Glutamate and cysteine combine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004357
BFO_0000050: Glutathione synthesis and recycling
directly activates: Formation of 5-oxoproline from gamma-glutamylcysteine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis3059
directly activates: Catalysis3060
directly activates: Control489

A dipeptidase cleaves cysteinylglycine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004180
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: gamma-glutamylcysteine combines with glycine to form glutathione
directly activates: Catalysis2956
directly activates: Catalysis3060
directly activates: Control489

Cleavage of 5-oxoproline to form glutamate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0017168
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutamate and cysteine combine
directly activates: Catalysis2956

Formation of 5-oxoproline from gamma-glutamylcysteine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

gamma-glutamylcysteine combines with glycine to form glutathione
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004363
BFO_0000050: Glutathione synthesis and recycling
directly activates: Export of glutathione to the extracellular space
directly activates: Glutathione conjugation of luminal substrates
directly activates: GST dimers conjugate GSH with cytosolic substrates
directly activates: Catalysis3063
directly activates: Catalysis3064

Export of glutathione to the extracellular space
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: Glutathione is hydrolyzed
directly activates: Catalysis3061

Glutathione is hydrolyzed
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005886
type: GO_0003840
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cysteinylglycine and gamma-glutamate:AA are imported into the cell

Cysteinylglycine and gamma-glutamate:AA are imported into the cell
type: GO_0003674
BFO_0000050: Glutathione synthesis and recycling
directly activates: A dipeptidase cleaves cysteinylglycine
directly activates: 5-oxoproline can be formed from gamma-glutamyl-AA products
directly activates: Catalysis2957
directly activates: Catalysis3062

5-oxoproline can be formed from gamma-glutamyl-AA products
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003839
BFO_0000050: Glutathione synthesis and recycling
directly activates: Cleavage of 5-oxoproline to form glutamate
directly activates: Catalysis3058

Glutathione conjugation of luminal substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: MGST trimers conjugate GSH with luminal substrates

GST dimers conjugate GSH with cytosolic substrates
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004364
BFO_0000050: Glutathione conjugation
label: Glutathione conjugation of cytosolic substrates

Glutathione conjugation
type: GO_0008150

Glutathione synthesis and recycling
type: GO_0008150
BFO_0000050: Glutathione conjugation