directly activates: I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol
directly activates: Catalysis2071

I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0052832
BFO_0000050: Synthesis of IP2, IP, and Ins in the cytosol

Inositol phosphate metabolism
type: GO_0008150

Synthesis of IP3 and IP4 in the cytosol
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IP3 and IP4 transport between cytosol and nucleus
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

Synthesis of IPs in the nucleus
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IPs transport between nucleus and cytosol
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

Synthesis of pyrophosphates in the cytosol
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IP6 and IP7 transport between cytosol and nucleus
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IPs transport between cytosol and ER lumen
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

Synthesis of IPs in the ER lumen
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IPs transport between ER lumen and cytosol
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IPs transport between ER lumen and nucleus
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

IPs transport between nucleus and ER lumen
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism

Synthesis of IP2, IP, and Ins in the cytosol
type: GO_0008150
BFO_0000050: Inositol phosphate metabolism