Glutamate and cysteine combine
A dipeptidase cleaves cysteinylglycine
Cleavage of 5-oxoproline to form glutamate
Formation of 5-oxoproline from gamma-glutamylcysteine
gamma-glutamylcysteine combines with glycine to form glutathione
Export of glutathione to the extracellular space
Glutathione is hydrolyzed
Cysteinylglycine and gamma-glutamate:AA are imported into the cell
5-oxoproline can be formed from gamma-glutamyl-AA products
Glutathione conjugation of luminal substrates
MGST trimers conjugate GSH with luminal substrates
GST dimers conjugate GSH with cytosolic substrates
Glutathione conjugation of cytosolic substrates
Glutathione conjugation
Glutathione synthesis and recycling