IDUA
label: UniProt:P35475 IDUA

HSS
label: SGSH
label: UniProt:P51688 SGSH

NAGLU
label: UFHSD1
label: UniProt:P54802 NAGLU

HPA2
label: HPSE2
label: UniProt:Q8WWQ2 HPSE2

HS-GAGs translocate to the lysosome for degradation
type: GO_0003674
BFO_0000050: HS-GAG degradation
directly activates: Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
directly activates: Catalysis1330

Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0030305
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1332

Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
type: Restriction
  on property: enabled by
  some values from: HPA2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0030305
BFO_0000050: HS-GAG degradation

Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1333

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
directly activates: Catalysis1334

HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
directly activates: Catalysis1335

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
directly activates: Catalysis1336

Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004423
BFO_0000050: HS-GAG degradation
directly activates: Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
directly activates: Catalysis1337

Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
type: Restriction
  on property: enabled by
  some values from: IDUA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0003940
BFO_0000050: HS-GAG degradation
directly activates: N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
directly activates: Catalysis1338

N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
type: Restriction
  on property: enabled by
  some values from: HSS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0016250
BFO_0000050: HS-GAG degradation
directly activates: HGSNAT acetylates another terminal N-glucosamine in heparan
directly activates: Catalysis1339

HGSNAT acetylates another terminal N-glucosamine in heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005765
type: GO_0015019
BFO_0000050: HS-GAG degradation
directly activates: Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
directly activates: Catalysis1340

Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: Restriction
  on property: enabled by
  some values from: NAGLU
type: GO_0004561
BFO_0000050: HS-GAG degradation
directly activates: Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
directly activates: Catalysis1341
directly activates: Control223

Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004566
BFO_0000050: HS-GAG degradation
directly activates: Beta-galactosidase (GLB1) can cleave galactose from the linker chain
directly activates: Catalysis1342

Beta-galactosidase (GLB1) can cleave galactose from the linker chain
type: Restriction
  on property: BFO_0000066
  some values from: GO_0043202
type: GO_0004565
BFO_0000050: HS-GAG degradation

HS-GAG degradation
type: GO_0008150