IDUA
UniProt:P35475 IDUA
HSS
SGSH
UniProt:P51688 SGSH
NAGLU
UFHSD1
UniProt:P54802 NAGLU
HPA2
HPSE2
UniProt:Q8WWQ2 HPSE2
HS-GAGs translocate to the lysosome for degradation
Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)
Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)
Alpha-L-iduronidase (IDUA) hydrolyses the unsulfated alpha-L-iduronosidic linkage in heparan sulfate
N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses sulfate from the N-sulphoglucosamine residue of heparan sulfate
HGSNAT acetylates the terminal N-glucosamine in heparan sulfate
Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses N-acetyl-D-glucosamine residues from heparan sulfate
Iduronate 2-sulfatase (IDS) hydrolyses sulfates from L-iduronate 2-sulfate units of heparan sulfate
Alpha-L-iduronidase (IDUA) hydrolyses another unsulfated alpha-L-iduronosidic linkage in heparan sulfate
N-sulphoglucosamine sulphohydrolase (SGSH) hydrolyses another sulfate from the N-sulphoglucosamine residue of heparan sulfate
HGSNAT acetylates another terminal N-glucosamine in heparan
Alpha-N-acetylglucosaminidase (NAGLU) hydrolyses another N-acetyl-D-glucosamine residue from heparan
Beta-glucuronidase (GUSB) hydrolyses glucuronate from the linker chain
Beta-galactosidase (GLB1) can cleave galactose from the linker chain
HS-GAG degradation