NARS
label: UniProt:O43776 NARS

FARS1
label: FARS2
label: HSPC320
label: UniProt:O95363 FARS2

HARS
label: HRS
label: UniProt:P12081 HARS

PKCA
label: PRKACA
label: PRKCA
label: UniProt:P17252 PRKCA

EIF4B
label: UniProt:P23588 EIF4B

G7A
label: UniProt:P26640 VARS
label: VARS
label: VARS2

AKT1
label: PKB
label: RAC
label: UniProt:P31749 AKT1

APOBEC1
label: UniProt:P41238 APOBEC1

QARS
label: UniProt:P47897 QARS

MAPKAPK2
label: UniProt:P49137 MAPKAPK2

AARS
label: UniProt:P49588 AARS

HARS2
label: HARSL
label: HARSR
label: HO3
label: UniProt:P49590 HARS2

PAP
label: PAPOLA
label: UniProt:P51003 PAPOLA

EEF1A
label: EEF1A1
label: EF1A
label: LENG7
label: UniProt:P68104 EEF1A1

PRKCD
label: UniProt:Q05655 PRKCD

KIAA0028
label: LARS2
label: UniProt:Q15031 LARS2

EIF4H
label: KIAA0038
label: UniProt:Q15056 EIF4H
label: WBSCR1
label: WSCR1

EARS2
label: KIAA1970
label: UniProt:Q5JPH6 EARS2

AARS2
label: AARSL
label: KIAA1270
label: UniProt:Q5JTZ9 AARS2

KIAA1885
label: UniProt:Q5ST30 VARS2
label: VARS2
label: VARS2L
label: VARSL

RARS2
label: RARSL
label: UniProt:Q5T160 RARS2

PARS2
label: UniProt:Q7L3T8 PARS2

SEP1
label: UniProt:Q8IZH2 XRN1
label: XRN1

KAT2B
label: PCAF
label: UniProt:Q92831 KAT2B

KIAA0221
label: RENT1
label: UPF1
label: UniProt:Q92900 UPF1

DCPS
label: DCS1
label: HINT5
label: HSPC015
label: UniProt:Q96C86 DCPS

MARS2
label: UniProt:Q96GW9 MARS2

NARS2
label: UniProt:Q96I59 NARS2

HCA137
label: NCOA6IP
label: PIMT
label: TGS1
label: UniProt:Q96RS0 TGS1

TARS2
label: TARSL1
label: UniProt:Q9BW92 TARS2

CARS2
label: OK/SW-cl.10
label: UniProt:Q9HA77 CARS2

IARS2
label: UniProt:Q9NSE4 IARS2

UniProt:Q9UGM6 WARS2
label: WARS2

DICER
label: DICER1
label: HERNA
label: KIAA0928
label: UniProt:Q9UPY3 DICER1

CTDP1
label: FCP1
label: UniProt:Q9Y5B0 CTDP1

Dissociation of L13a from the 60s ribosomal subunit
type: GO_0003674
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression
directly activates: INF-gamma induced phosphorylation of L13a
directly activates: Catalysis95

INF-gamma induced phosphorylation of L13a
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004672
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression
directly activates: Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA

Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA
type: GO_0003674
BFO_0000050: L13a-mediated translational silencing of Ceruloplasmin expression

pyrophosphate + H2O => 2 orthophosphate [cytosolic]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004427
BFO_0000050: Cytosolic tRNA aminoacylation

pyrophosphate + H2O => 2 orthophosphate [mitochondrial]
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004427
BFO_0000050: Mitochondrial tRNA aminoacylation

Cleavage of mRNA at the 3'-end
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004519
BFO_0000050: mRNA 3'-end processing
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: mRNA polyadenylation
directly activates: Catalysis114

mRNA polyadenylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: Restriction
  on property: enabled by
  some values from: PAP
type: GO_0004652
BFO_0000050: mRNA 3'-end processing
directly activates: Recruitment of TAP to the EJC

Binding of SLBP to Replication-Dependent Histone Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
directly activates: Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA

Recruitment of U7 snRNP:ZFP100 complex to the SLBP Bound Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
directly activates: Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA

Cleavage of the 3'-end of Replication Dependent Histone Pre-mRNA
type: GO_0003674
BFO_0000050: SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: Docking of Mature Replication Dependent Histone mRNA with the NPC
directly activates: Control35

Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA
type: GO_0008334
BFO_0000050: SLBP independent Processing of Histone Pre-mRNAs
directly activates: Cleavage of the 3'-end of the Histone Pre-mRNA

Cleavage of the 3'-end of the Histone Pre-mRNA
type: GO_0003674
BFO_0000050: SLBP independent Processing of Histone Pre-mRNAs
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: Docking of Mature Histone mRNA complex:TAP at the NPC
directly activates: Control38

Recognition of AAUAAA sequence by CPSF
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Recruitment of CstF to the CPSF Bound Pre-mRNA

Recruitment of CstF to the CPSF Bound Pre-mRNA
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex

Binding of Cleavage factors and Poly(A)Polymerase to the CstF:CPSF:Pre-mRNA Complex
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Cleavage and polyadenylation of Intronless Pre-mRNA
directly activates: Cleavage of Intronless Pre-mRNA at 3'-end

Cleavage and polyadenylation of Intronless Pre-mRNA
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
directly activates: Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
directly activates: Control41

Cleavage of Intronless Pre-mRNA at 3'-end
type: GO_0003674
BFO_0000050: Processing of Intronless Pre-mRNAs
BFO_0000050: Cleavage of Growing Transcript in the Termination Region
directly activates: Cleavage and polyadenylation of Intronless Pre-mRNA

Formation of ARC coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of DRIP coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of TRAP coactivator complex
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

Formation of CSL-NICD coactivator complex
type: GO_0003674
BFO_0000050: Notch-HLH transcription pathway

Formation of NR-MED1 Coactivator Complex
type: GO_0003674
BFO_0000050: Nuclear Receptor transcription pathway

KRAB-ZNF / KAP Interaction
type: GO_0003674
BFO_0000050: Generic Transcription Pathway

WWTR1 (TAZ) binds TEAD
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of CTGF
directly activates: TemplateReactionRegulation40
directly activates: TemplateReactionRegulation41
directly activates: TemplateReactionRegulation42

YAP1 binds TEAD
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of CTGF
directly activates: TemplateReactionRegulation40
directly activates: TemplateReactionRegulation41
directly activates: TemplateReactionRegulation42

WWTR1 (TAZ), TBX5, and PCAF form a complex
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression
directly activates: Expression of NPPA (ANF)
directly activates: TemplateReactionRegulation43

WWTR1 (TAZ) binds RUNX2
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Phosphorylated SMAD2 and SMAD3 form a complex with SMAD4
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: The SMAD2/3:SMAD4 complex transfers to the nucleus
directly activates: WWTR1 binds SMAD2/3:SMAD4 heterotrimer

The SMAD2/3:SMAD4 complex transfers to the nucleus
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
directly activates: SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
directly activates: SMAD2/3:SMAD4 heterotrimer binds SP1
directly activates: MEN1 binds SMAD2/3:SMAD4 heterotrimer
directly activates: SMAD2/3:SMAD4 complex positively regulates JUNB transcription
directly activates: SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
directly activates: TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
directly activates: TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
directly activates: PARP1 binds SMAD2/3:SMAD4 heterotrimer
directly activates: PPM1A protein phosphatase binds phosphorylated SMAD2/3
directly activates: BiochemicalReaction4524
directly activates: BiochemicalReaction6282
directly activates: Catalysis115
directly activates: Catalysis123
directly activates: Control22
directly activates: Control356
directly activates: Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling

Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: NEDD4L binds phosphorylated linker region of SMAD2/3
directly activates: SMURF2 binds SMAD3 phosphorylated in the linker region

WWTR1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: WWTR1:SMAD translocates to the nucleus

WWTR1:SMAD translocates to the nucleus
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: WWTR1:SMAD stimulates transcription of SMAD7
directly activates: WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
directly activates: Control16
directly activates: Control17
directly activates: Control18
directly activates: Control19

WWTR1:SMAD stimulates transcription of SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: RNF111 binds SMAD7
directly activates: BiochemicalReaction4112
directly activates: BiochemicalReaction4119
directly activates: BiochemicalReaction4121
directly activates: BiochemicalReaction4124

WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

RNF111 binds SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: RNF111 ubiquitinates SMAD7
directly activates: Catalysis116

RNF111 ubiquitinates SMAD7
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: Degradation of Ub-SMAD7

SMAD2/3:SMAD4 heterotrimer forms a complex with RBL1, E2F4/5 and DP1/2
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
directly activates: Control20

MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: TemplateReaction36
directly activates: TemplateReactionRegulation52

SMAD2/3:SMAD4 heterotrimer binds SP1
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
directly activates: SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
directly activates: Control21

SMAD2/3:SMAD4:SP1 complex stimulates transcription of CDKN2B
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

MEN1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SMAD2/3:SMAD4 complex positively regulates JUNB transcription
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

SKI/SKIL binds SMAD complex, suppressing TGF-beta signaling
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL

SMAD2/3 activation induces binding of RNF111/SMURF2 to SKI/SKIL
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Ubiquitination of SKI/SKIL by RNF111/SMURF2
directly activates: Catalysis117

Ubiquitination of SKI/SKIL by RNF111/SMURF2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Degradation of ubiquitinated SKI/SKIL

TRIM33 (Ectodermin) binds SMAD heterotrimer in the nucleus
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: TRIM33 monoubiquitinates SMAD4
directly activates: Catalysis118

TRIM33 monoubiquitinates SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Ubiquitinated SMAD4 translocates from the nucleus to the cytosol

Ubiquitinated SMAD4 translocates from the nucleus to the cytosol
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: USP9X (FAM) binds to ubiquitinated SMAD4

USP9X (FAM) binds to ubiquitinated SMAD4
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: USP9X (FAM) deubiquitinates SMAD4
directly activates: Catalysis119

USP9X (FAM) deubiquitinates SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004221
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

NEDD4L binds phosphorylated linker region of SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: NEDD4L ubiquitinates SMAD2/3

NEDD4L ubiquitinates SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Degradation of SMAD2/3:SMAD4 complex

SMURF2 binds SMAD3 phosphorylated in the linker region
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: SMURF2 monoubiquitinates SMAD3
directly activates: Catalysis120

SMURF2 monoubiquitinates SMAD3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

TGIF recruits HDAC1 to SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

PARP1 binds SMAD2/3:SMAD4 heterotrimer
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: PARP1 ADP-ribosylates SMAD3 and SMAD4
directly activates: Catalysis121

PARP1 ADP-ribosylates SMAD3 and SMAD4
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003950
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

PPM1A protein phosphatase binds phosphorylated SMAD2/3
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: PPM1A dephosphorylates nuclear SMAD2/3
directly activates: Catalysis122

PPM1A dephosphorylates nuclear SMAD2/3
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004722
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity
directly activates: Dephosphorylated SMAD2/3 translocates to the cytosol

Dephosphorylated SMAD2/3 translocates to the cytosol
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

UBF-1 Binds rDNA Promoter
type: GO_0003674
BFO_0000050: RNA Polymerase I Promoter Opening
directly activates: Phosphorylation of UBF-1:rDNA Promoter
directly activates: Catalysis124

Phosphorylation of UBF-1:rDNA Promoter
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004707
BFO_0000050: RNA Polymerase I Promoter Opening
directly activates: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
directly activates: Control25

Formation of SL1
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Acetylation of SL1
directly activates: Catalysis125

Acetylation of SL1
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: enabled by
  some values from: KAT2B
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016407
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
directly activates: Control25

Recruitment of Acetylated SL1 to phosUBF-1:rDNA Promoter
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter

Assembly of RNA Polymerase I Holoenzyme (human)
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Binding of Rrn3 to RNA Polymerase I

Binding of Rrn3 to RNA Polymerase I
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter

Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Initiation
directly activates: Loss of Rrn3 from RNA Polymerase I promoter escape complex

Loss of Rrn3 from RNA Polymerase I promoter escape complex
type: GO_0003674
BFO_0000050: RNA Polymerase I Promoter Escape

Elongation of pre-rRNA transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase I Chain Elongation

TTF-I binds to the Sal Box
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Termination
directly activates: Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box

Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Termination
directly activates: PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box

PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Termination
directly activates: Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box

Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box
type: GO_0003674
BFO_0000050: RNA Polymerase I Transcription Termination

RNA Polymerase III Abortive Initiation At Type 1 Open Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters

RNA Polymerase III Abortive Initiation At Type 2 Open Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters

RNA Polymerase III Abortive Initiation At Type 3 Open Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters

RNA Polymerase III Productive Transcription
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Chain Elongation
directly activates: RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
directly activates: RNA Polymerase III Transcriptional Pause at Terminator Sequence

RNA Polymerase III Promoter Opening at Type 1 Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 1 Promoter
directly activates: RNA Polymerase III Abortive Initiation At Type 1 Open Promoters
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters

RNA Polymerase III Promoter Opening at Type 2 Promoters
type: GO_0003674
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 2 Promoter
directly activates: RNA Polymerase III Abortive Initiation At Type 2 Open Promoters
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters

RNA Polymerase III Promoter Opening at Type 3 Promoters
type: GO_0003674
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 3 Promoter
directly activates: RNA Polymerase III Abortive Initiation At Type 3 Open Promoters
directly activates: RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters

RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: Resumption of RNA Polymerase III Productive Transcription

RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: Initiation of RNA Polymerase III Productive Transcription

RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: Initiation of RNA Polymerase III Productive Transcription

RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters
type: GO_0006383
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
directly activates: Initiation of RNA Polymerase III Productive Transcription

RNA Polymerase III Termination and release of transcribed mRNA
type: GO_0006386
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Transcription Termination

RNA Polymerase III Transcriptional Pause at Terminator Sequence
type: GO_0003674
BFO_0000050: RNA Polymerase III Abortive And Retractive Initiation
BFO_0000050: RNA Polymerase III Transcription Termination

Binding of TFIIIA To type 1 Promoter
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 1 Promoter
directly activates: Binding of TFIIIC to TFIIIA:Type I Promoter complex

Binding of TFIIIC to TFIIIA:Type I Promoter complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 1 Promoter
directly activates: Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex

Binding of TFIIIB to TFIIIC:TFIIIA:Type I Promoter complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 1 Promoter
directly activates: Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex

Recruitment of RNA polymerase III to TFIIIB:TFIIIC:TFIIIA:Type 1 Promoter Complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 1 Promoter
directly activates: RNA Polymerase III Promoter Opening at Type 1 Promoters

Binding of TFIIIC to Type 2 promoter
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 2 Promoter
directly activates: Binding of TFIIIB to TFIIC: Type 2 Promoter Complex

Binding of TFIIIB to TFIIC: Type 2 Promoter Complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 2 Promoter
directly activates: Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex

Recruitment of RNA Polymerase III to the TFIIIB:TFIIIC: Type 2 Promoter Complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 2 Promoter
directly activates: RNA Polymerase III Promoter Opening at Type 2 Promoters

Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 3 Promoter
directly activates: Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex

Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 3 Promoter
directly activates: Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex

Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex
type: GO_0003674
BFO_0000050: RNA Polymerase III Transcription Initiation From Type 3 Promoter
directly activates: RNA Polymerase III Promoter Opening at Type 3 Promoters

Initiation of RNA Polymerase III Productive Transcription
type: GO_0006383
BFO_0000050: RNA Polymerase III Chain Elongation
directly activates: RNA Polymerase III Productive Transcription

Resumption of RNA Polymerase III Productive Transcription
type: GO_0006383
BFO_0000050: RNA Polymerase III Chain Elongation
directly activates: RNA Polymerase III Productive Transcription

TFAM binds to mitochondrial promoters
type: GO_0003674
BFO_0000050: Mitochondrial transcription initiation
directly activates: Association of TFAM:mt promoter complex with POLRMT:TFB2M

Association of TFAM:mt promoter complex with POLRMT:TFB2M
type: GO_0003674
BFO_0000050: Mitochondrial transcription initiation
directly activates: Association of mTERF with the termination sequence

Association of mTERF with the termination sequence
type: GO_0003674
BFO_0000050: Mitochondrial transcription termination

Abortive initiation after formation of the first phosphodiester bond
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive Initiation After Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive Initiation Before Second Transition
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Formation of DSIF complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2644
directly activates: DSIF complex binds to RNA Pol II (hypophosphorylated)

Formation of Elongin BC complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Formation of elongin complex

Formation of FACT complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2652
directly activates: BiochemicalReaction2662
directly activates: Recruitment of elongation factors to form elongation complex

Formation of NELF complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2645
directly activates: Formation of DSIF:NELF:early elongation complex

Formation of P-TEFb complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2661
directly activates: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
directly activates: Catalysis1150
directly activates: Catalysis137

Formation of elongin complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction2652
directly activates: BiochemicalReaction2662
directly activates: Recruitment of elongation factors to form elongation complex

Resumption of elongation after recovery from pausing
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Pol II elongation complex moves on the template as transcript elongates

2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Resumption of elongation after recovery from pausing

7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: TFIIS-mediated recovery of elongation from arrest
directly activates: Abortive termination of elongation after arrest

TFIIS-mediated recovery of elongation from arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: Pol II elongation complex moves on the template as transcript elongates

Abortive termination of early transcription elongation by DSIF:NELF
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Abortive termination of elongation after arrest
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Elongating transcript encounters a lesion in the template
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events
directly activates: BiochemicalReaction205

Fall Back to Closed Pre-initiation Complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Pre-transcription Events

Recognition and Binding of Core Promoter Elements by TFIID
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex

Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex

Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Binding of TFIIE to the growing preinitiation complex

Binding of TFIIE to the growing preinitiation complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: Formation of the closed pre-initiation complex

Formation of the closed pre-initiation complex
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
directly activates: RNA Polymerase II Promoter Opening: First Transition
directly activates: Catalysis127

RNA Polymerase II Promoter Opening: First Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004386
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance
directly activates: Fall Back to Closed Pre-initiation Complex
directly activates: NTP Binds Active Site of RNA Polymerase II

NTP Binds Active Site of RNA Polymerase II
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Newly Formed Phosphodiester Bond Stabilized and PPi Released

Newly Formed Phosphodiester Bond Stabilized and PPi Released
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Initiation
directly activates: Addition of the third nucleotide on the nascent transcript
directly activates: Catalysis128
directly activates: Catalysis129

Addition of the third nucleotide on the nascent transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation Before Second Transition
directly activates: Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
directly activates: Catalysis130
directly activates: Catalysis131

Addition of the fourth nucleotide on the Nascent Transcript: Second Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
type: GO_0004386
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation Before Second Transition
directly activates: Addition of Nucleotides 5 through 9 on the growing Transcript
directly activates: Catalysis132

Addition of Nucleotides 5 through 9 on the growing Transcript
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Abortive Initiation After Second Transition
directly activates: Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
directly activates: Catalysis133

Addition of nucleotides 10 and 11 on the growing transcript: Third Transition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Addition of nucleotides between position +11 and +30
directly activates: Catalysis134

Addition of nucleotides between position +11 and +30
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003899
BFO_0000050: RNA Polymerase II Promoter Escape
directly activates: Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex

Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: Phosphorylation (Ser5) of RNA pol II CTD
directly activates: Catalysis135

Phosphorylation (Ser5) of RNA pol II CTD
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
directly activates: RNA Polymerase II CTD (phosphorylated) binds to CE

RNA Polymerase II CTD (phosphorylated) binds to CE
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
BFO_0000050: mRNA Capping
directly activates: Activation of GT

Activation of GT
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
BFO_0000050: mRNA Capping
directly activates: SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)

SPT5 subunit of Pol II binds the RNA triphosphatase (RTP)
type: GO_0003674
BFO_0000050: RNA Pol II CTD phosphorylation and interaction with CE
BFO_0000050: mRNA Capping
directly activates: Capping complex formation

Hypophosphorylation of RNA Pol II CTD by FCP1P protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: Restriction
  on property: enabled by
  some values from: CTDP1
type: GO_0004721
BFO_0000050: Formation of the Early Elongation Complex
directly activates: DSIF complex binds to RNA Pol II (hypophosphorylated)

DSIF complex binds to RNA Pol II (hypophosphorylated)
type: GO_0003674
BFO_0000050: Formation of the Early Elongation Complex
directly activates: Formation of DSIF:NELF:early elongation complex

Formation of DSIF:NELF:early elongation complex
type: GO_0003674
BFO_0000050: Formation of the Early Elongation Complex
directly activates: Abortive termination of early transcription elongation by DSIF:NELF
directly activates: Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
directly activates: Catalysis137

Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0016301
BFO_0000050: Formation of RNA Pol II elongation complex
directly activates: Recruitment of elongation factors to form elongation complex

Recruitment of elongation factors to form elongation complex
type: GO_0003674
BFO_0000050: Formation of RNA Pol II elongation complex
directly activates: Addition of nucleotides leads to transcript elongation

Addition of nucleotides leads to transcript elongation
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
directly activates: 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
directly activates: Elongating transcript encounters a lesion in the template
directly activates: Pol II elongation complex moves on the template as transcript elongates

Pol II elongation complex moves on the template as transcript elongates
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: Separation of elongating transcript from template

Separation of elongating transcript from template
type: GO_0003674
BFO_0000050: RNA Polymerase II Transcription Elongation
directly activates: Cleavage of Growing Transcript in the Termination Region

Capping complex formation
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
directly activates: Catalysis138

Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004651
BFO_0000050: mRNA Capping
directly activates: Formation of the CE:GMP intermediate complex
directly activates: Catalysis139

Formation of the CE:GMP intermediate complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004484
BFO_0000050: mRNA Capping
directly activates: Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
directly activates: Catalysis140

Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004484
BFO_0000050: mRNA Capping
directly activates: Dissociation of transcript with 5'-GMP from GT

Dissociation of transcript with 5'-GMP from GT
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Methylation of GMP-cap by RNA Methyltransferase
directly activates: Catalysis141

Methylation of GMP-cap by RNA Methyltransferase
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004482
BFO_0000050: mRNA Capping
directly activates: Recognition and binding of the mRNA cap by the cap-binding complex

Recognition and binding of the mRNA cap by the cap-binding complex
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Binding of SLBP to Replication-Dependent Histone Pre-mRNA
directly activates: Recruitment of U7 snRNP:ZFP100 complex to the Histone Pre-mRNA
directly activates: Recognition of AAUAAA sequence by CPSF
directly activates: Hypophosphorylation of RNA Pol II CTD by FCP1P protein
directly activates: Internal Methylation of mRNA
directly activates: Catalysis136
directly activates: Catalysis142

Formation of cap binding complex (CBC)
type: GO_0003674
BFO_0000050: mRNA Capping
directly activates: Recognition and binding of the mRNA cap by the cap-binding complex

Internal Methylation of mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0001734
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Formation of pre-mRNPs
type: GO_0003674
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA
directly activates: Formation of the Spliceosomal E complex
directly activates: Formation of AT-AC A complex
directly activates: mRNA Splicing

Formation of the Spliceosomal E complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the Spliceosomal A Complex

Formation of the Spliceosomal A Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the Spliceosomal B Complex

Formation of the Spliceosomal B Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of an intermediate Spliceosomal C complex

Formation of the Cleavage and Polyadenylation Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of an intermediate Spliceosomal C complex

Formation of an intermediate Spliceosomal C complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of the active Spliceosomal C complex

Formation of the active Spliceosomal C complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Lariat Formation and 5'-Splice Site Cleavage

Lariat Formation and 5'-Splice Site Cleavage
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Formation of Exon Junction Complex

Formation of Exon Junction Complex
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Cleavage at the 3'-Splice Site and Exon Ligation

Cleavage at the 3'-Splice Site and Exon Ligation
type: GO_0003674
BFO_0000050: U2 Dependent Splicing
directly activates: Cleavage of mRNA at the 3'-end
directly activates: Formation of stem-loop structure in ApoB mRNA
directly activates: Catalysis113

Formation of AT-AC A complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: Formation of AT-AC B Complex

Formation of AT-AC B Complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: Formation of AT-AC C complex

Formation of AT-AC C complex
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: ATAC spliceosome mediated Lariat formation,5' splice site cleavage

ATAC spliceosome mediated Lariat formation,5' splice site cleavage
type: GO_0003674
BFO_0000050: U12 Dependent Splicing
directly activates: ATAC spliceosome mediated 3' splice site cleavage, exon ligation

ATAC spliceosome mediated 3' splice site cleavage, exon ligation
type: GO_0003674
BFO_0000050: U12 Dependent Splicing

Recruitment of TAP to the EJC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Docking of the TAP:EJC Complex with the NPC
directly activates: Control32

Docking of the TAP:EJC Complex with the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Transport of the export-competent complex through the NPC
directly activates: Control33

Transport of the export-competent complex through the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: Release from the NPC and Disassembly of the mRNP
directly activates: Control34

Release from the NPC and Disassembly of the mRNP
type: GO_0006406
BFO_0000050: Transport of Mature mRNA derived from an Intron-Containing Transcript
directly activates: eIF4F binds to mRNP

Docking of Mature Replication Dependent Histone mRNA with the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
directly activates: Control36

Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
directly activates: Control37

Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex
type: GO_0006406
BFO_0000050: Transport of the SLBP Dependant Mature mRNA
directly activates: eIF4F binds to mRNP

Docking of Mature Histone mRNA complex:TAP at the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
directly activates: Control39

Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC
type: GO_0006405
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: Release of the SLBP independent Histone mRNA from the NPC
directly activates: Control40

Release of the SLBP independent Histone mRNA from the NPC
type: GO_0006406
BFO_0000050: Transport of the SLBP independent Mature mRNA
directly activates: eIF4F binds to mRNP

Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC
type: GO_0006406
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
directly activates: Control42

Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
directly activates: Control43

Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC
type: GO_0006405
BFO_0000050: Transport of Mature mRNA Derived from an Intronless Transcript
directly activates: eIF4F binds to mRNP

Formation of stem-loop structure in ApoB mRNA
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: Binding of A1CF to stem-looped RNA

Binding of A1CF to stem-looped RNA
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: Binding of APOBEC-1 to form editosome

Binding of APOBEC-1 to form editosome
type: GO_0003674
BFO_0000050: Formation of the Editosome
directly activates: C4 deamination of cytidine
directly activates: Catalysis143

C4 deamination of cytidine
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: Restriction
  on property: enabled by
  some values from: APOBEC1
type: GO_0004126
BFO_0000050: mRNA Editing: C to U Conversion
directly activates: Cleavage of mRNA at the 3'-end
directly activates: Catalysis113

Formation of dsRNA structure by looping
type: GO_0003674
BFO_0000050: mRNA Editing: A to I Conversion
directly activates: Binding of ADAR1 homodimer to dsRNA duplex
directly activates: Binding of ADAR2 homodimer to dsRNA duplex

Formation of ADAR1 homodimer
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Binding of ADAR1 homodimer to dsRNA duplex

Binding of ADAR1 homodimer to dsRNA duplex
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Deamination at C6 position of adenosine in Editosome (ADAR1)
directly activates: Catalysis144

Formation of ADAR2 homodimer
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Binding of ADAR2 homodimer to dsRNA duplex

Binding of ADAR2 homodimer to dsRNA duplex
type: GO_0003674
BFO_0000050: Formation of editosomes by ADAR proteins
directly activates: Deamination at C6 position of adenosine in Editosome (ADAR2)
directly activates: Catalysis145

Deamination at C6 position of adenosine in Editosome (ADAR1)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003726
BFO_0000050: C6 deamination of adenosine

Deamination at C6 position of adenosine in Editosome (ADAR2)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003726
BFO_0000050: C6 deamination of adenosine

alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AARS
type: Restriction
  on property: enabled by
  some values from: AARS
type: Restriction
  on property: enabled by
  some values from: AARS
type: Restriction
  on property: enabled by
  some values from: AARS
type: GO_0004813
BFO_0000050: Cytosolic tRNA aminoacylation

arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004814
BFO_0000050: Cytosolic tRNA aminoacylation

asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: NARS
type: Restriction
  on property: enabled by
  some values from: NARS
type: Restriction
  on property: enabled by
  some values from: NARS
type: Restriction
  on property: enabled by
  some values from: NARS
type: GO_0004816
BFO_0000050: Cytosolic tRNA aminoacylation

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004815
BFO_0000050: Cytosolic tRNA aminoacylation

cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004817
BFO_0000050: Cytosolic tRNA aminoacylation

glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004818
BFO_0000050: Cytosolic tRNA aminoacylation

glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004819
BFO_0000050: Cytosolic tRNA aminoacylation

glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004820
BFO_0000050: Cytosolic tRNA aminoacylation

histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HARS
type: Restriction
  on property: enabled by
  some values from: HARS
type: Restriction
  on property: enabled by
  some values from: HARS
type: Restriction
  on property: enabled by
  some values from: HARS
type: GO_0004821
BFO_0000050: Cytosolic tRNA aminoacylation

isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004822
BFO_0000050: Cytosolic tRNA aminoacylation

leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004823
BFO_0000050: Cytosolic tRNA aminoacylation

lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004824
BFO_0000050: Cytosolic tRNA aminoacylation

methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004825
BFO_0000050: Cytosolic tRNA aminoacylation

phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004826
BFO_0000050: Cytosolic tRNA aminoacylation

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004827
BFO_0000050: Cytosolic tRNA aminoacylation

serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004828
BFO_0000050: Cytosolic tRNA aminoacylation

threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004829
BFO_0000050: Cytosolic tRNA aminoacylation

tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004830
BFO_0000050: Cytosolic tRNA aminoacylation

tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004831
BFO_0000050: Cytosolic tRNA aminoacylation

valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: G7A
type: Restriction
  on property: enabled by
  some values from: G7A
type: Restriction
  on property: enabled by
  some values from: G7A
type: Restriction
  on property: enabled by
  some values from: G7A
type: GO_0004832
BFO_0000050: Cytosolic tRNA aminoacylation

alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: AARS2
type: Restriction
  on property: enabled by
  some values from: AARS2
type: Restriction
  on property: enabled by
  some values from: AARS2
type: Restriction
  on property: enabled by
  some values from: AARS2
type: GO_0004813
BFO_0000050: Mitochondrial tRNA aminoacylation

arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: RARS2
type: Restriction
  on property: enabled by
  some values from: RARS2
type: Restriction
  on property: enabled by
  some values from: RARS2
type: Restriction
  on property: enabled by
  some values from: RARS2
type: GO_0004814
BFO_0000050: Mitochondrial tRNA aminoacylation

asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: NARS2
type: Restriction
  on property: enabled by
  some values from: NARS2
type: Restriction
  on property: enabled by
  some values from: NARS2
type: Restriction
  on property: enabled by
  some values from: NARS2
type: GO_0004816
BFO_0000050: Mitochondrial tRNA aminoacylation

aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004815
BFO_0000050: Mitochondrial tRNA aminoacylation

cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: CARS2
type: Restriction
  on property: enabled by
  some values from: CARS2
type: Restriction
  on property: enabled by
  some values from: CARS2
type: Restriction
  on property: enabled by
  some values from: CARS2
type: GO_0004817
BFO_0000050: Mitochondrial tRNA aminoacylation

glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: EARS2
type: Restriction
  on property: enabled by
  some values from: EARS2
type: Restriction
  on property: enabled by
  some values from: EARS2
type: Restriction
  on property: enabled by
  some values from: EARS2
type: GO_0004818
BFO_0000050: Mitochondrial tRNA aminoacylation

glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: QARS
type: Restriction
  on property: enabled by
  some values from: QARS
type: Restriction
  on property: enabled by
  some values from: QARS
type: Restriction
  on property: enabled by
  some values from: QARS
type: GO_0004819
BFO_0000050: Mitochondrial tRNA aminoacylation

glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004820
BFO_0000050: Mitochondrial tRNA aminoacylation

histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: HARS2
type: Restriction
  on property: enabled by
  some values from: HARS2
type: Restriction
  on property: enabled by
  some values from: HARS2
type: Restriction
  on property: enabled by
  some values from: HARS2
type: GO_0004821
BFO_0000050: Mitochondrial tRNA aminoacylation

isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: IARS2
type: Restriction
  on property: enabled by
  some values from: IARS2
type: Restriction
  on property: enabled by
  some values from: IARS2
type: Restriction
  on property: enabled by
  some values from: IARS2
type: GO_0004822
BFO_0000050: Mitochondrial tRNA aminoacylation

leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: KIAA0028
type: Restriction
  on property: enabled by
  some values from: KIAA0028
type: Restriction
  on property: enabled by
  some values from: KIAA0028
type: Restriction
  on property: enabled by
  some values from: KIAA0028
type: GO_0004823
BFO_0000050: Mitochondrial tRNA aminoacylation

lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004824
BFO_0000050: Mitochondrial tRNA aminoacylation

methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: MARS2
type: Restriction
  on property: enabled by
  some values from: MARS2
type: Restriction
  on property: enabled by
  some values from: MARS2
type: Restriction
  on property: enabled by
  some values from: MARS2
type: GO_0004825
BFO_0000050: Mitochondrial tRNA aminoacylation

phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: FARS1
type: Restriction
  on property: enabled by
  some values from: FARS1
type: Restriction
  on property: enabled by
  some values from: FARS1
type: Restriction
  on property: enabled by
  some values from: FARS1
type: GO_0004826
BFO_0000050: Mitochondrial tRNA aminoacylation

proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: PARS2
type: Restriction
  on property: enabled by
  some values from: PARS2
type: Restriction
  on property: enabled by
  some values from: PARS2
type: Restriction
  on property: enabled by
  some values from: PARS2
type: GO_0004827
BFO_0000050: Mitochondrial tRNA aminoacylation

serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004828
BFO_0000050: Mitochondrial tRNA aminoacylation

threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: TARS2
type: Restriction
  on property: enabled by
  some values from: TARS2
type: Restriction
  on property: enabled by
  some values from: TARS2
type: Restriction
  on property: enabled by
  some values from: TARS2
type: GO_0004829
BFO_0000050: Mitochondrial tRNA aminoacylation

tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UGM6 WARS2
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UGM6 WARS2
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UGM6 WARS2
type: Restriction
  on property: enabled by
  some values from: UniProt:Q9UGM6 WARS2
type: GO_0004830
BFO_0000050: Mitochondrial tRNA aminoacylation

tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: GO_0004831
BFO_0000050: Mitochondrial tRNA aminoacylation

valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005759
type: Restriction
  on property: enabled by
  some values from: KIAA1885
type: Restriction
  on property: enabled by
  some values from: KIAA1885
type: Restriction
  on property: enabled by
  some values from: KIAA1885
type: Restriction
  on property: enabled by
  some values from: KIAA1885
type: GO_0004832
BFO_0000050: Mitochondrial tRNA aminoacylation

Partial Deadenylation of mRNA by the PAN2-PAN3 Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: Deadenylation of mRNA by PARN
directly activates: Deadenylation of mRNA by the CCR4-NOT Complex
directly activates: Catalysis187
directly activates: Catalysis188

Deadenylation of mRNA by PARN
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: 3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
directly activates: Binding of Lsm1-7 Complex to Deadenylated mRNA
directly activates: Catalysis189

Deadenylation of mRNA by the CCR4-NOT Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004535
BFO_0000050: Deadenylation of mRNA
directly activates: 3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
directly activates: Binding of Lsm1-7 Complex to Deadenylated mRNA
directly activates: Catalysis189

3' to 5' Exoribonuclease Digestion of mRNA by the Exosome Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000175
BFO_0000050: mRNA Decay by 3' to 5' Exoribonuclease
directly activates: Scavenging of the 7-methylguanosine Cap by DCPS
directly activates: Catalysis190

Scavenging of the 7-methylguanosine Cap by DCPS
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: Restriction
  on property: enabled by
  some values from: DCPS
type: GO_0004532
BFO_0000050: mRNA Decay by 3' to 5' Exoribonuclease

Binding of Lsm1-7 Complex to Deadenylated mRNA
type: GO_0003674
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease
directly activates: Decapping of mRNA by the DCP1-DCP2 Complex
directly activates: Catalysis191

Decapping of mRNA by the DCP1-DCP2 Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0016896
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease
directly activates: 5' to 3' Exoribonuclease Digestion of Decapped mRNA
directly activates: Catalysis192

5' to 3' Exoribonuclease Digestion of Decapped mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: Restriction
  on property: enabled by
  some values from: SEP1
type: GO_0004534
BFO_0000050: mRNA Decay by 5' to 3' Exoribonuclease

UPF1 Binds an mRNP with a Termination Codon Preceding an Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
directly activates: Catalysis193

SMG1 Phosphorylates UPF1 (Enhanced by Exon Junction Complex)
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A

Phosphorylated UPF1 Recruits SMG5, SMG7, SMG6, and PP2A
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: SMG6 Cleaves mRNA with Premature Termination Codon
directly activates: Catalysis194

SMG6 Cleaves mRNA with Premature Termination Codon
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex
directly activates: Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
directly activates: Catalysis195
directly activates: Catalysis196

Decay of mRNA in SMG6:SMG5:SMG7:mRNA Complex
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: Restriction
  on property: enabled by
  some values from: KIAA0221
type: GO_0004004
type: GO_0004722
BFO_0000050: Nonsense Mediated Decay Enhanced by the Exon Junction Complex

Formation of UPF1:eRF3 Complex on mRNA with a Premature Termination Codon and No Exon Junction Complex
type: GO_0003674
BFO_0000050: Nonsense Mediated Decay Independent of the Exon Junction Complex

Microprocessor complex cleaves pri-miRNA to pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin-5 recognizes 3' overhang of pre-miRNA
directly activates: Catalysis198

Exportin-5 recognizes 3' overhang of pre-miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0003723
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Exportin complex translocates pre-miRNA to cytosol
directly activates: Catalysis199

Exportin complex translocates pre-miRNA to cytosol
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0051033
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Dicer cleaves pre-miRNA to yield duplex miRNA
directly activates: Catalysis200

Dicer cleaves pre-miRNA to yield duplex miRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: GO_0004525
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Duplex miRNA is loaded into Argonaute
directly activates: Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC

Duplex miRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Removal of miRNA passenger strand

Removal of miRNA passenger strand
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Binding of Inexactly Matching Target RNAs by RISC.

Dicer cleaves double-stranded RNA to yield double-stranded siRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: Restriction
  on property: enabled by
  some values from: DICER
type: GO_0004525
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Duplex siRNA is loaded into Argonaute
directly activates: Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC

Duplex siRNA is loaded into Argonaute
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Cleavage-based removal of the siRNA passenger strand by AGO2
directly activates: Removal of siRNA passenger strand
directly activates: Catalysis202

Cleavage-based removal of the siRNA passenger strand by AGO2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis
directly activates: Cleavage of Target RNAs by Endonucleolytic RISC
directly activates: Binding of Inexactly Matching Target RNAs by RISC.
directly activates: Catalysis203

Removal of siRNA passenger strand
type: GO_0003674
BFO_0000050: Small Interfering RNA (siRNA) Biogenesis

Cleavage of Target RNAs by Endonucleolytic RISC
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004521
BFO_0000050: Post-transcriptional Silencing By Small RNAs

Binding of Inexactly Matching Target RNAs by RISC.
type: GO_0003674
BFO_0000050: Post-transcriptional Silencing By Small RNAs

Binding of Exactly Matching Target RNAs by Nonendonucleolytic RISC
type: GO_0003674
BFO_0000050: Post-transcriptional Silencing By Small RNAs

AUF1(hnRNP D0) Dimers Bind AU-rich Element in 3' UTR of Transcripts
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Association of AUF1 with Translation and Heat Shock Proteins

Association of AUF1 with Translation and Heat Shock Proteins
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Ubiquitination of AUF1 (hnRNP D0)

Ubiquitination of AUF1 (hnRNP D0)
type: GO_0003674
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)
directly activates: Destruction of AUF1 and mRNA
directly activates: Catalysis204

Destruction of AUF1 and mRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004175
BFO_0000050: Destabilization of mRNA by AUF1 (hnRNP D0)

Butyrate Response Factor1 (BRF1) Binds AU-rich Element in 3' UTR of mRNA
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: BRF1 Complex Recruits RNA Degradation Activities
directly activates: Phosphorylation of BRF1 by Protein Kinase B/Akt
directly activates: Phosphorylation of BRF1 by MK2
directly activates: Catalysis205
directly activates: Catalysis206

BRF1 Complex Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Phosphorylation of BRF1 by Protein Kinase B/Akt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: Phosphorylated BRF1 (Ser92, Ser203) Binds 14-3-3

Phosphorylation of BRF1 by MK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
directly activates: Phosphorylated BRF1 (Ser54, Ser92, Ser203) Binds 14-3-3

Phosphorylated BRF1 (Ser92, Ser203) Binds 14-3-3
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Phosphorylated BRF1 (Ser54, Ser92, Ser203) Binds 14-3-3
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)

Tristetraproline (TTP) Binds AU-rich Elements in 3' UTR of Target mRNAs
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)
directly activates: TTP Recruits RNA Degradation Activities
directly activates: Phosphorylation of Tristetraproline (TTP) by MK2
directly activates: Catalysis207

TTP Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)

Phosphorylation of Tristetraproline (TTP) by MK2
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: Restriction
  on property: enabled by
  some values from: MAPKAPK2
type: GO_0004674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)
directly activates: Phosphorylated Tristetraproline (TTP) binds 14-3-3beta

Phosphorylated Tristetraproline (TTP) binds 14-3-3beta
type: GO_0003674
BFO_0000050: Destabilization of mRNA by Tristetraprolin (TTP)

KSRP Binds AU-rich Element in 3' UTR of mRNA
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP
directly activates: KSRP Recruits RNA Degradation Activities
directly activates: Phosphorylation of KSRP by Protein Kinase B/Akt
directly activates: Catalysis208

KSRP Recruits RNA Degradation Activities
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of KSRP by Protein Kinase B/Akt
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: Restriction
  on property: enabled by
  some values from: AKT1
type: GO_0004674
BFO_0000050: Destabilization of mRNA by KSRP
directly activates: Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus

Phosphorylated KSRP (Ser193) Binds 14-3-3zeta in the Nucleus
type: GO_0003674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of KSRP by MAP kinase p38
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0004674
BFO_0000050: Destabilization of mRNA by KSRP

Phosphorylation of HuR by PKCalpha
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: Restriction
  on property: enabled by
  some values from: PKCA
type: GO_0004674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Phosphorylated HuR (Ser221, Ser158) Binds mRNA

Phosphorylation of HuR by PKCdelta
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: Restriction
  on property: enabled by
  some values from: PRKCD
type: GO_0004674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Phosphorylated HuR (Ser221, Ser318) Binds mRNA

Phosphorylated HuR (Ser221, Ser158) Binds mRNA
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

Phosphorylated HuR (Ser221, Ser318) Binds mRNA
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

HuR Binds mRNAs in the Nucleus
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Association of HuR with the CRM1 Nuclear Export Machinery

Association of HuR with the CRM1 Nuclear Export Machinery
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR
directly activates: Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm

Export of HuR:mRNA Complex from the Nucleus to the Cytoplasm
type: GO_0003674
BFO_0000050: Stabilization of mRNA by HuR

Release of 40S and 60S subunits from the 80S ribosome
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: eIF3 and eIF1A bind to the 40S subunit
directly activates: The 60S subunit joins the translation initiation complex

eIF3 and eIF1A bind to the 40S subunit
type: GO_0003674
BFO_0000050: Formation of a pool of free 40S subunits
directly activates: Formation of the ternary complex, and subsequently, the 43S complex

De novo formation of eIF2:GTP
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Met-tRNAi binds to eIF2:GTP to form the ternary complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex
directly activates: Formation of the 43S pre-initiation complex

Formation of the 43S pre-initiation complex
type: GO_0003674
BFO_0000050: Formation of the ternary complex, and subsequently, the 43S complex

Release of eIF4E from the inactive eIF4E:4E-BP complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of the cap-binding eIF4F complex

Formation of the cap-binding eIF4F complex
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: eIF4F binds to mRNP

eIF4F binds to mRNP
type: GO_0003674
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Cap-bound mRNA is activated by helicases
directly activates: Catalysis212
directly activates: Catalysis213
directly activates: Catalysis214

Cap-bound mRNA is activated by helicases
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003724
type: GO_0004386
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
directly activates: Formation of translation initiation complexes containing mRNA that does not circularize
directly activates: Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
directly activates: Translation initiation complex formation

Formation of translation initiation complexes containing mRNA that does not circularize
type: GO_0003674
BFO_0000050: Translation initiation complex formation

Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation
type: GO_0003674
BFO_0000050: Translation initiation complex formation
directly activates: L13a-mediated translational silencing of Ceruloplasmin expression

Ribosomal scanning
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: Start codon recognition
directly activates: Catalysis216

Start codon recognition
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Ribosomal scanning and start codon recognition
directly activates: eIF2:GTP is hydrolyzed, eIFs are released
directly activates: Control46

eIF2:GTP is hydrolyzed, eIFs are released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: The 60S subunit joins the translation initiation complex
directly activates: Formation of eIF2:GDP:eIF2B intermediate

eIF5B:GTP is hydrolyzed and released
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: Aminoacyl-tRNA binds to the ribosome at the A-site

The 60S subunit joins the translation initiation complex
type: GO_0003674
BFO_0000050: GTP hydrolysis and joining of the 60S ribosomal subunit
directly activates: eIF5B:GTP is hydrolyzed and released

Formation of eIF2:GDP:eIF2B intermediate
type: GO_0003674
BFO_0000050: Recycling of eIF2:GDP
directly activates: eIF2 activation
directly activates: Catalysis217

eIF2 activation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003743
BFO_0000050: Recycling of eIF2:GDP
directly activates: Met-tRNAi binds to eIF2:GTP to form the ternary complex
directly activates: Control44

Synthesis of nascent polypeptide containing signal sequence
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)

Association of a nascent polypeptide:mRNA:ribosome complex with a signal recognition particle (SRP)
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: The SRP receptor binds the SRP:nascent peptide:ribosome complex

The SRP receptor binds the SRP:nascent peptide:ribosome complex
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Translocation of signal-containing nascent peptide to Endoplasmic Reticulum

Translocation of signal-containing nascent peptide to Endoplasmic Reticulum
type: GO_0003674
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: Signal peptide cleavage from ribosome-associated nascent protein
directly activates: Catalysis218

Signal peptide cleavage from ribosome-associated nascent protein
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005789
type: GO_0004252
BFO_0000050: SRP-dependent cotranslational protein targeting to membrane
directly activates: BiochemicalReaction3599
directly activates: Catalysis1573

eEF1A complexes with GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: Restriction
  on property: enabled by
  some values from: EEF1A
type: GO_0019001
BFO_0000050: Eukaryotic Translation Elongation
directly activates: eEF1A:GTP:aminoacyl tRNA ternary complex formation.

eEF1A:GTP:aminoacyl tRNA ternary complex formation.
type: GO_0003674
BFO_0000050: Eukaryotic Translation Elongation
directly activates: Aminoacyl-tRNA binds to the ribosome at the A-site

Aminoacyl-tRNA binds to the ribosome at the A-site
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: Hydrolysis of eEF1A:GTP
directly activates: Catalysis220

Hydrolysis of eEF1A:GTP
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0003924
BFO_0000050: Peptide chain elongation
directly activates: Peptide transfer from P-site tRNA to the A-site tRNA
directly activates: Regeneration of eEF1A:GTP by eEF1B activity
directly activates: Catalysis221
directly activates: Catalysis222

Peptide transfer from P-site tRNA to the A-site tRNA
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000048
BFO_0000050: Peptide chain elongation
directly activates: Translocation of ribosome by 3 bases in the 3' direction

Translocation of ribosome by 3 bases in the 3' direction
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex

GTP-binding activates eEF2
type: GO_0003674
BFO_0000050: Peptide chain elongation
directly activates: Translocation of ribosome by 3 bases in the 3' direction

Regeneration of eEF1A:GTP by eEF1B activity
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0005085
BFO_0000050: Eukaryotic Translation Elongation
directly activates: eEF1A:GTP:aminoacyl tRNA ternary complex formation.

Formation of eEF1B complex
type: GO_0003674
BFO_0000050: Eukaryotic Translation Elongation
directly activates: Regeneration of eEF1A:GTP by eEF1B activity
directly activates: Catalysis222

GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination
directly activates: GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex

GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination
directly activates: Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex

Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex
type: GO_0006415
BFO_0000050: Eukaryotic Translation Termination

Nuclear export of snRNA transcripts
type: GO_0051168
BFO_0000050: snRNP Assembly
directly activates: snRNP complex assembly

Loading and methylation of Sm proteins onto SMN Complexes
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: GO_0000387
type: GO_0016274
BFO_0000050: snRNP Assembly
directly activates: snRNP complex assembly

snRNP complex assembly
type: GO_0000387
BFO_0000050: snRNP Assembly
directly activates: snRNA Cap hypermethylation
directly activates: Catalysis224

snRNA Cap hypermethylation
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005829
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: Restriction
  on property: enabled by
  some values from: HCA137
type: GO_0000387
type: GO_0008173
BFO_0000050: snRNP Assembly
directly activates: snRNP:Snurportin complex formation

snRNP:Snurportin complex formation
type: GO_0000387
BFO_0000050: snRNP Assembly
directly activates: snRNP nuclear import and release
directly activates: Control48

snRNP nuclear import and release
type: GO_0051170
BFO_0000050: snRNP Assembly

IGF2BP1 Binds Specific RNA Molecules
type: GO_0003674
BFO_0000050: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

IGF2BP2 Binds Specific RNA Molecules
type: GO_0003674
BFO_0000050: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

IGF2BP3 Binds Specific RNA Molecules
type: GO_0003674
BFO_0000050: Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)

Degradation of Ub-SMAD7
type: GO_0003674
BFO_0000050: SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

Degradation of ubiquitinated SKI/SKIL
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Degradation of SMAD2/3:SMAD4 complex
type: GO_0003674
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: Restriction
  on property: BFO_0000066
  some values from: GO_0005654
type: GO_0004842
BFO_0000050: Downregulation of SMAD2/3:SMAD4 transcriptional activity

mRNA 3'-end processing
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Processing of Capped Intronless Pre-mRNA
type: GO_0008150
BFO_0000050: Gene Expression

SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

SLBP independent Processing of Histone Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

Processing of Intronless Pre-mRNAs
type: GO_0008150
BFO_0000050: Processing of Capped Intronless Pre-mRNA

Gene Expression
type: GO_0008150

Generic Transcription Pathway
type: GO_0008150
BFO_0000050: Gene Expression

Notch-HLH transcription pathway
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

Nuclear Receptor transcription pathway
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

YAP1- and WWTR1 (TAZ)-stimulated gene expression
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
type: GO_0008150
BFO_0000050: Generic Transcription Pathway

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
type: GO_0008150
BFO_0000050: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

Downregulation of SMAD2/3:SMAD4 transcriptional activity
type: GO_0008150
BFO_0000050: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
type: GO_0008150
BFO_0000050: Gene Expression

RNA Polymerase I Transcription
type: GO_0008150
BFO_0000050: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

RNA Polymerase I Promoter Clearance
type: GO_0008150
BFO_0000050: RNA Polymerase I Transcription

RNA Polymerase I Promoter Opening
type: GO_0008150
BFO_0000050: RNA Polymerase I Promoter Clearance

RNA Polymerase I Transcription Initiation
type: GO_0008150
BFO_0000050: RNA Polymerase I Promoter Clearance

RNA Polymerase I Promoter Escape
type: GO_0008150
BFO_0000050: RNA Polymerase I Promoter Clearance

RNA Polymerase I Chain Elongation
type: GO_0008150
BFO_0000050: RNA Polymerase I Transcription

RNA Polymerase I Transcription Termination
type: GO_0008150
BFO_0000050: RNA Polymerase I Transcription

RNA Polymerase III Transcription
type: GO_0008150
BFO_0000050: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

RNA Polymerase III Abortive And Retractive Initiation
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription

RNA Polymerase III Transcription Initiation
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription

RNA Polymerase III Transcription Initiation From Type 1 Promoter
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation From Type 2 Promoter
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription Initiation

RNA Polymerase III Transcription Initiation From Type 3 Promoter
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription Initiation

RNA Polymerase III Chain Elongation
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription

RNA Polymerase III Transcription Termination
type: GO_0008150
BFO_0000050: RNA Polymerase III Transcription

Transcription from mitochondrial promoters
type: GO_0008150
BFO_0000050: RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription

Mitochondrial transcription initiation
type: GO_0008150
BFO_0000050: Transcription from mitochondrial promoters

POLRMT chain elongation
type: GO_0003674
BFO_0000050: Transcription from mitochondrial promoters
directly activates: Mitochondrial transcription termination

Mitochondrial transcription termination
type: GO_0008150
BFO_0000050: Transcription from mitochondrial promoters

RNA Polymerase II Transcription
type: GO_0008150
BFO_0000050: Gene Expression

RNA Polymerase II Pre-transcription Events
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Initiation And Promoter Clearance
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Initiation
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Polymerase II Promoter Escape
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Initiation And Promoter Clearance

RNA Pol II CTD phosphorylation and interaction with CE
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

RNA Polymerase II Transcription Elongation
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

Formation of the Early Elongation Complex
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Elongation

Formation of RNA Pol II elongation complex
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Elongation

RNA Polymerase II Transcription Termination
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription

Cleavage of Growing Transcript in the Termination Region
type: GO_0008150
BFO_0000050: RNA Polymerase II Transcription Termination

mRNA Capping
type: GO_0008150
BFO_0000050: Gene Expression

Processing of Capped Intron-Containing Pre-mRNA
type: GO_0008150
BFO_0000050: Gene Expression

mRNA Splicing
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

U2 Dependent Splicing
type: GO_0008150
BFO_0000050: mRNA Splicing
label: mRNA Splicing - Major Pathway
label: pre-mRNA splicing

U12 Dependent Splicing
type: GO_0008150
BFO_0000050: mRNA Splicing
label: mRNA Splicing - Minor Pathway

Transport of Mature Transcript to Cytoplasm
type: GO_0008150
BFO_0000050: Processing of Capped Intron-Containing Pre-mRNA

Transport of Mature mRNA derived from an Intron-Containing Transcript
type: GO_0008150
BFO_0000050: Transport of Mature Transcript to Cytoplasm

Transport of Mature mRNAs Derived from Intronless Transcripts
type: GO_0008150
BFO_0000050: Transport of Mature Transcript to Cytoplasm

Transport of the SLBP Dependant Mature mRNA
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of the SLBP independent Mature mRNA
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

Transport of Mature mRNA Derived from an Intronless Transcript
type: GO_0008150
BFO_0000050: Transport of Mature mRNAs Derived from Intronless Transcripts

mRNA Editing
type: GO_0008150
BFO_0000050: Gene Expression

mRNA Editing: C to U Conversion
type: GO_0008150
BFO_0000050: mRNA Editing

Formation of the Editosome
type: GO_0008150
BFO_0000050: mRNA Editing: C to U Conversion

mRNA Editing: A to I Conversion
type: GO_0008150
BFO_0000050: mRNA Editing

Formation of editosomes by ADAR proteins
type: GO_0008150
BFO_0000050: mRNA Editing: A to I Conversion

C6 deamination of adenosine
type: GO_0008150
BFO_0000050: mRNA Editing: A to I Conversion

tRNA Aminoacylation
type: GO_0008150
BFO_0000050: Gene Expression

Cytosolic tRNA aminoacylation
type: GO_0008150
BFO_0000050: tRNA Aminoacylation

Mitochondrial tRNA aminoacylation
type: GO_0008150
BFO_0000050: tRNA Aminoacylation

Deadenylation-dependent mRNA decay
type: GO_0008150
BFO_0000050: Gene Expression

Deadenylation of mRNA
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

mRNA Decay by 3' to 5' Exoribonuclease
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

mRNA Decay by 5' to 3' Exoribonuclease
type: GO_0008150
BFO_0000050: Deadenylation-dependent mRNA decay

Nonsense-Mediated Decay
type: GO_0008150
BFO_0000050: Gene Expression

Nonsense Mediated Decay Enhanced by the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay

Nonsense Mediated Decay Independent of the Exon Junction Complex
type: GO_0008150
BFO_0000050: Nonsense-Mediated Decay

Regulatory RNA pathways
type: GO_0008150
BFO_0000050: Gene Expression

MicroRNA (miRNA) Biogenesis
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Small Interfering RNA (siRNA) Biogenesis
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Post-transcriptional Silencing By Small RNAs
type: GO_0008150
BFO_0000050: Regulatory RNA pathways

Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
type: GO_0008150
BFO_0000050: Gene Expression

Destabilization of mRNA by AUF1 (hnRNP D0)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by Tristetraprolin (TTP)
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Destabilization of mRNA by KSRP
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Stabilization of mRNA by HuR
type: GO_0008150
BFO_0000050: Regulation of mRNA Stability by Proteins that Bind AU-rich Elements

Translation
type: GO_0008150
BFO_0000050: Gene Expression

Eukaryotic Translation Initiation
type: GO_0008150
BFO_0000050: Translation

Cap-dependent Translation Initiation
type: GO_0008150
BFO_0000050: Eukaryotic Translation Initiation

Formation of a pool of free 40S subunits
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Formation of the ternary complex, and subsequently, the 43S complex
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Translation initiation complex formation
type: GO_0008150
BFO_0000050: Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S

Ribosomal scanning and start codon recognition
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

GTP hydrolysis and joining of the 60S ribosomal subunit
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Recycling of eIF2:GDP
type: GO_0008150
BFO_0000050: Cap-dependent Translation Initiation

Cap-independent Translation Initiation
type: GO_0003674
BFO_0000050: Eukaryotic Translation Initiation

SRP-dependent cotranslational protein targeting to membrane
type: GO_0008150
BFO_0000050: Translation

Eukaryotic Translation Elongation
type: GO_0008150
BFO_0000050: Translation

Peptide chain elongation
type: GO_0008150
BFO_0000050: Eukaryotic Translation Elongation

Eukaryotic Translation Termination
type: GO_0008150
BFO_0000050: Translation

Metabolism of non-coding RNA
type: GO_0008150
BFO_0000050: Gene Expression
label: Non-coding RNA Metabolism

snRNP Assembly
type: GO_0008150
BFO_0000050: Metabolism of non-coding RNA

Binding of RNA by Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs)
type: GO_0008150
BFO_0000050: Gene Expression

L13a-mediated translational silencing of Ceruloplasmin expression
type: GO_0008150
BFO_0000050: Eukaryotic Translation Initiation

Expression of CTGF
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Expression of NPPA (ANF)
type: GO_0003674
BFO_0000050: YAP1- and WWTR1 (TAZ)-stimulated gene expression

Pol II mediated transcription of microRNA genes
type: GO_0003674
BFO_0000050: MicroRNA (miRNA) Biogenesis
directly activates: Microprocessor complex cleaves pri-miRNA to pre-miRNA
directly activates: Catalysis197