INPP5B
OCRL2
UniProt:P32019 INPP5B
IMPK
IPMK
UniProt:Q8NFU5 IPMK
C9orf12
IPPK
UniProt:Q9H8X2 IPPK
MINPP1
MIPP
UniProt:Q9UNW1 MINPP1
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane
PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by PLCD4 at the ER membrane
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by PTEN in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5[3]/ITPK1 in the cytosol
I(1,3,4,5)P4 is dephosphorylated to I(1,3,4)P3 by INPP5B at the plasma membrane
I(1,3,4)P3 is phosphorylated to I(1,3,4,5)P4 by ITPK1 in the cytosol
I(1,3,4)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
I(1,3,4,6)P4 is dephosphorylated to I(1,3,4)P3 by ITPK1 in the cytosol
I(1,3,4,6)P4 is dephosphorylated to I(3,4,6)P3 by ITPK1 in the cytosol
I(3,4,6)P3 is phosphorylated to I(1,3,4,6)P4 by ITPK1 in the cytosol
I(1,4,5)P3 transports from the cytosol to the nucleus
I(1,3,4,5)P4 transports from the cytosol to the nucleus
I(1,3,4,6)P4 transports from the cytosol to the nucleus
I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus
I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
I(1,3,4,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK (IP5-2K) in the nucleus
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus
5-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/2 in the nucleus
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/2 in the nucleus
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus
I(1,3,4,5,6)P5 transports from the nucleus to the cytosol
5-PP-IP4 transports from the nucleus to the cytosol
5-PP-IP5 transports from the nucleus to the cytosol
(PP)2-IP4 transports from the nucleus to the cytosol
I(1,3,4,5,6)P5 is dephosphorylated to I(3,4,5,6)P4 by ITPK1 in the cytosol
I(3,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by ITPK1 in the cytosol
I(1,3,4,5,6)P5 is phosphorylated to IP6 by IPPK in the cytosol
I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol
PP-IP4 is dephosphorylated to I(1,3,4,5,6)P5 by NUDT4 in the cytosol
1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol
5-PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol
1/3 PP-IP5 is dephosphorylated to IP6 by NUDT(1) in the cytosol
5-PP-IP5 is phosphorylated to 5-PPP-IP5 by IP6K1/3 in the cytosol
5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol
(PP)2-IP4 is dephosphorylated to 5-PP-IP5 by NUDT(1) in the cytosol
1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol
(PP)2-IP4 is dephosphorylated to 1/3-PP-IP5 by NUDT(1) in the cytosol
IP6 transports from the cytosol to the nucleus
1/3-PP-IP5 transports from the cytosol to the nucleus
I(1,3,4,5)P4 transports from the cytosol to the ER lumen
I(1,3,4,5,6)P5 transports from the cytosol to the ER lumen
IP6 transports from the cytosol to the ER lumen
I(1,3,4,5)P4 is dephosphorylated to I(1,4,5)P3 by MINPP1 in the ER lumen
I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen
IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen
I(1,4,5)P3 transports from the ER lumen to the cytosol
I(1,3,4,5,6)P5 transports from the ER lumen to the cytosol
I(1,4,5,6)P4 transports from the ER lumen to the nucleus
I(1,3,4,5,6)P5 transports from the ER lumen to the nucleus
IP6 transports from the nucleus to the ER lumen
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5(4) in the cytosol
I(1,4,5)P3 is dephosphorylated to I(1,4)P2 by INPP5A/B at the plasma membrane
I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol
I4P is dephosphorylated to Ins by IMPA1/2 in the cytosol
I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol
I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol
I(1,3,4)P3 is dephosphorylated to I(3,4)P2 by INPP1 in the cytosol
I(3,4)P2 is dephosphorylated to I3P by INPP4A/B in the cytosol
Glc6P is isomerised to I3P by ISYNA1 in the cytosol
I3P is dephosphorylated to Ins by IMPA1/2 in the cytosol
Inositol phosphate metabolism
Synthesis of IP3 and IP4 in the cytosol
IP3 and IP4 transport between cytosol and nucleus
Synthesis of IPs in the nucleus
IPs transport between nucleus and cytosol
Synthesis of pyrophosphates in the cytosol
IP6 and IP7 transport between cytosol and nucleus
IPs transport between cytosol and ER lumen
Synthesis of IPs in the ER lumen
IPs transport between ER lumen and cytosol
IPs transport between ER lumen and nucleus
IPs transport between nucleus and ER lumen
Synthesis of IP2, IP, and Ins in the cytosol